Lifetime of knowledge can clutter memories of older adults

When a person tries to access a memory, their brain quickly sifts through everything stored in it to find the relevant information. But as we age, many of us have difficulty retrieving memories. In a review publishing in the journal Trends in Cognitive Sciences on February 11, researchers propose an explanation for why this might be happening: the brains of older adults allocate more space to accumulated knowledge and have more material to navigate when attempting to access memories. While this wealth of prior knowledge can make memory retrieval challenging, the researchers say it has its upsides — this life experience can aid with creativity and decision-making.

Researchers Tarek Amer (@tarekamerphd) of Columbia University and Harvard University, Jordana Wynn (@jordwynn) of Harvard University, and Lynn Hasher of the University of Toronto looked at several behavioral and neuroimaging studies, which show that older adults have difficulty suppressing information that is no longer relevant and that when searching for a specific memory, they often retrieve other, irrelevant memories along with it. The studies also showed that when given a cognitive task, older adults rely more heavily on previous knowledge than younger adults do.

While the researchers focus primarily on the difficulties that these cluttered memories may pose, they also highlight a few situations in which these crowded memoryscapes may be useful. “Evidence suggests that older adults show preserved, and at times enhanced, creativity as a function of enriched memories,” the researchers write. They further hypothesize that older adults may be well served by their prior knowledge when it comes to decision-making, where they can pull on their accumulated wisdom.

With continued study and increased understanding of how memory works in older adults, researchers are hopeful that they may be able to find new ways to help them. They write, “It is possible that the increased binding and richer encodings of older adults can even be leveraged to improve older adults’ learning and memory.”

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Materials provided by Cell Press. Note: Content may be edited for style and length.

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Researchers make non-alcoholic beer taste like regular beer

Some people find the taste to be flat and watery and this has a natural explanation, according to Sotirios Kampranis, a Professor at the University of Copenhagen.

“What non-alcoholic beer lacks is the aroma from hops. When you remove the alcohol from the beer, for example by heating it up, you also kill the aroma that comes from hops. Other methods for making alcohol-free beer by minimizing fermentation also lead to poor aroma because alcohol is needed for hops to pass their unique flavor to the beer,” he says.

But now, Kampranis and his colleague Simon Dusséaux – both founders of the biotech company EvodiaBio – have cracked the code of how to make non-alcoholic beer that is full of hop aroma.

“After years of research, we have found a way to produce a group of small molecules called monoterpenoids, which provide the hoppy-flavor, and then add them to the beer at the end of the brewing process to give it back its lost flavor. No one has been able to do this before, so it’s a game changer for non-alcoholic beer,” says Sotirios Kampranis.

Instead of adding expensive aroma hops in the brewing tank, just to “throw away” their flavor at the end of the process, the researchers have turned baker’s yeast cells into micro-factories that can be grown in fermenters and release the aroma of hops, they state in a newly published study.

“When the hop aroma molecules are released from yeast, we collect them and put them into the beer, giving back the taste of regular beer that so many of us know and love. It actually makes the use of aroma hops in brewing redundant, because we only need the molecules passing on the scent and flavor and not the actual hops,” explains Sotirios Kampranis.

A lot more sustainable

On top of improving the taste of non-alcoholic beer, the method is also far more sustainable than the existing techniques, according to the researchers.

First of all, aroma hops are mainly farmed in the west coast of the U.S., which causes the need for extensive transportation and cooling down the crops in refrigerators.

Secondly, hops demand lots of water – more accurately you need 2,7 tons of water to grow one kilogram of hops. This combined makes it a not very climate-friendly production.

 “With our method, we skip aroma hops altogether and thereby also the water and the transportation. This means that one kilogram of hops aroma can be produced with more than 10.000 times less water and more than 100 times less CO2,” says Sotirios Kampranis.

Good news for society

The researchers are pleased to be able to contribute to a much healthier lifestyle and hope that their new invention will help more people cut down on alcohol because now they will have equally delicious alternatives.

“Long term, we hope to change the brewing industry with our method – also the production of regular beer, where the use of aroma hops is also very wasteful,” concludes Sotirios Kampranis.

The method is already being tested in breweries in Denmark and the plan is to have the technique ready for the entire brewing industry in October 2022.

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This bizarre looking helmet can create better brain scans

It may look like a bizarre bike helmet, or a piece of equipment found in Doc Brown’s lab in Back to the Future, yet this gadget made of plastic and copper wire is a technological breakthrough with the potential to revolutionize medical imaging. Despite its playful look, the device is actually a metamaterial, packing in a ton of physics, engineering, and mathematical know-how.

It was developed by Xin Zhang, a College of Engineering professor of mechanical engineering, and her team of scientists at BU’s Photonics Center. They’re experts in metamaterials, a type of engineered structure created from small unit cells that might be unspectacular alone, but when grouped together in a precise way, get new superpowers not found in nature. Metamaterials, for instance, can bend, absorb, or manipulate waves — such as electromagnetic waves, sound waves, or radio waves. Each unit cell, also called a resonator, is typically arranged in a repeating pattern in rows and columns; they can be designed in different sizes and shapes, and placed at different orientations, depending on which waves they’re designed to influence.

Metamaterials can have many novel functions. Zhang, who is also a professor of electrical and computer engineering, biomedical engineering, and materials science and engineering, has designed an acoustic metamaterial that blocks sound without stopping airflow (imagine quieter jet engines and air conditioners) and a magnetic metamaterial that can improve the quality of magnetic resonance imaging (MRI) machines used for medical diagnosis.

Now, Zhang and her team have taken their work a step further with the wearable metamaterial. The dome-shaped device, which fits over a person’s head and can be worn during a brain scan, boosts MRI performance, creating crisper images that can be captured at twice the normal speed.

The helmet is fashioned from a series of magnetic metamaterial resonators, which are made from 3D-printed plastic tubes wrapped in copper wiring, grouped on an array, and precisely arranged to channel the magnetic field of the MRI machine. Placing the magnetic metamaterial — in helmet form or as the originally designed flat array — near the part of the body to be scanned, says Zhang, could make MRIs less costly and more time efficient for doctors, radiologists, and patients — all while improving image quality.

Eventually, the magnetic metamaterial has the potential to be used in conjunction with cheaper low-field MRI machines to make the technology more widely available, particularly in the developing world.

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Materials provided by Boston University. Original written by Jessica Colarossi. Note: Content may be edited for style and length.

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End of Covid regulations: What if I’m still worried?

What would ending isolation rules in England mean for people who are worried about getting Covid?

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My toddler died after swallowing a button battery

The family of Hugh McMahon say the battery burned a hole the size of a 5p coin in his heart.

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Luc Montagnier, co-discoverer of HIV, dies aged 89

The French virologist jointly won the Nobel Prize but later drew criticism for unscientific claims.

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‘Dental deserts’ with no NHS provision on the rise in England, MPs warn

Campaign group Toothless in England say the government is ignoring “acute needs” of the public.

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A ‘fairly simple’ breakthrough makes accessing stored hydrogen more efficient

A new catalyst from the U.S. Department of Energy’s Ames Laboratory and collaborators extracts hydrogen from hydrogen storage materials easily and efficiently. The process occurs at mild temperatures and under normal atmospheric conditions, without using metals or additives. The breakthrough offers a promising new solution that addresses a long-standing challenge to adopting hydrogen fuel for transportation and other applications.

Hydrogen fuel is one potential solution in the nationwide effort to decrease reliance on fossil fuels. According to the DOE, improving hydrogen storage is key to advancing hydrogen fuel cell technologies. At Ames Laboratory, scientists Long Qi and Wenyu Huang research the extraction of hydrogen from a class of materials called liquid organic hydrogen carriers, or LOHCs.

One of the ways to store hydrogen is chemically. Chemical storage relies on materials that react with hydrogen molecules and store them as hydrogen atoms, such as in LOHCs. This type of storage allows large amounts of hydrogen to be stored in small volumes at ambient temperatures. However, for the hydrogen to be useful, catalysts are needed to activate LOHCs and release the hydrogen. This process is called dehydrogenation.

Qi explained that currently there are other dehydrogenation methods, but they raise some challenges. Some methods rely on metal-based catalysts, which involve critical platinum group metals. Supplies of these metals are limited and expensive. Other methods require additives to release the hydrogen. The additives are not reusable and result in a higher overall cost because they need to be added in each cycle.

The catalyst Qi and Huang developed does not require metals or additives. “It’s fairly simple,” Qi said. “Basically, just add the metal-free catalyst into the LOHC, and then the hydrogen gas is just popping out, even at room temperature.”

The catalyst is composed of nitrogen and carbon. The key to its efficiency is the structure of the nitrogen. Catalytic activity can take place at room temperature because of the unique closely spaced graphitic nitrogens as nitrogen assembly which were formed during the carbonization process. The nitrogen assembly catalyzes the cleavage of carbon-hydrogen (C-H) bonds in LOHCs and facilitates the desorption of hydrogen molecules. This process is what makes the catalyst more efficient than other catalysts in use.

Qi and Huang explained that based on DOE goals for vehicle technologies, the hydrogen storage capacity needs to be close to 6.5% by weight. They are optimistic about the future of their research to meet the goal with molecules that have a larger capacity.

“This research will positively impact the target of reducing carbon dioxide emission,” Huang said, “and we will need to develop more efficient catalytic systems.”

In 2019, the transportation industry accounted for 29% of the overall carbon dioxide emissions in the U.S. Qi said that the ease and efficiency of this process could benefit the transportation industry in the future. The benefits come from a combination of using LOHCs and a catalyst like this one. The combination can extract usable hydrogen from storage at a lower cost and under milder conditions than current technologies. A greater hydrogen density can provide a greater charge for hydrogen fuel cells which could provide power to vehicles over greater distances.

Both Qi and Huang emphasized that this research is an important step to support the national mission to become carbon-neutral by 2050 by providing an easy and efficient way to dehydrogenate LOHCs.

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Materials provided by DOE/Ames Laboratory. Note: Content may be edited for style and length.

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JET fusion facility sets a new world energy record

European scientists have achieved a major success on the road to energy production through fusion plasmas: They produced stable plasmas with 59 megajoules of energy output at the world’s largest fusion facility, JET, in Culham near Oxford, UK. The team, which also includes researchers from the Max Planck Institute for Plasma Physics (IPP), used the fuel of future fusion power plants. These were the first experiments of their kind in the world in more than 20 years.

Following the example of the sun, fusion power plants aim to fuse the hydrogen isotopes deuterium and tritium and release large amounts of energy in the process. The only plant in the world currently capable of operating with such fuel is the European joint project JET, the Joint European Torus in Culham near Oxford, UK. However, the last experiments with the fuel for future fusion power plants were conducted there in 1997. Because tritium is a very rare raw material that also poses special handling challenges, research teams usually use hydrogen or deuterium for plasma experiments. In future power plants, tritium will be formed from lithium during energy production.

Experiments with deuterium-tritium mixtures in preparation for ITER

“We can explore the physics in fusion plasmas very well by working with hydrogen or deuterium, so this is the standard worldwide,” explains IPP’s Dr. Athina Kappatou, who with her IPP colleagues Dr. Philip Schneider and Dr. Jörg Hobirk led significant parts of the European collaborative experiments at JET.” However, for the transition to the international, large-scale, fusion experiment ITER, it is important that we prepare for the conditions prevailing there.” ITER is currently under construction in Cadarache, in southern France, and is expected to be able to release ten times as much energy as is fed into the plasma in terms of heating energy, using deuterium-tritium fuel.

To bring the JET experiment as close as possible to future ITER conditions, the previous carbon lining of the plasma vessel was replaced by a mixture of beryllium and tungsten, as is also planned for ITER, between 2009 and 2011. The metal tungsten is more resistant than carbon, which, moreover, stores too much hydrogen. However, the now metallic wall places new demands on the quality of the plasma control. The current experiments demonstrate the successes of the researchers: At temperatures ten times higher than those at the center of the sun, record levels of generated fusion energy have been achieved.

World record under ITER-like conditions

Prior to the change of the wall material, JET had set the world energy record in 1997 with a plasma that produced 22 megajoules of energy. This record stood until now. “In the latest experiments, we wanted to prove that we could create significantly more energy even under ITER-like conditions,” explains IPP physicist Dr. Kappatou. Several hundred scientists and researchers were involved in years of preparation for the experiments. They used theoretical methods to calculate in advance the parameters they needed to obtain to generate the plasma in order to achieve their goals. The experiments confirmed the predictions in late 2021 and delivered a new world record: JET produced stable plasmas with deuterium-tritium fuel that released 59 megajoules of energy.

To produce net energy — that is, to release more energy than the heatering systems provide — the experimental facility is too small. This will not be possible until the larger-scale ITER experiment in southern France comes online. “The latest experiments at JET are an important step toward ITER,” concludes Prof. Sibylle Günter, Scientific Director of the Max Planck Institute for Plasma Physics. “What we have learned in the past months will make it easier for us to plan experiments with fusion plasmas that generate much more energy than is needed to heat them.”

Background information: Megawatts vs. Megajoules

In the recent record-breaking experiment, the fusion reactions in JET released a total of 59 megajoules of energy in the form of neutrons during a five-second phase of a plasma discharge. Expressed in units of power (energy per time), JET achieved a power output of just over 11 megawatts averaged over five seconds. The previous energy record, set in 1997, was just under 22 megajoules of total energy and 4.4 megawatts of power averaged over five seconds.

About JET

JET was jointly designed and built by the members of the European fusion program EUROfusion and has been jointly operated since 1983. The English fusion center “Culham Centre for Fusion Energy” in Culham near Oxford is responsible for the technical operations, while temporarily seconded researchers and technicians from the EUROfusion laboratories work on the facility on a campaign basis. With numerous secondments, IPP is an important participant in the JET program.

About Max Planck Institute for Plasma Physics

The research conducted at the Max Planck Institute for Plasma Physics (IPP) in Germany (locations: Garching near Munich and Greifswald) is concerned with investigating the physical basis of a fusion power plant. Like the sun, such a plant aims to generate energy from fusion of atomic nuclei. IPP’s research is part of the European fusion program. With its workforce of approximately 1,100 IPP is one of the largest fusion research centers in Europe.

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New planet detected around Proxima Centauri, closest star our solar system

A team of astronomers using the European Southern Observatory’s Very Large Telescope (ESO’s VLT) in Chile have found evidence of another planet orbiting Proxima Centauri, the closest star to our Solar System. This candidate planet is the third detected in the system and the lightest yet discovered orbiting this star. At just a quarter of Earth’s mass, the planet is also one of the lightest exoplanets ever found.

“The discovery shows that our closest stellar neighbour seems to be packed with interesting new worlds, within reach of further study and future exploration,” explains João Faria, a researcher at the Instituto de Astrofísica e Ciências do Espaço, Portugal and lead author of the study published today in Astronomy & Astrophysics. Proxima Centauri is the closest star to the Sun, lying just over four light-years away.

The newly discovered planet, named Proxima d, orbits Proxima Centauri at a distance of about four million kilometres, less than a tenth of Mercury’s distance from the Sun. It orbits between the star and the habitable zone — the area around a star where liquid water can exist at the surface of a planet — and takes just five days to complete one orbit around Proxima Centauri.

The star is already known to host two other planets: Proxima b, a planet with a mass comparable to that of Earth that orbits the star every 11 days and is within the habitable zone, and candidate Proxima c, which is on a longer five-year orbit around the star.

Proxima b was discovered a few years ago using the HARPS instrument on ESO’s 3.6-metre telescope. The discovery was confirmed in 2020 when scientists observed the Proxima system with a new instrument on ESO’s VLT that had greater precision, the Echelle SPectrograph for Rocky Exoplanets and Stable Spectroscopic Observations (ESPRESSO). It was during these more recent VLT observations that astronomers spotted the first hints of a signal corresponding to an object with a five-day orbit. As the signal was so weak, the team had to conduct follow-up observations with ESPRESSO to confirm that it was due to a planet, and not simply a result of changes in the star itself.

“After obtaining new observations, we were able to confirm this signal as a new planet candidate,” Faria says. “I was excited by the challenge of detecting such a small signal and, by doing so, discovering an exoplanet so close to Earth.”

At just a quarter of the mass of Earth, Proxima d is the lightest exoplanet ever measured using the radial velocity technique, surpassing a planet recently discovered in the L 98-59 planetary system. The technique works by picking up tiny wobbles in the motion of a star created by an orbiting planet’s gravitational pull. The effect of Proxima d’s gravity is so small that it only causes Proxima Centauri to move back and forth at around 40 centimetres per second (1.44 kilometres per hour).

“This achievement is extremely important,” says Pedro Figueira, ESPRESSO instrument scientist at ESO in Chile. “It shows that the radial velocity technique has the potential to unveil a population of light planets, like our own, that are expected to be the most abundant in our galaxy and that can potentially host life as we know it.”

“This result clearly shows what ESPRESSO is capable of and makes me wonder about what it will be able to find in the future,” Faria adds.

ESPRESSO’s search for other worlds will be complemented by ESO’s Extremely Large Telescope (ELT), currently under construction in the Atacama Desert, which will be crucial to discovering and studying many more planets around nearby stars.

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Materials provided by ESO. Note: Content may be edited for style and length.

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