Why Bigger Goals Can Be Easier to Achieve

I originally shared this post on January 6 in Conscious Growth Club’s member forums, as a follow-up to our quarterly goal planning process. I thought it would be nice to share it here as well. Many CGCers found it helpful.

Let me share an unusual insight about why it’s often easier to achieve goals that seem bigger than anything you’ve done before.

This builds upon the Chapter 1 vs Chapter 2 idea shared on yesterday’s review call, but I don’t think you need to have heard that part to understand this.

[The idea I shared on the review call was based on a common piece of advice for new fiction writers – that you should delete whatever you wrote for Chapter 1 and begin your book with Chapter 2. This is because your original Chapter 1 will typically include too much backstory and exposition, and it’s frequently better to get into the juicy parts of your story sooner. I used this as an analogy for setting goals, suggesting that people ought to skip past the Chapter 1 version of their goals (which often involve overly mental or numbers-based framing – boring!) and get into the juicy parts of Chapter 2 and beyond by focusing on the meaning, ripples, and emotional journey.]

Acknowledging Your Old Story

When I was in my scarcity phase of life, I was very sensitive to prices. Since money was tight, I saw anything free as so much better than anything paid. If something cost $5, that would feel sooooo different than free. Even $1 vs free was a big deal. If I would buy a veggie sandwich at Subway, I would skip the avocado for $1 extra, even though I loved avocado. Would that $1 difference really matter? It felt like it mattered.

There’s still a part of my mind that thinks this way today because I conditioned it to think that way in the past. But it’s also linked up with relatively low-cost expenses because that was my training data set at the time.

As my income increased, I formed different associations to more expensive items. So part of my mind still wants to run extra assessment cycles over the difference between a $5 and $10 option, but when I think about a $500 vs $1000 expense, those land in my abundance training data set, so that seems easy because I don’t have major negative associations to those kinds of expenses. Consequently, it feels like $500 expenses are cheaper than $5 ones because I have less resistance to spending an extra $500 than I do to spending $5.

Same thing goes for taxes. Paying a $50K tax bill seems easy. Paying a $1K tax bill seems more painful. Those two tax bills are associated with different training sets and different chapters of my life.

Even today I will often think more about whether a $5 expense is worth it, but I can spend $500 like it’s just free money.

This also applies to the income side. It feels difficult to try to earn an extra $100. But earning an extra $20K or $50K is easy, and earning an extra $100K just seems fun and flowing. And I think that’s because with respect to those numbers, I’m not struggling with past associations getting in my way.

So that’s an interesting oddity about moving into a fresh Chapter 2 reality. It gives you a chance to break through your old associations and write a new story for your character.

Stretching Your Intentionality

Trying to fight or overcome my character’s pre-trained tendencies keeps me stuck in Chapter 1. But if I skip ahead to Chapter 2 in my imagination, there’s a blank page where I can write something new, if I’m willing to take the leap into unexplored territory.

This is one reason it’s so important and useful to stretch your intentionality further forward. Stretch beyond the story that’s already been written by your past, and extend your mind and goals into open spaces. You can often make much faster progress that way.

This requires the willingness to stretch your character and identity. Can you start seeing yourself as a different person? It helps if you’re able to stretch your character into some unexplored territory where you can begin writing some fresh story, so you can bypass some constraints of your past story.

It’s a bit like moving to a new city or going to a new school. If no one in the new territory knows you as your past self, you have more freedom to write a fresh story. I felt like I became a different person each time I had a significant move or school change. Same goes for getting into a new social circle.

It’s extra crucial to connect with a social group that gives you room to grow and that won’t keep associating you with your Chapter 1 self. It’s best to loosen up those connections that will resist your efforts to write some fresh story for your character. I think we do a good job of this in CGC by fostering a culture that encourages exploration and change, not tying anyone to stick with their past selves. You probably won’t find many members here who’d try to talk you out of writing a fresh chapter of your life story, but I know that some members struggle with other social connections that resist those kinds of changes.

Keep in mind (and in heart) that when you break free and begin writing your Chapter 2 story, you encourage others to do the same, even if they may initially resist what you’re doing. You’re not really serving anyone by clinging to Chapter 1.

The Power of Unwritten Story

One pattern I see frequently in people who have some great transformational breakthroughs is that they stop focusing their attention where the resistance is, and they head for fresh territory. They start writing their new story where the story hasn’t been written yet.

Chapter 1 is the story of the old reality. That’s where all the problems and difficulties are. It’s so tempting to focus your attention there by saying, “I need to clear all of this out, and then I can begin writing Chapter 2.” But that will almost always keep you stuck in Chapter 1, which will just keep generating more of the same kinds of problems to anchor you there. You’ll probably never make it to Chapter 2 with that approach. Usually life doesn’t reward this approach very well either. You probably won’t get much cooperation, so you’ll have to self-power your way through every little problem and project, which becomes exhausting after a while. I really don’t recommend this.

It seems like a cheat to start writing Chapter 2 before you’ve finished Chapter 1, but is it really? If you were writing a novel or a movie script, would your best inspiration and motivation come from writing about the old reality? Do you think George Lucas got inspired to write Star Wars by thinking about a farmer boy with some droids? Did he finish writing Chapter 1 before giving much thought to what would come next? Seriously… who finds the inspiration for great story from anything in Chapter 1? You may begin writing there, but the inspiration for the story comes from much further along.

When people focus on Chapter 1 goals – the telltale signs being that the goals are super objective (often numbers-based), lack motivational fire, and don’t involve any meaningful character or identity shifts – they usually don’t get very far with them. And they often wonder what’s the point. And they’re right. There’s little point in working on such goals. It’s like watching Luke Skywalker setting quarterly goals to optimize the farm.

You’re munching on your popcorn watching Luke on the screen, and your mind is wondering when the real story will begin because you know that you’re just seeing the pre-transformational backstory during the first several minutes.

And oddly it’s easier for Luke to become a Jedi than it would be for him to optimize the farm. When he leaves Tatooine, he’s free to write fresh story. While his new reality may seem more daunting, it’s also 100X more motivating, and that makes all the difference in the galaxy.

He still, however, takes his (newest) farm droids with him on his new journey, so he doesn’t entirely break free from his past. But that doesn’t matter because he’s writing such a completely different story that the droids can’t offer any meaningful resistance. They get swept up in his new story too and become helpful allies. C3PO’s whining serves as humor and to remind us how much Luke has grown, but C3PO is powerless to derail Luke’s new story.

I find that to be the case in real life as well. When writing fresh story, I still carry elements of the past with me, but they no longer serve as anchors to resistance. The new story gives those old story elements new meaning. For instance, fretting over a $5 expense serves as a reminder to appreciate abundance and not to take it for granted, and that actually sweetens the experience. It also makes it easy to relate to people who struggle with finances because that mode of thinking is still with me. I wrote some extra script after that part of my story, but scarcity thinking is still part of my story. The scarcity mindset plays a different role now, anchoring to gratitude and compassion instead of to resistance and frustration. Sometimes I think of it as cute, much as you could see R2D2 in that way.

Finding Your Best Motivational Fuel

Chapter 1 doesn’t provide the motivational fuel to get through Chapter 1. That fuel comes from hooking your body, mind, heart, and spirit into Chapter 2 and beyond. Once you anchor your intentions into your new reality and your new identity, your perspective on Chapter 1 will shift. How this plays out is different for everyone, but it generally involves finding shortcuts that speed you through Chapter 1 and/or realizing that some of the old problems don’t even need to be solved or dealt with anymore.

Did Luke ever go back to Tatooine and wrap up his affairs with the farm? Did he inherit the place from his uncle and aunt after they died? Did the Empire seize it for unpaid taxes? Did he turn it into a rebel burner commune? Does it matter?

It’s hard to find people who regret getting into their Chapter 2 story, even when the transition out of Chapter 1 is messy and inelegant (which it usually is). The #1 regret is that people wish they’d done it sooner, often many years sooner. People regret spending so much time figuring out, optimizing, and trying to advance their Chapter 1 story. In retrospect, they look back and wonder why it took them so long to progress to the juiciest and most engaging parts of their story arc. In many cases they waited until life kicked them out of Chapter 1, and they were forced by circumstances to finally get into Chapter 2, but then it wasn’t the Chapter 2 experience they’d have chosen if they’d done it more consciously and deliberately.

Look at your goals and ask yourself if you’re drawing motivation, inspiration, and story progression from Chapter 2 and beyond… or if you’re still trying to optimize the farm. You can tinker on the farm – that’s your choice – but life won’t likely open up the floodgates of support and synchronous aid till you make a more interesting story pitch.

Your own body is unlikely to cooperate much with a Chapter 1 story pitch either. It probably won’t fill your heart with the best motivation and your mind with the best idea flow until you give it a compelling reason to amp up the energy flow. That compelling reason won’t be found in Chapter 1.

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Covid: Plan to tackle England’s NHS backlog delayed

The health secretary denies the full plan has been held back because of an intervention by the Treasury.

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Tinnitus biobank needed to explain ringing ears condition

A charity says a biobank library of human tissue is needed so experts can try to cure tinnitus.

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Strobe light for 5G: Imaging system spotlights the tiny mechanical hearts at the core of every cellphone

Inside every cellphone lies a tiny mechanical heart, beating several billion times a second. These micromechanical resonators play an essential role in cellphone communication. Buffeted by the cacophony of radio frequencies in the airwaves, these resonators select just the right frequencies for transmitting and receiving signals between mobile devices.

With the growing importance of these resonators, scientists need a reliable and efficient way to make sure the devices are working properly. That’s best accomplished by carefully studying the acoustic waves that the resonators generate.

Now, researchers at the National Institute of Standards and Technology (NIST) and their colleagues have developed an instrument to image these acoustic waves over a wide range of frequencies and produce “movies” of them with unprecedented detail.

The researchers measured acoustic vibrations as rapid as 12 gigahertz (GHz, or billions of cycles per second) and may be able to extend those measurements to 25 GHz, providing the necessary frequency coverage for 5G communications as well as for potentially powerful future applications in quantum information.

The challenge of measuring these acoustic vibrations is likely to increase as 5G networks dominate wireless communications, generating even tinier acoustic waves.

The new NIST instrument captures these waves in action by relying on a device known as an optical interferometer. The illumination source for this interferometer, ordinarily a steady beam of laser light, is in this case a laser that pulses 50 million times a second, which is significantly slower than the vibrations being measured.

The laser interferometer compares two pulses of laser light that travel along different paths. One pulse travels through a microscope that focuses the laser light on a vibrating micromechanical resonator and is then reflected back. The other pulse acts as a reference, traveling along a path that is continually adjusted so that its length is within a micrometer (one millionth of a meter) of the distance traveled by the first pulse.

When the two pulses meet, the light waves from each pulse overlap, creating an interference pattern — a set of dark and light fringes where the waves cancel or reinforce one another. As subsequent laser pulses enter the interferometer, the interference pattern changes as the microresonator vibrates up and down. From the changing pattern of the fringes, researchers can measure the height (amplitude) and phase of the vibrations at the location of the laser spot on the micromechanical resonator.

NIST researcher Jason Gorman and his colleagues deliberately chose a reference laser that pulses between 20 and 250 times more slowly than the frequency at which the micromechanical resonator vibrates. That strategy enabled the laser pulses illuminating the resonator to, in effect, slow down the acoustic vibrations, similar to the way that a strobe light appears to slow down dancers in a nightclub.

The slowdown, which converts acoustic vibrations that oscillate at GHz frequencies to megahertz (MHz, millions of cycles per second), is important because the light detectors used by the NIST team operate much more precisely, with less noise, at these lower frequencies.

“Moving to lower frequencies removes interference from communication signals typically found at microwave frequencies and allows us to use photodetectors with lower electrical noise,” said Gorman.

Each pulse lasts only 120 femtoseconds (quadrillionths of a second), providing highly precise moment-to-moment information on the vibrations. The laser scans across the micromechanical resonator so that the amplitude and phase of the vibrations can be sampled across the entire surface of the vibrating device, producing high-resolution images over a wide range of microwave frequencies.

By combining these measurements, averaged over many samples, the researchers can create three-dimensional movies of a microresonator’s vibrational modes. Two types of microresonators were used in the study; one had dimensions of 12 micrometers (millionths of a meter) by 65 micrometers; the other measured 75 micrometers on a side — about the width of a human hair.

Not only can the images and movies reveal whether a micromechanical resonator is operating as expected, they can also indicate problem areas, such as places where acoustic energy is leaking out of the resonator. The leaks make resonators less efficient and lead to loss of information in quantum acoustic systems. By pinpointing problematic areas, the technique gives scientists the information they need to improve resonator design.

In the Feb. 4, 2022, edition of Nature Communications, the researchers reported that they could image acoustic vibrations that have an amplitude (height) as small as 55 femtometers (quadrillionths of a meter), about one-five-hundredth the diameter of a hydrogen atom.

Over the past decade, physicists have suggested that micromechanical resonators in this frequency range may also serve to store fragile quantum information and to transfer the data from one part of a quantum computer to another.

Establishing an imaging system that can routinely measure micromechanical resonators for these applications will require further research. But the current study is already a milestone in assessing the ability of micromechanical resonators to accurately perform at the high frequencies that will be required for effective communication and for quantum computing in the near future, Gorman said.

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Preventing pandemics costs far less than controlling them

We can pay now or pay far more later. That’s the takeaway of a new peer-reviewed study, published Feb. 4 in the journal Science Advances, that compares the costs of preventing a pandemic to those incurred trying to control one.

“It turns out prevention really is the best medicine,” said Stuart Pimm, Doris Duke Professor of Conservation Ecology at Duke University, who was co-lead author of the study. “We estimate we could greatly reduce the likelihood of another pandemic by investing as little as 1/20th of the losses incurred so far from COVID into conservation measures designed to help stop the spread of these viruses from wildlife to humans in the first place.”

A smart place to start, the study shows, would be investing in programs to end tropical deforestation and international wildlife trafficking, stop the wild meat trade in China, and improve disease surveillance and control in wild and domestic animals worldwide.

COVID, SARS, HIV, Ebola and many other viruses that have emerged in the last century originated in wild places and wild animals before spreading to humans, the study’s authors note. Tropical forest edges where humans have cleared more than 25% of the trees for farming or other purposes are hotbeds for these animal-to-human virus transmissions, as are markets where wild animals, dead or alive, are sold.

“The bottom line is, if we don’t stop destroying the environment and selling wild species as pets, meat or medicine, these diseases are just going to keep coming. And as this current pandemic shows, controlling them is inordinately costly and difficult,” Pimm said. “It’s been two years since COVID emerged and the cure still isn’t working. Not enough people are vaccinated in the U.S, where shots are available and we can afford them, and not enough vaccines are going to other countries that can’t afford them.”

The new study, by epidemiologists, economists, ecologists, and conservation biologists at 21 institutions, calculates that by investing an amount equal to just 5% of the estimated annual economic losses associated with human deaths from COVID into environmental protection and early-stage disease surveillance, the risks of future zoonotic pandemics could be reduced by as much as half. That could help save around 1.6 million lives a year and reduce mortality costs by around $10 trillion annually.

“We’re talking about an investment of tens of billions of dollars a year. Government have that kind of money,” Pimm said.

One key recommendation of the new study is to use some of this money to train more veterinarians and wildlife disease biologists.

Another key recommendation is to create a global database of virus genomics that could be used to pinpoint the source of newly emerging pathogens early enough to slow or stop their spread, and, ultimately, speed the development of vaccines and diagnostic tests.

Aaron Bernstein of Boston Children’s Hospital and the Center for Climate, Health and the Global Environment at Harvard T.H. Chan School of Public Health, and Andrew Dobson of Princeton University were co-lead authors of the study with Pimm.

The need to put preventive measures in place as soon as possible is increasingly urgent, said Dobson. “Epidemics are occurring more frequently, they are getting larger, and spreading to more continents.”

“Prevention is much cheaper than cures,” noted Bernstein. Compared to the costs and social and economic disruptions associated with trying to control pathogens after they have already spread to humans, “preventing epidemics before they break out is the ultimate economic bargain.”

Researchers at 17 additional universities, medical centers, environmental nonprofits or government agencies in the United States, China, Brazil, South Africa, and Kenya coauthored the study.

The coauthors include Binbin V. Li, assistant professor of environmental science at Duke Kunshan University in China, who holds a secondary appointment at Duke’s Nicholas School of the Environment.

Funding for the study came from Johnson & Johnson; the U.S. Department of Agriculture; the Norwegian Agency for Development Cooperation; Brazil’s National Institute for Scientific and Technological Development; the U.S. Agency for International Development, and the National Natural Science Foundation of China.

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The abyssal world: Last terra incognita of the Earth surface

The first unified vision of the world ocean biodiversity, based on analysis of DNA sequences from the surface to deep-ocean sediments, unveils the rich and unknown life in the abyssal realm, the last terra incognita of the Earth surface. This collective effort was made possible by 15 international deep-sea expeditions, including scientists from MARUM.

The deep-ocean floor is the least explored ecosystem on the planet, despite covering more than 60% of the Earth surface. Largely unknown life in abyssal sediments, from benthic animals to microbes, helps to recycle and/or sequester the sinking (in)organic matter originating from pelagic communities that are numerically dominated by microscopic plankton. Benthic ecosystems thus underpin two major ecosystem services of planetary importance: the healthy functioning of ocean food-webs and the burial of carbon on geological timescales, both of which are critical regulators of the Earth climate. Researchers from the Norwegian Research Centre (NORCE), Bjerknes Centre for Climate research, the University of Geneva, as well as from the CNRS/Genoscope and IFREMER in France, have massively sequenced eukaryotic DNA contained in deep-sea sediments from all major oceanic basins, and compared these new data to existing global-scale plankton datasets from the sunlit and dark water column, obtained by the Tara Oceans and Malaspina circumglobal expeditions. This provides the first unified vision of the full ocean eukaryotic biodiversity, from the surface to the deep-ocean sediment, allowing marine ecological questions to be addressed for the first time at a global scale and across the three-dimensional space of the ocean, representing a major step towards “One Ocean ecology.”

“With nearly 1700 samples and two billion DNA sequences from the surface to the deep-ocean floor worldwide, high-throughput environmental genomics vastly expands our capacity to study and understand deep-sea biodiversity, its connection to the water masses above and to the global carbon cycle,” says Tristan Cordier, Researcher at NORCE and Bjerknes Centre for Climate Research, Norway, and lead author of the study.

What lives in this dark and hostile environment?

By comparing sediment DNA sequences with the ones from pelagic realms, it was possible to distinguish indigenous benthic organisms from sinking plankton that had reached the seafloor from the overlying water column. Results indicate that this benthic biodiversity could be three times larger than in the water masses above; and this diversity is composed of very different taxonomic groups that are mostly unknown.

“We compared our deep-sea benthic DNA sequences to all references sequences available for known eukaryotes. Our data indicates that nearly two third of this benthic diversity cannot be assigned to any known group, revealing a major gap in our knowledge of marine biodiversity,” says Jan Pawlowski, Professor at the Department of Genetics and Evolution of the University of Geneva and at the Institute of Oceanology of the Polish Academy of Sciences in Sopot.

What can plankton DNA in deep-sea sediments tell us?

Analysis of the abundance and composition of plankton DNA in deep-sea sediments confirmed that polar regions are hotspots of carbon sequestration. Moreover, the composition of the plankton DNA in sediments predicts the variation of the strength of the biological pump, an ecosystem process that transfer atmospheric carbon dioxide into the deep ocean, hence regulating the global climate.

“For the first time, we can understand which members of plankton communities are contributing most to the biological pump, arguably the most fundamental ecosystem processes in the oceans,” says Colomban de Vargas, Researcher at CNRS in Roscoff, France.

How will the deep-sea be impacted by global changes?

This genomic dataset represents the first consistent snapshot of whole eukaryotic diversity in the modern ocean. It provides a unique opportunity to reconstruct ancient oceans from the DNA contained in the cumulative sediment record, to assess how climate has impacted plankton and benthic communities in the past.

“Our data will not only address global-scale questions on the biodiversity, biogeography and connectivity of marine eukaryotes. It can also serve as a basis to reconstruct the past functioning of the biological pump from ancient sedimentary DNA archives. It would then inform on its future strength in a warmer ocean, which is key for modelling the future carbon cycle under climate change,” explains Tristan Cordier.

“Our study further demonstrates that deep-sea biodiversity research is of paramount importance. Huge numbers of unknown organisms inhabit ocean-floor sediments and must play a fundamental role in ecological and biogeochemical processes. A better knowledge of this rich diversity is crucial if we are to protect these vast, relatively pristine ecosystems from the impacts of possible future human incursions and understand the effects on it of climate change,” concludes Andrew J. Gooday, Emeritus Fellow at the National Oceanography Centre, Southampton, who was also involved in the research.

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Discovery unravels how atomic vibrations emerge in nanomaterials

A hundred years of physics tells us that collective atomic vibrations, called phonons, can behave like particles or waves. When they hit an interface between two materials, they can bounce off like a tennis ball. If the materials are thin and repeating, as in a superlattice, the phonons can jump between successive materials.

Now there is definitive, experimental proof that at the nanoscale, the notion of multiple thin materials with distinct vibrations no longer holds. If the materials are thin, their atoms arrange identically, so that their vibrations are similar and present everywhere. Such structural and vibrational coherency opens new avenues in materials design, which will lead to more energy efficient, low-power devices, novel material solutions to recycle and convert waste heat to electricity, and new ways to manipulate light with heat for advanced computing to power 6G wireless communication.

The discovery emerged from a long-term collaboration of scientists and engineers at seven universities and two U.S. Department of Energy national laboratories. Their paper, Emergent Interface Vibrational Structure of Oxide Superlattices, was published January 26 in Nature.

Eric Hoglund, a postdoctoral researcher at the University of Virginia School of Engineering and Applied Science, took point for the team. He earned his Ph.D. in materials science and engineering from UVA in May 2020 working with James M. Howe, Thomas Goodwin Digges Professor of materials science and engineering. After graduation, Hoglund continued working as a post-doctoral researcher with support from Howe and Patrick Hopkins, Whitney Stone Professor and professor of mechanical and aerospace engineering.

Hoglund’s success illustrates the purpose and potential of UVA’s Multifunctional Materials Integration Initiative, which encourages close collaboration among different researchers from different disciplines to study material performance from atoms to applications.

“The ability to visualize atomic vibrations and link them to functional properties and new device concepts, enabled by collaboration and co-advising in materials science and mechanical engineering, advances MMI’s mission,” Hopkins said.

Hoglund employed microscopy techniques to answer questions raised in experimental results Hopkins published in 2013, reporting on thermal conductivity of superlattices, which Hoglund likens to a Lego building block.

“You can achieve desired material properties by changing how different oxides couple to each other, how many times the oxides are layered and the thickness of each layer,” Hoglund said.

Hopkins expected the phonon to get resistance as it traveled through the lattice network, dissipating thermal energy at each interface of the oxide layers. Instead, thermal conductivity went up when the interfaces were really close together.

“This led us to believe that phonons can form a wave that exists across all subsequent materials, also known as a coherent effect,” Hopkins said. “We came up with an explanation that fit the conductivity measurements, but always felt this work was incomplete.”

“It turns out, when the interfaces become very close, the atomic arrangements unique to the material layer cease to exist,” Hoglund said. “The atom positions at the interfaces, and their vibrations, exist everywhere. This explains why nanoscale-spaced interfaces produce unique properties, different from a linear mixture of the adjoining materials.”

Hoglund collaborated with Jordan Hachtel, an R&D associate in the Center for Nanophase Materials Sciences at Oak Ridge National Laboratory, to connect local atomic structure to vibrations using new generations of electron microscopes at UVA and Oak Ridge. Working with high-spatial-resolution spectroscopic data, they mapped interlayer vibrations across interfaces in a superlattice.

“That’s the major advance of the Nature paper,” Hopkins said. “We can see the position of atoms and their vibrations, this beautiful image of a phonon wave based on a certain pattern or type of atomic structure.”

The Collaborative Trek to Collective Success

The highly collaborative effort began in 2018 when Hoglund was sharing research plans to characterize atomic vibrations at interfaces in perovskite oxides.

“I was going to Oak Ridge to work with Jordan for a week, so Jim and Patrick suggested I take the superlattice samples and just see what we can see,” Hoglund recalled. “The experiments that Jordan and I did at Oak Ridge boosted our confidence in using superlattices to measure vibrations at the atomic or nano-scale.”

During one of his later trips to Tennessee, Hoglund met up with Joseph R. Matson, a Ph.D. student conducting related experiments at Vanderbilt University’s Nanophotonic Materials and Devices laboratory led by Joshua D. Caldwell, the Flowers Family Chancellor Faculty Fellow and associate professor of mechanical engineering and electrical engineering. Using Vanderbilt’s instruments, they conducted Fourier-transform infrared spectroscopy experiments to probe optical vibrations in the entire superlattice. These well-established macroscopic measurements validated Hoglund’s novel microscopy approach.

From these experiments, Hoglund deduced that the properties he cared about — thermal transport and infrared response — stemmed from the interface’s influence on the superlattice’s well-ordered framework of oxygen atoms. The oxygen atoms arrange themselves in an eight-sided structure called an octahedra, with a metal atom suspended inside. The interaction between oxygen and metal atoms causes the octahedra to rotate across the material structure. The oxygen and metal arrangements in this framework generate the unique vibrations and give rise to the material’s thermal and spectral properties.

Back at UVA, Hoglund’s chance conversation with Jon Ihlefeld, associate professor of materials science and engineering and electrical and computer engineering, brought additional members and expertise to the effort. Ihlefeld mentioned that researchers affiliated with Sandia National Laboratories, Thomas Beechem, associate professor of mechanical engineering at Purdue University, and Zachary T. Piontkowski, a senior member of Sandia’s technical staff, were also trying to explain the optical behavior of phonons and had likewise found the exact same oxide superlattices to be an ideal material for their study.

Coincidentally, Hopkins had an ongoing research collaboration with Beechem, albeit with other material systems. “Rather than competing, we agreed to work together and make this something bigger than either of us,” Hoglund said.

Beechem’s involvement had an added benefit, bringing Penn State physicist and materials scientist Roman Engel-Herbert and his student Ryan C. Haisimaier into the partnership to grow material samples for the microscopy experiments underway at UVA, Oak Ridge and Vanderbilt. Up to this point, Ramamoorthy Ramesh, University of California, Berkeley, professor of physics and materials science and engineering, and his Ph.D. students Ajay K. Yadav and Jayakanth Ravichandran were the growers on the team, providing samples to Hopkins’ ExSiTE research group.

“We realized we had all of this really neat experimental data connecting vibrations at atomic and macroscopic length scales, but all of our explanations were still somewhat conjectures that we could not prove absolutely without theory,” Hoglund said.

Hachtel reached out to Vanderbilt colleague Sokrates T. Pantelides, University Distinguished Professor of Physics and Engineering, William A. & Nancy F. McMinn professor of physics, and professor of electrical engineering. Pantelides and his research group members De-Liang Bao and Andrew O’Hara employed density functional theory to simulate atomic vibrations in a virtual material with a superlattice structure.

Their theoretical and computational methods supported exactly the results produced by Hoglund and other experimentalists on the team. The simulation also enabled the experimentalists to understand how every atom in the superlattice vibrates with high precision and how this was related to structure.

At this point, the team had 17 authors: three microscopists, four optical spectroscopists, three computational scientists, five growers and two material scientists. It was time, they thought, to share their findings with the scientific community at large.

An initial peer reviewer of their manuscript advised the team to establish a more direct, causal connection between material structure and material properties. “We measured some cool new phenomena making connections over multiple length scales that should affect material properties, but we had not yet convincingly demonstrated whether and how the known properties changed,” Hoglund said.

Two graduate students in Hopkins’ ExSiTE lab, senior scientist John Tomko and Ph.D. student Sara Makarem, helped provide the final proof. Tomko and Makarem probed the superlattices using infrared lasers and demonstrated that the structure controlled non-linear optical properties and the lifetime of phonons.

“When you send in a photon of one unit of energy, the superlattices double that unit of energy,” Hopkins said. “John and Sara built a new capability in our lab to measure this effect, which we express as the second harmonic generation efficiency of these superlattices.” Their contribution expands the ExSiTE lab capabilities to understand new light-phonon interactions.

“I think this will enable advanced materials discovery,” Hopkins said. “Scientists and engineers working with other classes of materials may now look for similar properties in their own studies. I fully expect we will find that these phonon waves, this coherent effect, exists in a lot of other materials.”

The long-standing collaboration continues. Hoglund is in his second year as a postdoctoral researcher, working with both Howe and Hopkins. Together with Pantelides, Hachtel and Ramesh, he expects they will have new and exciting atomic structure-vibration ideas to share in the near future.

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RNA ‘heroes’ can disarm bad-actor proteins in leukemia

Scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) believe it may be possible to prevent DNA changes driven by two proteins highly active in leukemia and other cancers. They reported a new mechanistic target for drug development Jan. 21 in the journal eLife.

The proteins, called METTL-3 and METTL-14, can alter the chemical structure of DNA — the molecular vault in cells that stores a person’s genetic information. This is a new understanding, said article senior author Yogesh Gupta, PhD, assistant professor of biochemistry at UT Health San Antonio’s Greehey Children’s Cancer Research Institute. For 27 years since the discovery of METTL-3 and -14, scientists believed that the proteins could only alter a separate molecule called RNA, but not DNA, he said.

RNA molecules, which float inside cells either reading out DNA instructions to make proteins or influencing this process indirectly, can form different shapes such as hairpins. Dr. Gupta, lead author; Shan Qi, a PhD student in the Gupta lab; and the team observed that RNA of a certain structure like a hairpin can act as a glue that binds to METTL-3 and -14, preventing it from changing DNA’s chemical structure.

“It is a desirable therapeutic target,” Dr. Gupta said. “By uncovering the DNA-altering function of METTL-3 and -14 and learning that it can be regulated by certain RNAs, we provided information that will help in drug discovery research.

“Our next step is to understand DNA, RNA and METTL-3 and -14 interaction so that we can identify the areas on the proteins for the purpose of drug development,” he said.

This work was supported by the Max and Minnie Tomerlin Voelcker Fund, the Cancer Prevention & Research Institute of Texas, the Institute for Integration of Medicine and Science/Clinical and Translational Science Award, the Greehey Children’s Cancer Research Institute, The University of Texas System and the National Institute of Allergy and Infectious Diseases (1R01AI161363).

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Materials provided by University of Texas Health Science Center at San Antonio. Original written by Will Sansom. Note: Content may be edited for style and length.

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Making metal–halide perovskites useful in planar devices through a new hybrid structure

Metal halide perovskites (MHPs) are a class of materials with promising properties for semiconductor applications, such as thin-film transistors (TFTs). In particular, tin (Sn)-based MHPs could be an environmentally benign alternative to lead-based ones, which are toxic. However, some critical issues need to be resolved before Sn-based MHPs can be leveraged in planar semiconductor devices.

When arranged into a 2D structure (or quasi-2D structure with a few layers), defects in the crystal structure of Sn-based MHPs called “grain boundaries” hamper the mobility of charge carriers throughout the material. If used in a TFT, this phenomenon results in a large series resistance that ultimately degrades performance. In contrast, a TFT made using an Sn-based MHP arranged into a 3D structure faces a different yet still crippling problem. The extremely high carrier density of the 3D material causes the transistor to be permanently ON unless very high voltages are applied. Needless to say, this renders such a device useless for many applications.

Fortunately, a team of scientists from Tokyo Tech, Japan, have found a solution to these limitations. In a recent study published in Advanced Scienceand led by Assistant Professor Junghwan Kim and Honorary Professor Hideo Hosono, the researchers proposed a novel concept based on a hybrid structure for Sn-based MHPs, called the “2D/3D core-shell structure.” In this structure, 3D MHP cores are fully isolated from one another and connected only through short 2D MHP strips (or “shells”). This alternating arrangement solves both of the abovementioned drawbacks simultaneously. But how?

The trick to lowering the series resistance of 2D MHPs is to eliminate the carrier mobility problems at grain boundaries, which are caused by misalignments between the conductive octahedra of the perovskite. Thanks to the way in which the 3D cores connect to the 2D segments, these misalignments disappear and the series resistance is greatly lowered. As for the high carrier density of 3D MHPs, this problem is simply not present when using the 2D/3D core-shell structure. Since the 3D cores are isolated, their carrier density is no longer relevant; instead, the 2D segments act as a bottleneck and limit the effective carrier density of the overall material.

To demonstrate the effectiveness of this novel structure, the team fabricated a complementary metal-oxide-semiconductor (CMOS) inverter by combining 2D/3D TFTs with a standard indium gallium zinc oxide TFT. “Our device exhibited a high voltage gain of 200 V/V at a drain voltage of 20 V. This performance is the best reported so far for a CMOS inverter made using Sn-MHP TFTs,” highlights Prof. Kim.

The innovative 2D/3D structure presented in this study will help scientists worldwide take advantage of the attractive electronic properties of perovskites. Moreover, their approach is not limited to a narrow class of materials or device types. “The proposed strategy could be applied to various solution-derived semiconductor systems, opening doors to flexible and printable electronics,” says Prof. Kim.

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Materials provided by Tokyo Institute of Technology. Note: Content may be edited for style and length.

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Too many disk galaxies than theory allows

The Standard Model of Cosmology describes how the universe came into being according to the view of most physicists. Researchers at the University of Bonn have now studied the evolution of galaxies within this model, finding considerable discrepancies with actual observations. The University of St. Andrews in Scotland and Charles University in the Czech Republic were also involved in the study. The results have now been published in the Astrophysical Journal.

Most galaxies visible from Earth resemble a flat disk with a thickened center. They are therefore similar to the sports equipment of a discus thrower. According to the Standard Model of Cosmology, however, such disks should form rather rarely. This is because in the model, every galaxy is surrounded by a halo of dark matter. This halo is invisible, but exerts a strong gravitational pull on nearby galaxies due to its mass. “That’s why we keep seeing galaxies merging with each other in the model universe,” explains Prof. Dr. Pavel Kroupa of the Helmholtz Institute for Radiation and Nuclear Physics at the University of Bonn.

This crash has two effects, the physicist explains: “First, the galaxies penetrate in the process, destroying the disk shape. Second, it reduces the angular momentum of the new galaxy created by the merger.” Put simply, this greatly decreases its rotational speed. The rotating motion normally ensures that the centrifugal forces acting during this process cause a new disk to form. However, if the angular momentum is too small, a new disk will not form at all.

Large discrepancy between prediction and reality

In the current study, Kroupa’s doctoral student, Moritz Haslbauer, led an international research group to investigate the evolution of the universe using the latest supercomputer simulations. The calculations are based on the Standard Model of Cosmology; they show which galaxies should have formed by today if this theory were correct. The researchers then compared their results with what is currently probably the most accurate observational data of the real Universe visible from Earth.

“Here we encountered a significant discrepancy between prediction and reality,” Haslbauer says: “There are apparently significantly more flat disk galaxies than can be explained by theory.” However, the resolution of the simulations is limited even on today’s supercomputers. It may therefore be that the number of disk galaxies that would form in the Standard Model of Cosmology has been underestimated. “However, even if we take this effect into account, there remains a serious difference between theory and observation that cannot be remedied,” Haslbauer points out.

The situation is different for an alternative to the Standard Model, which dispenses with dark matter. According to the so-called MOND theory (the acronym stands for “MilgrOmiaN Dynamics), galaxies do not grow by merging with each other. Instead, they are formed from rotating gas clouds that become more and more condensed. In a MOND universe, galaxies also grow by absorbing gas from their surroundings. However, mergers of full-grown galaxies are rare in MOND. “Our research group in Bonn and Prague has uniquely developed the methods to do calculations in this alternative theory,” says Kroupa, who is also a member of the Transdisciplinary Research Units “Modelling” and “Matter” at the University of Bonn. “MOND’s predictions are consistent with what we actually see.”

Challenge for the Standard Model

However, the exact mechanisms of galaxy growth are not yet fully understood, even with MOND. Additionally, in MOND, Newton’s laws of gravity do not apply under certain circumstances, but need to be replaced by the correct ones. This would have far-reaching consequences for other areas of physics. “Nevertheless, the MOND theory solves all known extragalactic cosmological problems despite being originally formulated to address galaxies only,” says Dr. Indranil Banik, who was involved in this research. “Our study proves that young physicists today still have the opportunity to make significant contributions to fundamental physics,” Kroupa adds.

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Materials provided by University of Bonn. Note: Content may be edited for style and length.

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