Dogs can detect Parkinson’s years before symptoms—with 98% accuracy

People with Parkinson’s disease (PD) have an odour that can be reliably detected from skin swabs by trained dogs, a new study has shown.

The research, in collaboration with Medical Detection Dogs and the Universities of Bristol and Manchester, was published on July 15 in The Journal of Parkinson’s Disease.

Two dogs were trained by the charity, Medical Detection Dogs, to distinguish between sebum swabs from people with and without Parkinson’s disease.

In a double blind trial, they showed sensitivity of up to 80% and specificity of up to 98%.

Not only that, they detected it in samples from patients who also had other health conditions.

The dogs were trained over a number of weeks on over 200 odor samples from individuals that had tested positive for PD and control samples from people who did not have the disease. Samples were presented to the dogs on a stand system and the dogs were rewarded for correctly indicating a positive sample and for correctly ignoring a negative sample.

In the double-blind testing, meaning that only a computer knew where the correct samples were, each line was also presented in reverse order so that samples for which no decision was made were re-presented. Then any unsearched samples were collected together in new lines, until a decision had been made for all samples.

A definitive diagnostic test for Parkinson’s Disease (PD) remains elusive, so identification of potential biomarkers could help diagnosis and timely intervention.

Claire Guest, Medical Detection Dogs CEO and Chief Scientific Officer, says: “We are extremely proud to say that once again, dogs can very accurately detect disease.

“There is currently no early test for Parkinson’s disease and symptoms may start up to 20 years before they become visible and persistent leading to a confirmed diagnosis.

“Timely diagnosis is key as subsequent treatment could slow down the progression of the disease and reduce the intensity of symptoms.”

Nicola Rooney, Associate Professor at Bristol Veterinary School at the University of Bristol and lead author, says: “Identifying diagnostic biomarkers of PD, particularly those that may predict development or help diagnose disease earlier is the subject of much ongoing research. The dogs in this study achieved high sensitivity and specificity and showed there is an olfactory signature distinct to patients with the disease. Sensitivity levels of 70% and 80% are well above chance and I believe that dogs could help us to develop a quick non-invasive and cost-effective method to identify patients with Parkinson’s disease.”

Perdita Barran, Professor of Mass Spectrometry at The University of Manchester, said: “It’s wonderful to be part of this research inspired by Joy Milne and our Nose2Diagnose programme. This study adds to the growing body of evidence showing that simple, non-invasive skin swabs can be used to diagnose Parkinson’s disease, offering a faster and more accessible method for early detection.”

The two dogs in the study were Golden Retriever, Bumper and Black Labrador, Peanut.

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Can’t sleep, can’t focus, can’t thrive? ADHD and insomnia may be a vicious cycle

Insomnia could explain why adults with ADHD traits report having a lower quality of life, according to new research led by the University of Southampton and the Netherlands Institute of Neuroscience.

A study published on July 15 in BMJ Mental Health found that having higher ADHD traits was associated with a lower quality of life and that insomnia could be part of the reason why.

At least one in four people with attention deficit hyperactivity disorder (ADHD) report having a sleep disorder, with insomnia being the most common of these.

“Our findings show a link between ADHD traits, insomnia severity, and reduced life satisfaction,” says Dr Sarah L. Chellappa, Associate Professor in Psychology at the University of Southampton and senior author on the research paper.

“We know that sleep disruption can impact neurobehavioral and cognitive systems, including attention and emotional regulation. At the same time, sleep disruption may arise from ADHD-related impulsivity and hyperactivity, suggesting a reinforcing cycle between sleep disorders and ADHD.”

Researchers from the University of Southampton and the Netherlands Institute for Neuroscience (Prof Eus Van Someren) examined data from the Netherlands Sleep Registry, an online survey with more than ten thousand adult participants.

The team analysed responses from 1,364 participants who had answered questions about ADHD traits, sleep disturbances, circadian factors, depression, and quality of life.

They found ADHD traits were associated with worse depression, more severe insomnia, lower sleep quality, and a preference for going to bed and waking up later.

ADHD and insomnia severity both predicted a lower quality of life, with analysis suggesting insomnia was the potential link in this association.

“Adults with ADHD traits may be more likely to have low sleep quality, insomnia complaints, and low mood levels, all of which lead to reduced life satisfaction,” says Professor Samuele Cortese, a co-author on the paper, also from the University of Southampton.

“There needs to be more research to understand this complex interplay. By improving our understanding, we could uncover treatment options that improve the quality of life of people with ADHD. For instance, targeting insomnia complaints in individuals with higher ADHD traits, with Cognitive Behavioural Therapy for Insomnia or Sleep Restriction therapy may help improve their quality of life.”

The paper Associations of ADHD symptom severity, sleep/circadian factors, depression, and quality of life is published in BMJ Mental Health and is available online.

The research was supported by the Netherlands Organisation for Scientific Research and the European Research Council.

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Scholars just solved a 130-year literary mystery—and it all hinged on one word

A medieval literary puzzle which has stumped scholars including M.R. James for 130 years has finally been solved. Cambridge scholars now believe the Song of Wade, a long lost treasure of English culture, was a chivalric romance not a monster-filled epic. The discovery solves the most famous mystery in Chaucer’s writings and provides rare evidence of a medieval preacher referencing pop culture in a sermon.

The breakthrough, detailed on July 15 in The Review of English Studies, involved working out that the manuscript refers to ‘wolves’ not ‘elves’, as scholars previously assumed.

Dr James Wade and Dr Seb Falk, colleagues at Girton College, Cambridge, argue that the only surviving fragment of the Song of Wade, first discovered by M.R. James in Cambridge in 1896, has been “radically misunderstood” for the last 130 years.

“Changing elves to wolves makes a massive difference,” Seb Falk said. “It shifts this legend away from monsters and giants into the human battles of chivalric rivals.”

James Wade said: “It wasn’t clear why Chaucer mentioned Wade in the context of courtly intrigue. Our discovery makes much more sense of this.”

“Here we have a late-12th-century sermon deploying a meme from the hit romantic story of the day,” Seb Falk said. “This is very early evidence of a preacher weaving pop culture into a sermon to keep his audience hooked.”

“Many church leaders worried about the themes of chivalric romances – adultery, bloodshed, and other scandalous topics – so it’s surprising to see a preacher dropping such “adult content” into a sermon,”said James Wade.

For the first time, the researchers have identified the great late-medieval writer Alexander Neckam (1157-1217) as the most likely author of the Humiliamini sermon. The 800-year-old document is part of MS 255, a Peterhouse Cambridge collection of medieval sermons.

Discoveries made 130 years apart

In 1896, M. R. James was looking through Latin sermons from Peterhouse’s library in Cambridge when he was surprised to find passages written in English. He consulted another Cambridge scholar, Israel Gollancz, and together they announced that these were verses from a lost 12th-century romantic poem which they called the Song of Wade. M. R. James promised further comment but this never came.

Nearly 130 years passed with no new evidence coming to light. Several scholars have attempted to work out the meaning of the sermon’s Wade quotation and speculated on what the full legend might have been like.

“Lots of very smart people have torn their hair out over the spelling, punctuation, literal translation, meaning, and context of a few lines of text,” said James Wade.

James Wade and Seb Falk argue that three words have been misread by scholars, because of misleading errors made by a scribe who transcribed the sermon. Most problematically, the letters ‘y’ and ‘w’ became muddled. Correcting these and other errors transforms the translated text from:

‘Some are elves and some are adders; some are sprites that dwell by waters: there is no man, but Hildebrand only.’

to:

‘Thus they can say, with Wade: ‘Some are wolves and some are adders; some are sea-snakes that dwell by the water. There is no man at all but Hildebrand.’

Hildebrand was Wade’s supposed father. While some folk-legends and epics refer to Hildebrand as a giant, if the Wade legend was a chivalric romance, as this study argues, Hildebrand was probably understood to be a normal man.

Chaucer and Wade

The Song of Wade was hugely popular throughout the Middle Ages. For several centuries, its central character remained a major romance hero, among other famous knights such as Lancelot and Gawain. Chaucer twice evoked Wade in the middle of this period, in the late 1300s, but these references have baffled generations of Chaucer scholars.

At a crucial moment in Troilus and Criseyde, Pandarus tells the ‘tale of Wade’ to Criseyde after supper. Today’s study argues that the Wade legend served Pandarus because he not only needed to keep Criseyde around late, but also to stir her passions. By showing that Wade was a chivalric romance, Chaucer’s reference makes much more sense.

In ‘The Merchant’s Tale’, Chaucer’s main character, January, a 60-year-old knight, refers to Wade’s boat when arguing that it is better to marry young women than old. The fact that his audience would have understood the reference in the context of chivalric romance, rather than folk tales or epics, is significant, the researchers argue.

“This reveals a characteristically Chaucerian irony at the heart of his allusion to Wade’s boat,” said James Wade.

The sermon

To make sense of the fragment, the researchers gave more attention to the Humiliamini sermon in its entirety than scholars have previously.

“The sermon itself is really interesting,” said Seb Falk. “It’s a creative experiment at a critical moment when preachers were trying to make their sermons more accessible and captivating.”

“I once went to a wedding where the vicar, hoping to appeal to an audience who he figured didn’t often go to church, quoted the Black Eyed Peas’ song ‘Where is the Love?’ in an obvious attempt to seem cool. Our medieval preacher was trying something similar to grab attention and sound relevant.”

The sermon offers a lesson in humility, a central concern of medieval theologians, but does so in unusual ways. It focuses on a debased Adam and compares human behaviours to animal traits. It presents powerful men who become like wolves because they plunder what doesn’t belong to them. And it compares the actions of cunning, deceitful and rapacious people to those of adders or water-snakes.

“This sermon still resonates today,” James Wade says. “It warns that it’s us, humans, who pose the biggest threat, not monsters.”

The preacher brings in a second topical reference to underline this point, telling the story of a real-life knight and crusader named Hugh of Gournay, who switched sides four times between England and France. The story doesn’t appear in any other surviving source, but the way the preacher tells it, he must have known his listeners would recognise it.

“It’s a bold image,” said Seb Falk: “the repentant Hugh wrapping a noose around his neck and throwing himself on the mercy of the French king is a powerful and really fresh symbol of chivalric humility.”

The researchers noticed multiple similarities in the arguments and writing style of Alexander Neckam, leading them to believe that he probably wrote the sermon.

But whether Neckam himself or an acolyte, the author must have been familiar with Wade and confident that his intended audience would get the reference.

Seb Falk said: “This sermon demonstrates new scholarship, rhetorical sophistication, and inventiveness, and it has strategic aims. It’s the ideal vehicle for the Wade quotation which served an important purpose.”

Seb Falk is a scholar of medieval history and history of science. James Wade is a scholar of English literature from the Middle Ages forward. Both are Fellows at Girton College, Cambridge.

Extract from the new translation of the sermon referring to Wade:

‘Dear [brothers], as to the fact that he says, ‘humble yourselves’, etc. – it could be considered that humility which is against the mighty hand of God is of a particular kind. For there are three kinds of humility: the humility of guilt; the humility of punishment; and the humility of penance.

Now, by the humility of guilt our first parent [Adam] was so humbled that, although he was made master of the whole world before his sins and ruled over everything that was in the world, after his sin, on the other hand, he could not even defend himself from a worthless worm, that is, from a flea or louse. He who was similar to God before sin, was made dissimilar through sin; since ‘by this poison a rose is sometimes turned into spikenard.’

Thus Adam was, from a human, made as if he was non-human; not only Adam, but almost everyone becomes as if non-humans. Thus they can say, with Wade: ‘Some are wolves and some are adders; Some are sea-snakes that dwell by the water. There is no man at all but Hildebrand.’

Similarly, today some are wolves, such as powerful tyrants, who if they can justly take the things of those subject to them, take them; but if not, [do so] by any means. Some imitate serpents, of which there are three kinds. Others become lions, like the proud ones whom God opposes; enough has been said of pride in the art of preaching. Others are foxes, such as cunning detractors and flatterers who speak with a double heart, who have honey in their mouth but bile in their heart. Others are gluttons like pigs, of whom the prophet says ‘their throats are open graves’; and thus each is judged similarly. Indeed, this humility is bad and perverse.’

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Is there a healthy way to tan?

Chris and Xand van Tulleken weigh up the pros and cons of being in direct sunshine.

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Physician associates need new job title, says review

It also recommends PAs and AAs wear standardised clothing and badges to distinguish them from doctors.

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Why are measles cases rising in the UK?

What are the symptoms of measles and how dangerous is the disease?

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Premises plea as wellbeing charity told to move

Simply Limitless must leave its base in Kidderminster in weeks after the landlord found new tenants.

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Yin Productivity

This week I began exploring a yin-based approach to my days. First I journaled about how I might differentiate yin productivity from yang productivity. I figured yang was mainly about deciding, controlling, and directing the flow of action whereas yin would be more about sensing and allowing action to flow through very flexibly. I also figured that yang would be more outcome-oriented whereas yin might be more experience-oriented.

It’s been a very interesting experience to deliberately lean in a yin direction so far, especially yesterday when I opted to use this approach all day. I did my best to release any attachment to getting any particular task done or advancing any specific project. I focused more on sensing what energies wanted to flow through and be part of my day. All throughout the day, I was more attuned to the energy flows and my inner sensing than I was to objective results.

The flow of action was light and breezy. I felt very relaxed and chill. It was like being carried by currents of energy all through the day. I felt like I wasn’t working particularly hard or doing very much. Yet at the end of the day, I reviewed all that I got done, and it was quite a lot.

I got up at 5am, went for a run, and then met Rachelle in the park to go for a walk together. I started listening to a new audiobook (James Fadiman’s Microdosing book) while running. I read some more of Ram Dass’ Be Here Now and also began reading Alexander Shulgin’s PIHKAL book. So I felt inspired to engage with three different books, yet that didn’t feel like too much because all the books had strong energy ties among them. They cover similar ground from different perspectives. What I read from each book seemed to have a synchronous relationship to the flow of the day. If my thinking had been more objective or yang-like, I’d have likely stuck with one book till it was done. It actually felt nicer to float through a few books.

I made clear, crisp decisions in some areas that were a bit stuck and then advanced them with a variety of easy actions. I sensed it was the right timing for those decisions to flow through, like they were finally ready to emerge and resolve themselves. I also did some journaling to further advance some ideas I’d been working on, and that went very smoothly too. Overall I got my life much better aligned with some long-term avenues that have been unfolding.

I also went out twice to run errands, once in the morning and once in the afternoon. On an objective level, that might seem less efficient than batching the errands. However, the second errand wasn’t really on my radar when I followed my inner nudge to go out to do the first one, even though both were related. I felt like perhaps I needed to advance and complete the first errand for the second to energetically arise.

I liked how both trips infused my day with more variety. These errands were short and easy, and I enjoyed doing them very much as part of the day. They got me away from my desk and out and around other people in the city for a bit. I felt like I was keeping the energy swirling and in positive motion. It was toasty outside (105ºF outside during the second errand – that’s about 41ºC), and the sun’s warmth felt so nice to me too. I’m used to the sunny Vegas summers.

When some ideas came to mind about potential actions to take, I wrote some of them down but only one or two at a time. That was mainly to get them out of my head, so I wouldn’t dwell upon them and could mentally relax more, not with the intention of compiling a to-do list like I might have done in yang mode. I ended up eventually doing all of the items I’d written down, yet I only did them if and when I felt their energy inviting me to go in that direction and feeling good motivation to engage. I did them out of sequence from the order I wrote them yet with no feeling of pressure to do them or not. I felt more of a sense of curiosity about them when I wrote them down, not really sure if they’d come through. They were just options and possibilities, not decisions or commitments. Writing these ideas down was a bit like saying, “I see you. Let me know if you want to flow into action later.”

There was a strangeness to the day as well. I felt like I was attuned to a deeper sense of cooperation and coordination with life. I didn’t feel that I was making decisions as much as I was accepting energy-level invitations that I was sensing. I didn’t feel that those invitations were arising from within me (like from my subconscious) as much as I was picking up on signals being broadcast on a more spirity level of reality. Those signals were very present-moment, always shifting as the day progressed. They were often subtle, more like whispers or hints of possible energy flows. Nothing ever felt demanding or mandatory.

Sometimes I felt a more yang-like idea emerge, in which case I acknowledged it as yang energy and declined it. I could feel that some directions would require more force to advance them. I went with options that felt light and breezy, doing my best to flow into action with them as those invites came through – without hesitation or delay. There was no rushing or pressing. It just felt easier to glide into action once I had a clear enough sense of where the flow was inviting me to go.

I feel my inner senses have become even louder and clearer this year, so this was a great way to practice listening to them more closely, especially when the communication is subtle. I don’t feel this would have worked if my mind was cluttered or pre-occupied with predetermined to-dos. The action flow was great, and I actually felt that the day turned out better, both experientially and in terms of what outcomes got advanced, than if I’d tried to control and direct it based on individual goals. The flow of action also felt very well-synched to my mood and energy levels.

I want to float with this approach all throughout this week as best I can. I’m enjoying it immensely so far. Overall I’d say that yesterday’s flow felt marvelous yet also a bit mysterious.

I’m continuing this process today, and writing and sharing this little blog post happened because it showed up as a very yin-feeling invite this morning. I had no goal or even intention to write or publish anything today. I actually wrote and shared this as a personal update in my exploration log in the CGC forums a few hours prior, following a breezy nudge after breakfast. Then later in the morning, I felt the invite to add a bit more detail and publish it here, sensing that others might appreciate it. Perhaps someone would find this idea timely and synchronous relative to their own explorations. So if this does seem synchronous for you, perhaps this is a special invite flowing through for you to give this yin productivity approach a little test in your own life. Please let me know if you do that and how it goes. It’s nice to compare notes on this sort of thing.

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Fasting twice a week could be a game-changer for type 2 diabetes

Intermittent energy restriction, time-restricted eating and continuous energy restriction can all improve blood sugar levels and body weight in people with obesity and type 2 diabetes, according to a study presented at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, California.

“This study is the first to compare the effects of three different dietary interventions intermittent energy restriction (IER), time-restricted eating (TRE) and continuous energy restriction (CER) in managing type 2 diabetes with obesity,” said Haohao Zhang, Ph.D., chief physician at The First Affiliated Hospital of Zhengzhou University in Zhengzhou, China.

Although researchers identified improved HbA1c levels, and adverse events were similar across the three groups, the IER group showed greater advantages in reducing fasting blood glucose, improving insulin sensitivity, lowering triglycerides, and strengthening adherence to the dietary interventions.

“The research fills a gap in directly comparing 5:2 intermittent energy restriction with a 10-hour time-restricted eating in patients with obesity and type 2 diabetes. The findings provide scientific evidence for clinicians to choose appropriate dietary strategies when treating such patients,” Zhang said.

Zhang and colleagues performed a single-center, randomized, parallel-controlled trial at the First Affiliated Hospital of Zhengzhou University from November 19, 2021 to November 7, 2024.

Ninety patients were randomly assigned in a 1:1:1 ratio to the IER, TRE or CER group, with consistent weekly caloric intake across all groups. A team of nutritionists supervised the 16-week intervention.

Of those enrolled, 63 completed the study. There were 18 females and 45 males, with an average age of 36.8 years, a mean diabetes duration of 1.5 years, a baseline BMI of 31.7 kg/m², and an HbA1c of 7.42%.

At the end of the study, there were no significant differences in HbA1c reduction and weight loss between the IER, TRE and CER groups. However, the absolute decrease in HbA1c and body weight was greatest in the IER group.

Compared to TRE and CER, IER significantly reduced fasting blood glucose and triglycerides and increased the Matsuda index, a measure of whole-body insulin sensitivity. Uric acid and liver enzyme levels exhibited no statistically significant changes from baseline in any study group.

Two patients in the IER group and the TRE group, and three patients in the CER group, experienced mild hypoglycemia.

The IER group had the highest adherence rate (85%), followed by the CER group at 84% and the TRE group at 78%. Both the IER and CER groups showed statistically significant differences compared with the TRE group.

Zhang said these findings highlight the feasibility and effectiveness of dietary interventions for people who have obesity and type 2 diabetes.

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Semaglutide melts fat—but may quietly strip away your strength

Women and older adults taking the anti-obesity drug semaglutide may be at higher risk for muscle loss, but higher protein intake may help prevent muscle loss in these patients, according to a small study presented at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif.

Losing muscle (or lean mass) is a common side effect of weight loss in adults with obesity and may negatively affect metabolism and bone health. This is because muscle helps control blood sugar after meals and plays an important role in keeping bones strong, according to study lead researcher Melanie Haines, M.D., of Massachusetts General Hospital and Harvard Medical School in Boston, Mass.

Approximately 40% of the weight lost from taking semaglutide — a type of weight-loss medication known as a GLP-1 — comes from lean mass, including muscle. It is not yet known who is at highest risk for muscle loss or how it affects blood sugar levels, Haines said.

The researchers studied 40 adults with obesity for three months. Of these patients, 23 were prescribed semaglutide, while 17 followed a diet and lifestyle program for weight loss called Healthy Habits for Life (HHL). The researchers evaluated how their muscle mass changed.

Study participants who were prescribed semaglutide lost more weight than those who participated in the diet and lifestyle program, but the percent of weight loss that was lean mass was similar between the two groups.

After accounting for weight loss, the researchers found that in the semaglutide group, being older, female or eating less protein was linked to greater muscle loss. Also in this group, losing more muscle was linked to less improvement in blood sugar (HbA1c levels).

“Older adults and women may be more likely to lose muscle on semaglutide, but eating more protein may help protect against this,” Haines said. “Losing too much muscle may reduce the benefits of semaglutide on blood sugar control. This means preserving muscle during weight loss with semaglutide may be important to reduce insulin resistance and prevent frailty in people with obesity.”

Haines said that more studies are needed to find the best way to lose fat but keep muscle when using GLP-1 medications.

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