Now imagine a drumhead that is ultra-thin, about 10 mm wide, and perforated with many triangular holes.

Researchers at the Niels Bohr Institute, University of Copenhagen, in collaboration with the University of Konstanz and ETH Zurich, have managed to get vibrations to travel around this membrane, almost without any loss. In fact, so little loss that it is far better than even electronic circuit signal handling. The result is now published in the journal Nature.

Phonons – Sound Signals or Vibrations That Spread Through a Solid Material

The signal consists of phonons – which can be translated to what one might call vibrations in a solid material. The atoms vibrate and push each other, so to speak, so a given signal can move through the material. It is not far-fetched to imagine encoding a signal, which is then sent through the material, and here signal loss comes into play.

If the signal loses strength or parts of the signal are lost in heat or incorrect vibrations, one ends up not being able to decode it correctly.

System Reliability is Crucial

The signals that researchers have succeeded in sending through the membrane are distinguished by being almost lossless. The membrane as a platform for sending information is incredibly reliable.

Loss is measured as a decrease in the amplitude of the sound wave as it moves around the membrane. When researchers direct the signal through the material and around the holes in the membrane – where the signal even changes direction – the loss is about one phonon out of a million.

The amplitude of current fluctuations in a similar electronic circuit decreases about a hundred thousand times faster.

Basic Research with Perspectives

Researchers at the Niels Bohr Institute, Assistant Professor Xiang Xi and Professor Albert Schliesser, explain that the result should not be thought of in a specific, future application – but there are still rich possibilities. Currently, there is a global effort to build a quantum computer, which is dependent on super-precise transfer of signals between its different parts.

Another field within quantum research deals with sensors that, for example, can measure the smallest biological fluctuations in our own body – here too, signal transfer is crucial.

But Xiang Xi and Albert Schliesser are currently most interested in exploring the possibilities even further.

“Right now, we want to experiment with the method to see what we can do with it. For example, we want to build more complex structures and see how we can get phonons to move around them, or build structures where we get phonons to collide like cars at an intersection. This will give us a better understanding of what is ultimately possible and what new applications there are,” says Albert Schliesser. As they say: “Basic research is about producing new knowledge.”

Sea spiders (Pycnogonida) are marine arthropods with highly unusual anatomy: their trunk is very narrow and short, many of their internal organ systems extend into their long legs, and their abdomen is extremely reduced, to the point of being almost unrecognizable. Together with much better known animals such as spiders, scorpions, mites, or horseshoe crabs, sea spiders belong to the group called chelicerates, named after their claw-like mouthparts, the chelicerae. The bizarre body plan of these “no-bodies” raises fascinating questions: what genetic factors underlie its formation? And what can this tell us about the evolutionary history of chelicerates? The answers lie in their genome.

A high-resolution genome

To produce the genome assembly, researchers combined complementary sequencing technologies. First, the genetic material of a single P. litorale individual was obtained using so-called “long-read sequencing,” a technology that is able to capture very long stretches of DNA. This facilitates the correct assembly of otherwise challenging repeated or complex genomic regions. Then, the spatial organization of the genome was assayed in a second P. litorale individual, revealing which DNA pieces lie close to each other in the cell nucleus. By leveraging the distance information, the correct order of the sequenced DNA stretches can be ascertained. This combination of data sources led to the assembly of 57 pseudochromosomes, representing almost the entirety of the sea spider genome in unprecedented resolution. This was additionally supplemented by novel datasets of gene activity in various developmental stages of P. litorale. “The genomes of many non-canonical laboratory organisms are challenging to assemble, and Pycnogonum is no exception. Only the combination of modern high-throughput data sources made a high-quality genome possible,” says the study’s first author Nikolaos Papadopoulos from the Department of Evolutionary Biology at the University of Vienna. “This can now serve as a stepping stone for further research.”

Lost genes, visible effects

The research team paid special attention to the so-called Hox cluster – a gene family that is evolutionarily conserved across the animal kingdom. “In arthropods, Hox genes play a central role in the correct specification of the different body segments; but also in many other animal groups they are essential ‘master controllers’ during body plan development,” explains Andreas Wanninger, one of the project leads at the Department for Evolutionary Biology at the University of Vienna. The exciting secret of Pycnogonum litorale: a part of the Hox cluster is missing completely from the genome, namely abdominal-A (Abd-A), a gene typically involved in specification and development of the posterior part of the body. Its absence could be linked to the extreme reduction of the pycnogonid abdomen. Similar conditions have been observed in other arthropods with reduced posteriors, such as certain mites and barnacles. Thus, sea spiders offer another example for the well-documented evolutionary relationship between Hox gene loss and body part reduction.

The genome also offers insights into broader evolutionary patterns. Unlike spiders and scorpions, whose genomes show clear signs of ancient whole-genome duplications, no such traces can be found in the genome of P. litorale. As pycnogonids are considered the sister taxon to all chelicerates, this suggests that the genome of the chelicerate ancestor did not already have these duplications; rather, they must have happened much later in evolution, for certain chelicerate sub-groups.

A new reference genome

This newly assembled high-quality genome paves the way for further comparative studies. P. litorale thus becomes a novel valuable reference species in regards to questions about the interrelationships between chelicerates and the evolution of their body plans, as well as the genetic mechanisms that underlie the diversity of arthropods. “From an evolutionary developmental perspective, sea spiders are very interesting: their mode of development may be ancestral for arthropods, but at the same time they boast multiple body plan innovations unique to themselves. Beyond this, they also possess remarkable regenerative abilities,” explains last author Georg Brenneis of the Department of Evolutionary Biology at the University of Vienna. He adds: “Now that we have the genome and comprehensive datasets on gene activities during development, we can systematically study all of these aspects on the molecular level.”

The researchers will use the novel reference genome for further studies on gene regulation, development, and regeneration in chelicerates, aiming to better understand the processes underlying the evolutionary success of this group.

Researchers at Lawson Research Institute (Lawson), the research arm of St. Joseph’s Health Care London, are investigating whether Ambroxol — a cough medicine used safely for decades in Europe — can slow dementia in people with Parkinson’s disease.

Published on June 30 in the prestigious JAMA Neurology, this 12-month clinical trial involving 55 participants with Parkinson’s disease dementia (PDD) monitored memory, psychiatric symptoms and GFAP, a blood marker linked to brain damage. Parkinson’s disease dementia causes memory loss, confusion, hallucinations and mood changes. About half of those diagnosed with Parkinson’s develop dementia within 10 years, profoundly affecting patients, families and the health care system.

Led by Cognitive Neurologist Dr. Stephen Pasternak, the study gave one group daily Ambroxol while the other group received a placebo. “Our goal was to change the course of Parkinson’s dementia,” says Pasternak. “This early trial offers hope and provides a strong foundation for larger studies.”

Key findings from the clinical trial include:

• Ambroxol was safe, well-tolerated and reached therapeutic levels in the brain
• Psychiatric symptoms worsened in the placebo group but remained stable in those taking Ambroxol.
• Participants with high-risk GBA1 gene variants showed improved cognitive performance on Ambroxol
• A marker of brain cell damage (GFAP) increased in the placebo group but stayed stable with Ambroxol, suggesting potential brain protection.

Although Ambroxol is approved in Europe for treating respiratory conditions and has a long-standing safety record — including use at high doses and during pregnancy — it is not approved for any use in Canada or the U.S.

“Current therapies for Parkinson’s disease and dementia address symptoms but do not stop the underlying disease,” explains Pasternak. “These findings suggest Ambroxol may protect brain function, especially in those genetically at risk. It offers a promising new treatment avenue where few currently exist.”

Ambroxol supports a key enzyme called glucocerebrosidase (GCase), which is produced by the GBA1 gene. In people with Parkinson’s disease, GCase levels are often low. When this enzyme doesn’t work properly, waste builds up in brain cells, leading to damage. Pasternak learned about Ambroxol during a fellowship at The Hospital for Sick Children (SickKids) in Toronto, where it was identified as a treatment for Gaucher disease — a rare genetic disorder in children caused by a deficiency of GCase.

He is now applying that research to explore whether boosting GCase with Ambroxol could help protect the brain in Parkinson’s-related diseases. “This research is vital because Parkinson’s dementia profoundly affects patients and families,” says Pasternak. “If a drug like Ambroxol can help, it could offer real hope and improve lives.”

Funded by the Weston Foundation, this study is an important step toward developing new treatments for Parkinson’s disease and other cognitive disorders, including dementia with Lewy bodies. Pasternak and his team plan to start a follow-up clinical trial focused specifically on cognition later this year.

For the project, a high-quality 360° VR video was produced in Europe’s largest Douglas fir forest, the Sonnenberg nature reserve near Parchim – complete with original sounds and the scent of essential oils from the Douglas fir. The participants experienced the virtual forest scenery either as a full sensory experience (with images, sound and scent) or in a reduced form whereby forest stimuli appealing to just a single sense – visual, auditory or olfactory – were used. In variants where only hearing or scent was activated, participants were placed in a neutral virtual environment to minimize visual stimuli and the influence of VR technology.

Significantly better effect with sensory combination

More than 130 participants were first put into an acute stress situation using stress-inducing images. Then, equipped with VR glasses, they experienced one of the four forest stimulation/ bathing variants. The results show that the combination of all three sensory stimuli led to a significantly greater improvement in mood and a stronger feeling of connection with nature compared to when individual sensory stimuli were presented. In addition to positive effects on mood, there were also limited improvements in working memory – the cognitive function that enables us to store, process and retrieve information in the short term.

However, the researchers point out that the effects are area-specific and cannot yet be considered universally valid. Further studies with larger samples are needed to confirm the results and provide a better understanding of the mechanisms behind the restorative effects of virtual nature experiences.

“We can already say that digital nature experiences can absolutely produce an emotional effect – even if they don’t replace actual nature,” reports Leonie Ascone, lead author of the study and researcher in the Neuronal Plasticity working group at the University Medical Center Hamburg-Eppendorf (UKE).

Potential for clinics, waiting rooms and urban spaces

Simone Kühn, head of the study and Director of the Center for Environmental Neuroscience at the Max Planck Institute for Human Development, adds: “Especially in places with limited access to nature – such as clinics, waiting areas or urban interiors – multisensory VR applications or targeted nature staging could support mental well-being. The images, sounds and scents of nature offer previously underestimated potential for improving mood and mental performance in everyday situations.” Kühn conducts intensive research into the effects of the environment on the human brain and, together with colleagues from universities in Vienna, Exeter and Birmingham, was recently able to prove that just from watching nature videos, patients perceive physical pain as less intense (Steininger et al., 2025).

In brief:

• Forest bathing in Virtual Reality improves emotional well-being and increases connectedness to nature, particularly when several senses (sight, hearing, smell) are simultaneously engaged
• The study used a 360° VR forest video complete with original sounds and the scent of Douglas fir essential oils
• There is potential for application especially in clinical, urban and other environments with limited access to nature

Pregnancy that lasts long enough to support full fetal development is a hallmark evolutionary breakthrough of placental mammals – a group that includes humans. At the center of this is the fetal-maternal interface: the site in the womb where a baby’s placenta meets the mother’s uterus, and where two genetically distinct organisms – mother and fetus – are in intimate contact and constant interaction. This interface has to strike a delicate balance: intimate enough to exchange nutrients and signals, but protected enough to prevent the maternal immune system from rejecting the genetically “foreign” fetus.

To uncover the origins and mechanisms behind this intricate structure, the team analyzed single-cell transcriptomes – snapshots of active genes in individual cells – from six mammalian species representing key branches of the mammalian evolutionary tree. These included mice and guinea pigs (rodents), macaques and humans (primates), and two more unusual mammals: the tenrec (an early placental mammal) and the opossum (a marsupial that split off from placental mammals before they evolved complex placentas).

A Cellular “Atlas of Mammal Pregnancy”

By analyzing cells at the fetal-maternal interface, the researchers were able to trace the evolutionary origin and diversification of the key cell types involved. Their focus was on two main players: placenta cells, which originate from the fetus and invade maternal tissue, and uterine stromal cells, which are of maternal origin and respond to this invasion.

Using molecular biology tools, the team identified distinct genetic signatures – patterns of gene activity unique to specific cell types and their specialized functions. Notably, they discovered a genetic signature associated with the invasive behavior of fetal placenta cells that has been conserved in mammals for over 100 million years. This finding challenges the traditional view that invasive placenta cells are unique to humans, and reveals instead that they are a deeply conserved feature of mammalian evolution. During this time, the maternal cells weren’t static, either. Placental mammals, but not marsupials, were found to have acquired new forms of hormone production, a pivotal step toward prolonged pregnancies and complex gestation, and a sign that the fetus and the mother could be driving each other’s evolution.

Cellular Dialogue: Between Cooperation and Conflict

To better understand how the fetal-maternal interface functions, the study tested two influential theories about the evolution of cellular communication between mother and fetus.

The first, the “Disambiguation Hypothesis,” predicts that over evolutionary time, hormonal signals became clearly assigned to either the fetus or the mother – a possible safeguard to ensure clarity and prevent manipulation. The results confirmed this idea: certain signals, including WNT proteins, immune modulators, and steroid hormones, could be clearly traced back to one source tissue.

The second, the “Escalation Hypothesis” (or “genomic Conflict”), suggests an evolutionary arms race between maternal and fetal genes – with, for example, the fetus boosting growth signals while the maternal side tries to dampen them. This pattern was observed in a small number of genes, notably IGF2, which regulates growth. On the whole, evidence pointed to fine-tuned cooperative signaling.

“These findings suggest that evolution may have favored more coordination between mother and fetus than previously assumed,” says Daniel J. Stadtmauer, lead author of the study and now a researcher at the Department of Evolutionary Biology, University of Vienna. “The so-called mother-fetus power struggle appears to be limited to specific genetic regions. Rather than asking whether pregnancy as a whole is conflict or cooperation, a more useful question may be: where is the conflict?”

Single-Cell Analysis: A Key to Evolutionary Discovery

The team’s discoveries were made possible by combining two powerful tools: single-cell transcriptomics – which captures the activity of genes in individual cells – and evolutionary modeling techniques that help scientists reconstruct how traits might have looked in long-extinct ancestors. By applying these methods to cell types and their gene activity, the researchers could simulate how cells communicate in different species, and even glimpse how this dialogue has evolved over millions of years.

“Our approach opens a new window into the evolution of complex biological systems – from individual cells to entire tissues,” says Silvia Basanta, co-first author and researcher at the University of Vienna. The study not only sheds light on how pregnancy evolved, but also offers a new framework for tracking evolutionary innovations at the cellular level – insights that could one day improve how we understand, diagnose, or treat pregnancy-related complications.

The research was conducted in the labs of Mihaela Pavličev at the Department of Evolutionary Biology, University of Vienna, and Günter Wagner at Yale University. Wagner is Professor Emeritus at Yale and a Senior Research Fellow at the University of Vienna. The study was supported by the John Templeton Foundation and the Austrian Science Fund (FWF).

Tiny traces of life in ancient mud

Led by the European Research Council Synergy Grant project Into the Blue — i2B, the research team studied sediment cores collected from the seafloor of the central Nordic Seas and Yermak Plateau, north of Svalbard. These cores hold tiny chemical fingerprints from algae that lived in the ocean long ago. Some of these algae only grow in open water, while others thrive under seasonal sea ice that forms and melts each year.

“Our sediment cores show that marine life was active even during the coldest times,” said Jochen Knies, lead author of the study, based at UiT The Arctic University of Norway and co-lead of the Into The Blue — i2B project. “That tells us there must have been light and open water at the surface. You wouldn’t see that if the entire Arctic was locked under a kilometre-thick slab of ice.”

One of the key indicators the team looked for was a molecule called IP₂₅, which is produced by algae that live in seasonal sea ice. Its regular appearance in the sediments shows that sea ice came and went with the seasons, rather than staying frozen solid all year round.

Simulating ancient Arctic climates

To test the findings based on the geological records, the research team used the AWI Earth System Model — a high-resolution computer model — to simulate Arctic conditions during two especially cold periods: the Last Glacial Maximum around 21,000 years ago, and a deeper freeze about 140,000 years ago when large ice sheets covered a lot of the Arctic.

“The models support what we found in the sediments,” said Knies. “Even during these extreme glaciations, warm Atlantic water still flowed into the Arctic gateway. This helped keep some parts of the ocean from freezing over completely.”

The models also showed that the ice wasn’t static. Instead, it shifted with the seasons, creating openings in the ice where light could reach the water — and where life could continue to thrive. This research not only reshapes our view of past Arctic climates but also has implications for future climate predictions. Understanding how sea ice and ocean circulation responded to past climate extremes can improve models that project future changes in a warming world.

“These reconstructions help us understand what’s possible — and what’s not — when it comes to ice cover and ocean dynamics,” said Gerrit Lohmann, co-author of this study, based at Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) and co-lead of Into The Blue — i2B. “That matters when trying to anticipate how ice sheets and sea ice might behave in the future.”

Re-thinking the giant ice shelf theory

Some scientists have argued that features on the Arctic seafloor suggest that a huge, grounded ice shelf once covered the entire ocean. But this new study offers another explanation.

“There may have been short-lived ice shelves in some parts of the Arctic during especially severe cold phases,” said Knies. “But we don’t see any sign of a single, massive ice shelf that covered everything for thousands of years.”

One possible exception could have occurred about 650,000 years ago, when biological activity in the sediment record dropped sharply. But even then, the evidence points to a temporary event, not a long-lasting frozen lid over the Arctic.

Understanding the Arctic’s future

The study sheds new light on how the Arctic has behaved under extreme conditions in the past. This matters because the Arctic is changing rapidly today. Knowing how sea ice and ocean circulation responded to past climate shifts helps scientists understand what might lie ahead.

“These past patterns help us understand what’s possible in future scenarios,” said Knies. “We need to know how the Arctic behaves under stress — and what tipping points to watch for — as the Arctic responds to a warming world.”

The full paper, “Seasonal sea ice characterized the glacial Arctic-Atlantic gateway over the past 750,000 years,” is available in Science Advances.

This research is part of the European Research Council Synergy Grant project Into the Blue — i2B and the Research Council of Norway Centre of Excellence, iC3: Centre for ice, Cryosphere, Carbon, and Climate.

Kovalev, EIPOD Postdoctoral Fellow at EMBL Hamburg’s Schneider Group and EMBL-EBI’s Bateman Group, is a physicist passionate about solving biological problems. He is particularly hooked by rhodopsins, a group of colorful proteins that enable aquatic microorganisms to harness sunlight for energy.

“In my work, I search for unusual rhodopsins and try to understand what they do,” said Kovalev. “Such molecules could have undiscovered functions that we could benefit from.”

Some rhodopsins have already been modified to serve as light-operated switches for electrical activity in cells. This technique, called optogenetics, is used by neuroscientists to selectively control neuronal activity during experiments. Rhodopsins with other abilities, such as enzymatic activity, could be used to control chemical reactions with light, for example.

Having studied rhodopsins for years, Kovalev thought he knew them inside out – until he discovered a new, obscure group of rhodopsins that were unlike anything he had seen before.

As it often happens in science, it started serendipitously. While browsing online protein databases, Kovalev spotted an unusual feature common to microbial rhodopsins found exclusively in very cold environments, such as glaciers and high mountains. “That’s weird,” he thought. After all, rhodopsins are something you typically find in seas and lakes.

These cold-climate rhodopsins were almost identical to each other, even though they evolved thousands of kilometres apart. This couldn’t be a coincidence. They must be essential for surviving in the cold, concluded Kovalev, and to acknowledge this, he named them ‘cryorhodopsins’.

Rhodopsins out of the blue

Kovalev wanted to know more: what these rhodopsins look like, how they work, and, in particular, what color they are.

Color is the key feature of each rhodopsin. Most are pink-orange – they reflect pink and orange light, and absorb green and blue light, which activates them. Scientists strive to create a palette of different colored rhodopsins, so they could control neuronal activity with more precision. Blue rhodopsins have been especially sought-after because they are activated by red light, which penetrates tissues more deeply and non-invasively.

To Kovalev’s amazement, the cryorhodopsins he examined in the lab revealed an unexpected diversity of colors, and, most importantly, some were blue.

The color of each rhodopsin is determined by its molecular structure, which dictates the wavelengths of light it absorbs and reflects. Any changes in this structure can alter the color.

“I can actually tell what’s going on with cryorhodopsin simply by looking at its color,” laughed Kovalev.

Applying advanced structural biology techniques, he figured out that the secret to the blue color is the same rare structural feature that he originally spotted in the protein databases.

“Now that we understand what makes them blue, we can design synthetic blue rhodopsins tailored to different applications,” said Kovalev.

Next, Kovalev’s collaborators examined cryorhodopsins in cultured brain cells. When cells expressing cryorhodopsins were exposed to UV light, it induced electric currents inside them. Interestingly, if the researchers illuminated the cells right afterwards with green light, the cells became more excitable, whereas if they used UV/red light instead, it reduced the cells’ excitability.

“New optogenetic tools to efficiently switch the cell’s electric activity both ‘on’ and ‘off’ would be incredibly useful in research, biotechnology and medicine,” said Tobias Moser, Group Leader at the University Medical Center Göttingen who participated in the study. “For example, in my group, we develop new optical cochlear implants for patients that can optogenetically restore hearing in patients. Developing the utility of such a multi-purpose rhodopsin for future applications is an important task for the next studies.”

“Our cryorhodopsins aren’t ready to be used as tools yet, but they’re an excellent prototype. They have all the key features that, based on our findings, could be engineered to become more effective for optogenetics,” said Kovalev.

Evolution’s UV light protector

When exposed to sunlight even on a rainy winter day in Hamburg, cryorhodopsins can sense UV light, as shown using advanced spectroscopy by Kovalev’s collaborators from Goethe University Frankfurt led by Josef Wachtveitl. Wachtveitl’s team showed that cryorhodopsins are in fact the slowest among all rhodopsins in their response to light. This made the scientists suspect that those cryorhodopsins might act like photosensors letting the microbes ‘see’ UV light – a property unheard of among other cryorhodopsins.

“Can they really do that?” Kovalev kept asking himself. A typical sensor protein teams up with a messenger molecule that passes information from the cell membrane to the cell’s inside.

Kovalev grew more convinced, when together with his collaborators from Alicante, Spain, and his EIPOD co-supervisor, Alex Bateman from EMBL-EBI, they noticed that the cryorhodopsin gene is always accompanied by a gene encoding a tiny protein of unknown function – likely inherited together, and possibly functionally linked.

Kovalev wondered if this might be the missing messenger. Using the AI tool AlphaFold, the team were able to show that five copies of the small protein would form a ring and interact with the cryorhodopsin. According to their predictions, the small protein sits poised against the cryorhodopsin inside the cell. They believe that when cryorhodopsin detects UV light, the small protein could depart to carry this information into the cell.

“It was fascinating to uncover a new mechanism via which the light-sensitive signal from cryorhodopsins could be passed on to other parts of the cell. It is always a thrill to learn what the functions are for uncharacterised proteins. In fact, we find these proteins also in organisms that do not contain cryorhodopsin, perhaps hinting at a much wider range of jobs for these proteins.”

Why cryorhodopsins evolved their astonishing dual function – and why only in cold environments – remains a mystery.

“We suspect that cryorhodopsins evolved their unique features not because of the cold, but rather to let microbes sense UV light, which can be harmful to them,” said Kovalev. “In cold environments, such as the top of a mountain, bacteria face intense UV radiation. Cryorhodopsins might help them sense it, so they could protect themselves. This hypothesis aligns well with our findings.”

“Discovering extraordinary molecules like these wouldn’t be possible without scientific expeditions to often remote locations, to study the adaptations of the organisms living there,” added Kovalev. “We can learn so much from that!”

Unique approach to unique molecules

To reveal the fascinating biology of cryorhodopsins, Kovalev and his collaborators had to overcome several technical challenges.

One was that cryorhodopsins are nearly identical in structure, and even a slight change in the position of a single atom can result in different properties. Studying molecules at this level of detail requires going beyond standard experimental methods. Kovalev applied a 4D structural biology approach, combining X-ray crystallography at EMBL Hamburg beamline P14 and cryo-electron microscopy (cryo-EM) in the group of Albert Guskov in Groningen, Netherlands, with protein activation by light.

“I actually chose to do my postdoc at EMBL Hamburg, because of the unique beamline setup that made my project possible,” said Kovalev. “The whole P14 beamline team worked together to tailor the setup to my experiments – I’m very grateful for their help.”

Another challenge was that cryorhodopsins are extremely sensitive to light. For this reason, Kovalev’s collaborators had to learn to work with the samples in almost complete darkness.