Clive Myrie: What I saw during my 24 hours at a London hospital

As part of the BBC’s special report, Clive Myrie meets the people at the Royal Free Hospital relying on the NHS for care.

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Phoenix galaxy cluster in the act of extreme cooling

The core of a massive cluster of galaxies appears to be pumping out far more stars than it should. Now researchers at MIT and elsewhere have discovered a key ingredient within the cluster that explains the core’s prolific starburst.

In a new study published in Nature, the scientists report using NASA’s James Webb Space Telescope (JWST) to observe the Phoenix cluster — a sprawling collection of gravitationally bound galaxies that circle a central massive galaxy some 5.8 billion light years from Earth. The cluster is the largest of its kind that scientists have so far observed. For its size and estimated age, the Phoenix should be what astronomers call “red and dead” — long done with any star formation that is characteristic of younger galaxies.

But astronomers previously discovered that the core of the Phoenix cluster appeared surprisingly bright, and the central galaxy seemed to be churning out stars at an extremely vigorous rate. The observations raised a mystery: How was the Phoenix fueling such rapid star formation?

In younger galaxies, the “fuel” for forging stars is in the form of extremely cold and dense clouds of interstellar gas. For the much older Phoenix cluster, it was unclear whether the central galaxy could undergo the extreme cooling of gas that would be required to explain its stellar production, or whether cold gas migrated in from other, younger galaxies.

Now, the MIT team has gained a much clearer view of the cluster’s core, using JWST’s far-reaching, infrared-measuring capabilities. For the first time, they have been able to map regions within the core where there are pockets of “warm” gas. Astronomers have previously seen hints of both very hot gas, and very cold gas, but nothing in between.

The detection of warm gas confirms that the Phoenix cluster is actively cooling and able to generate a huge amount of stellar fuel on its own.

“For the first time we have a complete picture of the hot-to-warm-to-cold phase in star formation, which has really never been observed in any galaxy,” says study lead author Michael Reefe, a physics graduate student in MIT’s Kavli Institute for Astrophysics and Space Research. “There is a halo of this intermediate gas everywhere that we can see.”

“The question now is, why this system?” adds co-author Michael McDonald, associate professor of physics at MIT. “This huge starburst could be something every cluster goes through at some point, but we’re only seeing it happen currently in one cluster. The other possibility is that there’s something divergent about this system, and the Phoenix went down a path that other systems don’t go. That would be interesting to explore.”

Hot and cold

The Phoenix cluster was first spotted in 2010 by astronomers using the South Pole Telescope in Antarctica. The cluster comprises about 1,000 galaxies and lies in the constellation Phoenix, after which it is named. Two years later, McDonald led an effort to focus in on Phoenix using multiple telescopes, and discovered that the cluster’s central galaxy was extremely bright. The unexpected luminosity was due to a firehose of star formation. He and his colleagues estimated that this central galaxy was turning out stars at a staggering rate of about 1,000 per year.

“Previous to the Phoenix, the most star-forming galaxy cluster in the universe had about 100 stars per year, and even that was an outlier. The typical number is one-ish,” McDonald says. “The Phoenix is really offset from the rest of the population.”

Since that discovery, scientists have checked in on the cluster from time to time for clues to explain the abnormally high stellar production. They have observed pockets of both ultrahot gas, of about 1 million degrees Fahrenheit, and regions of extremely cold gas, of 10 kelvins, or 10 degrees above absolute zero.

The presence of very hot gas is no surprise: Most massive galaxies, young and old, host black holes at their cores that emit jets of extremely energetic particles that can continually heat up the galaxy’s gas and dust throughout a galaxy’s lifetime. Only in a galaxy’s early stages does some of this million-degree gas cool dramatically to ultracold temperatures that can then form stars. For the Phoenix cluster’s central galaxy, which should be well past the stage of extreme cooling, the presence of ultracold gas presented a puzzle.

“The question has been: Where did this cold gas come from?” McDonald says. “It’s not a given that hot gas will ever cool, because there could be black hole or supernova feedback. So, there are a few viable options, the simplest being that this cold gas was flung into the center from other nearby galaxies. The other is that this gas somehow is directly cooling from the hot gas in the core.”

Neon signs

For their new study, the researchers worked under a key assumption: If the Phoenix cluster’s cold, star-forming gas is coming from within the central galaxy, rather than from the surrounding galaxies, the central galaxy should have not only pockets of hot and cold gas, but also gas that’s in a “warm” in-between phase. Detecting such intermediate gas would be like catching the gas in the midst of extreme cooling, serving as proof that the core of the cluster was indeed the source of the cold stellar fuel.

Following this reasoning, the team sought to detect any warm gas within the Phoenix core. They looked for gas that was somewhere between 10 kelvins and 1 million kelvins. To search for this Goldilocks gas in a system that is 5.8 billion light years away, the researchers looked to JWST, which is capable of observing farther and more clearly than any observatory to date.

The team used the Medium-Resolution Spectrometer on JWST’s Mid-Infrared Instrument (MIRI), which enables scientists to map light in the infrared spectrum. In July of 2023, the team focused the instrument on the Phoenix core and collected 12 hours’ worth of infrared images. They looked for a specific wavelength that is emitted when gas — specifically neon gas — undergoes a certain loss of ions. This transition occurs at around 300,000 kelvins, or 540,000 degrees Fahrenheit — a temperature that happens to be within the “warm” range that the researchers looked to detect and map. The team analyzed the images and mapped the locations where warm gas was observed within the central galaxy.

“This 300,000-degree gas is like a neon sign that’s glowing in a specific wavelength of light, and we could see clumps and filaments of it throughout our entire field of view,” Reefe says. “You could see it everywhere.”

Based on the extent of warm gas in the core, the team estimates that the central galaxy is undergoing a huge degree of extreme cooling and is generating an amount of ultracold gas each year that is equal to the mass of about 20,000 suns. With that kind of stellar fuel supply, the team says it’s very likely that the central galaxy is indeed generating its own starburst, rather than using fuel from surrounding galaxies.

“I think we understand pretty completely what is going on, in terms of what is generating all these stars,” McDonald says. “We don’t understand why. But this new work has opened a new way to observe these systems and understand them better.”

This work was funded, in part, by NASA.

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Record-speed waves on extremely water-repellent surfaces

Ripples, like ones produced by raindrops falling in a puddle, are also called capillary waves. Studied since antiquity, they have garnered considerable interest in modern science due to their ability to reveal information about the medium on which they travel. This makes them particularly valuable for studying soft and biological matter in microfluidic applications, which focus on how fluids behave in microscopic environments.

Now physicists and biomedical researchers from Aalto University’s Department of Neuroscience and Biomedical Engineering and Department of Applied Physics have unearthed new characteristics of capillary waves, setting a record for their speed while doing so.

The paper was published today in Nature Communications.

By creating a synthetic surface inspired by lotus leaves, the interdisciplinary team, led by Assistant Professor Heikki Nieminen and Professor Robin Ras, brought new wave phenomena to light. Under water, an extremely water-repellent material known as a superhydrophobic surface, holds a plastron — a gas layer only micrometres thick — in place. The plastron in turn can protect the superhydrophobic surface against corrosion and contamination, or improve its hydrodynamics.

With the objective to deepen the understanding of superhydrophobicity, the team investigated the mechanical response of the plastron to highly focused ultrasound. In doing so, they generated ripples, which they dubbed ‘plastronic waves’.

‘Plastronic waves travelled along the water, the superhydrophobic surface and the gas layer 45 times faster than capillary waves normally do,’ Nieminen says.

Setting a wave speed record is only part of the result; using the same waves to monitor the plastron’s stability is another. Maintaining the delicate gas layer on top of the superhydrophobic surface is both highly important and very challenging.

‘Superhydrophobicity relies on the plastron’s stability to open new possibilities in submerged applications, for example, in improving equipment lifespan and operational efficiency in both industrial and biomedical environments. Our new technique is a tool for monitoring the gas layer’s stability better than previously,’ says the first author of the study, Postdoctoral Researcher Maxime Fauconnier, who also carried out the experiment.

In addition to furthering fundamental science, the discovery represents possible early stages for use in fields like biotechnology and materials science.

‘We showed that we could measure how the plastron changes and gradually dissolves into the water, by monitoring the variation of wave speed over time. This system could be used as a sensor in other applications. It could be useful in pharmacology and cell technology, for example,’ Fauconnier says.

The work was funded by the Research Council of Finland, the Finnish Cultural Foundation and the European Union’s HORIZON research and innovation programme.

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Jumping workouts could help astronauts on the moon and Mars, study in mice suggests

Jumping workouts could help astronauts prevent the type of cartilage damage they are likely to endure during lengthy missions to Mars and the Moon, a new Johns Hopkins University study suggests.

The research adds to ongoing efforts by space agencies to protect astronauts against deconditioning/getting out of shape due to low gravity, a crucial aspect of their ability to perform spacewalks, handle equipment and repairs, and carry out other physically demanding tasks.

The study, which shows knee cartilage in mice grew healthier following jumping exercises, appears in the journal npj Microgravity.

“Since the next step in human exploration of space is going to Mars and spending long periods of time in permanent bases on the moon, cartilage damage is a really major issue that space agencies need to address despite how very poorly understood it is,” said study author Marco Chiaberge, an astrophysicist at Johns Hopkins University, the Space Telescope Science Institute, and the European Space Agency. “The positive effect we saw in these mice is huge, and the magnitude of it was unexpected. They can basically make their cartilage thicker if they jump. Maybe astronauts could use similar training before their flight as a preventive measure.”

Healthy cartilage is essential for pain-free movement, as it cushions joints and decreases bone friction. But cartilage heals slowly and does not regenerate as fast as other tissue. Prolonged periods of inactivity — whether from bed rest, injury, or space travel — can accelerate cartilage breakdown. Space radiation can also accelerate this effect, and European Space Agency experiments have shown evidence of cartilage degradation in astronauts who spend several months aboard the International Space Station.

“Think about sending somebody on a trip to Mars, they get there and they can’t walk because they developed osteoarthritis of the knees or the hips and their joints don’t function,” Chiaberge said. “Astronauts also perform spacewalks often. They serviced the Hubble Space Telescope five times, and in the future, they will need to spend more time in space and the Moon, where we will build larger telescopes to explore the universe and where they will need to stay as healthy as possible.”

Previous research has shown that treadmill running may help slow cartilage breakdown in rodents. The new Johns Hopkins study adds to the evidence by demonstrating that jump-based exercise may prevent articular cartilage loss in knees and could actually improve cartilage health.

The researchers found that mice in a nine-week program of reduced movement experienced cartilage thinning and cellular clustering, both early indicators of arthritis. But mice that performed jump training three times a week showed the opposite effect — thicker, healthier cartilage with normal cellular structure.

The study found the mice with reduced movement had a 14% reduction in cartilage thickness, while those in the jump-training group had a 26% increase compared to a control group. Additionally, the jumping mice had 110% thicker cartilage than the reduced activity group.

Jumping also enhanced bone strength. The team found shin bones in the jumping mice had 15% higher mineral density. Trabecular bone — spongy bone tissue that absorbs impact — was significantly thicker and more robust.

“Leg strength is particularly important and most highly impacted by microgravity, so any procedures that can address multiple aspects of muscle deconditioning, and maybe even reduce the two-hour daily exercise requirement in space, would be most welcome,” said author Mark Shelhamer, a professor of otolaryngology at the Johns Hopkins School of Medicine and former NASA Human Research Program Chief Scientist. “The same reasoning applies to bone integrity, including cartilage. There is increasing recognition of the importance of cartilage as a distinct component in bone integrity, and this study contributes to that understanding.”

While more research is needed to confirm whether humans would enjoy the same benefits, the findings offer promising information to protect cartilage and bone structure. Jumping exercises could be included in pre-flight routines to prepare joints for space travel, and specially designed exercise machines could help integrate similar workouts in space.

The study could help scientists explore how jump-based training might not only aid patients with arthritis but also boost cartilage health with generally applicable exercises, said author Chen-Ming Fan, a musculoskeletal biologist at Carnegie Science.

The researchers emphasized the need for further research to determine the ideal exercise volume and frequency for preserving and strengthening cartilage. Future work will also explore whether jump training could help reverse cartilage loss and whether the exercise could help astronauts restrengthen their cartilage and recover damage from space flight.

“Now that we got our first clue that one type of exercise can increase cartilage, which was completely unknown before, we could start looking into other types of cartilage. What about the meniscus? Could it also get thicker?” said Fan, who is also an adjunct professor at Johns Hopkins. “This research could help performance-enhancement studies, rather than just focusing on pathological conditions, and help athletes or virtually anyone interested in doing the right exercises to improve their performance.”

Other authors are Neelima Thottappillil, Anderson Furlanetto, Dylan Odell, Christine Wang, Stephen Hope, Stephen Smee, Joseph Rehfus, Colin Norman, and Aaron W. James of Johns Hopkins; Anna-Maria Liphardt of Universitätsklinikum Erlangen, Friedrich-Alexander-Universität; Anja Niehoff of German Sport University Cologne; and Marc J. Philippon and Johnny Huard of Steadman Philippon Research Institute.

This research was supported by a Space@Hopkins Seed Grant and by the Carnegie Science Endowment fund.

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Inside the Royal Free – what it tells us about the NHS

From frustrated staff and ageing equipment to life-saving care, what life on the frontline is like.

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NHS ‘recovery plan’ fails to deliver new dentists or more appointments

NHS leaders say the contract for dentists to carry out NHS work needs redrawing.

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Record NHS baby deaths fine ‘follows empty promises’

The parents of Wynter Andrews, who died under NHS care in 2019, say a trust has “failed to learn”.

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How much is the NHS going to cost us?

Spending on the NHS has been going up for decades and is set to rise further. BBC Verify has examined some of the key numbers.

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Global warming and mass extinctions: What we can learn from plants from the last ice age

Global warming is producing a rapid loss of plant species — according to estimates, roughly 600 plant species have died out since 1750 — twice the number of animal species lost. But which species are hit hardest? And how does altered biodiversity actually affect interactions between plants? Experts from the Alfred Wegener Institute have tackled these questions and, in two recent studies, presented the answers they found buried in the past: using fragments of plant genetic material (DNA) deposited in lake sediments, they were able to gain new insights into how the composition of flora changed 15,000 to 11,000 years ago during the warming at the end of the last ice age, which is considered to be the last major mass extinction event before today. This comparison can offer an inkling of what might await us in the future. The researchers have just published their findings in the journal Nature Communications.

“Everyone knows that the woolly mammoth went extinct, but virtually no-one mentions the plants that were lost at the end of the last ice age,” says Prof Ulrike Herzschuh from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI). “Until recently, we lacked suitable methods for investigating the extinction of plant species in detail.” In terms of fossil plant remains, mainly pollen was used, which doesn’t allow individual species to be identified and therefore offers no evidence of which species have died out.”Using cutting-edge methods, we analysed old DNA from sediment cores taken from lakes in Alaska and Siberia, which allowed us to reconstruct the changes in vegetation in these regions.” The cores contain fragmented DNA from deposited plant biomass from the past 30,000 years, which the experts enriched, sequenced, and compared with databases for identification purposes at special-purpose labs for old DNA.

Temperature can change how plants interact

“We’ve now been able to determine in detail when and where species appeared and disappeared in Alaska and Siberia,” says Ulrike Herzschuh. “Our research shows that the composition of plant species changed substantially at the end of the last ice age, and that this was accompanied by fundamental changes in the ecological conditions.” The researchers identified a connection between temperature and plant-to-plant interactions: in cold climate periods, plant species support one another, while they mainly compete during warm periods. “In the DNA from the lake sediments, we found e.g. many cushion plants, which most likely supported the expansion of other species by forming sheltered habitats,” says Ulrike Herzschuh. This has effects on both biodiversity and richness range size.

In a warmer climate, woody plant species dominate: ‘Today, we see that plant diversity declines due to the migration of trees and shrubs into tundra regions, whereas during cold periods, higher plant diversity prevailed.

What does that tell us about vegetation changes in the high latitudes, where cushion plants still play a pivotal role today? In today’s Arctic, this supportive quality could actually threaten their own survival. “Since the warming of the Arctic has already progressed quite far, woody plants can survive even in the high latitudes. The cushion plants could facilitate their spreading, hastening their own extinction in the process.”

Which plant species are particularly at risk?

The end of the last ice age also caused some types of vegetation to disappear entirely — as the experts were able to confirm using their new methods. Take the mammoth steppe, for example: during the last ice age, this type of vegetation spread across the Northern Hemisphere, only to die out during the transition to the current age. In this regard, identifying the extinct plant species was especially challenging. “To identify the species that no longer existed, we had to use a trick,” Ulrike Herzschuh explains. Normally, species are identified on the basis of DNA fragments, which are compared with the entries in genetic databases. But these databases include information on today’s plants, not on extinct species. “We examined all the DNA fragments from our cores and then used statistical models to filter out those with unmistakeable similarities to modern plants, step by step.”

This also allowed the experts to determine which species could be at the greatest risk of extinction in a warming world: grasses and shrubs are at a higher risk of disappearing than woody plant species, which can spread further when temperatures rise. In addition, species in regions with high biodiversity are more often at risk than are less “special” species. One surprising finding: the extinction rate was at its highest at the beginning of the current warm phase — often with a delay of several thousand years after the actual environmental changes. “That means the full impacts of today’s human activities might not become apparent until the distant future.”

Relevance for today’s Arctic

The results of the two studies offer fundamental insights into how environmental changes in connection with warming affect biodiversity, and which mechanisms are central in this regard. As such, for the first time the experts were able to determine extinction rates for plants, which can now be used as reference data to better assess the ongoing changes in Arctic ecosystems. “Our studies show how important it is to understand biodiversity and ecological interactions, also in the long term, in order to better predict the impacts of climate change,” Ulrike Herzschuh summarises. “Using the information locked in old DNA from sediments, we can gain the fundamental knowledge needed to do so.”

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Models show intensifying wildfires in a warming world due to changes in vegetation and humidity; only a minor role for lightning

Extreme fire seasons in recent years highlight the urgent need to better understand wildfires within the broader context of climate change. Under climate change, many drivers of wildfires are expected to change, such as the amount of carbon stored in vegetation, rainfall, and lightning strikes. Quantifying the relative importance of these processes in recent and future wildfire trends has remained challenging, because previous climate computer model simulations did not capture the full coupling between climate change, lightning, wildfires, smoke and corresponding shifts in solar radiation and heat.

A new study published in the journal Science Advances by an international team of climate scientists presents the first realistic supercomputer simulation that resolves the complex interactions between fire, vegetation, smoke and the atmosphere. The authors find that increasing greenhouse gas emissions will likely increase the global lightning frequency by about 1.6% per degree Celsius global warming, with regional hotspots in the eastern United States, Kenya, Uganda and Argentina. Locally this could intensify wildfire occurrences. However, the dominant drivers for the growing area burned by fires each year remain shifts in global humidity and a more rapid growth of vegetation, which can serve as wildfire fuel.

The study further identifies regions, where the intensification of fires caused by global warming will be most pronounced. Among the regions exhibiting the strongest anthropogenic trends in biomass burning are southern and central equatorial Africa, Madagascar, Australia, parts of the Mediterranean and western North-America. “Our results show that with every degree global warming the global mean area burned by fires each year will increase by 14%. This can have substantial effects on ecosystems, infrastructure and human health and livelihoods.” says Dr. Vincent VERJANS, former postdoctoral research fellow at the IBS Center for Climate Physics (now at Barcelona Supercomputing Center) and lead author of the study.

Moreover, the researchers also highlight that with more fires on a global scale, also the levels of fire smoke will increase. Smoke plumes emerging from wildfires will have an effect on air pollution and also lead to reduced penetration of sunlight. The latter changes the heat and infrared radiation in the atmosphere. “Our new computer model simulations show for the first time that accounting for these effects in a comprehensive earth system model, can influence regional temperatures. Fire regions and their downwind smoke plume extensions will experience on average somewhat reduced warming due to the solar dimming effect.” says co-author Prof. Christian FRANZKE from the IBS Center for Climate Physics at Pusan National University, South Korea. However, in addition to reducing sunlight (direct aerosol effect) which is accounted for in the new computer simulations, aerosols from biomass burning can also change the formation of clouds (indirect effect). “This part is still somewhat uncertain, and more research needs to be conducted to understand how fires will impact clouds and subsequently surface temperatures,” adds Prof. Franzke.

While this study makes important strides in representing climate-lightning-wildfire interactions in the current generation of Earth System models, it also identifies key aspects that require further consideration. A critical example is the extent to which Arctic wildfires will increase in a warmer world. In their model simulations, the increase in Arctic wildfire activity is weaker than the observed trends in recent years. “This may indicate that current climate models underestimate future Arctic wildfire risks. Among other things, this would have important consequences for predictions of aerosols released from wildfires, which in turn will affect the climate and influence air quality,” says Dr. Vincent VERJANS.

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