Researchers have identified a key pathway that links how neurons send signals to each other, or synaptic activity, to the expression of genes necessary for long-term changes in the brain, providing crucial insights into the molecular processes underlying memory formation.

“These findings illuminate a critical mechanism that connects local synaptic activity to the broader gene expression changes necessary for learning and memory,” said Mark Dell’Acqua, professor of pharmacology at the University of Colorado Anschutz Medical Campus and senior author of the study. “This paper is mainly a basic science finding of a fundamental process of what nerve cells do. Understanding this relay system not only enhances our knowledge of brain function but could also better inform therapeutic treatments for cognitive disorders.”

The nucleus where the genes that modify neuron function are controlled is a long distance away from where neurons receive input from their synapses, which are located in distant dendrites that extend like branches from the trunk of a tree. This research focuses on the cAMP-response element binding protein (CREB), a transcription factor known to regulate genes vital for dynamic changes at synapses which is essential for neuronal communication. Despite CREB’s well-documented role in supporting learning and memory, the exact mechanisms leading to CREB activation during neuronal activity remain unclear.

Using advanced microscopy techniques, graduate student Katlin Zent in Dr. Dell’Acqua’s research group revealed a crucial relay mechanism involving the activation of receptors and ion channels generating calcium signals that rapidly communicates from synapses in remote dendrite branches to the nucleus in the neuron cell body.

“Going forward, this research will enable us to better examine the way these pathways are utilized in different disease states,” said Dell’Acqua. “We could see exactly what parts of this new mechanism are interfered with and where, giving us a better idea of how this pathway affecting learning and memory is impacted. This research highlights potential targets for interventions aimed at conditions like Alzheimer’s disease and other memory-related disorders.”

“Although past evidence showing causal links between modelling and getting rewarded for violence had an immediate impact on aggressive behavior in 4-year-old children, few studies have investigated long-term risks with antisocial behavior. We studied such risks in mid-adolescence, explained Pagani, who is also a researcher at the Centre de recherche Azrieli du CHU Sainte-Justine. It was ideal to study this question with typically developing middle-class children because, as a population, they have the lowest chances of engaging in aggression and behavior harmful to others.”

Close to 2,000 children

In all, Pagani and her team looked at 963 girls and 982 boys born between the springs of 1997 and 1998 who were enrolled in the Quebec Longitudinal Study of Child Development. Parents reported the frequency of their child’s exposure to violent television content at ages 3.5 and 4.5 years old. Boys and girls then self-reported on several aspects of antisocial behavior at age 15.

The study defines screen violence as anything “characterized by physical aggression, verbal aggression, and relational aggression […] depicting situations that intentionally attempt or cause harm to others.” Children, the study says “are attracted to fast-paced, stimulating violent content, which often features appealing characters like superheroes who commit and are rewarded for aggressive acts, thus increasing the likelihood of exposure.”

The researchers then conducted analyses to examine whether exposure to violent television content at ages 3.5 and 4.5 years predicted later antisocial behavior eleven years later.

The researcher added, “We statistically took into account alternative child and family factors that could have explained our results, to be as close as possible to the truth in the relationships we were looking at.”

Boys stand out

At age 15, for boys only, preschool violent televiewing predicted increases in antisocial behavior. Being exposed to violent content in early childhood predicted later aggressive behaviors such as hitting or beating another person, with the intention of obtaining something, stealing, with or without any apparent reason.

Risks also included threats, insults, and gang fight involvement. The use of weapons is also among the behavioral outcomes predicted by exposure to childhood television violence in this study. No effects were found for girls, which was not surprising given that boys are generally more exposed to such content.

Pagani concluded, “Our study provides compelling evidence that early childhood exposure to media violence can have serious, long-lasting consequences, particularly for boys. This underscore the urgent need for public health initiatives that targets campaigns to inform parents and communities about the long-term risks and empower them to make informed choices about young children’s screen content exposure.”

The entire team of students from Université de Montréal and researchers from the United States and Italy established that, “Parents and communities can play a crucial role in limiting future problems by carefully avoiding young children’s exposure to violent media content.”

Psoriasis is a hereditary, chronic skin condition that can also result in inflammation of the joints. In Sweden, almost 300,000 people live with some form of the condition. Chronic inflammatory bowel diseases (IBD), especially Crohn’s disease, are more common in patients with psoriasis than in the rest of the population.

“Previous research has also shown that people with psoriasis have more gastrointestinal problems than the general population. However we didn’t know much about why this is the case. With our study, we can now show that people with psoriasis often have invisible inflammation in their small intestines, with an increased risk of what’s called leaky gut,” says Maria Lampinen, researcher at Uppsala University.

Pro-inflammatory activity in the gut

The study involved 18 patients with psoriasis and 15 healthy controls as subjects. None of the participants had been diagnosed with gastrointestinal diseases. Samples were taken from both their small and large bowel. The researchers then studied different types of immune cells in the mucous membrane.

“It turned out that psoriasis sufferers had higher numbers of certain types of immune cells in their small intestine, and the cells showed signs of pro-inflammatory activity. Interestingly, we found the same type of immune cells in skin flare-ups from psoriasis patients, suggesting that the inflammation of the skin may have an impact on the gut, or vice versa.

Increased propensity for leaky gut

Normally, the intestinal mucosa act as a protective barrier that also allows nutrients and water to pass through it. In some autoimmune diseases, the intestinal barrier may function poorly. This is called having a leaky gut, and leads to bacteria and harmful substances leaking through the intestinal barrier and causing inflammation. This can also cause more widespread inflammation when these substances are spread via the bloodstream.

Half of the psoriasis patients in the study had increased intestinal barrier permeability or leaky gut. These same patients also reported more gastrointestinal symptoms such as abdominal pain and bloating than patients with a normal intestinal barrier. They also had elevated levels of inflammatory substances in their intestines.

“Given that the psoriasis patients in our study had relatively mild skin disease and showed no visible intestinal inflammation in a gastroscopy, they had surprisingly clear changes in their small intestine compared to healthy controls. These changes could explain why psoriasis sufferers often have gastrointestinal problems, and an increased risk of developing Crohn’s disease.

Important research for these patients

The Psoriasisförbundet (the Swedish Psoriasis Association) member magazine published an article about this study. Following its publication, Maria Lampinen received many e-mails from people who recognised this phenomenon.

“They wanted to know more about the link between the gut and the skin because they recognised that symptoms from their gut and skin were often linked. So it feels like this research is needed and is important for the patients themselves. A greater understanding of gastrointestinal problems in psoriasis patients can help the healthcare system to pay more attention to the link between the gut and the skin in patients with psoriasis, and in the long term it could also lead to better treatment of these problems.

The study was funded by the Psoriasis Association’s managed funds and Hudfonden (the Skin Foundation), among others.

Trust in scientists is at a moderately high level worldwide, according to a new study. This is the conclusion of an international team of 241 researchers led by Viktoria Cologna of ETH Zurich and Niels G. Mede of the University of Zurich (UZH). “Our results show that most people in most countries have a relatively high level of trust in scientists,” says principal investigator Viktoria Cologna, “and want them to play an active role in society and politics.” The study found no evidence for the oft-repeated claim of a crisis of trust in science.

The study is the result of the TISP Many Labs study, a collaborative effort that allowed the authors to survey 71,922 people in 68 countries, including many under-researched countries in the Global South. For the first time since the coronavirus pandemic, the study provides global, representative survey data on the populations and regions of the world in which researchers are perceived to be most trustworthy, the extent to which they should engage with the public, and whether science is prioritizing important research issues.

No crisis of trust in science

Across 68 countries, the study finds that the majority of the public has a relatively high level of trust in scientists (mean trust level = 3.62, on a scale of 1 = very low trust to 5 = very high trust). The majority of respondents also perceive scientists as qualified (78%), honest (57%) and concerned about people’s well-being (56%).

However, the results also reveal some areas of concern. Globally, less than half of respondents (42%) believe that scientists pay attention to the views of others. “Our results also show that many people in many countries feel that the priorities of science are not always well aligned with their own priorities,” says co-author Niels G. Mede. “We recommend that scientists take these results seriously and find ways to be more receptive to feedback and open to dialogue with the public.”

Polarization of population groups and differences between countries

The findings confirm the results of previous studies that show significant differences between countries and population groups. In particular, people with right-wing political views in Western countries tend to have less trust in scientists than those with left-wing views. This suggests that attitudes toward science tend to polarize along political lines. In most countries, however, political orientation and trust in scientists were not related.

Call for active engagement of scientists

A majority of respondents want science to play an active role in society and policy-making. Globally, 83% of respondents believe that scientists should communicate with the public about science, providing an impetus for increased science communication efforts. Only a minority (23%) believe that scientists should not actively advocate for specific policies. 52% believe that scientists should be more involved in the policy-making process.

Participants gave high priority to research to improve public health, solve energy problems, and reduce poverty. On the other hand, research to develop defense and military technology was given a lower priority. In fact, participants explicitly believe that science is prioritizing the development of defense and military technology more than they would like, highlighting a potential misalignment between public and scientific priorities.