The use of natural and minimally processed ingredients in many modern diets has decreased, more often being replaced with ingredients that have been industrially processed, artificially flavored, colored or chemically altered.

Foods such as breakfast cereals, margarines/spreads, packaged snacks, hot dogs, soft drinks and energy drinks, candies and desserts, frozen pizzas, ready-to-eat meals, mass-produced packaged breads and buns, and more, include synthesized ingredients and are highly processed.

These ultra-processed foods usually have longer shelf lives and are highly appealing, as they are convenient and contain a combination of sugar, fat, salt and carbohydrates which affect the brain’s reward system, making it hard to stop eating.

For the study, researchers set out to assess the association of ultra-processed food intake and their relationship to intramuscular fat in the thigh.

“The novelty of this study is that it investigates the impact of diet quality, specifically the role of ultra-processed foods in relation to intramuscular fat in the thigh muscles assessed by MRI,” said author Zehra Akkaya, M.D., researcher and former Fulbright Scholar in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. “This is the first imaging study looking into the relationship between MRI-based skeletal muscle quality and quality of diet.”

For the study, researchers analyzed data from 666 individuals who participated in the Osteoarthritis Initiative who were not yet affected by osteoarthritis, based on imaging. The Osteoarthritis Initiative is a nationwide research study, sponsored by the National Institutes of Health, that helps researchers better understand how to prevent and treat knee osteoarthritis.

“Research from our group and others has previously shown that quantitative and functional decline in thigh muscles is potentially associated with onset and progression of knee osteoarthritis,” Dr. Akkaya said. “On MRI images, this decline can be seen as fatty degeneration of the muscle, where streaks of fat replace muscle fibers.”

Of the 666 individuals, (455 men, 211 women) the average age was 60 years. On average, participants were overweight with a body mass index (BMI) of 27. Approximately 40% of the foods that they ate in the past year were ultra-processed.

The researchers found that the more ultra-processed foods people consumed, the more intramuscular fat they had in their thigh muscles, regardless of energy (caloric) intake.

“In an adult population at risk for but without knee or hip osteoarthritis, consuming ultra-processed foods is linked to increased fat within the thigh muscles,” Dr. Akkaya said. “These findings held true regardless of dietary energy content, BMI, sociodemographic factors or physical activity levels.”

Targeting modifiable lifestyle factors — mainly prevention of obesity via a healthy, balanced diet and adequate exercise — has been the mainstay of initial management for knee osteoarthritis, Dr. Akkaya noted.

“Osteoarthritis is an increasingly prevalent and costly global health issue. It is the largest contributor to non-cancer related health care costs in the U.S. and around the world,” Dr. Akkaya said. “Since this condition is highly linked to obesity and unhealthy lifestyle choices, there are potential avenues for lifestyle modification and disease management.”

By exploring how ultra-processed food consumption impacts muscle composition, this study provides valuable insights into dietary influences on muscle health.

“Understanding this relationship could have important clinical implications, as it offers a new perspective on how diet quality affects musculoskeletal health,” Dr. Akkaya said.

Co-authors are Gabby B. Joseph, Ph.D., Katharina Ziegeler, M.D., Wynton M. Sims, John A. Lynch, Ph.D., and Thomas M. Link, M.D., Ph.D.

“Two years ago, we demonstrated an aquatic soft robot that was able to reach average speeds of 3.74 body lengths per second,” says Jie Yin, corresponding author of a paper on the work and an associate professor of mechanical and aerospace engineering at North Carolina State University. “We have improved on that design. Our new soft robot is more energy efficient and reaches a speed of 6.8 body lengths per second. In addition, the previous model could only swim on the surface of the water. Our new robot is capable of swimming up and down throughout the water column.”

The soft robot has fins shaped like those of a manta ray, and is made of a material that is stable when the fins are spread wide. The fins are attached to a flexible, silicone body that contains a chamber that can be pumped full of air. Inflating the air chamber forces the fins to bend — similar to the down stroke when a manta flaps its fins. When the air is let out of the chamber, the fins spontaneously snap back into their initial position. 

“Pumping air into the chamber introduces energy into the system,” says Haitao Qing, first author of the paper and a Ph.D. student at NC State. “The fins want to return to their stable state, so releasing the air also releases the energy in the fins. That means we only need one actuator for the robot and allows for more rapid actuation.”

Studying the fluid dynamics of manta rays also played a key role in controlling the vertical movement of the soft robot.

“We observed the swimming motion of manta rays and were able to mimic that behavior in order to control whether the robot swims toward the surface, swims downward, or maintains its position in the water column,” says Jiacheng Guo, co-author of the paper and a Ph.D. student at the University of Virginia. “When manta rays swim, they produce two jets of water that move them forward. Mantas alter their trajectory by altering their swimming motion. We adopted a similar technique for controlling the vertical movement of this swimming robot. We’re still working on techniques that will give us fine control over lateral movements.”

“Specifically, simulations and experiments showed us that the downward jet produced by our robot is more powerful than its upward jet,” says Yuanhang Zhu, co-author of the paper and an assistant professor of mechanical engineering at the University of California, Riverside. “If the robot flaps its fins quickly, it will rise upward. But if we slow down the actuation frequency, this allows the robot to sink slightly in between flapping its fins — allowing it to either dive downward or swim at the same depth.”

“Another factor that comes into play is that we are powering this robot with compressed air,” Qing says. “That’s relevant because when the robot’s fins are at rest, the air chamber is empty, reducing the robot’s buoyancy. And when the robot is flapping its fins slowly, the fins are at rest more often. In other words, the faster the robot flaps its fins, the more time the air chamber is full, making it more buoyant.”

The researchers have demonstrated the soft robot’s functionality in two different ways. First, one iteration of the robot was able to navigate a course of obstacles arrayed on the surface and floor of a water tank. Second, the researchers demonstrated that the untethered robot was capable of hauling a payload on the surface of the water, including its own air and power source.

“This is a highly engineered design, but the fundamental concepts are fairly simple,” Yin says. “And with only a single actuation input, our robot can navigate a complex vertical environment. We are now working on improving lateral movement, and exploring other modes of actuation, which will significantly enhance this system’s capabilities. Our goal is to do this with a design that retains that elegant simplicity.”

The paper, “Spontaneous Snapping-Induced Jet Flows for Fast, Maneuverable Surface and Underwater Soft Flapping Swimmer,” is published open access in the journal Science Advances. The paper was co-authored by Yinding Chi and Yaoye Hong, former Ph.D. students at NC State; and by Daniel Quinn and Haibo Dong of UVA.

This work was done with support from the National Science Foundation under grants 2126072 and 2329674; and from the Office of Naval Research under grant N00014-22-1-2616.

The study, featured on the Dec. 4 cover of the journal Science Advances, used stable isotope analysis to model the diet of the mother of an infant discovered at a 13,000-year-old Clovis burial site in Montana. Before this study, prehistoric diet was inferred by analyzing secondary evidence, such as stone tools or the preserved remains of prey animals.

The findings support the hypothesis that Clovis people specialized in hunting large animals rather than primarily foraging for smaller animals and plants.

The Clovis people inhabited North America around 13,000 years ago. During that time period, animals like mammoths lived across both northern Asia and the Americas. They migrated long distances, which made them a reliable fat- and protein-rich resource for highly mobile humans.

“The focus on mammoths helps explain how Clovis people could spread throughout North America and into South America in just a few hundred years,” said co-lead author James Chatters of McMaster University.

“What’s striking to me is that this confirms a lot of data from other sites. For example, the animal parts left at Clovis sites are dominated by megafauna, and the projectile points are large, affixed to darts, which were efficient distance weapons,” said co-lead author Ben Potter, an archaeology professor at the University of Alaska Fairbanks.

Hunting mammoths provided a flexible way of life, Potter said. It allowed the Clovis people to move into new areas without having to rely on smaller, localized game, which could vary significantly from one region to the next.

“This mobility aligns with what we see in Clovis technology and settlement patterns,” Potter said. “They were highly mobile. They transported resources like toolstone over hundreds of miles.”

Researchers were able to model the Clovis people’s diet by first analyzing isotopic data published during earlier studies by other researchers of the remains of Anzick-1, an 18-month-old Clovis child. By adjusting for nursing, they were able to estimate values for his mother’s diet.

“Isotopes provide a chemical fingerprint of a consumer’s diet and can be compared with those from potential diet items to estimate the proportional contribution of different diet items,” said Mat Wooller, an author on the study and director of the Alaska Stable Isotope facility at UAF.

The team compared the mother’s stable isotopic fingerprint to those from a wide variety of food sources from the same time period and region. They found that about 40% of her diet came from mammoth, with other large animals like elk and bison making up the rest. Small mammals, sometimes thought to have been an important food source, played a very minor role in her diet.

Finally, the scientists compared the mother’s diet to those of other omnivores and carnivores from the same time period, including American lions, bears and wolves. The mother’s diet was most similar to that of the scimitar cat, a mammoth specialist.

Findings also suggest that early humans may have contributed to the extinction of large ice age animals, especially as environmental changes reduced their habitats.

“If the climate is changing in a way that reduces the suitable habitat for some of these megafauna, then it makes them potentially more susceptible to human predation. These people were very effective hunters,” said Potter.

“You had the combination of a highly sophisticated hunting culture — with skills honed over 10,000 years in Eurasia — meeting naïve populations of megafauna under environmental stress,” said Chatters.

An important aspect of this research, according to Potter and Chatters, is their outreach to Native Americans in Montana and Wyoming about their concerns and interest in this work.

“It is important and ethical to consult with Indigenous peoples on questions relating to their heritage,” they said.

They worked with Shane Doyle, executive director of Yellowstone Peoples, who reached out to numerous tribal government representatives throughout Montana, Wyoming and Idaho. “The response has been one of appreciative consideration and inclusion,” said Doyle.

“I congratulate the team for their astounding discovery about the lifeways of Clovis-era Native people and thank them for being tribally inclusive and respectful throughout their research,” he said. “This study reshapes our understanding of how Indigenous people across America thrived by hunting one of the most dangerous and dominant animals of the day, the mammoth.”

Other authors of the paper include Stuart J. Fiedel, independent researcher; Juliet E. Morrow, University of Arkansas; and Christopher N. Jass, Royal Alberta Museum.

Guided by previous research of spider brains, the scientists uncovered evidence of a “waste canal system” in the human brain that internalizes waste from healthy neurons. They discovered that this system can undergo catastrophic swelling, which leads to the degeneration of brain tissue, a hallmark of Alzheimer’s disease.

With over 50 million affected people worldwide, Alzheimer’s disease is among the leading causes of death in the U.S.

The findings, which have been published by The Journal of Comparative Neurology, offer a compelling new explanation for commonly described brain pathologies observed in Alzheimer’s disease, including amyloid-beta plaques, tau tangles, and spongiform abnormalities.

Supported by the Vermont Biomedical Research Network (VBRN), the research was carried out in collaboration among Dr. Ruth Fabian-Fine (Saint Michael’s College, UVM Robert Larner, M.D. College of Medicine), Dr. John DeWitt (UVM Robert Larner, M.D. College of Medicine, UVM Medical Center), Dr. Adam Weaver (Saint Michael’s College), and Saint Michael’s undergraduate research students Abigail Roman and Melanie Winters, both members of the Class of 2025.

“The Vermont Biomedical Network has been thrilled to support Dr. Fabian-Fine’s research from its initial focus on animal neuroscience to the more recent and potentially groundbreaking emphasis on the cellular basis of human neurodegeneration,” said UVM’s Dr. Christopher Francklyn, the Director of VBRN. “Her exciting work, and the outstanding training she has provided to her undergraduate co-investigators, epitomizes what NIH hopes to accomplish with its national IDEA program.”

Neuroscientist Dr. Fabian-Fine and her team initially investigated the underlying causes for neurodegeneration in Central American wandering spiders that suffer from conditions similar to degenerative diseases in humans. Because the spider neurons were a larger size, the scientists were better able to observe their brain functions. They quickly discovered a waste-internalizing glial canal system that undergoes structural abnormalities in degenerating spider brains, which leads to uncontrolled depletion and death of brain cells.

This discovery prompted Fabian-Fine, a Vermont Center for Cardiovascular and Brain Health Pipeline Investigator, to explore whether a similar system could be found in both rodent and human brain tissue, so she teamed up with neuropathologist Dr. DeWitt at UVM’s Larner College of Medicine. The collaborative undertaking led the scientists to gather overwhelming evidence that neurodegeneration in human and rodent brains may have similar underlying causes compared to those observed in spider brains. The scientists’ report outlines possible underlying causes for neurodegeneration that may offer a promising new avenue for drug development that can address the structural abnormalities that lead to neurodegeneration.

Dozens of student researchers at Saint Michael’s College contributed to the multi-year research that provided the foundation for this breakthrough. Experiments occurred at Saint Michael’s College, the University of Vermont Medical Center, and at the UVM’s Center for Biomedical Shared Resources.

Further, the results of the study by Oregon Health & Science University involving neurosurgery patients suggests new possibilities for tapping into those areas to improve learning among people bedeviled by math.

“This work lays the foundation to deeper understanding of number, math and symbol cognition — something that is uniquely human,” said senior author Ahmed Raslan, M.D., professor and chair of neurological surgery in the OHSU School of Medicine. “The implications are far-reaching.”

The study published today in the journal PLOS ONE.

Raslan and co-authors recruited 13 people with epilepsy who were undergoing a commonly used surgical intervention to map the exact location within their brains where seizures originate, a procedure known as stereotactic electroencephalography. During the procedure, researchers asked the patients a series of questions that prompted them to think about numbers as symbols (for example, 3), as words (“three”) and as concepts (a series of three dots).

As the patients responded, researchers found activity in a surprising place: the putamen.

Located deep within the basal ganglia above the brain stem, the putamen is an area of the brain primarily associated with elemental functions, such as movement, and some cognitive function, but rarely with higher-order aspects of human intelligence like solving calculus. Neuroscientists typically ascribe consciousness and abstract thought to the cerebral cortex, which evolved later in human evolution and wraps around the brain’s outer layer in folded gray matter.

“That likely means the human ability to process numbers is something that we acquired early during evolution,” Raslan said. “There is something deeper in the brain that gives us this capacity to leap to where we are today.”

Researchers also found activity as expected in regions of the brain that encode visual and auditory inputs, as well as the parietal lobe, which is known to be involved in numerical and calculation-related functions.

From a practical standpoint, the findings could prove useful in avoiding important areas during surgeries to remove tumors or epilepsy focal points, or in placing neurostimulators designed to stop seizures.

“Brain areas involved in processing numbers can be delineated and extra care taken to avoid damaging these areas during neurosurgical interventions,” said lead author Alexander Rockhill, Ph.D., a postdoctoral researcher in Raslan’s lab.

Researchers credited the patients involved in the study.

“We are extremely grateful to our epilepsy patients for their willingness to participate in this research,” said co-author Christian Lopez Ramos, M.D., a neurosurgical resident at OHSU. “Their involvement in answering our questions during surgery turned out to be the key to advancing scientific understanding about how our brain evolved in the deep past and how it works today.”

Indeed, the study follows previous lines of research involving mapping of the human brain during surgery.

“I have access to the most valuable human data in nature,” Raslan said. “It would be a shame to miss an opportunity to understand how the brain and mind function. All we have to do is ask the right questions.”

In the next stage of this line of research, Raslan anticipates discerning areas of the brain capable of performing other higher-level functions.

In addition to Raslan, Rockhill and Lopez Ramos, co-authors include Hao Tan, M.D., Beck Shafie, Maryam Shahin, M.D., Adeline Fecker, Mostafa Ismail, Daniel Cleary, M.D., and Kelly Collins, M.D., of OHSU; and Caleb Nerison, D.O., now of Lexington Medical Center in South Carolina.