At water depths greater than 3,000 meters, the remote-controlled submersible vehicle MARUM-QUEST took samples from the newly discovered hydrothermal field. Named after Jøtul, a giant in Nordic mythology, the field is located on the 500-kilometer-long Knipovich Ridge. The ridge lies within the triangle formed by Greenland, Norway and Svalbard on the boundary of the North American and European tectonic plates. This kind of plate boundary, where two plates move apart, is called a spreading ridge. The Jøtul Field is located on an extremely slow spreading ridge with a growth rate of the plates of less than two centimeters per year. Because very little is known about hydrothermal activity on slow spreading ridges, the expedition focused on obtaining an overview of the escaping fluids, as well as the size and composition of active and inactive smokers in the field.

“The Jøtul Field is a discovery of scientific interest not only because of its location in the ocean but also due to its climate significance, which was revealed by our detection of very high concentrations of methane in the fluid samples, among other things,” reports Gerhard Bohrmann. Methane emissions from hydrothermal vents indicate a vigorous interaction of magma with sediments. On its journey through the water column, a large proportion of the methane is converted into carbon dioxide, which increases the concentration of CO₂ in the ocean and contributes to acidification, but it also has an impact on climate when it interacts with the atmosphere. The amount of methane from the Jøtul Field that eventually escapes directly into the atmosphere, where it then acts as a greenhouse gas, still needs to be studied in more detail. There is also little known about the organisms living chemosynthetically in the Jøtul Field. In the darkness of the deep ocean, where photosynthesis cannot occur, hydrothermal fluids form the basis for chemosynthesis, which is employed by very specific organisms in symbiosis with bacteria.

In order to significantly expand on the somewhat sparse information available on the Jøtul Field, a new expedition of the MARIA S. MERIAN will start in late summer of this year under the leadership of Gerhard Bohrmann. The focus of the expedition is the exploration and sampling of as yet unknown areas of the Jøtul Field. With extensive data from the Jøtul Field it will be possible to make comparisons with the few already known hydrothermal fields in the Arctic province, such as the Aurora Field and Loki’s Castle.

An international team, led by Penn State researchers, using the NIRSpec instrument aboard JWST as part of the RUBIES survey identified three mysterious objects in the early universe, about 600-800 million years after the Big Bang, when the universe was only 5% of its current age. They announced the discovery today (June 27) in Astrophysical Journal Letters.

The team studied spectral measurements, or intensity of different wavelengths of light emitted from the objects. Their analysis found signatures of “old” stars, hundreds of millions of years old, far older than expected in a young universe.

The researchers said they were also surprised to discover signatures of huge supermassive black holes in the same objects, estimating that they are 100 to 1,000 times more massive than the supermassive black hole in our own Milky Way. Neither of these are expected in current models of galaxy growth and supermassive black hole formation, which expect galaxies and their black holes to grow together over billions of years of cosmic history.

“We have confirmed that these appear to be packed with ancient stars — hundreds of millions of years old — in a universe that is only 600-800 million years old. Remarkably, these objects hold the record for the earliest signatures of old starlight,” said Bingjie Wang, a postdoctoral scholar at Penn State and lead author on the paper. “It was totally unexpected to find old stars in a very young universe. The standard models of cosmology and galaxy formation have been incredibly successful, yet, these luminous objects do not quite fit comfortably into those theories.”

The researchers first spotted the massive objects in July of 2022, when the initial dataset was released from JWST. The team published a paper in Nature several months later announcing the objects’ existence.

At the time, the researchers suspected the objects were galaxies, but followed up their analysis by taking spectra to better understand the true distances of the objects, as well as the sources powering their immense light.

The researchers then used the new data to draw a clearer picture of what the galaxies looked like and what was inside of them. Not only did the team confirm that the objects were indeed galaxies near the beginning of time, but they also found evidence of surprisingly large supermassive black holes and a surprisingly old population of stars.

“It’s very confusing,” said Joel Leja, assistant professor of astronomy and astrophysics at Penn State and co-author on both papers. “You can make this uncomfortably fit in our current model of the universe, but only if we evoke some exotic, insanely rapid formation at the beginning of time. This is, without a doubt, the most peculiar and interesting set of objects I’ve seen in my career.”

The JWST is equipped with infrared-sensing instruments capable of detecting light that was emitted by the most ancient stars and galaxies. Essentially, the telescope allows scientists to see back in time roughly 13.5 billion years, near the beginning of the universe as we know it, Leja said.

One challenge to analyzing ancient light is that it can be hard to differentiate between the types of objects that could have emitted the light. In the case of these early objects, they have clear characteristics of both supermassive black holes and old stars. However, Wang explained, it’s not yet clear how much of the observed light comes from each — meaning these could be early galaxies that are unexpectedly old and more massive even than our own Milky Way, forming far earlier than models predict, or they could be more normal-mass galaxies with “overmassive” black holes, roughly 100 to 1,000 times more massive than such a galaxy would have today.

“Distinguishing between light from material falling into a black hole and light emitted from stars in these tiny, distant objects is challenging,” Wang said. “That inability to tell the difference in the current dataset leaves ample room for interpretation of these intriguing objects. Honestly, it’s thrilling to have so much of this mystery left to figure out.”

Aside from their unexplainable mass and age, if part of the light is indeed from supermassive black holes, then they also aren’t normal supermassive black holes. They produce far more ultraviolet photons than expected, and similar objects studied with other instruments lack the characteristic signatures of supermassive black holes, such as hot dust and bright X-ray emission. But maybe the most surprising thing, the researchers said, is how massive they seem to be.

“Normally supermassive black holes are paired with galaxies,” Leja said. “They grow up together and go through all their major life experiences together. But here, we have a fully formed adult black hole living inside of what should be a baby galaxy. That doesn’t really make sense, because these things should grow together, or at least that’s what we thought.”

The researchers were also perplexed by the incredibly small sizes of these systems, only a few hundred light years across, roughly 1,000 times smaller than our own Milky Way. The stars are approximately as numerous as in our own Milky Way galaxy — with somewhere between 10 billion and 1 trillion stars — but contained within a volume 1,000 times smaller than the Milky Way.

Leja explained that if you took the Milky Way and compressed it to the size of the galaxies they found, the nearest star would almost be in our solar system. The supermassive black hole in the center of the Milky Way, about 26,000 light years away, would only be about 26 light years away from Earth and visible in the sky as a giant pillar of light.

“These early galaxies would be so dense with stars — stars that must have formed in a way we’ve never seen, under conditions we would never expect during a period in which we’d never expect to see them,” Leja said. “And for whatever reason, the universe stopped making objects like these after just a couple of billion years. They are unique to the early universe.”

The researchers are hoping to follow up with more observations, which they said could help explain some of the objects’ mysteries. They plan to take deeper spectra by pointing the telescope at the objects for prolonged periods of time, which will help disentangle emission from stars and the potential supermassive black hole by identifying the specific absorption signatures that would be present in each.

“There’s another way that we could have a breakthrough, and that’s just the right idea,” Leja said. “We have all these puzzle pieces and they only fit if we ignore the fact that some of them are breaking. This problem is amenable to a stroke of genius that has so far eluded us, all of our collaborators and the entire scientific community.”

Wang and Leja received funding from NASA’s General Observers program. The research was also supported by the International Space Science Institute in Bern. The work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. Computations for the research were performed on Penn State’s Institute for Computational and Data Sciences’ Roar supercomputer.

Other co-authors on the paper are Anna de Graaff of the Max-Planck-Institut für Astronomie in Germany; Gabriel Brammer of the Cosmic Dawn Center and Niels Bohr Institute; Andrea Weibel and Pascal Oesch of the University of Geneva; Nikko Cleri, Michaela Hirschmann, Pieter van Dokkum and Rohan Naidu of Yale University; Ivo Labbé of Stanford University; Jorryt Matthee and Jenny Greene of Princeton University; Ian McConachie and Rachel Bezanson of the University of Pittsburgh; Josephine Baggen of Texas A&M University; Katherine Suess of the Observatoire de Sauverny in Switzerland; David Setton of Massachusetts Institute of Technology’s Kavli Institute for Astrophysics and Space Research; Erica Nelson of the University of Colorado; Christina Williams of the U.S. National Science Foundation’s National Optical-Infrared Astronomy Research Laboratory and the University of Arizona.

The device consists of a soft, stretchable electrode attached to a silicone patch. It can be worn like a sticker on either the fingertip or forearm. The electrode, in direct contact with the skin, is connected to an external power source via wires. By sending a mild electrical current through the skin, the device can produce sensations of either pressure or vibration depending on the signal’s frequency.

“Our goal is to create a wearable system that can deliver a wide gamut of touch sensations using electrical signals — without causing pain for the wearer,” said study co-first author Rachel Blau, a nano engineering postdoctoral researcher at the UC San Diego Jacobs School of Engineering.

Existing technologies that recreate a sense of touch through electrical stimulation often induce pain due to the use of rigid metal electrodes, which do not conform well to the skin. The air gaps between these electrodes and the skin can result in painful electrical currents.

To address these issues, Blau and a team of researchers led by Darren Lipomi, a professor in the Aiiso Yufeng Li Family Department of Chemical and Nano Engineering at UC San Diego, developed a soft, stretchy electrode that seamlessly conforms to the skin.

The electrode is made of a new polymer material constructed from the building blocks of two existing polymers: a conductive, rigid polymer known as PEDOT:PSS, and a soft, stretchy polymer known as PPEGMEA. “By optimizing the ratio of these [polymer building blocks], we molecularly engineered a material that is both conductive and stretchable,” said Blau.

The polymer electrode is laser-cut into a spring-shaped, concentric design and attached to a silicone substrate. “This design enhances the electrode’s stretchability and ensures that the electrical current targets a specific location on the skin, thus providing localized stimulation to prevent any pain,” said Abdulhameed Abdal, a Ph.D. student in the Department of Mechanical and Aerospace Engineering at UC San Diego and the study’s other co-first author. Abdal and Blau worked on the synthesis and fabrication of the electrode with UC San Diego nano engineering undergraduate students Yi Qie, Anthony Navarro and Jason Chin.

In tests, the electrode device was worn on the forearm by 10 participants. In collaboration with behavioral scientists and psychologists at the University of Amsterdam, the researchers first identified the lowest level of electrical current detectable. They then adjusted the frequency of the electrical stimulation, allowing participants to experience sensations categorized as either pressure or vibration.

“We found that by increasing the frequency, participants felt more vibration rather than pressure,” said Abdal. “This is interesting because biophysically, it was never known exactly how current is perceived by the skin.”

The new insights could pave the way for the development of advanced haptic devices for applications such as virtual reality, medical prosthetics and wearable technology.

This work was supported by the National Science Foundation Disability and Rehabilitation Engineering program (CBET-2223566). This work was performed in part at the San Diego Nanotechnology Infrastructure (SDNI) at UC San Diego, a member of the National Nanotechnology Coordinated Infrastructure, which is supported by the National Science Foundation (grant ECCS-1542148).

In a study published June 26 in Nature Communications, the team reported finding major differences between postmortem and living prefrontal cortex brain tissues as they relate to one of the most abundant RNA modifications in the brain, known as adenosine-to-inosine (A-to-I) editing. This discovery will play a significant role in shaping the development of diagnostics and therapies for brain diseases.

While DNA holds the genetic blueprint for humans, RNA actually carries out its instructions to create functional proteins that play important roles in how the body functions, including the complex functions of the central nervous system. RNA’s function and stability are controlled by many modifications, each holding a specific purpose. These modifications, known as RNA editing, are a continuous process occurring in all our cells and tissues, facilitated by enzymes known as ADAR. This process can continue to occur in individual cells for some time after the death of the person whose tissues the cells were part of.

The conversion of adenosine nucleosides to inosine (A-to-I) is a common and well-studied RNA modification and is orchestrated by proteins in the ADAR family, primarily ADAR1 and ADAR2. In the mammalian brain, thousands of highly regulated A-to-I editing sites have been discovered across anatomical regions and cell types, some by Mount Sinai researchers. These sites are known to be involved in neuronal maturation and brain development. Aberrant regulation of A-to-I editing has been linked to neurological disorders.

“Until now, the investigation of A-to-I editing and its biological significance in the mammalian brain has been restricted to the analysis of postmortem tissues. By using fresh samples from living individuals, we were able to uncover significant differences in RNA editing activity that previous studies, relying only on postmortem samples, may have overlooked,” said Michael Breen, PhD, co-senior author of the study and Assistant Professor of Psychiatry, and Genetics and Genomic Sciences, at Icahn Mount Sinai. “We were particularly surprised to find that RNA editing levels were significantly higher in postmortem brain tissue compared to living tissue, which is likely due to postmortem changes such as inflammation and hypoxia that do not occur in living brains. Additionally, we discovered that RNA editing in living tissue tends to involve evolutionarily conserved and functionally important sites that are also dysregulated in human disease, emphasizing the need to study both living and postmortem samples for a comprehensive understanding of brain biology.”

After death, the lack of oxygen quickly damages brain cells, causing an irreversible cascade of damage that can alter ADAR expression and A-to-I editing. “We hypothesized that molecular responses to postmortem-induced hypoxic and immune responses can significantly alter the landscape of A-to-I editing. This can lead to misunderstandings about RNA editing in the brain if we only study postmortem tissues,” said Miguel Rodríguez de los Santos, PhD, co-first author of the study and a postdoctoral fellow in the Department of Psychiatry at Mount Sinai. “Studying living brain tissue provides us with a clearer picture of RNA editing biology in the human brain.”

To investigate, the research team anchored their study around the Living Brain Project, in which dorsolateral prefrontal cortex (DLPFC) tissues from living people are obtained during neurosurgical procedures for deep brain stimulation, an elective treatment for neurological illness. For comparison, a cohort of postmortem DLPFC tissues across three brain banks was assembled to match the living cohort for key demographic and clinical variables. The team investigated multiple genomic data types from the Living Brain Project, including bulk tissue RNA sampling, single-nuclei RNA sequencing, and whole-genome sequencing. The generation of this data is being described in multiple forthcoming Living Brain Project manuscripts.

The researchers identified more than 72,000 locations where A-to-I editing occurs more often or differently in postmortem than in living DLPFC brain tissue. They found higher levels of the enzymes ADAR and ADARB1, which are responsible for elevated editing patterns in postmortem brain tissues. Interestingly, they also found hundreds of sites with higher levels of A-to-I editing in living brain tissue. These sites are mostly found in the connections between neurons (called synapses) and are typically conserved through evolution, suggesting they play important roles in brain activity. Some well-known A-to-I editing sites were highly edited in living brains, indicating they may be involved in critical neuronal processes like synaptic plasticity, which is essential for learning and memory. However, many other A-to-I editing sites found in living brain tissues have unclear functions, and further research is needed to understand their impact on brain health.

“Utilizing fresh brain tissue from living human donors provided us the opportunity to investigate the brain without the confounds inherent to postmortem tissue analysis,” said Alexander W. Charney, MD, PhD, co-senior author of the study and Associate Professor of Psychiatry, Genetic and Genomic Sciences, Neuroscience, and Neurosurgery at Icahn Mount Sinai and co-lead of the Living Brain Project. “In doing so, we revealed more accurate insights into the prevalence and roles of A-to-I editing in the human brain. It is critical to note that our findings do not negate but instead provide missing context for using postmortem brain tissues in researching A-to-I regulation. Understanding these differences helps improve our knowledge of brain function and disease through the lens of RNA editing modifications, which can potentially lead to better diagnostic and therapeutic approaches.”

The research team will further analyze the RNA editing data to understand its implications better and to identify potential therapeutic targets for Parkinson’s disease. They are also expanding the research to include emerging work from this cohort that focuses on gene expression, proteomics, and multi-omics of the living brain.

“By harnessing the unique, transdisciplinary nature of the Living Brain Project, we can turn a cutting edge clinical care modality like deep brain stimulation into a platform for unprecedented insight into human brain biology that will give rise to new therapeutic opportunities,” said Brian Kopell, MD, co-first author of the study, Director of the Center for Neuromodulation at Mount Sinai and co-lead of the Living Brain Project

With these and other emerging applications in mind, MIT researchers demonstrated a new millimeter-wave multiple-input-multiple-output (MIMO) wireless receiver architecture that can handle stronger spatial interference than previous designs. MIMO systems have multiple antennas, enabling them to transmit and receive signals from different directions. Their wireless receiver senses and blocks spatial interference at the earliest opportunity, before unwanted signals have been amplified, which improves performance.

Key to this MIMO receiver architecture is a special circuit that can target and cancel out unwanted signals, known as a nonreciprocal phase shifter. By making a novel phase shifter structure that is reconfigurable, low-power, and compact, the researchers show how it can be used to cancel out interference earlier in the receiver chain.

Their receiver can block up to four times more interference than some similar devices. In addition, the interference-blocking components can be switched on and off as needed to conserve energy.

In a mobile phone, such a receiver could help mitigate signal quality issues that can lead to slow and choppy Zoom calling or video streaming.

“There is already a lot of utilization happening in the frequency ranges we are trying to use for new 5G and 6G systems. So, anything new we are trying to add should already have these interference-mitigation systems installed. Here, we’ve shown that using a nonreciprocal phase shifter in this new architecture gives us better performance. This is quite significant, especially since we are using the same integrated platform as everyone else,” says Negar Reiskarimian, the X-Window Consortium Career Development Assistant Professor in the Department of Electrical Engineering and Computer Science (EECS), a member of the Microsystems Technology Laboratories and Research Laboratory of Electronics (RLE), and the senior author of a paper on this receiver.

Reiskarimian wrote the paper with EECS graduate students Shahabeddin Mohin, who is the lead author, Soroush Araei, and Mohammad Barzgari, an RLE postdoc. The work was recently presented at the IEEE Radio Frequency Circuits Symposium and received the Best Student Paper Award.

Blocking interference

Digital MIMO systems have an analog and a digital portion. The analog portion uses antennas to receive signals, which are amplified, down-converted, and passed through an analog-to-digital converter before being processed in the digital domain of the device. In this case, digital beamforming is required to retrieve the desired signal.

But if a strong, interfering signal coming from a different direction hits the receiver at the same time as a desired signal, it can saturate the amplifier so the desired signal is drowned out. Digital MIMOs can filter out unwanted signals, but this filtering occurs later in the receiver chain. If the interference is amplified along with the desired signal, it is more difficult to filter out later.

“The output of the initial low-noise amplifier is the first place you can do this filtering with minimal penalty, so that is exactly what we are doing with our approach,” Reiskarimian says.

The researchers built and installed four nonreciprocal phase shifters immediately at the output of the first amplifier in each receiver chain, all connected to the same node. These phase shifters can pass signal in both directions and sense the angle of an incoming interfering signal. The devices can adjust their phase until they cancel out the interference.

The phase of these devices can be precisely tuned, so they can sense and cancel an unwanted signal before it passes to the rest of the receiver, blocking interference before it affects any other parts of the receiver. In addition, the phase shifters can follow signals to continue blocking interference if it changes location.

“If you start getting disconnected or your signal quality goes down, you can turn this on and mitigate that interference on the fly. Because ours is a parallel approach, you can turn it on and off with minimal effect on the performance of the receiver itself,” Reiskarimian adds.

A compact device

In addition to making their novel phase shifter architecture tunable, the researchers designed them to use less space on the chip and consume less power than typical nonreciprocal phase shifters.

Once the researchers had done the analysis to show their idea would work, their biggest challenge was translating the theory into a circuit that achieved their performance goals. At the same time, the receiver had to meet strict size restrictions and a tight power budget, or it wouldn’t be useful in real-world devices.

In the end, the team demonstrated a compact MIMO architecture on a 3.2-square-millimeter chip that could block signals which were up to four times stronger than what other devices could handle. Simpler than typical designs, their phase shifter architecture is also more energy efficient.

Moving forward, the researchers want to scale up their device to larger systems, as well as enable it to perform in the new frequency ranges utilized by 6G wireless devices. These frequency ranges are prone to powerful interference from satellites. In addition, they would like to adapt nonreciprocal phase shifters to other applications.

This research was supported, in part, by the MIT Center for Integrated Circuits and Systems.

This study, co-led by Dr Skye Yunshu TIAN from the University of Bonn, who conducted the major part of the research at The University of Hong Kong (HKU), along with Professor Moriaki YASUHARA from HKU School of Biological Sciences, the Swire Institute of Marine Science (SWIMS) and Institute for Climate and Carbon Neutrality (ICCN), as well as Dr Fabien L. CONDAMINE of Centre National de la Recherche Scientifique (CNRS), has now been published in the journal Nature.

The researchers began their investigation by examining sediment samples from the Indo-Australian Archipelago in the laboratory and identifying the fossils they contained. “We wanted to understand how the marine biodiversity of the Indo-Australian Archipelago evolved and persisted, and what factors were responsible for the disproportionately high diversity in the tropics,” said first author Skye Tian.

Their findings revealed that the archipelago had shown an increase in diversification since the early Miocene, around 20 million years ago. Approximately 2.6 million years ago, the number of species approached a plateau. Interestingly, there were no major extinction events during the entire study period. “The increase in diversity was primarily driven by the habitat factor, as tectonic collisions (movements of Earth’s plates) in Southeast Asia created extensive areas of shallow marine habitats,” Skye noted.

Around 14 million years ago, the region’s thermal stress, or excessive heat, began to moderate. “This moderation was crucial for the development of the hotspot,” Skye continued. “During the Eocene (56 to 34 million years ago), excessively high tropical temperatures in warm climate zones hindered the increase in diversity. The cooling after that allowed for a more favourable environment for biodiversity to flourish.” However, this rich biodiversity could be at risk. “Our palaeobiological results suggest that we could quickly lose the fantastic diversity of the tropical hotspot if the ongoing anthropogenic warming intensifies.” Skye added.

Professor Moriaki Yasuhara further elaborated: “This reconstruction of the long-term history of the Coral Triangle diversity hotspot enables us to better understand how diversity hotspot moved from ‘Tethys (ancient Mediterranian region)’ region to the present place of the Coral Triangle and developed there. These are what we didn’t know too clearly before. And also our results tells us why Coral Triangle diversity is much higher than that of the Caribbean Sea, that is probably because the Coral Triangle didn’t experience large extinction event by luck.”

To date, many investigations in the field have established intuitive links that are less direct than that: Air pollution exposure while young is consistently associated with lung problems during childhood — and childhood lung problems are consistently associated with lung issues as an adult.

The current study, published in the American Journal of Respiratory and Clinical Care Medicine, is one of only a few to show the direct connection between childhood air pollution exposure and adult lung health, a connection not fully explained by air pollution impacts on lung health during childhood. It opens the possibility of yet-to-be-understood factors explaining the path from early air pollution exposure to respiratory maladies many years later.

The team drew upon the USC Children’s Health Study, a large-scale, decades-long study following cohorts of Southern Californians starting at school-age and, for many participants, continuing into adulthood. Importantly, the link between childhood air pollution exposure and adult bronchitis symptoms persisted even when the researchers adjusted for asthma or bronchitis symptoms early in life — a finding that came as a surprise.

“We would expect that these observable impacts on childhood respiratory health would explain the relationship between childhood air pollution exposure and adult respiratory health,” said corresponding author Erika Garcia, PhD, MPH, assistant professor of population and public health sciences at the Keck School of Medicine. “Our results suggest that childhood air pollution exposure has more subtle effects on our respiratory system that still impact us in adulthood.”

Safeguarding lung health, now and later

The focus on exposure during youth is motivated in part by the fact that children are particularly vulnerable to the effects of air pollution. Their respiratory and immune systems are still developing and compared to adults, they breathe in more air relative to their body mass.

Ultimately the concern is twofold, for the health of young people today and for their future health when they grow up. Notably, among study participants with recent bronchitis symptoms as adults, average childhood exposure to a pollutant called nitrogen dioxide fell far below annual Environmental Protection Agency standards — just a bit over half the limit that was set in 1971 and remains in place today.

“This study highlights the importance of lowering air pollution, and especially exposure during the critical period of childhood,” Garcia said. “Because there’s only so much that we can do as individuals to control our exposure, the need to protect children from the adverse effects of air pollution is better addressed at the policy level.”

The study population comprised 1,308 Children’s Health Study participants with an average age of 32 at their adult assessment. The researchers asked about recent bouts of bronchitis symptoms — having either bronchitis, chronic cough, or congestion or phlegm production not associated with a cold. One-quarter of participants had experienced bronchitis symptoms within the previous 12 months.

Presence of bronchitis symptoms was associated with exposure between birth and age 17 to two types of pollutants. One type groups together tiny particles in the air such as dust, pollen, ash from wildfires, industrial emissions and products from vehicle exhaust. The other, nitrogen dioxide, is a byproduct of combustion in automobiles, planes, boats and power plants that is known to hurt lung function.

Long-running health research proves vital to igniting discovery

For as comprehensive an analysis as possible, average pollutant exposure over childhood was based on month-by-month estimates. The researchers matched up family home address at each time point with contemporaneous local air quality measurements taken by the EPA and through the Children’s Health Study.

“We’re fortunate to have this fantastic and nuanced longitudinal study,” Garcia said. “We can learn a lot about how earlier experiences impact adult health. That’s thanks to a long-term team effort from the participants themselves, their families, the schools they attended and all the research staff and investigators who conducted interviews and generated and analyzed data over the years.”

The current study included additional analyses to rule out factors such as prenatal exposure to nitrogen dioxide, current air pollution exposure as adults and the effects of socioeconomic status in childhood or adulthood as drivers of bronchitis symptoms in adults.

Pollution exposure in youth may hurt lung health for some more than others

Garcia and her colleagues also found that the effect of nitrogen dioxide and particulate matter exposure during childhood on bronchitis symptoms among adults was stronger for those who had been diagnosed with asthma as kids.

“There may be a subpopulation that is more sensitive to the effects of air pollution,” Garcia said. “We may want to be especially careful to protect them from exposure, so we can improve their outcomes later in life. Reducing air pollution would have benefits not only for current asthma in children but also for their respiratory health as they grow into adulthood.”

She and her colleagues are following up to examine how the level of air pollution exposure at different ages during youth influences breathing issues as an adult. Other future research directions building on the current study’s results could include looking into other markers of childhood and adult respiratory health, such as how well asthma was controlled, or exploring a potential genetic component.

About this study

The study’s co-authors are Zoe Birnhak, Scott West, Steve Howland, Rob McConnell, Shohreh. Farzan, Theresa Bastain, Rima Habre and Carrie Breton, all of the Keck School of Medicine; and Frederick Lurmann and Nathan Pavlovic of the environmental consulting firm Sonoma Technology.

This research received support from the National Institutes of Health (UH3OD023287, P30ES007048).

IIASA researchers adopted a waste systems perspective to identify hotspots of land-waste leakage, and determined which rivers, lakes, and coastal areas are particularly at risk. The results indicate a need for urgent action.

“Our study shows that the majority of leakage of municipal solid waste — everyday items that are discarded by people — into aquatic environments occur in Africa, China, India, and South Asia. It’s necessary to start focusing on improving waste management systems in these affected areas,” explains study lead author Adriana Gomez Sanabria, a researcher in the Pollution Management Research Group of the IIASA Energy, Climate, and Environment Program.

The study highlights that focusing on single waste streams can lead to unintended consequences. For example, as single-use plastic cups are replaced with paper cups, the amount of paper waste has increased. Therefore, it is crucial to set targets that address multiple waste streams simultaneously. Additionally, the study emphasizes the importance of universal waste collection as the primary strategy to prevent waste leakage into terrestrial and aquatic environments, even in a scenario where overall waste generation is reduced.

“Our analysis shows that there is a pressing need to establish a standardized framework to monitor waste generation, composition, and flows. This framework should help us track the effectiveness of actions, including political, economic, and technological measures aimed at reducing waste and improving waste management systems,” notes Florian Lindl, a study coauthor and researcher in the IIASA Pollution Management Research Group.

The research team notes that their study addresses a crucial gap in our understanding of how waste management systems play an important role in addressing various environmental impacts. By examining the interaction between waste management and waste leakage, effective strategies can be identified to reduce pollution in aquatic environments and preserve ecosystems. This knowledge is vital for shaping policies and promoting sustainable development practices that minimize the environmental footprint of our consumption habits.

“We need to understand that the primary function of waste management systems is to protect human health and the environment. As creators of the waste crisis, we must take responsibility by changing our behavior to reduce consumption through refuse, rethink, and reuse practices,” concludes Gomez Sanabria.