Top doctor alarmed by weight-loss drug misuse

The drugs should not be used as “a quick fix” to get “beach-body ready” this summer, NHS England’s medical director said.

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Balding at 16 and unable to look in the mirror

Poppie Davies wore a wig and talked about how isolated she felt with the condition.

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Silent Men film asks why so many still struggle to open up

Scottish filmmaker Duncan Cowles set out to ask why men tend to bottle up their emotions.

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New fabric makes urban heat islands more bearable

This year has already seen massive heatwaves around the globe, with cities in Mexico, India, Pakistan and Oman hitting temperatures near or past 50 degrees Celsius (122 degrees Fahrenheit).

As global temperatures and urban populations rise, the world’s cities have become “urban heat islands,” with tight-packed conditions and thermal radiation emitting from pavement and skyscraper trapping and magnifying these temperatures. With 68 percent of all people predicted to live in cities by 2050, this is a growing, deadly problem.

In a paper published today in Science, researchers from the UChicago Pritzker School of Molecular Engineering (PME) detail a new wearable fabric that can help urban residents survive the worst impacts of massive heat caused by global climate change, with applications in clothing, building and car design, and food storage.

In tests under the Arizona sun, the material kept 2.3 degrees Celsius (4.1 degrees Fahrenheit) cooler than the broadband emitter fabric used for outdoor endurance sports and 8.9 degrees Celsius (16 degrees Fahrenheit) cooler than the commercialized silk commonly used for shirts, dresses and other summer clothing.

This, the team hopes, will help many avoid the heat-related hospitalizations and deaths seen in global population centers this year alone.

“We need to reduce carbon emission and make our cities carbon negative or carbon neutral,” PME Asst. Prof. Po-Chun Hsu said. “But meanwhile, people are feeling the impact of these high temperatures.”

‘You have to consider the environment’

Existing cooling fabric for outdoor sports works by reflecting the sun’s light in a diffuse pattern so it doesn’t blind onlookers. But in an urban heat island, the sun is only one source of heat. While the sun bakes from above, thermal radiation emitted from buildings and pavement blast city-dwellers with blistering heat from the sides and below.

This means many materials that perform well in lab tests won’t help city-dwellers in Arizona, Nevada, California, Southeast Asia and China when predicted massive heatwaves hit them over the next few weeks.

“People normally focus on the performance or the material design of cooling textiles,” said co-first author Ronghui Wu, a postdoctoral researcher at PME. “To make a textile that has the potential to apply to real life, you have to consider the environment.”

One simple example of considering the environment is that people stand. They are wearing materials designed to reflect direct sunlight, but only their hats, shoulder coverings and the tops of their shoes — about 3 percent of their clothing — face that direct light. The other 97 of their clothes are being heated by the thermal radiation coming at them from the sides and below, which broadband emitter fabric does not fight.

The sun and sidewalk cook with different heats. Creating one material capable of protecting wearers from both provided a major engineering challenge for the team.

“Solar is visible light, thermal radiation is infrared, so they have different wavelengths. That means you need to have a material that has two optical properties at the same time. That’s very challenging to do,” said co-first author Chenxi Sui, a PhD candidate at PME. “You need to play with material science to engineer and tune the material to give you different resonances at different wavelengths.”

The costs of comfort

Cooling a home too often means warming the planet, with the carbon impact of air conditioning and refrigeration systems contributing to climate change.

“Our civilization actually uses about 10 to 15 percent of the energy in total just to make ourselves feel comfortable wherever we go,” Hsu said.

The risk from heat is not distributed evenly, however. In the U.S. and Japan, more than 90 percent of households have an air conditioner, a number that drops to 5 percent in India and parts of Africa.

The PME team’s new textile, which has received a provisional patent, can help provide a passive cooling system that can supplement and reduce the need for energy- and cost-intensive systems.

The applications go far beyond clothing.

A thicker version of the fabric protected by an invisible layer of polyethylene could be used on the sides of buildings or cars, lowering internal temperatures and reducing the cost and carbon impact of air conditioning. Similarly, the material could be used to transport and store milk and other foods that would otherwise spoil in the heat, cutting refrigeration’s impact.

“You can save a lot of cooling, electricity and energy costs because this is a passive process,” Sui said.

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A conservation market could incentivize global ocean protection

The countries of the world agreed: Our planet needs more protection from human activity. And with the globe facing an assortment of environmental crises, they realized the plan needed to be ambitious. Thirty-by-thirty was their proposal: protect 30% of the planet by 2030. But while conservation is popular in principle, the costs of actually enacting it often stall even the most earnest efforts.

Three researchers at UC Santa Barbara have proposed a market-based approach to achieving the 30×30 targets in the ocean. They tested whether a system that allowed countries to trade conservation credits could reduce costs, incentivizing nations to actually meet their goals. Allowing voluntary trade always reduced the cost of conservation, sometimes by more than 90%. The study, published in Science, is the first to draft and analyze a conservation market for achieving 30×30 targets in the ocean.

The 30×30 initiative is one aspect of the Convention on Biological Diversity, a multilateral treaty developed in the early 1990s. In fact, it’s target No. 3 of the larger Global Biodiversity Framework (GBF) adopted by the 196 countries that convened for the UN Biodiversity Conference in 2022. It calls for the effective protection and management of 30% of the world’s terrestrial, freshwater, coastal and marine areas by the year 2030 — a goal that many scientists say humanity must achieve to secure our planet’s long-term health. And while the GBF requires countries to commit to conservation targets, it does not outline which areas should be protected, how to do so inclusively or how to pay for it.

“This project started just over four years ago,” said co-author Juan Carlos Villaseñor-Derbez, who completed his doctorate at UCSB’s Bren School of Environmental Science & Management. At this point, countries were falling short of the 10% protection benchmark as they drafted plans for 30% protection. “It seemed like most nations were genuinely committed to marine conservation, but that the costs of conserving were preventing some from engaging in it at all.

“At the same time,” he added, “a lot of research had already shown that if you could get nations to cooperate around conservation, you could substantially reduce the costs of conserving.” He and his co-authors realized the world needed an institution, policy or framework that could support this.

Uneven costs and benefits

The cost of protecting acres of ocean is not the only aspect that differs from place to place. The ecological benefits of conservation also vary based on location. Achieving 30×30 in the ocean will require coastal nations to consider potential trade-offs associated with these protections. Because high-value fisheries can coincide with important marine ecosystems — such as coral reefs, seagrass meadows and kelp forests — meeting the obligation could come at a high cost for some nations but not others. “Without an innovative policy solution, the cost of conservation for many nations could stall progress toward 30×30,” said Villasenor-Derbez.

This variability means that trade could incentivize additional gains. Instead of investing in areas with high conservation costs, or low benefits, nations could exchange their duties to double down on regions where protection yields higher returns.

Environmental economists and scientists at UC Santa Barbara’s Environmental Markets Lab (emLab) wondered if a conservation credit system could help meet 30×30 targets in the ocean. They devised a system whereby nations could trade their conservation obligation with other nations through a “transferable conservation market” policy built around ecological principles.

“Like existing mandates, this approach requires every country to protect a certain fraction (say 30%) of its marine habitat,” said Distinguished Professor Christopher Costello, emLab’s director. “But unlike other approaches, we allow those obligations to be traded across countries, within strict ecological constraints.” In this way, countries with higher conservation costs pay others to increase their conservation efforts. This study estimates the potential global cost savings under various trading constraints.

“For example, Norway, which has valuable fisheries, might pay Palau, a country that has already invested significantly in coastal conservation, to conserve additional areas on Norway’s behalf,” Costello said. This enables Norway to fulfill its conservation obligations in another part of the world.

Achieving 30×30 in the ocean

Costello, Villaseñor-Derbez and co-author Professor Andrew Plantinga developed a model to estimate the potential costs and benefits that could be achieved through a conservation market like this. They combined distribution data for 23,699 marine species with fisheries revenue data to build conservation supply curves for the world’s coastal nations.

They then defined “trade bubbles” based on biological and geographic factors. A country could trade conservation credits only with other nations within these predefined bubbles in order to ensure conservation was equitably spread across Earth’s different marine habitats. The authors examined five bubble policies that allow nations to trade within hemispheres, biogeographic realms, provinces, ecoregions, or globally, to determine potential costs.

Regardless of how they tweaked this setup, a market for marine conservation always reduced the costs of conservation. The model estimated savings could range from 37.4% all the way to 98% under the 30×30 target.

“It just highlighted how inefficient it is to require uniform conservation obligations from each nation,” Villaseñor-Derbez said. “After all, national boundaries don’t really overlap or line-up with the distribution patterns of marine biodiversity.”

Savings were highest in a global market, where every nation stands to gain from trade. But a global market could inadvertently focus conservation efforts on only a single type of habitat, neglecting others. That was precisely why the team introduced the trade bubble constraint.

“When nations facing large costs are allowed to trade, they can ask themselves ‘should I conserve in my waters at this high cost, or can I find someone in my bubble that has habitat just as good as mine but at a lower price?'” Villaseñor-Derbez said. The same would be true for a selling nation. They could decide whether to conserve more than they are required depending on the trading price.

Of course, a country could always go it alone, fulfilling their conservation obligations (and theirs alone) entirely within their own territory. Indeed, this is precisely how the 30×30 initiative currently looks. But the authors’ analysis suggests that very few countries will. Most find it far more economical to either buy or sell conservation obligations.

Conservation colonialism vs fair compensation

If a market system were established, some might wonder what would prevent wealthy nations from simply “paying off” their conservation obligations and offloading them onto poorer nations. For Costello, Villaseñor-Derbez and Plantinga, the market itself offers a solution. “All such exchanges are purely voluntary,” said Plantinga, who heads emLab’s Productive Landscapes Group. “The selling nation (the poor country in this example) only engages in trade if they find it advantageous.”

In fact, the market could be a boon for developing nations. The current 30×30 scheme requires even a cash-poor country with high conservation to conserve 30% of their territorial waters. The market approach offers a degree of flexibility: The country can weigh their finances against their conservation costs. They can then decide how much of their obligation to fulfill within their own waters, how much to buy from another nation, and how much to offer up for sale. This flexibility is not possible under the current approach to 30×30.

This system could also incentivize habitat restoration, target No. 2 of the GBF. Nations that tend to specialize in exploiting marine resources could compensate those who specialize in conserving marine biodiversity. “Our approach provides an explicit payment for conserving marine ecosystems,” Costello said. “Under the current system, there is rarely a payment to conserve.”

Lowering costs incentivizes action. This measurable effect is a central tenet of economics employed by governments, companies and industries across sectors and countries. So why not harness this principle for conservation? According to the authors, these savings could be redirected towards solving other pressing issues.

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Can engineered plants help make baby formula as nutritious as breast milk?

Worldwide, a majority of babies — approximately 75% — drink infant formula in their first six months of life, either as a sole source of nutrition or as a supplement to breastfeeding. But while formula provides essential food for growing babies, it currently does not replicate the full nutritional profile of breast milk.

That’s in part because human breast milk contains a unique blend of approximately 200 prebiotic sugar molecules that help prevent disease and support the growth of healthy gut bacteria. However, most of these sugars remain difficult, if not impossible, to manufacture.

New research led by scientists at the University of California, Berkeley, and the University of California, Davis, shows how genetically engineered plants may help close this gap.

In a new study published today in the journal Nature Food, the study team reprogrammed plants’ sugar-making machinery to produce a diverse array of these human milk sugars, also called human milk oligosaccharides. The findings could lead to healthier and more affordable formula for babies, or more nutritious non-dairy plant milk for adults.

“Plants are these phenomenal organisms that take sunlight and carbon dioxide from our atmosphere and use them to make sugars. And they don’t just make one sugar — they make a whole diversity of simple and complex sugars,” said study senior author Patrick Shih, an assistant professor of plant and microbial biology and an investigator at UC Berkeley’s Innovative Genomics Institute. “We thought, since plants already have this underlying sugar metabolism, why don’t we try rerouting it to make human milk oligosaccharides?”

All complex sugars — including human milk oligosaccharides — are made from building blocks of simple sugars, called monosaccharides, which can be linked together to form a vast array of chains and branched chains. What makes human milk oligosaccharides unique are the specific set of linkages, or rules, for connecting simple sugars together that are found in these molecules.

To convince plants to make human milk oligosaccharides, study first author Collin Barnum engineered the genes responsible for the enzymes that make these specific linkages. Working with Daniela Barile, David Mills and Carlito Lebrilla at UC Davis, he then introduced the genes into the Nicotiana benthamiana plant, a close relative of tobacco.

The genetically modified plants produced 11 known human milk oligosaccharides, along with a variety of other complex sugars with similar linkage patterns.

“We made all three major groups of human milk oligosaccharides,” Shih said. “To my knowledge, no one has ever demonstrated that you could make all three of these groups simultaneously in a single organism.“

Barnum then worked to create a stable line of N. benthamiana plants that were optimized to produce a single human milk oligosaccharide called LNFP1.

“LNFP1 is a five-monosaccharide-long human milk oligosaccharide that is supposed to be really beneficial, but so far cannot be made at scale using traditional methods of microbial fermentation,” said Barnum, who completed the work as a graduate student at UC Davis. “We thought that if we could start making these larger, more complex human milk oligosaccharides, we could solve a problem that that industry currently can’t solve.”

Currently, a small handful of human milk oligosaccharides can be manufactured using engineered E. coli bacteria. However, isolating the beneficial molecules from other toxic byproducts is a costly process, and only a limited number of baby formulas include these sugars in their mixtures.

As part of the study, Shih and Barnum worked with collaborator Minliang Yang at North Carolina State University to estimate the cost of producing human milk oligosaccharides from plants at an industrial scale and found that it would likely be cheaper than using microbial platforms.

“Imagine being able to make all the human milk oligosaccharides in a single plant. Then you could just grind up that plant, extract all the oligosaccharides simultaneously and add that directly into infant formula,” Shih said. “There would be a lot of challenges in implementation and commercialization, but this is the big goal that we’re trying to move toward.”

Additional authors include Bruna Paviani, Garret Couture, Chad Masarweh, Ye Chen, Yu-Ping Huang, David A. Mills, Carlito B. Lebrilla and Daniela Barile of UC Davis; Kasey Markel of UC Berkeley; and Minliang Yang of North Carolina State University.

This work was supported in part by the National Institutes of Health (NIGMS T32 Training Program), the U.S. Department of Energy and the National Center for Complementary and Integrative Health (R00AT009573)

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‘Do not cry for me’, says cancer campaigner in final post

Tributes are paid to Kate Rackham who helped set up the Fighting to be Heard charity after her diagnosis.

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England’s hospital waiting lists rise to 7.57m

Jump in England comes after ministers claimed the NHS backlog had started to come down.

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Warning over habitual delays for cancer treatment

A survey found the number of cancer centres experiencing severe delays had almost doubled in a year.

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Pacific coast gray whales have gotten 13% shorter in the past 20-30 years, Oregon State study finds

Gray whales that spend their summers feeding in the shallow waters off the Pacific Northwest coast have undergone a significant decline in body length since around the year 2000, a new Oregon State University study found.

The smaller size could have major consequences for the health and reproductive success of the affected whales, and also raises alarm bells about the state of the food web in which they coexist, researchers say.

“This could be an early warning sign that the abundance of this population is starting to decline, or is not healthy,” said K.C. Bierlich, co-author on the study and an assistant professor at OSU’s Marine Mammal Institute in Newport. “And whales are considered ecosystem sentinels, so if the whale population isn’t doing well, that might say a lot about the environment itself.”

The study, published in Global Change Biology, looked at the Pacific Coast Feeding Group (PCFG), a small subset of about 200 gray whales within the larger Eastern North Pacific (ENP) population of around 14,500. This subgroup stays closer to shore along the Oregon coast, feeding in shallower, warmer waters than the Arctic seas where the bulk of the gray whale population spends most of the year.

Recent studies from OSU have shown that whales in this subgroup are smaller and in overall worse body condition than their ENP counterparts. The current study reveals that they’ve been getting smaller in recent decades.

The Marine Mammal Institute’s Geospatial Ecology of Marine Megafauna (GEMM) Lab has been studying this subgroup of gray whales since 2016, including flying drones over the whales to measure their size. Using images from 2016-2022 of 130 individual whales with known or estimated age, researchers determined that a full-grown gray whale born in 2020 is expected to reach an adult body length that is 1.65 meters (about 5 feet, 5 inches) shorter than a gray whale born prior to 2000. For PCFG gray whales that grow to be 38-41 feet long at full maturity, that accounts for a loss of more than 13% of their total length.

If the same trend were to happen in humans, that would be like the height of the average American woman shrinking from 5 feet, 4 inches to 4 feet, 8 inches tall over the course of 20 years.

“In general, size is critical for animals,” said Enrico Pirotta, lead author on the study and a researcher at the University of St. Andrews in Scotland. “It affects their behavior, their physiology, their life history, and it has cascading effects for the animals and for the community they’re a part of.”

Whale calves that are smaller at weaning age may be unable to cope with the uncertainty that comes with being newly independent, which can affect survival rates, Pirotta said.

For adult gray whales, one of the biggest concerns is reproductive success.

“With them being smaller, there are questions of how effectively these PCFG gray whales can store and allocate energy toward growing and maintaining their health. Importantly, are they able to put enough energy toward reproduction and keep the population growing?” Bierlich said.

Scarring on PCFG whales from boat strikes and fishing gear entanglement also makes the team concerned that smaller body size with lower energy reserves may make the whales less resilient to injuries.

The study also examined the patterns of the ocean environment that likely regulate food availability for these gray whales off the Pacific coast by tracking cycles of “upwelling” and “relaxation” in the ocean. Upwelling sweeps nutrients from deeper to shallower regions, while relaxation periods then allow those nutrients to remain in shallower areas where light allows for growth of plankton and other tiny organisms, including the prey of gray whales.

“Without a balance between upwelling and relaxation, the ecosystem may not be able to produce enough prey to support the large size of these gray whales,” said co-author Leigh Torres, associate professor and director of the GEMM Lab at OSU.

The data show that whale size declined concurrently with changes in the balance between upwelling and relaxation, Pirotta said.

“We haven’t looked specifically at how climate change is affecting these patterns, but in general we know that climate change is affecting the oceanography of the Northeast Pacific through changes in wind patterns and water temperature,” he said. “And these factors and others affect the dynamics of upwelling and relaxation in the area.”

Now that they know the PCFG gray whales’ body size is declining, researchers say they have a lot of new questions about downstream consequences of that decline and the factors that could be contributing to it.

“We’re heading into our ninth field season studying this PCFG subgroup,” Bierlich said. “This is a powerful dataset that allows us to detect changes in body condition each year, so now we’re examining the environmental drivers of those changes.”

The other co-authors on the paper were Lisa Hildebrand, Clara Bird and Alejandro Ajó at OSU and Leslie New at Ursinus College in Pennsylvania.

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