Recent research by Professor Joseph MICHALSKI, a geologist in the Department of Earth Sciences at The University of Hong Kong (HKU), has revealed intriguing insights into the volcanic activity on Mars. He proposes that Mars has significantly more diverse volcanism than previously realised, driven by an early form of crust recycling called vertical tectonics. The findings, recently published in Nature Astronomy, shed light on the ancient crust of Mars and its potential implications for understanding early crustal recycling on both Mars and Earth.

Traditionally, Mars has been known to have large shield volcanoes similar to those in Hawaii. However, it was not known that Mars also possessed the diverse, explosive volcanoes that form on Earth due to crustal recycling.

The recent research conducted by Professor Michalski and his international team discover a vast number of diverse volcanoes in the ancient crust of Mars. ‘We have known for decades that Mars has volcanoes, but most of the recognised volcanoes correspond to large basaltic shield volcanoes similar to the ones that make up Hawaii,’ he explains. ‘In this work, we show that the ancient crust has many other types of volcanoes such as lava domes, stratovolcanoes, calderas and large shields of ash, not lava. Further, most scientists see Mars as a planet composed of basalt, which has low silica content and represents little crustal evolution, but these volcanoes have high silica content which means they formed from a complex process of magma evolution not known before.’

The paper suggests that intense volcanism occurred on ancient Mars, causing the crust to collapse into the mantle, where the rocks re-melted, resulting in magmas that have high silica. This tectonic process, called vertical tectonics, is hypothesised to have occurred on the ancient Earth, but rocks on Earth from that period (the Archean, more than 3 billion years ago) are highly modified by later geological activity, so we cannot see evidence for this process clearly on this planet. Therefore, exploring other planets like Mars, which has volcanism but no plate tectonics, can help reveal the mysteries of early crustal recycling on both the Red Planet, and by analogy, on early Earth.

Professor Michalski concluded, ‘Mars contains critical geological puzzle pieces that help us understand not only that planet, but the Earth as well. Martian volcanism is much more complex and diverse than has been previously thought.’

‘This is a significant discovery because it has revealed that crustal recycling can occur not only in plate tectonic regimes dominated by horizontal movements, but can also occur in pre-plate tectonic regimes dominated by vertical movements. This finding can help earth scientists revolve the long-term controversial issues of how and when felsic continents formed in our planet (Earth)’, said Professor Guochun ZHAO, the Chair Professor of HKU Earth Sciences.

The study by Eva Untersmayr-Elsenhuber and her team from MedUni Vienna’s Center for Pathophysiology, Infectiology and Immunology builds on earlier research on immune disorders and the intestinal barrier function in patients with ME/CFS. It is well known that ME/CFS patients often differ greatly in the clinical manifestations of their disease. However, despite intensive research, there is still no measurable parameter (biomarker) that clearly indicates the disease.

As the MedUni Vienna research team shows, ME/CFS patients can be divided into subgroups based on the function of their immune system. The study was able to identify various biomarkers in the patients that indicate immune system disorders or reduced intestinal barrier function. As a result, differences relevant to clinical care were identified in ME/CFS patients that would have remained undetected without the previous immunological stratification of the ME/CFS patient group. “In our study, we see that the immunological evaluation of ME/CFS patients is of crucial importance. Patients suffering from immunodeficiencies are characterised by an altered innate immune function. In ME/CFS patients with an intact immune system, the intestinal barrier function was reduced,” explains the study’s principal investigator Eva Untersmayr-Elsenhuber. According to the researchers, this not only provides a more detailed insight in different disease mechanisms, but also indicates that depending on the patient’s immune competence, some treatment approaches might be more suitable than others.

The next step will be to review the study results on a larger scale. In order to advance research in the field, the first ME/CFS Biobank in Austria is currently being set up at MedUni Vienna with the support of the WE&ME Foundation. “ME/CFS Biobank Austria” collects human samples, which will be made available for future research projects. Untersmayr-Elsenhuber: “To ensure that ME/CFS research can take place quickly and transnationally in the future, we have been coordinating with research groups in the UK, the Netherlands and Germany from the outset.”

25 per cent of those affected are bedridden

ME/CFS is a severe multisystemic disease that often leads to a high degree of disability. 60 per cent of patients are unable to work full-time and 25 per cent are bedridden. The exact causes of the disease are still unclear. As diagnosis is difficult due to the lack of biomarkers, the number of people affected cannot be precisely quantified. According to current studies, between 26,000 and 80,000 people in Austria suffer from chronic fatigue. Due to Covid-19, this number could double in the next few years. The links between infection with SARS-CoV-2 and ME/CFS are also the subject of intensive research.

Medical resources are generally stretched during holidays (including weekends) due to factors like staffing and hospital policies. This may amplify holiday effects: disparities and variations of health outcomes between holidays and weekdays. Dr. Sassa and colleagues studied this holiday effect with a focus on birth, especially high-risk births as measured by babies born preterm and/or with a low birthweight.

The authors used birth certificate data from over 21 million individuals born from 1979-2018 (which included birthday, birthweight, and gestational age) to categorize individuals into five groups: low birthweight (<2,500g), preterm birth (<37 weeks), low birthweight and preterm birth, and full-term birth. For this analysis, the authors compared weekdays (Monday-Friday) with weekend days (Saturday and Sunday), national holidays, substitute holidays, Golden Week (four consecutive spring festival days in Japan April 29 — May 5), and the new year period (December 29 — January 3). Leap days and multiple births were excluded.

They found that all births were significantly less common on weekend or holiday periods versus weekends (p < 0.01). High-risk births became more frequent over the four decades studied, and the trend of non-weekend or holiday births was especially evident for high-risk births, which were found to take place particularly frequently on Thursday and Friday. Though this study doesn’t include data on medical interventions or pregnancies that didn’t end in a live birth, which could potentially impact the findings, its broad scale suggests medical staff may often control births so that they take place before a weekend or holiday, especially for high-risk births. The authors note that this may be prudent since there are often fewer staff or resources available on weekend/holiday days, but since some holiday births are inevitable, it’s critical for hospitals to plan to minimize risks to those mothers who do give birth on non-weekdays.

The authors add: “Delving into decades of birth data in Japan, our research illuminates a fascinating trend — deliveries on holidays, especially those deemed high-risk, show a distinct decline. This discovery prompts a call for innovative solutions and systemic strategies to safeguard maternal and neonatal well-being anytime, demonstrating the need for creative thinking in optimizing medical resources for everyone.”

Vittrup Man is the nickname of a Stone Age skeleton recovered from a peat bog in Northwest Denmark, dating to between 3300-3100 BC. The fragmented nature of the remains, including a smashed skull, indicate that he was killed in a ritualistic sacrifice, a common practice in this region at this time. After a DNA study found Vittrup Man’s genetic signature to be distinct from contemporary, local skeletons, Fischer and colleagues were inspired to combine additional evidence to reconstruct the life history of this Stone Age individual at an unprecedented resolution.

Strontium, carbon and oxygen isotopes from Vittrup Man’s tooth enamel indicate a childhood spent along the coast of the Scandinavian Peninsula. Corroborating this, genetic analysis found a close relationship between Vittrup Man and Mesolithic people from Norway and Sweden. Additional isotope and protein analysis of the teeth and bones indicate a shift in diet from coastal food (marine mammals and fish) in early life to farm food (including sheep or goat) in later life, a transition that happened in the later teen years.

These results suggest that Vittrup Man spent his early years in a northern foraging society before relocating to a farming society in Denmark. It isn’t clear why this individual moved, though the authors suggest he might have been a trader or captive who became integrated into local society. Mysteries remain about Vittrup Man, but this detailed understanding of his geographic and dietary life history provides new insights into interactions between Mesolithic and Neolithic societies in Europe.

The authors add: “To our knowledge, this is the first time that research has been able to map a north European inhabitant’s life history in such a high degree of detail and in such high distance of time.”

Of the 161 people buried at Seminario Vescovile, an archaeological site in Verona from 3rd to 1st century BCE, 16 were buried with some kind of animal remains. Some of the graves contained the remains of animals often eaten by people — including many pigs, a chicken and part of a cow — which may have represented food offerings to the dead. But four of the people buried on the site were buried alongside the remains of dogs and/or horses, which are not commonly eaten.

To look for patterns that might explain these animal burials, the researchers analyzed the demographics, diets, genetics and burial conditions of the interred humans and animals, but this did not lead to any notable correlations. In particular, the people interred with animals do not seem to be closely related to each other, which would have suggested that this was a practice of a certain family. The people buried with dogs or horses also varied — they include a baby buried with a complete dog skeleton, a young man buried with parts of a horse, a middle-aged man buried with a small dog and a middle-aged woman buried with an entire horse, multiple other horse parts and a dog skull.

The lack of patterns among these graves mean that multiple interpretations of these human-animal co-burials remain possible, the authors say. For example, animals like dogs and horses often had religious symbolism in ancient cultures — but at the same time, specific individuals may also have been buried with their animal companions. In addition, the authors note, these human-animal burial practices might have been determined by the interplay between different individual traits and societal customs.

The authors add: “This study, which is part of the CELTUDALPS research project (co-financed by the Swiss National Science Foundation and the Province of South Tyrol, and coordinated by Marco Milella of the University of Bern and Albert Zink of the Institute for Mummy Studies, Eurac Research), explores burials of horses and dogs with humans, and may hint at unknown rituals and beliefs during the late centuries BCE in Italy.”