NHS whistleblowers need more protection, expert warns

NHS whistleblowers are being victimised, risking another big hospital scandal, an expert tells the BBC.

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Family to tell first penicillin patient’s story at conference

PC Albert Alexander received the newly-discovered antibiotic after being injured in 1941.

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NHS England chief Amanda Pritchard says strike disruption will get worse

Amanda Pritchard told the BBC that July’s strikes could be the worst yet for patients.

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NHS England head urges football clubs to consider gambling ad impact

Clubs should think carefully before accepting sponsorship from gambling firms, says NHS England head.

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‘Patients paying the price’ for strikes – NHS chief executive

Amanda Pritchard says patients are facing disruption for “both sides” failing to find agreement in a dispute over pay in the health service.

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Cancer: Mum writes book to help child cope with her diagnosis

When Hollie was diagnosed with the big C, she feared her bond with Sydney would be lost forever.

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New image from James Webb Space Telescope reveals astonishing Saturn and its rings

Saturn’s iconic rings seem to glow eerily in this incredible infrared picture, which also unveils unexpected features in Saturn’s atmosphere. See link to image below.

This image serves as context for an observing program that will test the telescope’s capacity to detect faint moons around the planet and its bright rings. Any newly discovered moons could help scientists put together a more complete picture of the current system of Saturn, as well as its past.

Methane gas absorbs almost all the sunlight falling on the atmosphere at this picture’s specific infrared wavelength (3.23 microns). As a result, Saturn’s familiar striped patterns aren’t visible because the methane-rich upper atmosphere blocks our view of the primary clouds. Instead, Saturn’s disk appears dark, and we see features associated with high-altitude stratospheric aerosols, including large, dark, and diffuse structures in Saturn’s northern hemisphere that don’t align with the planet’s lines of latitude. Interestingly, researchers previously spotted similar wave-like in early JWST NIRCam observations of Jupiter.

Unlike the atmosphere, Saturn’s rings lack methane, so at this infrared wavelength, they are no darker than usual and thus easily outshine the darkened planet. This new image of Saturn also reveals intricate details within the ring system, showcasing several of the planet’s moons like Dione, Enceladus, and Tethys.

“We are very pleased to see JWST produce this beautiful image, which is confirmation that our deeper scientific data also turned out well,” said Dr. Matthew Tiscareno, a senior research scientist at the SETI Institute who led the process of designing this observation. “We look forward to digging into the deep exposures to see what discoveries may await.”

Over the past few decades, missions like NASA’s Pioneer 11, Voyagers 1 and 2, the Cassini spacecraft and the Hubble Space Telescope have observed Saturn’s atmosphere and rings. The image captured by JWST is just a taste of what this observatory will uncover about Saturn in the coming years as scientists. This image is part of a suite of deeply exposed images where researchers hope to identify new ring structures and perhaps even new moons of Saturn.

Moving from the inner to the outer features of Saturn’s rings, we can observe the dark C ring, the bright B ring, the narrow and dark Cassini Division, and the medium-bright A ring with the dark Encke Gap near its outer edge. Additionally, off the outer edge of the A ring, we can see the narrow strand known as the F ring. The rings cast a shadow on the planet and vice versa, creating intriguing visual effects.

In-depth exposures not shown in this image will allow scientists to investigate Saturn’s fainter rings, including the thin G ring and diffuse E ring, which are not visible here. Saturn’s rings consist of an assortment of rocky and icy fragments, ranging in size from smaller than a grain of sand to as large as mountains on Earth. Recently, researchers used JWST to explore Enceladus and discovered a substantial plume emanating from the moon’s southern pole. This plume contains particles and copious amounts of water vapor, contributing to Saturn’s E ring.

Comparing the northern and southern poles of Saturn in this image, we can observe typical seasonal changes. It’s currently summertime in Saturn’s northern hemisphere, while the southern hemisphere emerges from winter darkness. However, the northern pole appears unusually dark, potentially due to an unknown seasonal process affecting polar aerosols. A faint brightening at the edge of Saturn’s disk might be attributed to high-altitude methane fluorescence or emission from the ionosphere’s trihydrogen ion (H3+). Spectroscopy from JWST could help confirm these possibilities.

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New A.I. system can decode fruit fly behaviors: Why that’s ‘pivotal’ for future human genetics research

How can you tell if a fruit fly is hungry? Ask a computer.

While that may sound like a bad dad joke, it’s reality at Tulane University, where researchers have developed a new A.I. tool that can tell you if a fruit fly is hungry, sleepy or singing (yes, fruit flies sing).

Dubbed MAFDA (for Novel Machine-learning-based Automatic Fly-behavioral Detection and Annotation) the system uses cameras and a newly developed software to track and identify complex interactive behaviors of individual flies within a larger group. This allows researchers to compare and contrast the behaviors of fruit flies with different genetic backgrounds.

For more than a century, scientists have used fruit flies’ simple genome and short lifespan to decode mysteries of inheritance and immunity in humans with studies of Drosophila melanogaster nabbing six Nobel Prizes. Fruit flies and humans share 60 percent of the same DNA.

Previous algorithms were less accurate at tracking individual flies within a group, but the MAFDA system makes studying the tiny, winged insects easier.

“Fruit flies are like pioneers in the discovery of new things, from the chromosome theory of inheritance to innate immunity,” said corresponding author Wu-Min Deng, PhD., professor of biochemistry and molecular biology and the Gerald & Flora Jo Mansfield Piltz Endowed Professor in Cancer Research at Tulane School of Medicine. “To be able to quantify the flies’ behavior is really a step forward in behavior studies.”

Wenkan Liu, a School of Medicine graduate student who developed the MAFDA system, said the significance of the platform is “undeniable.”

“It speeds up research, minimizes human error, and provides intricate insights into behavior genetics,” Liu said. “This tool is potentially pivotal as it enhances reproducibility and paves the way for new explorations in large-scale behavioral analysis.”

MAFDA was developed as part of a recent study, which discovered that the gene that causes flies to perceive pheromones is the same gene that controls pheromone production. These findings, published in Science Advances, challenge the status quo view that separate genes control pheromone production and perception and have broad applications in the fields of human behavioral evolution, metabolism and sex dimorphism.

Going forward, the researchers hope to see MAFDA used in a variety of applications. Jie Sun, lead author and postdoctoral fellow at Tulane School of Medicine, said MAFDA could eventually be used to study other insects as well as mice and fish, and the system may be useful in studying drug effects.

“The more information we give the machine, the better it gets at correctly identifying different behaviors from courtship to feeding and so on,” Sun said. “This is a very important, meaningful tool.”

MAFDA is already in use on other research projects at Tulane, and researchers are working to package the system so it can be used by more scientists both at Tulane and around the world .

“That’s the goal,” Deng said. “The original idea was to be able to identify the health status of flies. That may be too much to ask right now, but we’re hoping this will be more broadly used by the community and hopefully in the future we can go in that direction.”

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Displays controlled by flexible fins and liquid droplets more versatile, efficient than LED screens

Flexible displays that can change color, convey information and even send veiled messages via infrared radiation are now possible, thanks to new research from the University of Illinois Urbana-Champaign. Engineers inspired by the morphing skins of animals like chameleons and octopuses have developed capillary-controlled robotic flapping fins to create switchable optical and infrared light multipixel displays that are 1,000 times more energy efficient than light-emitting devices.

The new study led by mechanical science and engineering professor Sameh Tawfick demonstrates how bendable fins and fluids can simultaneously switch between straight or bent and hot and cold by controlling the volume and temperature of tiny fluid-filled pixels. Varying the volume of fluids within the pixels can change the directions in which the flaps flip — similar to old-fashioned flip clocks — and varying the temperature allows the pixels to communicate via infrared energy.

The study findings are published in the journal Science Advances.

Tawfick’s interest in the interaction of elastic and capillary forces — or elasto-capillarity — started as a graduate student, spanned the basic science of hair wetting and led to his research in soft robotic displays at Illinois.

“An everyday example of elasto-capillarity is what happens to our hair when we get in the shower,” Tawfick said. “When our hair gets wet, it sticks together and bends or bundles as capillary forces are applied and released when it dries out.”

In the lab, the team created small boxes, or pixels, a few millimeters in size, that contain fins made of a flexible polymer that bend when the pixels are filled with fluid and drained using a system of tiny pumps. The pixels can have single or multiple fins and are arranged into arrays that form a display to convey information, Tawfick said.

“We are not limited to cubic pixel boxes, either,” Tawfick said. “The fins can be arranged in various orientations to create different images, even along curved surfaces. The control is precise enough to achieve complex motions, like simulating the opening of a flower bloom.”

The study reports that another feature of the new displays is the ability to send two simultaneous signals — one that can be seen with the human eye and another that can only be seen with an infrared camera.

“Because we can control the temperature of these individual droplets, we can display messages that can only be seen using an infrared device,” Tawfick said, “Or we can send two different messages at the same time.”

However, there are a few limitations to the new displays, Tawfick said.

While building the new devices, the team found that the tiny pumps needed to control the pixel fluids were not commercially available, and the entire device is sensitive to gravity — meaning that it only works while in a horizontal position.

“Once we turn the display by 90 degrees, the performance is greatly degraded, which is detrimental to applications like billboards and other signs intended for the public,” Tawfick said. “The good news is, we know that when liquid droplets become small enough, they become insensitive to gravity, like when you see a rain droplet sticking on your window and it doesn’t fall. We have found that if we use fluid droplets that are five times smaller, gravity will no longer be an issue.”

The team said that because the science behind gravity’s effect on droplets is well understood, it will provide the focal point for their next application of the emerging technology.

Tawfick said he is very excited to see where this technology is headed because it brings a fresh idea to a big market space of large reflective displays. “We have developed a whole new breed of displays that require minimal energy, are scaleable and even flexible enough to be placed onto curved surfaces.”

Illinois researchers Jonghyun Ha, Yun Seong Kim, Chengzhang Li, Jonghyun Hwang, Sze Chai Leung and Ryan Siu also participated in this research.

The Airforce Office of Scientific Research and the National Science Foundation supported this research.

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Immune-boosting therapy helps honey bees resist deadly viruses

Scientists have successfully tested a novel way of boosting honey bees’ immune systems to help them fend off deadly viruses, which have contributed to the major losses of the critical pollinator globally.

In a new study, the research team, which includes entomologists with the University of Florida, the Agricultural Research Service-USDA, Louisiana State University and the University of Nebraska-Lincoln, showed that prompting honey bees’ cells to produce free radicals helped the bees weather a host of viruses. In fact, the treatment greatly reduced, and in some cases, nearly eliminated virus activity in full scale field studies.

“This approach is especially exciting because it doesn’t just target a specific type of virus but helps with many different viruses,” said Daniel Swale, senior author of the study. Swale is the associate director for training and special projects in the UF Emerging Pathogens Institute and associate professor in the UF/IFAS entomology and nematology department.

“Additionally, we demonstrated that our treatment works both in the lab and in colonies that each contain 80,000 bees in the field. This is huge because, in a hive setting, bees are exposed to so many different viruses and stressors, so successfully controlling viruses in that environment is very encouraging,” said Swale, who completed some of this research while at Louisiana State University.

Honey bee colonies, and the beekeepers who manage them, play an important role in food production by pollinating many crops. In recent years, honey bee populations have seen significant declines, and viruses, while not the top cause of honey bee deaths, are among the main contributors.

“Varroa mites are the number one cause of honey bee losses, but it’s important to point out that varroa mites, aside from physically weakening bees, also transmit viruses to bees. If we can mitigate viruses in honey bee colonies, that would be a big step forward,” said Michael Simone-Finstrom, a co-author of the study and a research molecular biologist with the ARS Honey Bee Breeding, Genetics, and Physiology Research Lab in Baton Rouge, Louisiana.

In the experiment, the researchers used a compound called pinacidil to alter potassium ion channels, a protein found in the cells of bees’ and most living things. Altering these channels produced slightly more free radicals.

“While free radicals are often bad for cell health, in moderate amounts they can be therapeutic, as we see in this study. In this case, the additional free radicals signal to the immune system to ramp up, which helps the bees fight off viruses,” said Troy Anderson, a co-author of the paper and a professor of entomology at the University of Nebraska-Lincoln.

The scientists administered the drug to honey bee colonies by mixing it into sugar water and drizzling the water over the honey comb at night. The bees then consumed the sugar water and fed it to their young. During the day, bees are constantly moving in an out of the hive, so giving them the treatment at night maximizes the number of bees that will receive it.

The treatment protected bees from six potentially deadly honey bee viruses: Israeli acute paralysis virus, deformed wing viruses A and B, black queen cell virus and Lake Sinai viruses 1 and 2. The researchers also showed that pinacidil helped more bees survive in colonies heavily infested with varroa mites.

Administering pinacidil to commercial honey bee hives may only be feasible for some beekeepers, the researchers said, but the study opens the door to identifying other active ingredients that may work better and cost less.

“One of the big take-aways from this study is that potassium ion channels can be a target for improving immune system function in honey bees and possibly other insects. We would like to find a molecule, such as a peptide, or a new technology that has the same effect as pinacidil but is more accessible to beekeepers,” Swale said.

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