Covid: Is it safe to hit the office Christmas party?

What is the chance that after-work drinks with colleagues will turn into a Covid superspreader event?

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Covid booster: Hospitals and pharmacies urged to ramp up rollout

NHS England is to give new guidance to health staff about the rollout, as the government tries to beat Omicron.

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Covid: Omicron may require ‘very stringent response’, say Sage scientists

Officials should prepare for a “potentially significant” wave of cases, government scientific advisers say.

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Bringing 400-million-year-old fossilized armored worms to ‘virtual’ life

An international team of scientists from the United States and Australia, led by Sarah Jacquet at the University of Missouri, has documented the discovery of two new species of fossilized armored worms in Australia — Lepidocoleus caliburnus and Lepidocoleus shurikenus — dating from about 400 million years ago. Then, using the micro-CT imaging capabilities of the MU X-ray Microanalysis Core facility, the researchers were able to develop first-of-its-kind digital 3D-models of the species’ individual armor plates by virtually examining the armored skeletons of these ancient worms, called machaeridians.

Jacquet, an assistant professor of geological sciences in the MU College of Arts and Science, believes this study offers a new way for scientists to investigate how different biological armored systems worked throughout the fossil record.

“By using micro-CT, we can virtually separate the individual components of the armor,” Jacquet said. “That allows us to see how it protected these worms until, unfortunately, they went extinct during one of the major extinction events in the fossil record. We are able to manipulate the virtual models to determine how the individual armor pieces moved relative to each other, as well as determine the degree of overlap between them.”

At the time of their existence, these worms were likely living near coral reefs in shallow water on what is now land in Australia. The study identified these worms to have two overlapping armor systems — one going down the length of the organism’s skeleton, and the other down both sides of the worm. While no direct correlations have been made yet between these worms and any modern species, Jacquet believes her study can deepen our understanding of convergent evolution.

“Convergent evolution is where different and unrelated groups adapt similar features,” Jacquet said. “While this armor is a rather unique adaptation, and one that clearly does well for particular environments and protecting against particular predators, we do see other similar adaptations in a couple of unrelated animal groups, such as pangolins, pill bugs and millipedes.”

Jacquet said Lepidocoleus caliburnus is named after the famous sword “Excalibur” from the Arthurian legend, and Lepidocoleus shurikenus is named for its resemblance to the outline of shuriken, the Japanese word for throwing stars. She said future plans for this work include using virtual models to study how these armor systems fared against different types of stressors, such as under a predator attack.

“Sclerite assembly, articulation and protective system of Lower Devonian machaeridians,” was published in Papers in Paleontology. Other authors include Tara Selly and Jim Schiffbauer at MU, and Glenn Brock, who has dual appointments at Macquarie University in Australia and Northwest University in China.

Funding was provided by grants from the National Science Foundation (EAR CAREER-1652351 and EAR/IF-1636643) and internal research development grants from Macquarie University. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

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Materials provided by University of Missouri-Columbia. Note: Content may be edited for style and length.

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Synthetic tissue can repair hearts, muscles, and vocal cords

Combining knowledge of chemistry, physics, biology, and engineering, scientists from McGill University develop a biomaterial tough enough to repair the heart, muscles, and vocal cords, representing a major advance in regenerative medicine.

“People recovering from heart damage often face a long and tricky journey. Healing is challenging because of the constant movement tissues must withstand as the heart beats. The same is true for vocal cords. Until now there was no injectable material strong enough for the job,” says Guangyu Bao, a PhD candidate in the Department of Mechanical Engineering at McGill University.

The team, led by Professor Luc Mongeau and Assistant Professor Jianyu Li, developed a new injectable hydrogel for wound repair. The hydrogel is a type of biomaterial that provides room for cells to live and grow. Once injected into the body, the biomaterial forms a stable, porous structure allowing live cells to grow or pass through to repair the injured organs.

“The results are promising, and we hope that one day the new hydrogel will be used as an implant to restore the voice of people with damaged vocal cords, for example laryngeal cancer survivors,” says Guangyu Bao.

Putting it to the test

The scientists tested the durability of their hydrogel in a machine they developed to simulate the extreme biomechanics of human vocal cords. Vibrating at 120 times a second for over 6 million cycles, the new biomaterial remained intact while other standard hydrogels fractured into pieces, unable to deal with the stress of the load.

“We were incredibly excited to see it worked perfectly in our test. Before our work, no injectable hydrogels possessed both high porosity and toughness at the same time. To solve this issue, we introduced a pore-forming polymer to our formula,” says Guangyu Bao.

The innovation also opens new avenues for other applications like drug delivery, tissue engineering, and the creation of model tissues for drug screening, the scientists say. The team is even looking to use the hydrogel technology to create lungs to test COVID-19 drugs.

“Our work highlights the synergy of materials science, mechanical engineering and bioengineering in creating novel biomaterials with unprecedented performance. We are looking forward to translating them into the clinic,” said Professor Jianyu Li, who holds the Canada Research Chair in Biomaterials and Musculoskeletal Health.

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Materials provided by McGill University. Note: Content may be edited for style and length.

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Brief presence of water in Arabia Terra on Mars

As part of a team of collaborators from Northern Arizona University and Johns Hopkins University, NAU PhD candidate Ari Koeppel recently discovered that water was once present in a region of Mars called Arabia Terra.

Arabia Terra is in the northern latitudes of Mars. Named in 1879 by Italian astronomer Giovanni Schiaparelli, this ancient land covers an area slightly larger than the European continent. Arabia Terra contains craters, volcanic calderas, canyons and beautiful bands of rock reminiscent of sedimentary rock layers in the Painted Desert or the Badlands.

These layers of rock and how they formed was the research focus for Koeppel along with his advisor, associate professor Christopher Edwards of NAU’s Department of Astronomy and Planetary Science along with Andrew Annex, Kevin Lewis and undergraduate student Gabriel Carrillo of Johns Hopkins University. Their study, titled “A fragile record of fleeting water on Mars,” was funded by the NASA Mars Data Analysis Program and recently published in the journal Geology.

“We were specifically interested in using rocks on the surface of Mars to get a better understanding of past environments three to four billion years ago and whether there could have been climatic conditions that were suitable for life on the surface,” Koeppel said. “We were interested in whether there was stable water, how long there could have been stable water, what the atmosphere might have been like and what the temperature on the surface might have been like.”

In order to get a better understanding of what happened to create the rock layers, the scientists focused on thermal inertia, which defines the ability of a material to change temperature. Sand, with small and loose particles, gains and loses heat quickly, while a solid boulder will remain warm long after dark. By looking at surface temperatures, they were able to determine the physical properties of rocks in their study area. They could tell if a material was loose and eroding away when it otherwise looked like it was solid.

“No one had done an in-depth thermal inertia investigation of these really interesting deposits that cover a large portion of the surface of Mars,” Edwards said.

To complete the study, Koeppel used remote sensing instruments on orbiting satellites. “Just like geologists on Earth, we look at rocks to try to tell stories about past environments,” Koeppel said. “On Mars, we’re a little bit more limited. We can’t just go to a rock outcrop and collect samples — we’re pretty reliant on satellite data. So, there are a handful of satellites orbiting Mars, and each satellite hosts a collection of instruments. Each instrument plays its own role in helping us describe the rocks that are on the surface.”

Through a series of investigations using this remotely gathered data, they looked at thermal inertia, plus evidence of erosion, the condition of the craters and what minerals were present.

“We figured out these deposits are much less cohesive than everyone previously thought they were, indicating that this setting could only have had water for only a brief period of time,” said Koeppel. “For some people, that kind of sucks the air out of the story because we often think that having more water for more time means there’s a greater chance of life having been there at one point. But for us, it’s actually really interesting because it brings up a whole set of new questions. What are the conditions that could have allowed there to be water there for a brief amount of time? Could there have been glaciers that melted quickly with outbursts of huge floods? Could there have been a groundwater system that percolated up out of the ground for only a brief period of time only to sink back down?”

Koeppel started his college career in engineering and physics but switched to studying the geological sciences while earning his master’s degree at The City College of New York. He came to NAU to work with Edwards and immerse himself in the thriving planetary science community of Flagstaff.

“I got into planetary science because of my excitement for exploring worlds beyond Earth. The universe is astoundingly big, even Mars is just the tip of the iceberg,” Koeppel said. “But we’ve been studying Mars for a few decades now, and at this point, we have a huge accumulation of data. We’re beginning to study it at levels that are comparable to ways we’ve been able to study Earth, and it’s a really exciting time for Mars science.”

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Materials provided by Northern Arizona University. Note: Content may be edited for style and length.

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Closest pair of supermassive black holes yet

Using the European Southern Observatory’s Very Large Telescope (ESO’s VLT), astronomers have revealed the closest pair of supermassive black holes to Earth ever observed. The two objects also have a much smaller separation than any other previously spotted pair of supermassive black holes and will eventually merge into one giant black hole.

Voggel and her team were able to determine the masses of the two objects by looking at how the gravitational pull of the black holes influences the motion of the stars around them. The bigger black hole, located right at the core of NGC 7727, was found to have a mass almost 154 million times that of the Sun, while its companion is 6.3 million solar masses.

It is the first time the masses have been measured in this way for a supermassive black hole pair. This feat was made possible thanks to the close proximity of the system to Earth and the detailed observations the team obtained at the Paranal Observatory in Chile using the Multi-Unit Spectroscopic Explorer (MUSE) on ESO’s VLT, an instrument Voggel learnt to work with during her time as a student at ESO. Measuring the masses with MUSE, and using additional data from the NASA/ESA Hubble Space Telescope, allowed the team to confirm that the objects in NGC 7727 were indeed supermassive black holes.

Astronomers suspected that the galaxy hosted the two black holes, but they had not been able to confirm their presence until now since we do not see large amounts of high-energy radiation coming from their immediate surroundings, which would otherwise give them away. “Our finding implies that there might be many more of these relics of galaxy mergers out there and they may contain many hidden massive black holes that still wait to be found,” says Voggel. “It could increase the total number of supermassive black holes known in the local Universe by 30 percent.”

The search for similarly hidden supermassive black hole pairs is expected to make a great leap forward with ESO’s Extremely Large Telescope (ELT), set to start operating later this decade in Chile’s Atacama Desert. “This detection of a supermassive black hole pair is just the beginning,” says co-author Steffen Mieske, an astronomer at ESO in Chile and Head of ESO Paranal Science Operations. “With the HARMONI instrument on the ELT we will be able to make detections like this considerably further than currently possible. ESO’s ELT will be integral to understanding these objects.”

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Covid: Face masks rules return in England amid Omicron spread

Coverings become mandatory in shops and on public transport under measures to slow Omicron’s spread.

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Omicron: WHO warns of ‘high infection risk’ around globe

Omicron could lead to severe consequences in some regions, the World Health Organization has warned.

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Largest comet ever observed was active at near-record distance

A new study by University of Maryland astronomers shows that comet Bernardinelli-Bernstein (BB), the largest comet ever discovered, was active long before previously thought, meaning the ice within it is vaporizing and forming an envelope of dust and vapor known as a coma. Only one active comet has been observed farther from the sun, and it was much smaller than comet BB.

The finding will help astronomers determine what BB is made of and provide insight into conditions during the formation of our solar system. The finding was published in The Planetary Science Journal on November 29, 2021.

“These observations are pushing the distances for active comets dramatically farther than we have previously known,” said Tony Farnham, a research scientist in the UMD Department of Astronomy and the lead author of the study.

Knowing when a comet becomes active is key to understanding what it’s made of. Often called “dirty snowballs” or “icy dirtballs,” comets are conglomerations of dust and ice left over from the formation of the solar system. As an orbiting comet approaches its closest point to the sun, it warms, and the ices begin to vaporize. How warm it must be to start vaporizing depends on what kind of ice it contains (e.g., water, carbon dioxide, carbon monoxide or some other frozen compound).

Scientists first discovered comet BB in June 2021 using data from the Dark Energy Survey, a collaborative, international effort to survey the sky over the Southern hemisphere. The survey captured the bright nucleus of the comet but did not have high-enough resolution to reveal the envelope of dust and vapor that forms when the comet becomes active.

At 100 km across, comet BB is the largest comet ever discovered by far, and it is farther from the sun than the planet Uranus. Most comets are around 1 km or so and much closer to the sun when they are discovered. When Farnham heard about the discovery, he immediately wondered if images of comet BB had been captured by the Transient Exoplanet Survey Satellite (TESS), which observes one area of the sky for 28 days at a time. He thought TESS’s longer exposure times could provide more detail.

Farnham and his colleagues combined thousands of images of comet BB collected by TESS from 2018 through 2020. By stacking the images, Farnham was able to increase the contrast and get a clearer view of the comet. But because comets move, he had to layer the images so that comet BB was precisely aligned in each frame. That technique removed the errant specks from individual shots while amplifying the image of the comet, which allowed researchers to see the hazy glow of dust surrounding BB, proof that BB had a coma and was active.

To ensure the coma wasn’t just a blur caused by the stacking of images, the team repeated this technique with images of inactive objects from the Kuiper belt, which is a region much farther from the sun than comet BB where icy debris from the early solar system is plentiful. When those objects appeared crisp, with no blur, researchers were confident that the faint glow around comet BB was in fact an active coma.

The size of comet BB and its distance from the sun suggests that the vaporizing ice forming the coma is dominated by carbon monoxide. Since carbon monoxide may begin to vaporize when it is up to five times farther away from the sun than comet BB was when it was discovered, it is likely that BB was active well before it was observed.

“We make the assumption that comet BB was probably active even further out, but we just didn’t see it before this,” Farnham said. “What we don’t know yet is if there’s some cutoff point where we can start to see these things in cold storage before they become active.”

According to Farnham, the ability to observe processes like the formation of a cometary coma farther than ever before opens an exciting new door for astronomers.

“This is just the beginning,” Farnham said. “TESS is observing things that haven’t been discovered yet, and this is kind of a test case of what we will be able to find. We have the potential of doing this a lot, once a comet is seen, going back through time in the images and finding them while they are at farther distances from the sun.”

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Materials provided by University of Maryland. Original written by Kimbra Cutlip. Note: Content may be edited for style and length.

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