But now, researchers from Tohoku University have revealed an anomaly in this phenomenon. Through the analysis of data before and after the 2018 Northern Osaka Earthquake, they discovered that the atmospheric radon concentration decreased.

The results of their research were published online in Scientific Reports on April 2, 2021.

“For the first time, we found a decrease in the atmospheric radon associated with seismic quiescence before the mainshock of an inland earthquake,” said professor Jun Muto of the Graduate School of Science at Tohoku University. Muto, who led the research group with professor Hiroyuki Nagahama, collaborated with Osaka Medical and Pharmaceutical University and Kobe Pharmaceutical University.

Observation in atmospheric radon concentration levels from the Osaka Medical and Pharmaceutical University showed a decline about one year before the earthquake, a trend that continued until June 2020. Seismic activity in the vicinity of the monitoring site also declined prior to the earthquake along with a reduced seismic activity after the mainshock for the entire Kansai region, excluding the aftershock area.

All of this suggests that radon levels did not increase after the earthquake. It also paints a more complicated picture of the radon and fluid movements that cause radon exhalation in the subsurface when large earthquakes occur.

“The discovery revealed that more processes are occurring before earthquakes than previously thought,” said Muto. “Further analysis of other earthquakes will lead to a better understanding of the physiochemical processes at play and help us use atmospheric radon concentrations to clarify various crustal movements correlated with major earthquakes.”

The research group has established atmospheric radon concentration measurement monitoring networks at radioisotope facilities across Japan. Monitoring is also expected be carried out at nuclear power plants.

Expansion of the monitoring network will help clarify the area and timing of radon anomalies, the geological characteristics that cause such anomalies, and the relationship with the different earthquake types. All of this will help realize a radon-based earthquake prediction system.

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Materials provided by Tohoku University. Note: Content may be edited for style and length.

Gene editing allows scientists to modify sections of an organism’s DNA and is considered a promising treatment for a number of genetic diseases. There have been numerous advances in the laboratory over the last few decades, but there are still many challenges to overcome before gene editing can be widely used in the patient population. Launched in 2018, the Somatic Cell Gene Editing Consortium (SCGE) has brought together some of the leading researchers in the field to advance discovery and accelerate the translation of somatic gene editing advances in the lab to the clinical setting.

Over six years, the NIH will allocate approximately $190 million to SCGE to realize gene editing’s potential. The end result will be a freely available toolkit that will provide the biomedical research community with rigorously evaluated information about genome editors and methods for delivering and tracking gene editing molecules.

“NIH realized it was important for all of us who are investigating gene editing to work together toward a common goal,” said Carnegie Mellon University Professor of Chemistry Danith Ly who joined the consortium in 2019. “We’re designing molecules that can go into the cell and we’re cataloging each and every one. What we’ll end up with is a very valuable, rigorously evaluated resource for those who want to bring gene editing to patients.”

While much of the consortium’s work focuses on CRISPER-Cas related systems, the SCGE points out that it’s important to continue to develop other systems. They specifically single out the peptide nucleic acid-based gene editing technique developed by Carnegie Mellon’s Ly and Yale University’s Peter Glazer.

“Although there is a significant focus on CRISPR-Cas related systems within the SCGE, it is crucial to continue to explore alternate systems, in part because they may differ in both their potential for delivery and their biological or immunological responses,” the consortium wrote in Nature.

While CRISPR-Cas edits genes in cells that have been removed from the body, Ly and Glazer’s peptide nucleic acid (PNA) system is administered intravenously and edits cells in vivo. Using nanoparticles, a PNA molecule paired with a donor strand of DNA is delivered directly to a malfunctioning gene. Ly, a leading researcher in synthetic nucleic acid technology, has programmed PNA molecules to open double stranded DNA at the site of a targeted mutation. The donor DNA from the complex binds to the cell’s faulty DNA and triggers the DNA’s innate repair mechanisms to edit the gene. The team has used the technique to cure beta thalassemia in adult mice and in fetal mice in utero.

The PNA gene editing system doesn’t have the high-yield of CRISPER-Cas systems, but it does have the advantage of being less likely to make off-target modifications. According to Ly, that means their technique might be better for genetic diseases that only need to have a small percentage of cells corrected to make a therapeutic difference. For example, in the beta thalassemia studies, Ly and Glazer found that editing only six to seven percent of cells was curative.

Ly and Glazer plan to further refine and improve their technique through their participation in SCGE, and they look forward to sharing their results with the consortium and the greater biomedical community.

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Materials provided by Carnegie Mellon University. Original written by Jocelyn Duffy. Note: Content may be edited for style and length.

Zanzibar red colobus are found only in the Zanzibar archipelago and classified as Endangered by the IUCN Red List. Reliant on Unguja Island’s forests for their survival, around half of the species population is found in Jozani-Chwaka Bay National Park.

In the study, published in Oryx — The International Journal of Conservation, primatologists from Bangor University, in collaboration with national park managers from Zanzibar and the Wildlife Conservation Society (WCS), assessed mortality from vehicle collisions — a growing threat faced by primates living in increasingly fragmented habitats crisscrossed by roads.

They found that historic data from the road traversing the national park showed that one colobus was killed on average every 2-3 weeks by traffic. After speedbumps were installed, this was reduced to one every six weeks.

While great progress, this mortality rate is still a significant threat to the species — especially given that natural predation tends to target weaker individuals, yet roadkill is indiscriminate, killing reproductively active adults as well as the very young and old.

Bangor primatologist and Director of the Zanzibar Red Colobus Project, Dr. Alexander Georgiev, and senior author of this study, said: “Cars are not selective in the animals they kill. This means that while natural predators may target the very young and old more often, cars are equally likely to kill reproductively active young adults, who would contribute the most to population growth. And this may be a problem.”

Harry Olgun, now a PhD student at the University’s School of Natural Sciences, led this study as part of his Masters research on the road ecology of the Zanzibar red colobus. Olgun said: “After the road at Jozani was surfaced but before the speedbumps were installed, a colobus was reported to have been killed every two to three weeks, resulting in perhaps about 12-17 percent annual mortality, according to one estimate. The recent data show that speedbumps have made a huge difference for the safety of the colobus. Adding more speedbumps would help reduce the risk further.”

Dr. Tim Davenport, Director of Species Conservation & Science in Africa at WCS, who led the first countrywide census of the Zanzibar red colobus a few years ago and is a coauthor of the study, said: “As tourism grows in Zanzibar and habitat continues to shrink, using science to quantify and solve conservation problems has never been so important. Understanding the impact of vehicles on wildlife within a park, and implementing practical solutions is exactly what we as conservationists should be doing.”

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Materials provided by Wildlife Conservation Society. Note: Content may be edited for style and length.