Do Exosomes Live Up To Their Anti-Aging Claims? Here’s What Dermatologists Say.

If you’re on the lookout for the latest skin care ingredient that can smooth and plump your complexion, you’ve probably seen influencers talking about exosomes, which claim to offer a wealth of anti-aging benefits. But before you buy into the hype, have you really thought about what they are, and whether they’re effective?

Exosomes are tiny, naturally occurring vesicles that skin and other types of cells release. They transport bioactive molecules (think: peptides, fats and proteins) to other cells, explained Dr. Jacob Beer, a dermatologist at Beer Dermatology in West Palm Beach, Florida.

There are dozens of serums, creams and other skin care products, some selling for hundreds of dollars, that contain exosomes, and medical spas often incorporate them into procedures like microneedling and laser treatments. But it’s important to note that exosomes are not approved by the Food and Drug Administration for cosmetic use.

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Exosomes are a misunderstood skin care trend, though, since their behavior varies widely depending on their source and what they’re transporting, according to the experts we spoke to.

Still, exosomes “show promise” for skin rejuvenation, Beer said. “It’s important to just remember that not all exosomes are the same, not all preparations are the same, and some formulations have more data than others.”

Here’s what to know about exosomes and their potential benefits and risks.

What are exosomes, exactly?

Think of exosomes as tiny “message bubbles that cells send to each other,” explained Dr. Jennifer Holman, a dermatologist with U.S. Dermatology Partners Tyler in Texas. The bubbles contain instructions (in the form of proteins, growth signals and genetic material) that “tell cells how they should behave.”

They can be derived from different sources, such as platelets, stem cells, fat or plants, and carry “biologically active messenger cargo,” such as proteins, lipids or signaling molecules, added Dr. Krishna Vyas, a plastic surgeon in New York City. Those instructions can potentially influence inflammation, repair, recovery and regeneration in the “recipient cells.”

The skin benefits of exosomes.

Some exosomes have been studied more than others, and much of the research has involved small patient samples or hasn’t been done on human subjects, Beer said.

“Not all exosomes are created equal, as they don’t contain the same instructions,” Holman said, so their effectiveness depends on what’s inside the bubble.

Take platelet-derived exosomes, for example. Platelets are cells that are drawn to areas of injury and help the body heal. Holman said platelet-derived exosomes are tiny and combine with or dissolve in fats, so they can be applied topically and tell the skin to heal itself.

Some studies have shown that exosomes applied topically can lead to “collagen production, repair of elastin and new elastin production, decreased inflammation and redness, and speeds post procedural healing time,” Holman said.

Vyas noted: “These effects are thought to occur through regulation of inflammatory pathways and activation of fibroblasts, the cells responsible for collagen and elastin synthesis.”

Exosomes are also sometimes applied to the skin after microneedling, a treatment that uses tiny needles to treat acne scars, wrinkles and sagging skin. Vyas said this approach may enhance the topical penetration of exosomes. While this is an off-label use and potentially risky, a small study suggests that pairing exosomes and microneedling could reduce pore size and improve skin texture.

However, since there are no long-term, randomized clinical trials on exosomes, Vyas said their benefits should be considered “as promising but not conclusively established.”

Are exosomes safe?

Redness and irritation are commonly reported side effects of topical exosomes, Beer said. Those usually go away once you stop using the products.

However, when exosomes are administered with microneedling or injected into the skin (which is done in some medical spas), “all bets are off,” Beer said. There are cases of patients developing scars, discoloration, mycobacterial infections, or an immune response known as a granuloma.

“The greater concern lies in uncertainty surrounding long-term safety, repeated use and product consistency,” Vyas said.

Since exosomes are derived from different sources, there’s a lot of variability in products that makes quality control, reproducibility and safety challenging, he added. Exosomes aren’t FDA-approved for medical or cosmetic use in the U.S. So there’s no universal quality standard for products containing them, Holman said.

“Exosomes can be sold under cosmetic regulations as long as they are not making therapeutic claims,” Holman said.

Should you use exosomes?

Serums and moisturizers containing exosomes for topical use are mostly safe, Beer said.

Still, it’s difficult to know what type of exosome products contain or how they’re sourced because they’re not subject to the FDA’s labeling requirements, Vyas said. Some may make exaggerated claims about the product’s benefits, Holman noted. In South Korea, officials recently started prohibiting the term “exosomes” as a cosmetic advertising term to prevent misleading claims.

However, when it comes to injecting exosomes or pairing them with microneedling, Beer said, “I avoid that like the plague.”

Many providers don’t understand what exosomes are, the data behind them, or what can go wrong with their use (such as infections or immune reactions), Beer added. “I counsel my patients to avoid injecting or microneedling exosomes until we have better data because, however expensive the treatment was, it will likely be much more to correct it later.”

Complications from these procedures could mean numerous laser treatments to treat discoloration and scarring, for example, he noted.

Because of the variability of products, lack of transparency, and limited scientific data, Vyas said, “Exosome-based aesthetic products should be considered investigational rather than established therapies.”

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First British baby born using transplanted womb from dead donor

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A hidden force beneath the Atlantic ripped open a 500 kilometer canyon

On land, dramatic canyons such as the Grand Canyon are carved over time by flowing rivers. The ocean does not have rivers capable of cutting into rock on that scale. Even so, the seafloor hosts enormous features that surpass the size of the largest land canyons.

About 1,000 kilometers off the coast of Portugal lies one of the most striking examples. Known as the King’s Trough Complex, this vast underwater structure stretches roughly 500 kilometers and includes a series of parallel trenches and deep basins. At its eastern edge is Peake Deep, one of the deepest locations in the Atlantic Ocean.

What created such an immense formation? A team of international researchers led by the GEOMAR Helmholtz Centre for Ocean Research Kiel has uncovered new clues. Their findings appear in Geochemistry, Geophysics, Geosystems (G-Cubed), published by the American Geophysical Union (AGU).

“Researchers have long suspected that tectonic processes — that is, movements of the Earth’s crust — played a central role in the formation of the King’s Trough,” says lead author Dr. Antje Dürkefälden, marine geologist at GEOMAR. “Our results now explain for the first time why this remarkable structure developed precisely at this location.”

Seafloor Rifting Between Europe and Africa

The new research indicates that between about 37 and 24 million years ago, a plate boundary separating Europe and Africa temporarily passed through this part of the North Atlantic. As the tectonic plates shifted, the crust in this region was pulled apart and fractured, opening progressively from east to west, much like a zipper being undone.

An important piece of the puzzle lies even deeper. Before the plate boundary moved into the area, the oceanic crust there had already become unusually thick and heated. This condition resulted from hot material rising upward from Earth’s mantle. Known as a mantle plume, this steady column of molten rock originates far below the surface. The team believes this was an early offshoot of what is now the Azores mantle plume.

“This thickened, heated crust may have made the region mechanically weaker, so that the plate boundary preferentially shifted here,” explains co-author PD Dr. Jörg Geldmacher, marine geologist at GEOMAR. “When the plate boundary later moved further south towards the modern Azores, the formation of the King’s Trough also came to a halt.”

How Mantle Activity Shapes the Atlantic

The King’s Trough offers a clear example of how deep mantle processes and shifting tectonic plates interact. Activity far below the surface can prepare the crust for later deformation, influencing where major fractures and rifts eventually develop.

These findings also shed light on the broader geodynamic history of the Atlantic Ocean. Similar processes may still be underway today. Near the Azores, a comparable trench system called the Terceira Rift is forming in another region where the oceanic crust is unusually thick.

Mapping the King’s Trough

The conclusions are based on data collected during research expedition M168 aboard the research vessel METEOR in 2020, led by Antje Dürkefälden. The scientists used high resolution sonar to produce a detailed map of the seafloor. They then retrieved volcanic rock samples from several parts of the trench system using a chain bag dredge.

Back in the lab, the team examined the chemical makeup of the rocks. Selected samples were dated at the University of Madison (Wisconsin, USA). Additional bathymetric data came from the Portuguese research centre Estrutura de Missão para a Extensão da Plataforma Continental (EMEPC). Researchers from Kiel University and Martin Luther University Halle-Wittenberg also contributed to the study.

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Less sugar as a baby, fewer heart attacks as an adult

Limiting sugar consumption during early childhood may reduce the risk of serious heart problems later in life. A study published in The BMJ, based on data from the end of sugar rationing in the United Kingdom in 1953, found that people who consumed less sugar early on were less likely to develop conditions such as heart attack, heart failure, and stroke as adults.

The strongest protective effect, along with the greatest delay in the onset of heart disease — was observed among individuals whose sugar intake was restricted from conception (“in utero”) through about age 2.

Health experts have long suggested that the first 1000 days of life (from conception to around 2 years of age) represent a critical window when nutrition can influence long term health. Current guidelines recommend avoiding sugary drinks and ultra-processed foods (which often contain high amounts of sugar) as infants and toddlers begin eating solid foods.

A Natural Experiment Using UK Sugar Rationing

To explore whether limiting sugar during this early window affects future heart health, researchers took advantage of a unique historical event. Sugar rationing in the UK ended in September 1953, creating a natural comparison between children born before and after that policy change.

The analysis included 63,433 participants from the UK Biobank, with an average age of 55, who were born between October 1951 and March 1956 and had no prior history of heart disease. Of these, 40,063 were exposed to sugar rationing early in life, while 23,370 were not.

Researchers linked participants’ health records to monitor rates of cardiovascular disease (CVD), heart attack, heart failure, irregular heart rhythm (atrial fibrillation), stroke, and death from cardiovascular causes. The analysis accounted for genetic, environmental, and lifestyle factors that could influence heart health. An additional comparison group of adults born outside the UK, who did not experience sugar rationing or similar policy shifts around 1953, was also included to strengthen the findings.

Lower Cardiovascular Risk and Delayed Onset

The study found that longer exposure to sugar rationing corresponded with steadily lower risks of cardiovascular disease in adulthood. Part of this benefit appeared to stem from lower rates of diabetes and high blood pressure among those exposed to rationing early in life.

Compared with people who were never exposed to rationing, individuals exposed in utero plus 1-2 years had a 20% lower risk of CVD overall. They also had reduced risks of heart attack (25%), heart failure (26%), atrial fibrillation (24%), stroke (31%), and cardiovascular death (27%).

In addition to lower risk, heart problems tended to develop later. Those exposed to sugar rationing before birth and in early childhood experienced delays in the onset of cardiovascular conditions of up to two and a half years compared with those who were not exposed.

Researchers also observed modest but meaningful improvements in measures of healthy heart function among individuals who experienced rationing.

Sugar Limits and Modern Dietary Guidance

During the rationing period, sugar allowances for the entire population, including pregnant women and children, were capped at less than 40 g per day — and infants under age 2 were not allowed any added sugars. These limits align closely with today’s dietary recommendations for young children.

Because this was an observational study, it cannot prove that lower sugar intake directly caused better heart outcomes. The researchers note several limitations, including the lack of detailed individual dietary records and the possibility of recall bias.

Even so, they emphasize that the large scale and careful design of the study allowed them to compare different periods of exposure and examine potential pathways connecting early sugar intake with later cardiovascular health.

“Our results underscore the cardiac benefit of early life policies focused on sugar rationing. Further studies should investigate individual level dietary exposures and consider the interplay between genetic, environmental, and lifestyle factors to develop more personalized prevention strategies.”

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Young Mars volcano hides a powerful magma engine beneath the surface

Volcanic eruptions that look like single events are often the visible outcome of slow, complicated activity taking place deep underground. Beneath the surface, magma shifts position, changes chemically, and can sit for long stretches before finally erupting. To piece together what is happening below, scientists examine lava flows, rock textures, and minerals left behind at the surface. These clues help reveal the hidden magma systems that drive volcanic activity.

A recent study published in Geology shows that this same complexity exists on Mars. High resolution images of the landscape and mineral measurements collected from orbit indicate that some of the planet’s youngest volcanic regions have a much more detailed history than previously assumed. Instead of forming during brief, one time eruptions, these volcanoes were built by magma systems that remained active and changed over extended periods beneath the martian surface.

Study Focuses on Volcanic System Near Pavonis Mons

An international team of researchers from Adam Mickiewicz University in Poznań, the School of Earth, Environment and Sustainability (SEES) at the University of Iowa, and the Lancaster Environment Centre examined a long lasting volcanic system located south of Pavonis Mons, one of the largest volcanoes on Mars. By pairing careful surface mapping with mineral data gathered from orbiting spacecraft, the scientists reconstructed how the volcano and its underlying magma system developed over time with remarkable precision.

“Our results show that even during Mars’ most recent volcanic period, magma systems beneath the surface remained active and complex,” says Bartosz Pieterek of Adam Mickiewicz University. “The volcano did not erupt just once — it evolved over time as conditions in the subsurface changed.”

Multiple Eruptive Phases Traced by Mineral Signatures

The analysis revealed that the volcanic system progressed through several stages. Early activity involved lava spreading out from fissures in the ground, while later eruptions came from more focused vents that built cone shaped features. Although these lava deposits look different today, they were all fed by the same underlying magma reservoir. Each phase left behind a unique mineral fingerprint, allowing researchers to track how the magma’s composition shifted over time.

“These mineral differences tell us that the magma itself was evolving,” Pieterek explains. “This likely reflects changes in how deep the magma originated and how long it was stored beneath the surface before erupting.”

Orbital Data Offers Rare Insight Into Mars Interior

Since scientists cannot yet collect rock samples directly from Martian volcanoes, studies like this offer valuable information about the planet’s interior. The findings demonstrate how powerful orbital observations can be for uncovering the hidden structure and long term evolution of volcanic systems, both on Mars and on other rocky worlds.

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A simple water shift could turn Arctic farmland into a carbon sink

In their natural condition, peatlands rank among the planet’s most important carbon reservoirs. The soil is saturated with water and contains very little oxygen, which slows the breakdown of dead plants. Instead of fully decomposing, plant material builds up layer upon layer over thousands of years, forming deep deposits of peat that lock away carbon for the long term.

That balance changes when peatlands are drained for farming. Lowering the water table allows oxygen to enter the soil, speeding up microbial activity. As microbes break down the previously preserved plant matter, carbon that has been stored for centuries is released into the atmosphere as carbon dioxide (CO2).

Northern Peatlands Remain Understudied

Large areas of peatland across Europe and the Nordic region have been drained since the 1600s. Scientists have closely examined how drainage and shifting water levels affect greenhouse gas emissions in many of these regions.

Far less is known about the northernmost peatlands used for agriculture. These areas experience cold temperatures, short growing seasons, and extended daylight during summer months.

“From studies in warmer regions, we know that raising the groundwater level in drained and cultivated peatland often reduces CO2 emissions, because the peat decomposes more slowly,” explains NIBIO researcher Junbin Zhao.

“At the same time, wetter and low-oxygen conditions can increase methane, since the microbes that produce methane thrive when there is almost no oxygen in the soil.”

Nitrous oxide can also increase under certain moisture conditions. When soil is damp but not completely waterlogged, nitrogen breakdown may stop midway, producing nitrous oxide instead of harmless nitrogen gas.

“Because each greenhouse gas reacts differently to changes in water level, one gas can go down while another goes up. That’s why it’s important to look at the overall gas balance,” says Zhao.

“We need to measure CO2, methane, and nitrous oxide at the same time and throughout the whole season to understand the real net effect in the northernmost agricultural areas.”

Two Year Arctic Field Study in Northern Norway

To answer these questions, Zhao and his colleagues carried out a two year field study in 2022 and 2023 at NIBIO’s Svanhovd research station in the Pasvik Valley of Northern Norway. Automated chambers tracked CO2, methane, and nitrous oxide emissions multiple times per day throughout the growing season.

“The experiment included five plots that together reflected typical management conditions found in a drained agricultural field — with different groundwater levels, different amounts of fertiliser, and different numbers of harvests per season,” Zhao explains.

The team focused on three key questions:

  • Can raising the groundwater level make a cultivated Arctic peatland close to climate-neutral?
  • Does the water level affect soil CO2 emissions more than it affects plant CO2 uptake?
  • How do fertilization and harvesting influence the total climate balance?

Higher Groundwater Levels Cut CO2 Emissions

When the Pasvik peatland was heavily drained, it released large amounts of CO2, comparable to cultivated peatlands farther south. But when researchers raised the groundwater to between 25 and 50 cm below the surface, emissions dropped sharply.

“At these higher water levels, methane and nitrous oxide emissions were also low, giving a much better overall gas balance. Under such conditions, the field even absorbed slightly more CO2 than it released,” says Zhao.

This suggests that maintaining higher groundwater levels in Arctic farmland could serve as an effective climate strategy.

“Our findings are especially interesting because emissions were measured continuously around the clock. This meant we captured short spikes of unusually high emissions and natural daily fluctuations, details often missed when measurements are taken only occasionally.”

Why Cold Arctic Climates Amplify the Effect

Raising the water table makes the soil wetter and reduces oxygen around plant roots. Plants become somewhat less active and absorb less CO2 under these conditions.

Even so, overall CO2 emissions from the field decline.

“This is because wet conditions mean that the field needs less light before it starts to absorb more CO2 than it releases. When this threshold is reached earlier in the day, you get more hours with net carbon uptake,” Zhao explains.

“Our calculations show that this effect is especially strong in the north, due to the long, light summer nights. These provide many extra hours where the system remains on the positive side, which can increase total CO2 uptake significantly.”

Temperature turned out to be another crucial factor. Once soil temperatures climbed above about 12°C, microbial activity intensified.

“At higher temperatures, microorganisms break down organic material faster, and both CO2 and methane emissions rise,” says Zhao.

“This means that the effect of high water levels is greatest in cool climates — and that future warming could reduce the benefit. In practice, this means water levels must be considered together with temperature and local conditions.”

Fertilization and Harvesting Shape the Carbon Balance

Farm management practices also played a role. Adding more fertilizer boosted grass growth.

“More fertilizer produced more biomass but did not lead to noticeable changes in CO2 or methane emissions in our experiment,” says Zhao.

Harvesting had a clearer impact. When grass was cut and removed, the carbon stored in plant material left the system.

“If harvesting is very frequent, more carbon can be taken out than is built up again over time. The peat layer may gradually lose carbon even when water levels are kept high,” Zhao explains.

For that reason, Zhao emphasizes that water management, fertilizer use, and harvesting schedules must be evaluated together. Steps that lower emissions in the short term could reduce long term carbon storage, potentially weakening soil quality.

“One solution could be paludiculture, i.e. growing plant species that tolerate wet conditions so that biomass can be produced without keeping the soil dry.”

Local Differences Matter for Climate Accounting

The researchers also observed significant variation within the same field. Some areas absorbed CO2, while nearby sections released substantial amounts.

“Such local variation can greatly influence national climate accounting and how measures are designed, because one standard emission factor may not reflect reality everywhere,” Zhao says.

“The results from our study show a clear need for more detailed measurements and more precise water-level management in practice, especially where soils and farming conditions vary significantly between locations.”

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