Health24.com | Flu shots for kids protect everybody, a US study shows

  •  In the USA, there is an issue of vaccine hesitance when it comes to children
  • When kids get the flu shot, there is, however, a general reduction in flu hospitalisations
  • An expert described children as ‘magnifying influenza’

When elementary school students get their annual flu shot, everyone benefits, a new study shows.

An increased vaccination rate among grade-schoolers in California was associated with a decrease in flu hospitalisations for people in every other age bracket, researchers report.

The results come as no surprise to public health experts, given children’s well-earned reputation as a major vector for the spread of viral diseases.

“It basically correlates with everything we know about public health, about vaccination, and about children and children’s impact on spreading viral illness throughout a community,” said Dr Eric Cioe-Pena, director of global health for Northwell Health in New Hyde Park, New York.

Vaccine hesitance

However, the study does highlight the continuing need to convince reluctant parents of the importance of getting their kids an annual flu shot, Cioe-Pena added.

“We have an issue of vaccine hesitance in [the United States] when it comes to children,” said Cioe-Pena. “To me, if you don’t get to the root cause of the hesitance, it probably won’t have much of an impact.”

For this study, researchers led by Jade Benjamin-Chung, from the University of California, Berkeley, tracked a city-wide school flu vaccine program in Oakland, California, and compared its success to rates of flu-associated hospitalisations.

After four years, the programme had improved vaccination coverage by 11% among children attending more than 95 preschools and elementary schools in Oakland, the researchers reported.

The increased vaccination rate was associated with 37 fewer flu-related hospitalisations per 100 000 people among all other people in the community – children aged four and younger as well as people aged 13 and older.

Fewer school absences

There were also 160 fewer influenza hospitalisations per 100 000 among people aged 65 and older, the results showed.

The elementary school children also benefited; researchers observed a decrease in illness-related school absences during the flu season.

The findings were published online on 18 August in the journal PLOS Medicine.

“We know that children magnify influenza,” said Dr Amesh Adalja, a senior scholar with the Johns Hopkins Center for Health Security in Baltimore. “Trying to increase children’s vaccination rates can be expected to have a cascading impact on the flu season. Making it easy for children to get vaccinated is one way to improve our ability to deal with influenza.”

Children tend to benefit more from the flu vaccine, because their immune systems are fresher and more responsive, Adalja added.

Congregational settings

“In younger people, the vaccine induces more antibodies than in individuals 70 years or older,” Adalja explained. “Older people’s immune systems do not respond to the vaccine as well as a younger individual does. That’s why we use high-dose vaccines with the elderly population.”

Given these results, it might make sense to promote flu shots for children as much as they are promoted for the elderly and health care workers, said Dr Waleed Javaid, director of infection prevention and control at Mount Sinai Downtown in New York City.

“When we can enhance our protection of any aspect of society where we have congregational settings and people are going to mingle with each other – like [the] military or hospitals or schools – that protects society in general,” Javaid said.

Adalja agreed.

“Our goal in the United States is to vaccinate everybody above the age of six months with influenza vaccine. That should still be the goal,” Adalja said. “If you’re trying to prioritise within that group, then children should be a major priority group to be vaccinated because they do drive it, but I do think you also have to vaccinate the vulnerable – the elderly and people with other medical conditions. They have to be a priority group as well.”

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Hydroxychloroquine plus azithromycin increases heart risk, finds global study

The combination of hydroxychloroquine (HCQ) and azithromycin (AZM) has been linked to significant cardiovascular risks, including mortality, in the largest safety study ever performed on both HCQ and HCQ+AZM. This network study, led by the Observational Health Data Sciences and Informatics community, was recently published in Lancet Rheumatology.

OHDSI has established an international network of researchers and observational health databases with a central coordinating center housed at the Department of Biomedical Informatics at Columbia University.

In patients with rheumatoid arthritis, HCQ treatment in the short term (30 days) was found to not carry excess risk of complications associated with its use, but HCQ treatment in the long term had a 65% relative increase in cardiovascular-related mortality, compared to sulfasalazine.

HCQ + AZM had a cardiovascular mortality risk that was more than twice (2.19) as high as the comparative treatment even in the short term based on findings from more than 320,000 users of that combination therapy. This treatment also produced a 15-20% increased rate of angina/chest pain and heart failure.

This study, first published on MedRxiv, has already made significant impacts in the healthcare community. On April 23, the European Medicines Agency (EMA) cited the study in a warning about the risk of serious side effects with chloroquine and hydroxychloroquine. In July, the EMA again highlighted the study, among other efforts within the OHDSI community, in its eighth revision of The European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) Guide on Methodological Standards in Pharmacoepidemiology.

This is the first published study to be generated from the OHDSI COVID Study-a-thon, a global effort in March to set the foundation for OHDSI efforts to design and execute network observational studies around characterization, patient-level prediction and population-level effect estimation to inform decision-making around the global pandemic. Multiple studies, several of which are highlighted later, have been posted to MedRxiv and are currently under peer review.

HCQ, a drug commonly used in the treatment of malaria, lupus and rheumatoid arthritis (RA), gained early attention during the pandemic as a potential COVID-19 treatment. The short-term (<30 days) safety profile did not identify excess risk in any of 16 severe adverse events as compared to a similar RA drug, sulfasalazine (SSZ). Long-term HCQ therapy was associated with a 65% increase in cardiovascular mortality as compared to SSZ.

“Hydroxychloroquine, both alone and in combination with azithromycin, gained strong consideration as a potential COVID treatment without a large-scale study of its overall safety profile,” said Daniel Prieto-Alhambra, PhD, co-senior author on this study. “We had access to an unprecedented amount of data on this drug, and we were relieved to find no worrying side effects in the short-term use of hydroxychloroquine. However, when prescribed in combination with azithromycin, it may induce heart failure and cardiovascular mortality and we would urge caution in using the two together.”

This study examined more than 950,000 HCQ users through deidentified electronic health records and administrative claims data over a 20-year period. Records were collected from 14 different databases spanning six nations (Germany, Japan, Netherlands, Spain, United Kingdom, United States) and then mapped to the OMOP Common Data Model to generate this large-scale analysis.

“At medical school we were taught to ‘first do no harm’ and to me, our study focuses on this core belief of modern medicine,” said Jennifer Lane, MD, who served as co-lead author on this study along with Jamie Weaver. “OHDSI has the power to investigate this question in a very thorough way and to go through rigorous steps. We are looking at patients from the general population, which is why it is so important to look at data from multiple countries. There are reasons why you may get bias from one data source, but if we find a signal in the Netherlands, and we find it in Spain, and we find it in the U.S., then we know we have something.”

The study was developed and executed by the OHDSI (Observational Health Data Sciences and Informatics) community, a multi-stakeholder, interdisciplinary collaborative to bring out the value of health data through large-scale analytics. All solutions are open-source, and links to the study protocol, code and results are posted at the bottom of this release.

“It required a global effort to generate this level of reproducible, reliable real-world evidence to inform decision-making around COVID treatment,” said Patrick Ryan, PhD, co-senior author on this study. “Our community collaborated for years to develop the high-level analytics which set the course for these studies. Standardizing data for nearly 1,000,000 patients on hydroxychloroquine provides confidence in these findings, and we are pleased to see that this study has already helped make a positive clinical impact as treatment options continue to be evaluated.”

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Effectiveness of cloth masks depends on type of covering

Months into the COVID-19 pandemic, wearing a mask while out in public has become the recommended practice. However, many still question the effectiveness of this.

To allay these doubts, Padmanabha Prasanna Simha, from the Indian Space Research Organisation, and Prasanna Simha Mohan Rao, from the Sri Jayadeva Institute of Cardiovascular Sciences and Research, experimentally visualized the flow fields of coughs under various common mouth covering scenarios. They present their findings in the journal Physics of Fluids, from AIP Publishing.

“If a person can reduce the extent of how much they contaminate the environment by mitigating the spread, it’s a far better situation for other healthy individuals who may enter places that have such contaminated areas,” Simha said.

Density and temperature are intricately related, and coughs tend to be warmer than their surrounding area. Tapping into this connection, Simha and Rao utilized a technique called schlieren imaging, which visualizes changes in density, to capture pictures of voluntary coughs from five test subjects. By tracking the motion of a cough over successive images, the team estimated velocity and spread of the expelled droplets.

Unsurprisingly, they found N95 masks to be the most effective at reducing the horizontal spread of a cough. The N95 masks reduced a cough’s initial velocity by up to a factor of 10 and limit its spread to between 0.1 and 0.25 meters.

An uncovered cough, in contrast, can travel up to 3 meters, but even a simple disposable mask can bring this all the way down to 0.5 meters.

“Even if a mask does not filter out all the particles, if we can prevent clouds of such particles from traveling very far, it’s better than not doing anything,” said Simha. “In situations where sophisticated masks are not available, any mask is better than no mask at all for the general public in slowing the spread of infection.”

Some of the other comparisons, however, were striking.

For example, using an elbow to cover up a cough is typically considered a good alternative in a pinch, which is contradictory to what the pair found. Unless covered by a sleeve, a bare arm cannot form the proper seal against the nose necessary to obstruct airflow. A cough is then able to leak through any openings and propagate in many directions.

Simha and Rao hope their findings will put to rest the argument that regular cloth masks are ineffective, but they emphasize that masks must continue to be used in conjunction with social distancing.

“Adequate distancing is something that must not be ignored, since masks are not foolproof,” Simha said.

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Materials provided by American Institute of Physics. Note: Content may be edited for style and length.

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Accumulating extra genome copies may protect fly brain cells during aging

Scientists have discovered a novel anti-aging defence in the brain cells of adult fruit flies: producing extra copies of the genome, according to a new study published today in eLife.

The findings could help explain how the brain, which rarely produces new cells, is able to cope with the accumulation of cell damage over time and prevent excess cell loss during aging. They may also help scientists answer questions about human age-related brain diseases.

Most cells have two copies of each chromosome, one from each parent. This provides each cell with two complete copies of DNA, referred to as the genome. But some cells accumulate extra copies of chromosomes, although how and why they do this is not entirely clear. Some scientists have suggested that excess chromosomes might lead to age-related brain diseases.

“The brain of the fruit fly Drosophila melanogaster is an ideal model for studying age-related changes in the brain because the fly has a relatively short lifespan, its brain cells rarely multiply, and we have excellent tools for manipulating fly genetics,” says lead author Shyama Nandakumar, a doctoral student in the department of Molecular, Cellular, and Developmental Biology at the University of Michigan, Ann Arbor, US.

In the study, Nandakumar and colleagues examined adult fly brain cells and found that some accumulate extra copies of their genome, especially in parts of the brain responsible for vision — the region of the brain which shows more DNA damage with age.

Next, they subjected fly brain cells to oxidative stress or ultraviolet radiation, which damage DNA and can cause cell death. They found that this exposure increased the production of extra copies of chromosomes in the cells, and the cells were less likely to die as a result of the damage. “These data suggest that cells with extra copies of the genome are more resistant to cell death and may serve a beneficial or protective role in the aging brain,” Nandakumar explains.

Previous studies have found that patients with early stages of Alzheimer’s disease have extra chromosomes in their brain cells than people of the same age who do not have the condition. This has led scientists to question whether accumulating extra chromosomes leads to brain cell death and brain disease.

“Our study suggests that the production of extra copies of chromosomes might actually be a normal response to the accumulation of age-related damage in flies and may even help protect against cell death,” concludes senior author Laura Buttitta, Associate Professor of Molecular, Cellular and Developmental Biology at the University of Michigan. “Further studies are now needed to determine if this is also true in humans.”

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Materials provided by eLife. Note: Content may be edited for style and length.

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Health24.com | For many kids, picky eating isn’t just a phase

For parents hoping their “picky” eater will grow out of it, a new study may be unwelcome news.

Researchers found that choosy four-year-olds were still turning their noses up at many foods at age nine – suggesting their finicky eating is more of a trait than a phase.

The study, which followed over 300 children, found three patterns: The majority were consistently middle-of-the-road when it came to food fussiness – sometimes shunning unfamiliar cuisine, but remaining relatively open to trying new foods.

A sizable minority (29%) consistently ate everything their parents offered up.

No signs of underweight

Then there was the picky 14%. From age four to nine, they routinely refused new foods and maintained a limited culinary repertoire.

Still, researchers saw bright spots in the findings, published on in May in the journal Pediatrics.

For one, there were no signs that picky eaters were underweight. And the fact that the fussiness seems to be a trait – and not a failure on the parents’ part – might bring some solace.

“It can be very stressful for parents to deal with a picky eater,” noted senior researcher Dr Megan Pesch, a paediatrician at the University of Michigan’s C.S. Mott Children’s Hospital in Ann Arbor.

But if parents think they did something wrong to cause it, she added, these findings suggest otherwise.

“It’s not your fault,” Pesch said. “It seems to be part of a child’s disposition.”

Ultimatums don’t help

Nor do the findings mean that parents cannot do anything about picky eating, she stressed. The study merely followed families to see what happened naturally – and did not test any intervention to change kids’ habits.

What does seem clear is that mealtime ultimatums do not help.

In this study, mothers of picky eaters reported more efforts to control what their child consumed – including limits on sugary, fatty foods. (When kids are high on the finicky scale, Pesch noted, they often stick to those types of foods.)

Despite those battles, children’s fussiness held strong.

In fact, coercion is probably destined to fail, according to Nancy Zucker, director of the Duke Center for Eating Disorders at Duke University in Durham, North Carolina.

Zucker, who wrote an editorial published with the study, pointed to one of its key findings. Based on mothers’ responses to a standard questionnaire, the pickiest eaters also tended to be emotionally reactive in general.

Brighten the mood around food

And those kids will not respond well to dinner-table demands – “It won’t work,” Zucker said. “These children will just shut down.”

She agreed that the findings suggest picky eating is a trait.

“These kids may be more harm-avoidant,” Zucker said. “And when you think about it, eating is breaking a barrier – allowing something into your body. These children hold back when everyone else is running to the food.”

So what can parents do?

Zucker said that making meals a pleasant experience may at least brighten children’s moods around food. And that could, at some point, ease their boundaries.

Including kids in shopping and meal preparation, Zucker said, is one way to make it more enjoyable for them.

Concern about nutritional quality

Pesch agreed, adding that simple exposure may help, too. That is, keep making varied meals for the family so that the picky eater gets used to the sights and smells.

“But keep it low-pressure,” Pesch said. “Don’t try to force them to ‘clean their plates’.”

The study included 317 mother-child pairs who were followed from the time the child was about four until age nine. Mothers completed a “food fussiness” questionnaire, and 14% of kids scored high enough, and consistently enough, to be deemed persistently picky.

What’s the harm in being a picky eater? This study found no weight consequences: Finicky kids tended to weigh less than those who liked lots of foods – but they were not underweight.

There is, however, a concern, Zucker said, about the nutritional quality of their diets, as well as problems like chronic constipation.

Pesch also pointed out that the study looked at run-of-the-mill picky eating – where kids adhere to childhood favourites like macaroni and cheese, hot dogs and cereal. If a child is severely limiting food intake, she said, parents should talk to their paediatrician.

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Health24.com | ‘Morning sickness’ doesn’t stick to the a.m., study confirms

  • Nausea and vomiting during pregnancy can have a big impact on the lives of sufferers
  • Pregnant women may experience nausea and vomiting all day long
  • The term ‘morning sickness’ is, therefore, incorrect and can cause confusion

As many expectant mothers can unhappily attest, the nausea and vomiting known as “morning sickness” can occur at any time of the day.

In a new study, British researchers analysed diaries kept by 256 women from the day they learned they were expecting until the 60th day of their pregnancy.

While vomiting was most common between 7 a.m. and 1 p.m., nausea was likely all day long. And many women reported vomiting even into the evening.

The most common hour for nausea and vomiting was 9 a.m. to 10 a.m., when 82% experienced nausea and 29% experienced vomiting.

Significant negative impact

About 94% of the women had one symptom or the other during the study, and 58% experienced both, according to findings published recently in the British Journal of General Practice.

By comparing symptoms across the first seven weeks of pregnancy, the researchers found that the chances of nausea and vomiting rose.

The likelihood of nausea was highest in weeks five through seven, and vomiting in week seven. The study only examined the first seven weeks.

“If a pregnant woman experiences sickness in the afternoon she may feel that this is unusual and wrong, or if she experiences no vomiting but feels nauseous all day she might think she is not covered by the term ‘morning sickness’,” said study author Roger Gadsby. He’s an associate clinical professor at the University of Warwick Medical School in Coventry, UK.

Gadsby also noted that those women who have severe symptoms feel the term trivialises the condition.

“Nausea and vomiting in pregnancy (NVP) can have a significant negative impact on the lives of sufferers,” he pointed out in a university news release.

“It can cause feelings of depression, of being unable to look after the family, and of loss of time from paid work. Very severe NVP, called hyperemesis gravidarm, is the commonest cause of admission to hospital in the first trimester of pregnancy,” Gadsby said.

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