People tune out facts and trust their guts in medical emergencies

A study conducted by two associate professors of marketing at The University of Texas at Arlington shows that people are more likely to base decisions on anecdotal information instead of facts when they feel anxious and vulnerable.

Traci Freling and Ritesh Saini, both in the College of Business, published “When poignant stories outweigh cold hard facts: A meta-analysis of the anecdotal bias” in Organizational Behavior and Human Decision Processes.

“We found that people are more likely to consider personal anecdotes than fact-based information, especially when it deals with medical emergencies,” Freling said. “This has a high importance in the current environment, where everyone is concerned about the coronavirus.”

Freling said people are more likely to listen to personal stories instead of facts because emotions run high during medical emergencies like the COVID-19 pandemic.

“They are especially dismissive of facts if the incident is something they personally experienced,” Freling said. “Specifically, we show that when an issue is health-related, personally relevant or highly threatening, then decision-making is compromised and people tend to rely on anecdotes.”

Freling pointed to the run on toilet paper buying during the COVID-19 pandemic as one example of not basing decisions on facts. This example illustrates how consumers who feel vulnerable to a particular problem may rely more heavily on subjective, anecdotal information instead of objective, statistical facts to make decisions.

Former UTA faculty member Zhiyong Yang, now a professor at the University of North Carolina-Greensboro, and two graduate students contributed to the analysis.

The research also revealed that when emotional engagement is low, statistical evidence weighs more heavily.

“Primarily, when there is low-threat severity or it’s a non-health issue, people tend to take cold, hard facts into account rather than personal accounts and stories,” Freling said.

Additionally, Saini noted that people make “more fact-based decisions when choosing for others, but become surprisingly irrational when choosing for self.”

Elten Briggs, chair of the Department of Marketing, said Freling and Saini’s analysis could have implications on decision-making processes for business and industry, especially during medical crises.

“Their research provides guidance on how to craft more influential messaging during times like these, when anxiety is heightened for so many people,” Briggs said.

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Materials provided by University of Texas at Arlington. Note: Content may be edited for style and length.

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A twist connecting magnetism and electronic-band topology

Dirac matter is an intriguing class of materials with rather peculiar properties: electrons in these materials behave as if they had no mass. The most prominent Dirac material is graphene, but further members have been discovered during the past 15 years or so. Each one of them serves as a rich playground for exploring ‘exotic’ electronic behaviours, some of which hold the promise to enable novel components for electronics. However, even if Dirac matter and other so-called topological materials — in which electrons behave in similarly unexpected ways — are among the currently most intensively studied condensed-matter systems, there are only very few examples where the topology of the electronic bands is connected in a well-defined manner to the magnetic properties of the materials. One material in which such interplay between topological electronic states and magnetism has been observed is CaMnBi2, but the mechanism connecting the two remained unclear. Writing in Physical Review Letters, postdoc Run Yang and PhD student Matteo Corasaniti from the Optical Spectroscopy group of Prof. Leonardo Degiorgi at the Laboratory for Solid State Physics of ETH Zurich, working with colleagues at Brookhaven National Laboratory (US) and the Chinese Academy of Sciences in Beijing, now report a comprehensive study in which they provide clear evidence that it is a slight nudge on the magnetic moments, known as spin canting, that provokes substantial changes in the electronic band structure.

Compass points to the right direction on a bumpy road

CaMnBi2 and the related compound SrMnBi2 have recently attracted attention as they display quantum magnetism — the manganese ions are antiferromagnetically ordered at around room temperature and below — and at the same time they host Dirac electrons. That there is interplay between the two properties has been suspected for some while, not least as at ~50 K there appears an unexpected ‘bump’ in the conduction properties at these materials. But the precise nature of this anomaly was still poorly understood until now.

In earlier work studying optical properties, Corasaniti, Yang and co-workers had established already a link to the electronic properties of the material. They used in particular the fact that the bump-like anomaly in the transport properties can be shifted in temperature by replacing some of the calcium atoms with sodium. To get now to the microscopic origins of the observed behaviour, they studied samples with different sodium dopings by torque magnetometry. In this technique, the torque on a magnetic sample is measured when it is exposed to a suitably strong field, similarly as a compass needle aligns with the Earth magnetic field. And this approach proved to point the team to the origins of the anomaly.

A firm link between magnetic and electronic properties

In their magnetic-torque experiments, the researchers found that at temperatures where no anomaly is observed in the electronic transport measurements, the magnetic behaviour is such as one would expect for an antiferromagnet. This was not the case anymore at temperatures at which the anomaly is present. There, a ferromagnetic component appeared, which can be explained by a projection of magnetic moments onto the plane orthogonal to the easy spin c-axis of the original antiferromagnetic order. This phenomenon is known as spin-canting, induced by a so-called super-exchange mechanism.

These two sets of experiments — optical and torque measurements — were supported by dedicated first-principles calculations. In particular, for the case where spin canting was included in the calculations, a peculiar hybridization between the manganese and bismuth atoms was found to mediate the interlayer magnetic coupling and to govern the electronic properties in the material. Taken together, the study therefore establishes that sought-after direct link between the magnetic properties and changes to the electronic band structure, reflected in the bump anomaly of the transport properties.

With such detailed understanding on board, the door is now open to exploring not only the electronic properties of CaMnBi2 and related compounds, but also the possibilities arising from the connection between magnetic properties and topological states in these intriguing forms of matter.

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Materials provided by ETH Zurich Department of Physics. Note: Content may be edited for style and length.

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Health24.com | Could robots be deployed to front line in fighting the coronavirus?

Robots can provide significant help in the fight against coronavirus, experts say.

Their uses include: patient care such as telemedicine and decontamination; logistics such as delivery and handling contaminated waste; monitoring compliance with voluntary quarantines, and helping people maintain social connections, according to a paper published March 25 in the journal Science Robotics.

“Already, we have seen robots being deployed for disinfection, delivering medications and food, measuring vital signs, and assisting border controls,” the authors wrote.

Henrik Christensen, director of the Contextual Robotics Institute at the University of California, San Diego, is the lead author.

Other preventative measures

His team noted that robot-controlled ultraviolet (UV) surface disinfection has already been used because Covid-19 spreads not only from person to person but also via contaminated surfaces.

“Opportunities lie in intelligent navigation and detection of high-risk, high-touch areas, combined with other preventative measures,” the authors said in a university news release. “New generations of large, small, micro- and swarm robots that are able to continuously work and clean [i.e., not only removing dust but also truly sanitising/sterilising all surfaces] could be developed.”

In addition, they said “social robots” could foster interaction and adherence to treatment regimens without spreading disease.

“This is a challenging area of development because social interactions require building and maintaining complex models of people, including their knowledge, beliefs, emotions, as well as the context and environment of interaction,” they added.

Sustained research into robots

Christensen and his colleagues predicted that the coronavirus pandemic could be the tipping point of how organisations operate.

“Rather than cancelling large international exhibitions and conferences, new forms of gathering – virtual rather than in-person attendance – may increase,” they explained. “Virtual attendees may become accustomed to remote engagement via a variety of local robotic avatars and controls.”

They also predicted that the pandemic’s impact may drive sustained research in robotics to address infectious disease risks.

“Without a sustainable approach to research and evaluation, history will repeat itself, and technology robots will not be ready to assist for the next incident,” they concluded.

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Health24.com | Certain health conditions increase risks for severe coronavirus cases

New research suggests that having an underlying health condition might be one of the most significant risk factors for developing a severe case of the new coronavirus.

Scientists at the US Centers for Disease Control and Prevention took a look at a group of US adult Covid-19 patients and found roughly three-quarters of those who wound up in the hospital had at least one underlying health issue.

For 457 patients who were admitted to intensive care, 78% had other health conditions, while 71% of 732 patients admitted to the hospital, but not intensive care, had at least one other health issue.

The mortality data showed an even stronger correlation: Among all hospitalised Covid-19 adult patients with complete information on underlying conditions or risk factors, 184 deaths occurred. Of those, 173 (94%) involved patients with at least one underlying condition, according to the CDC’s Covid-19 Response Team, led by researcher Nancy Chow.

New findings ‘all too familiar’

Those conditions include diseases that strike people of all ages, including asthma and diabetes, along with heart disease and lung disease.

Unfortunately, those very conditions are quite common among Americans, the researchers noted: In 2018, the prevalence of diagnosed diabetes among US adults was just over 10%, while the prevalence of heart disease was 10.6% in 2017. Meanwhile, the prevalence of COPD (chronic obstructive pulmonary disease) among US adults was almost 6% and the prevalence of asthma among persons of all ages was nearly 8% in 2018.

The findings were recently published in the CDC publication Morbidity and Mortality Weekly Report.

Dr Robert Glatter is an emergency physician in New York City, tasked with treating many patients hit by coronavirus. He said the new findings are all too familiar.

“On the front lines what we are seeing is that patients with chronic lung disease, cardiovascular disease and diabetes are at higher risk for admission, as well as respiratory failure due to ARDS,” he said. “Patients with asthma, COPD, as well as sleep apnoea are at elevated risk for adverse outcomes including pneumonia, ARDs, and subsequent intubation.

That doesn’t mean that everyone with these conditions is certain to suffer severe illness, Glatter stressed.

Underlying conditions ‘a big player’

“It’s unclear if those patients with underlying chronic disease who adequately manage their conditions are at lower risk for complications and adverse outcomes,” he said.

Underlying conditions can be a big player in Covid-19 severity, but many young adults mistakenly believe that only older people are affected by the coronavirus – a misconception that puts themselves and others at risk, experts warned.

A growing number of 20- to 44-year-old Americans have been hospitalised for Covid-19.

While the rate of Covid-19 deaths is highest for those older than 85, the rate of confirmed cases is highest (29%) among 20- to 44-year-olds, according to the CDC.

Those between 65 and 84 years of age represented more than a third of hospitalised patients, the CDC says, but 20% of hospitalised patients were between 20 and 44.

It’s highly likely that someone in that younger group knows someone from a high-risk group, said Dr Michael Chang, an assistant professor of paediatrics at the University of Texas Health Science Center at Houston.

“Even if your individual risk of severe disease is low, it would be very unfair for those high-risk patients if your actions exposed them to what could be life-threatening disease,” Chang said in a UT Health news release.

Take physical distancing seriously

Young adults need to be aware that while their risk of death if they contract Covid-19 is lower than for older adults, they can spread the illness to their more vulnerable parents, grandparents and other loved ones, said Dr George Delclos, a professor of public health at UT Health.

High-risk people need to take physical distancing seriously to avoid contracting the coronavirus, said Catherine Troisi, an infectious disease epidemiologist at UT Health School of Public Health.

People with elevated risk include those who have underlying health conditions such as chronic lung disease, diabetes or heart disease; are overweight; have a weakened immune system; are pregnant; or are older than 65.

But everyone is at risk, including young people, Troisi emphasised.

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Image credit: CDC, Unsplash

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Health24.com | Mild coronavirus cases often appear with only gastro symptoms

When most people think of the new coronavirus, they imagine symptoms such as a dry cough and high fever. But new research out of China shows that a minority of cases appear with gastrointestinal symptoms only.

In about one-quarter of patients in the new study, diarrhoea and other digestive symptoms were the only symptoms seen in mild Covid-19 cases, and those patients sought medical care later than those with respiratory symptoms.

“Failure to recognise these patients early and often may lead to unwitting spread of the disease among outpatients with mild illness, who remain undiagnosed and unaware of their potential to infect others,” said a team from Union Hospital and Tongji Medical College in Wuhan, China, the original epicentre of the coronavirus pandemic.

“The data in this study highlight the presence and features of this important subgroup of Covid-19 patients and should be confirmed in larger international studies,” the researchers concluded.

Virus throws a curveball

One US expert agreed.

“We are only now learning the varied spectrum of symptoms for patients who present with Covid-19,” said Dr Robert Glatter, an emergency medicine physician at Lenox Hill Hospital in New York City.

“This virus has thrown a curveball at us, as we now realise that gastrointestinal symptoms may be the initial signs of the disease, even without cough, fever, or difficulty breathing,” he said. “The good news is that the majority of patients with gastrointestinal symptoms typically have mild disease.”

In the new study, the research team tracked data from 206 patients with mild Covid-19. Nearly one-quarter (48) had digestive symptoms only, 69 displayed both digestive and respiratory symptoms, and 89 had respiratory symptoms only.

Of the patients with digestive symptoms, 67 had diarrhoea, the study found. Of those, about one in five had diarrhoea as the first symptom in the course of their illness.

Patients with digestive symptoms ill for longer

Diarrhoea lasted between one to 14 days, with an average duration of more than five days and a frequency of about four bowel movements a day.

About one-third of patients with a digestive symptom did not have a fever, the investigators found.

Patients with digestive symptoms took longer to seek medical care than those with respiratory symptoms (16 days versus 11 days), a finding that was consistent with previous research.

The new study also found that patients with digestive symptoms had a longer total time between the start of symptoms and being clear of the coronavirus, were more likely to have coronavirus in their faeces (73% versus 14%), and were ill longer than those with respiratory symptoms.

The study was recently published online in the American Journal of Gastroenterology.

Study considered ‘vital’

The Chinese team stressed that of course there are many illnesses circulating in the community that can trigger gastrointestinal symptoms, “and most instances of new-onset diarrhoea, nausea, vomiting, or low appetite are not from Covid-19.”

Still, “clinicians should recognise that new-onset, acute digestive symptoms in a patient with a possible Covid-19 contact should at least prompt consideration of the illness,” the researchers explained.

Dr Brennan Spiegel is co-editor-in-chief of the journal. He called the study “vital because it represents the 80% or more of patients who do not have severe or critical disease. This is about the more common scenario of people in the community struggling to figure out if they might have Covid-19 because of new-onset diarrhoea, nausea, or vomiting.”

Glatter agreed.

“It’s vital to recognise this key aspect of how the disease presents, since it can trigger the need for self-quarantine,” he said.

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Image credit: Kolar IO, Unsplash

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Trial drug can significantly block early stages of COVID-19 in engineered human tissues

An international team led by University of British Columbia researcher Dr. Josef Penninger has found a trial drug that effectively blocks the cellular door SARS-CoV-2 uses to infect its hosts.

The findings, published today in Cell, hold promise as a treatment capable of stopping early infection of the novel coronavirus that, as of April 2, has affected more than 981,000 people and claimed the lives of 50,000 people worldwide.

The study provides new insights into key aspects of SARS-CoV-2, the virus that causes COVID-19, and its interactions on a cellular level, as well as how the virus can infect blood vessels and kidneys.

“We are hopeful our results have implications for the development of a novel drug for the treatment of this unprecedented pandemic,” says Penninger, professor in UBC’s faculty of medicine, director of the Life Sciences Institute and the Canada 150 Research Chair in Functional Genetics at UBC.

“This work stems from an amazing collaboration among academic researchers and companies, including Dr. Ryan Conder’s gastrointestinal group at STEMCELL Technologies in Vancouver, Nuria Montserrat in Spain, Drs. Haibo Zhang and Art Slutsky from Toronto and especially Ali Mirazimi’s infectious biology team in Sweden, who have been working tirelessly day and night for weeks to better understand the pathology of this disease and to provide breakthrough therapeutic options.”

ACE2 — a protein on the surface of the cell membrane — is now at centre-stage in this outbreak as the key receptor for the spike glycoprotein of SARS-CoV-2. In earlier work, Penninger and colleagues at the University of Toronto and the Institute of Molecular Biology in Vienna first identified ACE2, and found that in living organisms, ACE2 is the key receptor for SARS, the viral respiratory illness recognized as a global threat in 2003. His laboratory also went on to link the protein to both cardiovascular disease and lung failure.

While the COVID-19 outbreak continues to spread around the globe, the absence of a clinically proven antiviral therapy or a treatment specifically targeting the critical SARS-CoV-2 receptor ACE2 on a molecular level has meant an empty arsenal for health care providers struggling to treat severe cases of COVID-19.

“Our new study provides very much needed direct evidence that a drug — called APN01 (human recombinant soluble angiotensin-converting enzyme 2 — hrsACE2) — soon to be tested in clinical trials by the European biotech company Apeiron Biologics, is useful as an antiviral therapy for COVID-19,” says Dr. Art Slutsky, a scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital and professor at the University of Toronto who is a collaborator on the study.

In cell cultures analyzed in the current study, hrsACE2 inhibited the coronavirus load by a factor of 1,000-5,000. In engineered replicas of human blood vessel and kidneys — organoids grown from human stem cells — the researchers demonstrated that the virus can directly infect and duplicate itself in these tissues. This provides important information on the development of the disease and the fact that severe cases of COVID-19 present with multi-organ failure and evidence of cardiovascular damage. Clinical grade hrsACE2 also reduced the SARS-CoV-2 infection in these engineered human tissues.

“Using organoids allows us to test in a very agile way treatments that are already being used for other diseases, or that are close to being validated. In these moments in which time is short, human organoids save the time that we would spend to test a new drug in the human setting,” says Núria Montserrat, ICREA professor at the Institute for Bioengineering of Catalonia in Spain.

“The virus causing COVID-19 is a close sibling to the first SARS virus,” adds Penninger. “Our previous work has helped to rapidly identify ACE2 as the entry gate for SARS-CoV-2, which explains a lot about the disease. Now we know that a soluble form of ACE2 that catches the virus away, could be indeed a very rational therapy that specifically targets the gate the virus must take to infect us. There is hope for this horrible pandemic.”

This research was supported in part by the Canadian federal government through emergency funding focused on accelerating the development, testing, and implementation of measures to deal with the COVID-19 outbreak.

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