A new study in the Journal of Nutrition Education and Behavior, published by Elsevier, found kids who watched a child-oriented cooking show featuring healthy food were 2.7 times more likely to make a healthy food choice than those who watched a different episode of the same show featuring unhealthy food.

Researchers asked 125 10- to 12-year-olds, with parental consent, at five schools in the Netherlands to watch 10 minutes of a Dutch public television cooking program designed for children, and then offered them a snack as a reward for participating. Children who watched the healthy program were far more likely to choose one of the healthy snack options — an apple or a few pieces of cucumber — than one of the unhealthy options — a handful of chips or a handful of salted mini-pretzels.

“The findings from this study indicate cooking programs can be a promising tool for promoting positive changes in children’s food-related preferences, attitudes, and behaviors,” said lead author Frans Folkvord, PhD, of Tilburg University,Tilburg, Netherlands.

This study was conducted at the children’s schools, which could represent a promising alternative for children learning healthy eating behaviors. Prior research has found youth are more likely to eat nutrient-rich foods including fruits and vegetables if they were involved in preparing the dish, but modern reliance on ready-prepared foods and a lack of modeling by parents in preparing fresh foods have led to a drop in cooking skills among kids.

“Providing nutritional education in school environments instead may have an important positive influence on the knowledge, attitudes, skills, and behaviors of children,” Dr. Folkvord said.

This study indicates the visual prominence of healthier options in both food choice and portion size on TV cooking programs leads young viewers to crave those healthier choices then act on those cravings.

The effect that exposure to healthier options has on children is strongly influenced by personality traits. For example, children who don’t like new foods are less likely to show a stronger desire for healthier choices after watching a TV program featuring healthier foods than a child who does enjoy trying new foods. As they grow older, though, they start to feel more responsible for their eating habits and can fall back on information they learned as children. Researchers believe this may indicate watching programs with healthier options can still have a positive impact on children’s behavior, even if it is delayed by age.

“Schools represent the most effective and efficient way to reach a large section of an important target population, which includes children as well as school staff and the wider community,” Dr. Folkvord commented. “Positive peer and teacher modeling can encourage students to try new foods for which they exhibited distaste previously.”

Poor dietary habits during childhood and adolescence have multiple negative effects on several health and wellness indicators, including achievement and maintenance of healthy weights, growth and development patterns, and dental health.

“The likelihood of consuming fruits and vegetables among youth and adults is strongly related to knowing how to prepare most fruits and vegetables. Increased cooking skills among children can positively influence their consumption of fruit and vegetables in a manner that will persist into adulthood,” Dr. Folkvord added.

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The answer appears to be yes, according to two separate Harvard Medical School studies published in Nature.

The findings of the two studies, both conducted in mice, show that bile acids promote the differentiation and activity of several types of T cells involved in regulating inflammation and linked to intestinal inflammatory conditions. They also reveal that gut microbes are critical for converting bile acids into immune-signaling molecules.

The work suggests possible therapeutic pathways for modulating intestinal inflammation, a process that underlies the development of autoimmune conditions such as inflammatory bowel disease, commonly referred to as IBD.

The first study, led by immunologist Jun Huh and published Nov. 27 in Nature, reveals bile acids exert their immune-modulating effect by interacting with immune cells in the gut. Once bile acids leave the gallbladder and complete their fat-dissolving duties, they make their way down the digestive tract where they are modified into immune-regulatory molecules by gut bacteria. The modified bile acids then activate two class of immune cells: regulatory T cells (Tregs) and effector helper T cells, specifically Th17, each responsible for modulating immune response by either curbing or promoting inflammation.

Under normal conditions, the levels of proinflammatory Th17 cells and anti-inflammatory Treg cells balance each other, maintaining a degree of protection against pathogens without causing too much tissue-damaging inflammation. These cells play a key role in the context of intestinal infection. Th17 cells ignite inflammation to quell the infection, while Tregs curb inflammation once the threat has subsided. Unrestrained, the activity of Th17 can also lead to aberrant inflammation that promotes autoimmune disease and damages the intestine.

In their experiments, the researchers used undifferentiated, or naïve, mouse T cells, and exposed them to various bile acid metabolites one at a time. The experiments showed that two separate bile acid molecules exerted different effects on T cells — one molecule promoted Treg differentiation, while another molecule inhibited Th17 cell differentiation. When the researchers administered each molecule to mice, they observed the animals’ Th17 and Treg cells fell and rose, accordingly. Additionally, the researchers found that the two bile acid byproducts are also present in human stool, including stools of people with IBD — a finding that suggest the same mechanism is at play in humans.

“Our findings identify an important regulatory mechanism in gut immunity, showing that microbes in our intestines can modify bile acids and turn them into regulators of inflammation,” said Huh, assistant professor of immunology in the Blavatnik Institute at HMS.

If affirmed in further studies, the results can inform the development of small-molecule therapies that target Treg and Th17 cells as a way to control inflammation and treat autoimmune diseases affecting the gut.

The second study, published Dec. 25 in Nature and led by Dennis Kasper, focused on a subset of inflammation-taming regulatory T cells, or Tregs, that arise in the colon as a result of exposure to gut microbes. In contrast, most other immune cells originate in the thymus.

Low levels of colonic regulatory T cells (colonic Tregs) have been linked to the development of autoimmune conditions such as IBD and Crohn’s disease.

Kasper’s experiments demonstrate that gut microbes and diet work in concert to modify bile acids, which in turn affect the levels of colonic Tregs in mice. They also show that low levels of Treg cells induced by lack of bile acids or deficiency in bile acid sensors makes animals prone to developing inflammatory colitis — a condition that mimics human IBD.

To test the hypothesis that gut bacteria convert food-derived bile acids produced in response to food into immune signaling molecules, the researchers silenced bile acid-converting genes in various gut microbes and then put both the modified and nonmodified microbes in mice specially bred to have germ-free guts. Animals whose guts were populated by microbes without bile acid-converting genes had notably lower levels of Treg cells. The researchers then fed animals either nutrient-rich meals or minimal food.

Animals with normal microbe populations in their guts that were receiving minimal food had lower levels of colonic Tregs and lower bile acid levels than mice eating rich food. Yet animals with germ-free guts receiving rich food also had low levels of Treg cells — a finding which shows that both gut microbes and food-derived bile acids are required to modulate immune cell levels.

To test whether bile acids are directly involved in immune cell regulation, the researchers then mixed various bile acid molecules with the drinking water of animals that had low Treg cell levels and minimal diets. Several weeks later, these animals had an increase in the levels of inflammation-curbing Treg cells.

In a final step, the researchers gave three groups of mice a compound that induces colitis. One group was fed a minimal diet, another group received nutrient-rich meals and a third group received minimal food and drank water supplemented with bile acid molecules. As expected, only mice fed minimal diets not supplemented by bile acid molecules developed colitis. The experiment confirmed that bile acids play a critical role in Treg regulation, intestinal inflammation and colitis risk.

“Our results demonstrate an elegant three-way interaction between gut microbes, bile acids and the immune system,” said Kasper, who is professor of immunology in the Blavatnik Institute at HMS and the William Ellery Channing Professor of Medicine at HMS and Brigham and Women’s Hospital. “Importantly, our work suggests it is plausible to think of harnessing certain gut bacteria as a way to modulate disease risk.”

Monash University researchers are on the brink of commercialising the world’s most efficient lithium-sulphur (Li-S) battery, which could outperform current market leaders by more than four times, and power Australia and other global markets well into the future.

Dr Mahdokht Shaibani from Monash University’s Department of Mechanical and Aerospace Engineering led an international research team that developed an ultra-high capacity Li-S battery that has better performance and less environmental impact than current lithium-ion products.

The researchers have an approved filed patent (PCT/AU 2019/051239) for their manufacturing process, and prototype cells have been successfully fabricated by German R&D partners Fraunhofer Institute for Material and Beam Technology.

Some of the world’s largest manufacturers of lithium batteries in China and Europe have expressed interest in upscaling production, with further testing to take place in Australia in early 2020.

The study was published in Science Advances on Saturday, 4 January 2020.

Professor Mainak Majumder said this development was a breakthrough for Australian industry and could transform the way phones, cars, computers and solar grids are manufactured in the future.

“Successful fabrication and implementation of Li-S batteries in cars and grids will capture a more significant part of the estimated $213 billion value chain of Australian lithium, and will revolutionise the Australian vehicle market and provide all Australians with a cleaner and more reliable energy market,” Professor Majumder said.

“Our research team has received more than $2.5 million in funding from government and international industry partners to trial this battery technology in cars and grids from this year, which we’re most excited about.”

Using the same materials in standard lithium-ion batteries, researchers reconfigured the design of sulphur cathodes so they could accommodate higher stress loads without a drop in overall capacity or performance.

Inspired by unique bridging architecture first recorded in processing detergent powders in the 1970s, the team engineered a method that created bonds between particles to accommodate stress and deliver a level of stability not seen in any battery to date.

Attractive performance, along with lower manufacturing costs, abundant supply of material, ease of processing and reduced environmental footprint make this new battery design attractive for future real-world applications, according to Associate Professor Matthew Hill.

“This approach not only favours high performance metrics and long cycle life, but is also simple and extremely low-cost to manufacture, using water-based processes, and can lead to significant reductions in environmentally hazardous waste,” Associate Professor Hill said.

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A new study suggests the way some chemicals displace natural fat-like molecules (called lipids) in skin cells may explain how many common ingredients trigger allergic contact dermatitis, and encouragingly, suggests a new way to treat the condition.

The study was led by researchers at Columbia University Irving Medical Center, the Brigham and Women’s Hospital, and Monash University and published online today in Science Immunology.

Why some chemicals trigger dermatitis is a mystery

Poison ivy is a commonly known trigger for allergic contact dermatitis, an itchy skin rash. But many ingredients found in nonprescription topical products can trigger a similar type of rash.

An allergic reaction begins when the immune system’s T cells recognize a chemical as foreign. T cells do not directly recognize small chemicals, and research suggests that these compounds need to undergo a chemical reaction with larger proteins in order to make themselves visible to T cells.

“However, many small compounds in skincare products that trigger allergic contact dermatitis lack the chemical groups needed for this reaction to occur,” says study co-leader Annemieke de Jong, PhD, assistant professor of dermatology at Columbia University Vagelos College of Physicians and Surgeons.

“These small chemicals should be invisible to T cells, but they’re not.”

Skin cells unmask allergy-inducing chemicals

De Jong and her colleagues suspected that CD1a, a molecule that’s abundant on Langerhans cells (immune cells in the skin’s outer layer), might be responsible for making these chemicals visible to T cells.

In the current study, conducted with human cells in tissue culture, the researchers found that several common chemicals known to trigger allergic contact dermatitis were able to bind to CD1a molecules on the surface of Langerhans cells and activate T cells.

These chemicals included Balsam of Peru and farnesol, which are found in many personal care products, such as skin creams, toothpaste, and fragrances. Within Balsam of Peru, the researchers identified benzyl benzoate and benzyl cinnamate as the chemicals responsible for the reaction, and overall they identified more than a dozen small chemicals that activated T cells through CD1a.

“Our work shows how these chemicals can activate T cells in tissue culture, but we have to be cautious about claiming that this is definitively how it works in allergic patients,” de Jong says. “The study does pave the way for follow up studies to confirm the mechanism in allergic patients and design inhibitors of the response.”

New Ideas for Treatment

CD1a molecules normally bind the skin’s own naturally occurring lipids in its tunnel-like interior. These lipids protrude from the tunnel, creating a physical barrier that prevents CD1a from interacting with T cells.

Structural work done at Monash University showed that farnesol, one of the allergens identified in this study, can hide inside the tunnel of CD1a, displacing the natural lipids that normally protrude from the CD1a molecule. “This displacement makes the CD1a surface visible to the T cells, causing an immune reaction,” de Jong says.

This discovery raises the possibility that allergic contact dermatitis could be stopped by applying competing lipids to the skin to displace those triggering the immune reaction. “From previous studies, we know the identity of several lipids that can bind to CD1a but won’t activate T cells,” she says.

Currently, the only way to stop allergic contact dermatitis is to identify and avoid contact with the offending chemical. Topical ointments can help sooth the rashes, which usually clear up in less than a month. In severe cases, physicians may prescribe oral corticosteroids, anti-inflammatory agents that suppress the immune system, increasing the risk of infections and other side effects.

The remarkable tetrahedral structure has now been imaged for the first time with a scanning tunnelling microscope. This high-tech microscope can visualise single atoms. It operates at extremely low temperatures (269 degrees below zero) and uses quantum tunnelling of an electrical current from a sharp scanning metallic tip through the cluster and into the support. Quantum tunnelling is a process where electrical current flows between two conductors without any physical contact between them.

The researchers used intense plasmas in a complex vacuum chamber setup to sputter gold atoms from a macroscopic piece of gold. “Part of the sputtered atoms grow together to small particles of a few up to a few tens of atoms, due to a process comparable with condensation of water molecules to droplets,” says Zhe Li, the main author of the paper, currently at the Harbin Institute of Technology, Shenzhen. “We selected a beam of clusters consisting of exactly twenty gold atoms. We landed these species with one of the triangular facets onto a substrate covered with a very thin layer of kitchen salt (NaCl), precisely three atom layers thick.”

The study also revealed the peculiar electronic structure of the small gold pyramid. Similar to noble gas atoms or aromatic molecules, the cluster only has completely filled electron orbitals, which makes them much less reactive than clusters with one or a few atoms more or less.

Gold clusters ranging from a few to several dozens of atoms in size are known to possess remarkable properties.

The new discovery helps scientists evaluate the catalytic and optical performances of these clusters, which is relevant for designing cluster-based catalyst and optical devices. Recent applications of clusters include utilisation in fuel cells and carbon capture.

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