Health24.com | 4 in 5 adolescents worldwide don’t exercise enough

Four of five older children and teens around the world don’t get the recommended amount of physical activity, a new study says.

Researchers analysed data gathered between 2001 and 2016 from 1.6 million students, aged 11 to 17, in 146 countries. They found that 81% of them did not meet World Health Organization recommendations for an hour of moderate-to-vigorous physical activity every day.

‘Urgent policy action’

Girls were less active than boys in all but four countries: Tonga, Samoa, Afghanistan and Zambia. In nearly one-third of countries (29%), girls were more than 10 percentage points less likely to meet the WHO recommendations. The biggest gaps were in the United States and Ireland, at more than 15 percentage points.

In 73% of the countries, the gender gap increased between 2001 and 2016. In 2016, 90% or more of girls in 27 countries did not have sufficient levels of activity. Among boys, this occurred in only two countries.

Boys in the Philippines and girls in South Korea were the most inactive, while Bangladesh had the lowest rates of physical inactivity for both genders, according to the WHO-led study. It was published in The Lancet Child & Adolescent Health journal.

“Urgent policy action to increase physical activity is needed now, particularly to promote and retain girls’ participation in physical activity,” study author Regina Guthold said in a journal news release. She is a technical officer from Chronic Disease Risk Factor Surveillance at WHO in Geneva.

Physical inactivity can harm children’s health, the researchers noted.

Boosting physical activity

The benefits of physical activity during adolescence include improved heart, lung and muscular fitness, better bone health, and weight control. There is also growing evidence that physical activity benefits brain health and social skills.

Many of these benefits continue into adulthood, research suggests.

“The study highlights that young people have the right to play and should be provided with the opportunities to realise their right to physical and mental health and well-being,” said study co-author Fiona Bull. She is director of the Centre for Built Environment and Health at the University of Western Australia and president of the International Society for Physical Activity and Health.

“Policymakers and stakeholders should be encouraged to act now for the health of this and future young generations,” Bull said.

The researchers called for: expansion of policies and programmes known to boost adolescents’ physical activity; more action from sectors such as education, urban planning and road safety to provide more opportunities for young people to be active; and political and other leaders to promote the importance of physical activity for all people, including adolescents.

Image credit: iStock

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Building a better battery with machine learning

Designing the best molecular building blocks for battery components is like trying to create a recipe for a new kind of cake, when you have billions of potential ingredients. The challenge involves determining which ingredients work best together — or, more simply, produce an edible (or, in the case of batteries, a safe) product. But even with state-of-the-art supercomputers, scientists cannot precisely model the chemical characteristics of every molecule that could prove to be the basis of a next-generation battery material.

Instead, researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory have turned to the power of machine learning and artificial intelligence to dramatically accelerate the process of battery discovery.

As described in two new papers, Argonne researchers first created a highly accurate database of roughly 133,000 small organic molecules that could form the basis of battery electrolytes. To do so, they used a computationally intensive model called G4MP2. This collection of molecules, however, represented only a small subset of 166 billion larger molecules that scientists wanted to probe for electrolyte candidates.

Because using G4MP2 to resolve each of the 166 billion molecules would have required an impossible amount of computing time and power, the research team used a machine learning algorithm to relate the precisely known structures from the smaller data set to much more coarsely modeled structures from the larger data set.

“When it comes to determining how these molecules work, there are big tradeoffs between accuracy and the time it takes to compute a result,” said Ian Foster, Argonne Data Science and Learning division director and author of one of the papers. “We believe that machine learning represents a way to get a molecular picture that is nearly as precise at a fraction of the computational cost.”

To provide a basis for the machine learning model, Foster and his colleagues used a less computationally taxing modeling framework based on density functional theory, a quantum mechanical modeling framework used to calculate electronic structure in large systems. Density functional theory provides a good approximation of molecular properties, but is less accurate than G4MP2.

Refining the algorithm to better ascertain information about the broader class of organic molecules involved comparing the atomic positions of the molecules computed with the highly accurate G4MP2 versus those analyzed using only density functional theory. By using G4MP2 as a gold standard, the researchers could train the density functional theory model to incorporate a correction factor, improving its accuracy while keeping computational costs down.

“The machine learning algorithm gives us a way to look at the relationship between the atoms in a large molecule and their neighbors, to see how they bond and interact, and look for similarities between those molecules and others we know quite well,” said Argonne computational scientist Logan Ward, an author of one of the studies. “This will help us to make predictions about the energies of these larger molecules or the differences between the low- and high-accuracy calculations.”

“This whole project is designed to give us the biggest picture possible of battery electrolyte candidates,” added Argonne chemist Rajeev Assary, an author of both studies. “If we are going to use a molecule for energy storage applications, we need to know properties like its stability, and we can use this machine learning to predict properties of bigger molecules more accurately.”

A paper describing the formation of the G4MP2-based dataset, “Accurate quantum chemical energies for 133,000 organic molecules,” appeared in the June 27 online issue of Chemical Science.

A second paper describing the machine learning algorithm, “Machine learning prediction of accurate atomization energies of organic molecules from low-fidelity quantum chemical calculations,” appeared in the August 27 issue of MRS Communications.

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Materials provided by DOE/Argonne National Laboratory. Original written by Jared Sagoff. Note: Content may be edited for style and length.

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Health24.com | Regular fasting could lead to a longer, healthier life

Regular fasting is associated with lower rates of heart failure and a longer lifespan, according to two new studies.

Researchers sought to shed new light on the centuries-old debate about how fasting affects health. Recent studies have shown it contributes to reductions in blood pressure, “bad” LDL cholesterol and insulin resistance, a condition that can raise blood sugar. A 2017 study showed alternate-day fasting was as effective as daily calorie restriction for losing weight and keeping the pounds off.

A profound effect

The new studies focused on data from patients evaluated for heart disease in Utah and other Rocky Mountain states. The research included hundreds of members of The Church of Jesus Christ of Latter-day Saints, also known as Mormons, who typically fast one Sunday each month, for up to 24 hours.

In the first study, researchers zeroed in on how fasting impacts life span. About 2 000 people who had undergone a cardiac catheterisation procedure were followed for an average of 4.4 years, including 389 “routine fasters” who had been fasting regularly for at least five years.

After adjusting for various factors, researchers discovered the routine fasters had a 45% lower mortality rate than the non-fasters during the follow-up period.

“It’s very interesting … it’s a more profound effect than we anticipated,” said researcher Dr Benjamin Horne, who recently presented the preliminary findings at the American Heart Association’s Scientific Sessions.

Horne also was involved in the second fasting study, which used the same patient data to see how routine fasting affects heart failure and heart attacks. After adjusting for various factors, there was no significant difference in heart attacks, but routine fasters had a 71% lower rate of developing heart failure than non-fasters.

A very different lifestyle

“That’s a huge difference, and frankly, it was a little unexpected,” said Horne, director of cardiovascular and genetic epidemiology at Intermountain Medical Center in Salt Lake City, Utah.

Krista Varady, an associate professor of nutrition at the University of Illinois at Chicago, called it “an important study that hasn’t been done before. There’s a lot of short-term clinical trials for intermittent fasting, but we definitely don’t have any long-term data in humans looking at whether it can prevent things like heart failure.”

Varady, who was not involved in the research, said the study was limited by the fact that most of the fasters were Latter-day Saints.

“They lead a very different lifestyle compared to the average American,” she said. “For instance, they don’t smoke, don’t drink alcohol and are slightly more physically active. It just makes sense they’re going to live longer and have a lower chance of heart disease.”

Even though researchers adjusted for some of those factors, she said, “It is very difficult to tease apart the effects of fasting versus an otherwise healthy lifestyle in this population, despite the use of statistical corrections.”

The hours build up

A number of hot diet trends encourage people to restrict their eating to a window of eight to 12 hours and fasting the remaining 12 to 16 hours. But participants in the two new studies fasted even more hours each day, over the course of an average of 42.2 years, Horne said.

“We think that long-term fasting of about one day, once a month, over a period of decades is making the body activate those beneficial mechanisms for a few hours each day between dinner and breakfast when it usually wouldn’t. … Those hours build up over long periods of time and provide the benefits,” he said.

The research was limited by being an observational study that doesn’t prove cause and effect, Horne said. He’d like to see future studies that explore why fasting seems to protect against heart failure, and he also called for a large study on the psychological benefits of fasting.

“Some people who’ve started fasting say they unexpectedly feel they have more self-control over their appetite,” he said. “Potentially, there’s a direct result between fasting and the strengthening of the mind so people are able to eat a better diet.”

Varady called for future studies that follow people who restrict eating in a variety of ways – such time-restrictive fasters and alternate-day fasters. “This is a nice first step, but we need to do long-term research on different people doing different types of fasting.”

Image credit: iStock

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‘Proof NHS at risk under US trade deal’ – Labour

Jeremy Corbyn says his party has a 451-page dossier of evidence – but the Tories say he is lying.

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Breast cancer: Patient creates app to help with treatment

Karen Bonham struggled to find the information she needed ahead of radiotherapy – so she created an app.

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Autism: ‘Unprecedented’ demand creates long appointment waits

Patients could have waited more than 19 weeks – 50% longer than the target time – in some areas.

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Sarah Hyland Sends Body Positive Message to ‘Fellow Invisible Illness Warriors’

Sarah Hyland just gave her fans a lesson in self-love. In an emotional Instagram post on the changes her body has gone through as a result of living with kidney dysplasia, the actress, 29, opened up about her struggle with self-acceptance. 

RELATED: Modern Family's Sarah Hyland Is Frustrated with 'Doctors Not Listening' to Her Health Struggles

“To my fellow #invisibleillness warriors. It’s ok to be insecure about your body,” she wrote in the caption to her post from Sunday, which featured a photo of her in a sports bra and her abs on full display.

“Just remember to check in with yourself at least once a day and say thank you. Our bodies have endured unfathomable feats that our minds barely have time to comprehend what has actually happened. With inflammation, excess water gain, and medications, my skin has a hard time bouncing back.”

Hyland added that she first hated the sports bra photo, but ultimately she decided to change her attitude and celebrate her body as it is by sharing it.

“Love yourself and be patient,” she wrote. “We are all stronger than we think we are.”

Her fans were in full support of her message. After just a day, the star received more than 4,700 comments, with people praising her for her honest response. 

RELATED: Sarah Hyland Likes Working Out Naked in Front of Mirror For Motivation

Hyland's invisible illness, kidney dysplasia, is a congenital condition that causes painful cysts to form in her kidneys. In 2012, she underwent a kidney transplant, yet four years later, her body rejected the kidney that had been donated by her father, which had to be removed.

Four months later, she had a second transplant using her younger brother’s kidney, which Hyland felt conflicted about.  

“I was very depressed,” she said. “When a family member gives you a second chance at life, and it fails, it almost feels like it’s your fault. It’s not. But it does. For a long time, I was contemplating suicide, because I didn’t want to fail my little brother like I failed my dad.”

Since then, Hyland has had the support of her family, fans and fiancé, Wells Adams, to help her through her recovery from the transplant and her struggles with the emotional side of dealing with a serious medical condition. With her latest post, she's acknowledging these difficulties and encouraging others to feel strong and empowered.

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American Couple Says They’re Being Held ‘Hostage’ in Mexican Hospital Over $14K Medical Bill

An Atlanta couple forced to seek medical treatment while on a cruise vacation now say they’re being held “hostage” by a hospital in Mexico over an unpaid $14,000 medical bill.

Stephen Johnson, 31, and fiancée Tori Austin were two days into their trip on a Carnival Dream cruise ship when Johnson fell ill and was diagnosed on board with pancreatitis and diabetes, CBS affiliate WGCL reported.

At the behest of Carnival, Johnson sought treatment and was hospitalized in the Mexican town of Progreso, where he spent three days in intensive care, Good Morning America reported.

RELATED: This Couple Was Paying so Much for Their Son's Disability, a Doctor Suggested Getting a Divorce

Once he was on the mend, however, he was hit with a $14,000 bill that the couple is unable to pay, as they do not have health or travelers’ insurance.

“The plan is to pay the bill, it’s not to skip out on the bill,” Austin told GMA. “They saved his life. His life is more than $14,000.”

Austin said she offered $7,000 upfront and asked if they could work out a payment plan for when they were back in the U.S., but that her request was denied, and she and Johnson were barred from leaving the hospital.

RELATED: Couple Found Dead from Murder-Suicide After Man Said He Couldn't Afford Health Care for His Wife

“We tried to leave Tuesday, but we were physically assaulted by the administrative staff,” she alleged. “They physically were pushing on him.”

Austin also claimed that hospital staffers locked the windows to further prevent them leaving, and threatened to call the police should they make a break for it.

“It’s been a nightmare. We just want to come home,” she told WGCL. “$14,000 in a matter of hours, I don’t know who has that type of money.”

RELATED: This Woman Wants to Make It Less Awkward for Sick People to Ask for What They Need

Added Johnson, “[It’s] hell. I very much so am a hostage. Don’t get sick and have to come to this hospital, that’s one thing I can tell you. They won’t let you leave.”

A U.S. Department of State official confirmed to PEOPLE on Friday that a U.S. citizen was being treated at a Progreso hospital, and that a consular officer visited the citizen in the hospital on Thursday.

The official said the department was monitoring the situation closely.

RELATED: This Dad Says His Baby Was Charged $3,500 For His Own Delivery—How Common is That?

Austin, meanwhile, shared an emotional video to Facebook on Wednesday, telling her followers she and Johnson were “coming home” and that someone had offered to pay their entire bill.

“Thank you whoever gave the money,” Johnson could be heard yelling in the background of the video.

Austin later wrote on Facebook Friday morning that she and Johnson were still “waiting” in Mexico.

Carnival confirmed to PEOPLE in a statement that a guest on the Carnival Dream had suffered a medical emergency and “was required to seek medical treatment in Progreso.”

“We are not in a position to comment on the personal matters related to his health or the financial arrangements regarding his treatment, but our CareTeam is providing support,” the statement read.

Austin, however, praised the company in a Facebook post, and wrote that their support had been “great” throughout the ordeal, though she did not go into specifics.

The hospital did not immediately respond to PEOPLE’s request for comment.

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Jenna Dewan Shares Makeup-Free Selfie to Instagram to Send a Message About Self-Care  

Jenna Dewan is reminding everyone to take a break and schedule some self-care time. The actress and dancer, who is currently pregnant with her second child, shared a makeup-free selfie with an important message about getting a chance to rest, recover, and feel more gratitude. 

“A day off today and I haven’t moved from bed not kidding." she wrote in her post on Saturday. "Lots of time to rest, recuperate and reflect on how grateful i am for love, joy and especially my health. Remembering what’s important and to slow down every now and then :heart:"

RELATED: Jenna Dewan Twerks Through Her 'Late-Night' Fitness Routine Following Split from Channing Tatum

Unsurprisingly, fans were in awe of her natural beauty and had plenty to say about the star's photo. 

"Rest. Take care of yourself and your baby :hearts::hearts::hearts::hearts:," one fan wrote, with another adding, "Some days our body needs that :thumbsup:"

RELATED: Ellen DeGeneres’s On-Air Mistake Prompted Jenna Dewan to Talk About Ex Channing Tatum

This wasn't the first time that Dewan has posted images of her face au natural. In 2017, she shared another makeup-free selfie to Instagram, noting that she struggles with melasma—a skin condition causing dark spots or patches to appear on the face. Melasma can be triggered by too much time in the sun or hormonal changes brought on by birth control pills or pregnancy, for example. 

Needless to say, she looks incredible with or without makeup and melasma—and her message about scoring plenty of R&R is something everyone needs to remember as the holiday season hits.

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Did human hunting activities alone drive great auks’ extinction?

New insight on the extinction history of a flightless seabird that vanished from the shores of the North Atlantic during the 19th century has been published today in eLife.

The findings suggest that intense hunting by humans could have caused the rapid extinction of the great auk, showing how even species that exist in large and widespread populations can be vulnerable to exploitation.

Great auks were large, flightless diving birds thought to have existed in the millions. They were distributed around the North Atlantic, with breeding colonies along the east coast of North America and especially on the islands off Newfoundland. They could also be found on islands off the coasts of Iceland and Scotland, as well as throughout Scandinavia.

But these birds had a long history of being hunted by humans. They were poached for their meat and eggs during prehistoric times, and this activity was further intensified in 1500 AD by European seamen visiting the fishing grounds of Newfoundland. Their feathers later became highly sought after in the 1700s, contributing further to their demise.

“Despite the well-documented history of exploitation since the 16th century, it is unclear whether hunting alone could have been responsible for the species’ extinction, or whether the birds were already in decline due to natural environmental changes,” says lead author Jessica Thomas, who completed the work as part of her PhD studies at Bangor University, UK, and the University of Copenhagen, Denmark, and is now a postdoctoral researcher at Swansea University, Wales, UK.

To investigate this further, Thomas and her collaborators carried out combined analyses of ancient genetic data, GPS-based ocean current data, and population viability – a process that looks at the probability of a population going extinct within a given number of years. They sequenced complete mitochondrial genomes of 41 individuals from across the species’ geographic range and used their analyses to reconstruct the birds’ population structure and dynamics throughout the Holocene period, the last 11,700 years of Earth’s history.

“Taken together, our data don’t suggest that great auks were at risk of extinction prior to intensive human hunting behaviour in the early 16th century,” explains co-senior author Thomas Gilbert, Professor of Evolutionary Genomics at the University of Copenhagen. “But critically, this doesn’t mean that we’ve provided solid evidence that humans alone were the cause of great auk extinction. What we have demonstrated is that human hunting pressure was likely to have caused extinction even if the birds weren’t already under threat from environmental changes.”

Gilbert adds that their conclusions are limited by a couple of factors. The mitochondrial genome represents only a single genetic marker and, due to limited sample preservation and availability, the study sample size of 41 is relatively small for population genetic analyses.

“Despite these limitations, the findings help reveal how industrial-scale commercial exploitation of natural resources have the potential to drive an abundant, wide-ranging and genetically diverse species to extinction within a short period of time,” says collaborator Gary Carvalho, Professor in Zoology (Molecular Ecology) at Bangor University. This echoes the conclusions of a previous study* on the passenger pigeon, a bird that existed in significant numbers before going extinct in the early 20th century.

“Our work also emphasises the need to thoroughly monitor commercially harvested species, particularly in poorly researched environments such as our oceans,” concludes co-senior author Michael Knapp, Senior Lecturer in Biological Anthropology and Rutherford Discovery Fellow at the University of Otago, New Zealand. “This will help lay the platform for sustainable ecosystems and ensure more effective conservation efforts.”

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Materials provided by eLife. Note: Content may be edited for style and length.

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