Health24.com | Flavours draw young people to lifetime addiction of vaping

Tasty flavours entice young people to try e-cigarettes, getting them hooked on what can become a lifetime habit, a new study shows.

“Children and youth prefer sweet flavours. We know that flavours increase appeal to young or inexperienced users,” said lead researcher Andrea Villanti, an associate professor with the University of Vermont’s Center on Behavior and Health. “Something that tastes like candy is more palatable to a young person than tobacco flavour on its own.”

Only tobacco and menthol flavours

Her team found that young people who first try a flavoured vape, cigar or smokeless tobacco are much more likely to still be using that product a year later.

For example, twice as many kids and young adults who first try a flavoured e-cigarette will still be vaping a year later, compared with those who first try a tobacco-flavoured vape, the study found.

The results support recent efforts by the Trump administration and some states to ban flavoured e-cigarettes.

In response to growing pressure, e-cigarette maker Juul announced last week that it would suspend sales of all flavoured pods for its vaping device. Only tobacco and menthol flavours will remain on the market, pending review by the US Food and Drug Administration.

But Villanti noted that the problem extends far beyond vaping.

“E-cigarettes are getting a lot of attention right now, and they also have a lot of flavours, but this is a problem we have across all product categories,” Villanti said. “It’s not just an e-cigarette issue.”

Ongoing federally funded study

Regulations against flavourings in tobacco products remain weak, Villanti said. Cigarettes are the only tobacco product in which flavours are banned, although menthol cigarettes have been allowed to remain on the market.

To see whether flavours attract young people to tobacco and then help keep them using, Villanti and her team used data from an ongoing federally funded study that tracks tobacco use in the United States.

The researchers assessed data collected in 2013–2014 to see whether people are more likely to first try a flavoured e-cigarette or other tobacco product. They then looked at data gathered a year later to see if those who first tried a flavoured product were still using tobacco.

Seven out of 10 kids who were new users of tobacco first tried a flavoured product, as well as more than half of young adults, researchers found.

Those young adults who started with a flavoured product were more likely to stick with it, data from the second wave revealed. Current daily users included:

  • Twice as many first-time users of flavoured e-cigarettes or pipe tobacco
  • Three and a half times as many filtered cigar users
  • Twice as many hookah tobacco users
  • Half again as many users of cigarillos, cigars or smokeless tobacco

Even more compelling data

“If you’re younger than 25, the first product you probably use is flavoured and you’re more likely to continue to use tobacco products if you’re introduced to a flavoured product first,” said Dr Jamie Rutland, who reviewed the study. He’s an assistant clinical professor of pulmonology and critical care at the University of California, Riverside.

Adults also were more likely to keep using a tobacco product if they first tried a flavoured version, the study showed.

The new study “confirms what everybody already thought,” Rutland said, adding that flavours have contributed to the recent boom in vaping.

“This was a study done five years ago, when they collected the data,” noted Rutland, an American Lung Association national spokesman. “I think the data, if they collected it now, would be even more compelling.”

The new study was published in the journal JAMA Network Open.

Image credit: iStock

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Cells linked to leading cause of blindness in elderly

Age-related macular degeneration is one of the leading causes of blindness in the elderly, affecting more than 2 million people in the United States and leading to progressive loss of central vision. Genome wide studies have identified almost three dozen genes that play a role in the disease, but exactly where in the eye they inflict damage was not well known.

Researchers from Yale University, the Broad Institute of the Massachusetts Institute of Technology, and Harvard University report in the Oct. 25 issue of the journal Nature Communications that glial cells (or support cells), and vasculature cells tasked with providing blood to the retina as well as cone cells contribute to degeneration of the macula, in the central part of the retina.

“This study helps pinpoint cell types that can be investigated closely to develop new types of therapeutics,” said co-senior author Brian Hafler, assistant professor of ophthalmology and visual science and of pathology at Yale.

There are a limited number of effective long-term treatments available for the two forms of macular degeneration. The wet form is caused by growth of abnormal blood vessels underneath the macula, which can be mitigated by regular injections in the eye. Other than eye vitamin supplements, there is no treatment for the dry form of the disease, which is marked by accumulations of yellow deposits called drusen in the macula. While current treatments provide some benefits, over time there can be a continued, progressive loss of vision in both forms of the disease.

While genes associated with the risk of developing macular degeneration had been identified, the Yale/Harvard/MIT team used new single-cell sequencing to generate the first comprehensive human retinal atlas and employed data analysis technology to localize their effects to specific cell types associated with the disease.

While they found risk genes associated with cones, the cell type key to central vision, the researchers also found an association with glial and vascular cells — providing possible targets for novel therapies to improve and restore vision.

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Materials provided by Yale University. Original written by Bill Hathaway. Note: Content may be edited for style and length.

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Advance in search for new Clostridioides difficile vaccine

Scientists have made a breakthrough in the hunt for a new vaccine for killer hospital bug Clostridioides difficile (C. diff).

University of Exeter researchers first identified a gene in C. diff responsible for producing a protein that aids in binding the bacteria to the gut of its victims.

In collaboration with researchers at Paris-SUD University, they then showed that mice vaccinated with this protein generated specific antibodies to the protein — and that C. diff that did not produce this protein were less able to attach to the gut.

C. diff bacteria must bind to the gut to produce the toxin that causes illness, and the Exeter team are hopeful that vaccination against attachment will be effective in humans.

No C. diff vaccine is currently in widespread use. Some toxin-based vaccines are currently in clinical trials, but the Exeter research offers a promising new approach. C. diff infections, which commonly occur in people who have recently taken antibiotics, can cause severe illness and results in thousands of deaths each year, especially among the elderly and other vulnerable groups.

“Infection by C. diff often occurs when the natural gut bacteria are disrupted by antibiotics,” said Dr Stephen Michell, of the University of Exeter.

“With other bacteria missing, C. diff can attach to the gut and release a toxin that causes symptoms including diarrhea.

“We identified a gene — CD0873 — that generates a protein that helps C. diff bind to the gut.

“This binding is thought to be key for C. diff infections, so if we can prevent adhesion of bacteria then there’s a real possibility of preventing this disease.”

The researchers immunised mice with the CD0873 protein in isolation (not as part of a C. diff bacterium) and found a “strong” immune response.

When subsequently exposed to C. diff, these immunised mice were unaffected while non-immunised mice fell ill and lost about 10 percent of their body weight on average.

The research began as a collaboration between the University of Exeter, Novartis and the University of Nottingham, and this latest collaborative study involved the University of Bath and University Paris-Sud.

Both the universities of Bath and Exeter are part of the GW4 Alliance, a collaborative research alliance of research-intensive and innovative universities in the South West and Wales.

Scientists at University Paris-Sud conducted the experiments that showed that mice develop antibodies when immunised with the CD0873 protein.

The Bath researchers mapped the 3D molecular structure of CD0873 at high resolution using the high-brightness X-ray beam at the UK’s state-of-the-art facility, Diamond Light Source at Didcot in Oxfordshire providing more information on its function.

The new paper, published in the Journal of Biological Chemistry, is entitled: “Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile.”

A study published in 2015 said C diff caused almost half a million infections in the US in a year, directly leading to 15,000 deaths.

Whilst several C. diff toxin-targeted vaccines are currently in clinical trials, in 2017, pharmaceutical company Sanofi scrapped its efforts to find a toxin-based C. diff vaccine after many years, citing a low probability of success.

This alternative, adhesion-targeting vaccine identified by this important research may be a key new approach to disease control.

Dr Ray Sheridan, a consultant physician at the Royal Devon & Exeter Hospital, said: “A vaccine that stops the C. diff sticking to the gut wall and so stops it making the gut its new home would then stop the bug being able to cause diarrhoea or infection.

“This would need to go through clinical trials but if it worked it would potentially prevent C. diff infection altogether.

“Our current treatments rely on using more antibiotics, and we need to move away from that approach as antibiotics are one of the main causes of the C. diff problem in the first place by interfering with natural gut flora of bacteria.”

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Warming waters, local differences in oceanography affect Gulf of Maine lobster population

Two new studies published by University of Maine scientists are putting a long-standing survey of the American lobster’s earliest life stages to its most rigorous test yet as an early warning system for trends in New England’s iconic fishery. The studies point to the role of a warming ocean and local differences in oceanography in the rise and fall of lobster populations along the coast from southern New England to Atlantic Canada.

One of the papers, published in the scientific journal “Ecological Applications,” was led by Noah Oppenheim, who completed his research as a UMaine graduate student in 2016, with co-authors Richard Wahle, Damian Brady and Andrew Goode from UMaine’s School of Marine Sciences, and Andrew Pershing from the Gulf of Maine Research Institute. They report that the numbers of young-of-year lobsters populating shallow coastal nursery habitats each year, and temperature, provide a reasonably accurate prediction of trends in the lobster fishery some four to six years later.

Their model predicted regional differences in the recent record-breaking boom over the past decade, and now suggests the Gulf of Maine lobster fishery may be entering a period of decline; in effect a “cresting wave” of lobster abundance that may be heading northward in the region’s changing climate.

“Our model projects that the Gulf of Maine’s lobster landings will return to previous historical levels,” said Oppenheim, who is now executive director of the Pacific Coast Federation of Fishermen’s Associations and the Institute for Fisheries Resources in San Francisco. “These results don’t suggest a lobster crash, but this tool could give the fishing industry and policymakers additional lead time as they make decisions about their businesses and communities in the years ahead.

“We recommend that the stock assessment community and fishery managers use this information in concert with other indicators of the health of the fishery, as an independent early warning system,” Oppenheim said.

The second article, led by current UMaine marine science Ph.D. student Andrew Goode, underscores the importance of local differences in the oceanography of the Gulf of Maine for understanding where the lobster boom occurred.

“We suggest that this increase resulted from a complex interplay between lobster larval settlement behavior, climate change and local oceanographic conditions,” wrote Goode and his co-authors in their paper published in the journal “Global Change Biology.” The paper was co-authored by Brady, Wahle and Robert Steneck, all of the School of Marine Sciences.

Goode and his collaborators observed that an expanded area of thermally suitable habitat for larval settlement in the eastern Gulf of Maine may have helped drive and amplify the lobster boom in the region over the last decade — a boom that elevated the fishery to its current status as the most valuable single-species fishery in the nation. This cooler deepwater habitat may provide refuge for juvenile lobster from the negative impacts of ocean warming and buffer the Maine lobster fishery from similar declines as observed in southern New England.

While the paper points to a “brighter side of climate change” in this case, it does not deny the adverse effects of a warming ocean south of Cape Cod for other species.

At the center of these studies is the American Lobster Settlement Index (ALSI), a long-standing shallow water monitoring study serving as an important indicator of the strength of new lobster year classes repopulating coastal nursery habitats each year. The survey generating the annual index was founded in 1989 by Wahle, a UMaine research professor, director of the Lobster Institute, and co-author of both studies.

The ALSI collaborative includes government marine resource agencies, academic institutions and industry members in New England and Atlantic Canada who undertake and pay for the divers and boats to survey more than 100 sites spanning Rhode Island to Newfoundland. Wahle’s lab serves as the data hub for the survey.

“No one has a crystal ball, but in a field where sweeping statements are made about the global impacts of climate change, these studies underscore the importance of having a fine scale, local, understanding of both oceanography and organism biology as we project the impacts of a changing climate on the future of our coastal communities and economy,” Wahle said.

Story Source:

Materials provided by University of Maine. Note: Content may be edited for style and length.

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Health24.com | Don’t be fooled by foods that sound healthy but aren’t

You probably already realise that adding zucchini or carrots to a cake won’t magically make it low calorie or healthy. But you might not realise that there are many foods that sound healthy but really aren’t.

It might seem as though bran muffins are the perfect way to get needed fibre, but the 3g in an average bakery offering don’t justify all the white flour, sugar, fat and calories that go along with it. A better breakfast is to mix two tablespoons of wheat bran into hot, steel-cut oatmeal and top it with a handful of raisins.

Laden with salt

Sushi sounds like a great way to enjoy fish, but the ratio of fish to rice – usually white rice – makes the protein portion minuscule (and, ounce for ounce, extremely expensive). Opt for sashimi instead, which is simply slices of raw fish, or ask for brown rice in your rolls. Also, watch the soy sauce – it’s laden with salt – and limit mayonnaise-based spicy sauces that accompany many fancy rolls.

What could be bad about hazelnut and dark chocolate spreads? The problem is that sugar and palm oil are the first two ingredients in many popular store brands. If you love the flavour, dip whole roasted hazelnuts into melted dark chocolate as a treat, or whip up your own spread by blending freshly roasted hazelnuts in a food processor until a paste forms and then folding it into melted chocolate.

Beet and carrot chips sound yummy and should be low-calorie, right? Be aware that vegetable alternatives to potato chips still get more than half their calories from oil. One ounce has the same calories as a 6-ounce sweet potato, but few of the potato’s nutrients. If you want a veggie crunch, oven-bake very thin slices of your favourite vegetables.

Image credit: Luigi Pozzoli on Unsplash

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Patients to stand up at GP appointments in Loughborough University trials

The aim is to shorten consultations and see GPs act as healthier role models.

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Health24.com | WATCH: An unhealthy obsession with healthy eating

25 October 2019

WATCH: An unhealthy obsession with healthy eating

Do you find yourself constantly feeling guilty if you even look at a slice of pizza?

Stringr

Are you obsessed with defining and maintaining the perfect diet, rather than an ideal weight?

You may be suffering from orthorexia.

While it can be challenging to identify, it is defined as someone with obsessive behaviour in pursuit of a healthy diet.

People who suffer from the condition display signs and symptoms of anxiety disorders that frequently occur alongside other eating disorders.

Image credit: iStock

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Vaccine reminder system ‘inconsistent’, report concludes

A National Audit Office report investigated the reasons for falling pre-school vaccine uptake.

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Portuguese doctor suspended after baby born without a face

Dr Artur Carvalho is accused of negligence in the case of baby Rodrigo and others.

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Health24.com | “My fitness journey led me to complete body acceptance”

Yolandi Stegmann found herself at the lowest point of her existence at the end of last year. As a self-admitted emotional-eater, she decided that instead of turning to her usual crutch, she’d turn to exercise as a coping mechanism. “Whilst it started out as a desperate distraction, little did I know I had embarked on a [fitness] journey of self-discovery, healing, and growth,” she recalls.

Here’s how it went.

Yolandi Stegmann

  • Occupation: Lead payroll
  • Age: 35
  • City: Cape Town
  • Weight before: 86kg
  • Weight after: 73kg
  • Height: 1,76m
  • The time required to reach current weight: 10 months
  • The secret weapon to her weight loss: Every day is a new opportunity

The Gain

“My weight has always fluctuated,” Yolandi admits. When she did reach a goal weight, it was always a struggle to maintain it. “I ate a lot of junk food, mostly takeout, and I was an emotional eater.” Along with this, she would also enjoy several glasses of red wine — by several, we’re talking occasionally the whole bottle with a meal.

“I was very inactive during this period, your typical couch potato,” Yolandi continues. While she enjoyed hiking, she often felt self-conscious and uncomfortable. “I suffer from depression and anxiety,” she adds, noting that she often had to deal with feelings of not even wanting to get out of bed. “I finally reached a point where I’d stare at myself in the mirror wondering how I had gotten to this point.”

READ MORE: “Getting To Grips With My Emotional Eating Habit Helped Me Lose 28 Kgs — And Now I’m A Personal Trainer”

The Change

In December 2018, Yolandi went through a breakup that left her at the lowest point of her existence. “I turned to exercise as a way of processing this pain and rejection,” she explains. “I hated the way I looked. There was no self-love and I had zero self-confidence.” It was time for a change, she just wasn’t sure what or how yet.

“I wanted to incorporate regular exercise into my life,” Yolandi says. The gym environment didn’t appeal to her, but rather she opted for excising out in the fresh air. Enter ABC Bootcamp. “Joining a group would add accountability and having a personal trainer would provide direction and structure.”

When it came to food, Yolandi didn’t follow a specific diet or restrict her eating in any major way. “For me, it was imperative to implement permanent changes,” she explains. “I focused on improving my relationship with food and making healthier choices across the board.”

READ MORE: 5 Mindful Eating Tips That Will Change Your Relationship With Food

The Lifestyle

“During the first few months of ABC Bootcamp, my diet didn’t change that much,” Yolandi admits. “I cultivated healthier habits such as not skipping any meals, increasing my protein, drinking more water and choosing my carbs wisely.” And while she adds that she does still enjoy the occasional glass of red, she’s definitely cut back.

ABC Bootcamp consists of short-distance running, weight training, obstacle courses, core training, circuit training, and jump rope. “For the first few camps, I trained for a minimum of three times a week,” Yolandi adds. While it was a hard routine to stick to in the beginning, the girls at ABC would help to keep her motivated and committed.

The Rewards

“It took a while for me to see the kilos come off since I made gradual changes,” she continues. “But once I physically started to feel better, it became easier to stick to [this fitness journey].” After a few months, Yolandi started to notice the kilos coming off. “Once people started noticing a difference, for instance, the girls at camp, they started commenting, and this just motivated me to keep pushing,” she continues.

It was more than just a healthy eating and fitness journey for Yolandi. “It was also the emotional struggle that I had to overcome.” And the rewards were so worth it. “For the first time in years I am no longer self-conscious about my body,” she says. “I feel much healthier, more energetic and I am less easily fatigued.” She also completed the 40-day challenge at ABC Bootcamp which was a big achievement for her. Plus, it’s alleviated her depression and anxiety.

Yolandi’s Tips

  • Every day is a new beginning. If you weren’t happy with yesterday, try something different today. Get rid of that mindset that you’ll start tomorrow. Don’t set yourself up to fail — be realistic, and remember that something is always better than nothing.
  • Do NOT compare yourself to anyone else. Your journey is your journey so progress at your own pace. The only healthy and worthwhile comparison is you yesterday versus you today. Focus on your own goals and accomplishments and if you must compete, compete with yourself.
  • Surround yourself with people who are going to motivate and inspire you. You need support and encouragement so surround yourself with friends and family that will keep you motivated and accountable. Especially on those days where you just want to give up.

This article was originally published on www.womenshealthsa.co.za

Image credit: iStock

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