Bowel cancer rates rising ‘among young adults’

If the trend continues, age screening guidelines may need to be reconsidered, researchers say.

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Measles: Experts call for compulsory vaccination

Misleading campaigns claiming jabs are dangerous have left countries vulnerable, researchers say.

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NHS ‘should not prescribe acne drug’

Patients unable to have sex are calling for the NHS to stop prescribing acne drug Roaccutane.

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Children describe technology that gives them a sense of ambiguity as ‘creepy’

Many parents express concerns about privacy and online safety in technology designed for their children. But we know much less about what children themselves find concerning in emerging technologies.

Now University of Washington researchers have defined for the first time what children mean when they say technology is “creepy.” Kids in a new study described creepy technology as something that is unpredictable or poses an ambiguous threat that might cause physical harm or threaten an important relationship. The researchers also pinpointed five aspects of emerging technologies that could contribute to this feeling of ambiguity.

The team presented its results May 8 at the 2019 ACM CHI conference on Human Factors in Computing Systems in Glasgow, Scotland.

“Over the years of working with kids we realized they use the word ‘creepy’ a lot as a way to reject specific technologies,” said first author Jason Yip, an assistant professor in the UW’s Information School. “But kids have a difficult time articulating what makes something creepy. So we designed a series of activities to give them the chance to work out their own thoughts and help us understand.”

Previous research indicated that adults describe ambiguous threats as creepy, not scary, so the team conducted four separate design sessions to see if children felt similarly about creepy technology. These sessions had 11 children aged 7 to 11 prototype their own technologies or rank real or imagined technologies as “creepy,” “not creepy” or “don’t know.” Devices that could bring about physical harm or disrupt an important relationship were most consistently ranked as being creepy.

“When we were brainstorming about what kids were going to be worried about, we never considered that they might be concerned that somehow technology would get between them and their parents, and that this would be such a salient issue in their minds,” said co-author Alexis Hiniker, an assistant professor in the iSchool.

The team found five properties of technology that lead to those fears:

Deception versus transparency

Kids want to understand how technology works and what information a device is collecting. For example, when a child asked a digital voice assistant if it would kill him in his sleep and it said, “I can’t answer that,” the child was concerned.

“‘I’m afraid I don’t have an answer to that’ works well if I ask how many hairs are on the top of my head,” Yip said. “But with these types of questions, this response sounds deceptive.”

Ominous physical appearance

Kids are sensitive to how a technology looks, sounds and feels. But that doesn’t mean that only traditionally scary-looking technologies are creepy: The children were also wary of Maslo, an app with a large black dot as its interface, because it looked like a “black spirit” or a “black hole.”

Lack of control

Kids want to control technology’s access to their information and the flow of that information to their parents. For example, when kids were asked to design a technology that was trustworthy, some of the children designed an intelligent trash can that both scanned and deleted their facial recognition data each time they used it. Their trash can also had a button that allowed for manual deletion of data.

Unpredictability

Kids don’t like it when technology does things unexpectedly, like automatically knowing their name or laughing. To kids, laughing could communicate hidden, and possibly malicious, intent.

Mimicry

Kids also don’t like technology that pretends to be something else, especially when it’s trying to mimic people in their lives or themselves. Technology that mimics them could be trying to steal their identities or disrupting family relationships.

“All five themes are related to ambiguous threats. It’s a not specific monstrosity coming after them here like when something is scary; it’s more nuanced so that they’re not sure of the consequences of their actions,” Yip said. “The kids kept referencing the movie Coraline. In the story, the dolls ask Coraline to make a change: ‘If you sew buttons over your eyes and become just like us, we will love you forever.’ That prompts this feeling of, ‘Wait a second, sew buttons over my eyes? What am I compromising here?'”

The team found that trusted adults had some influence over whether or not the children thought that specific devices were creepy. For example, one child deemed smartphones “not creepy” because he saw his parents using them. Another kid thought that laptops were creepy because his parents taped a piece of paper over the camera to “keep the robbers away.”

The researchers acknowledge that their results could be used to make technology that tricks kids into a false sense of security. But the team thinks it is more important to have these results available to the public to help parents talk to their kids about technology and any types of fears that might arise.

“Children have access to so many different kinds of technologies compared to when we were growing up,” Hiniker said. “But their basic fears haven’t changed at all. Kids want to feel physically safe and anchored to trusted adults who are going to protect them.”

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Fearful customers sensitive to size and scope of a data breach while angry customers are not

Customers who feel afraid in the wake of a data breach care more about the size and scope of the breach than do angry customers, according to research from Binghamton University, State University of New York.

The findings also extend to the stock market, where a company’s stock price can be influenced by the size of the breach when the news coverage emphasizes fear, rather than anger.

“The emotions of fear and anger will elicit different reactions,” said Subimal Chatterjee, distinguished professor in marketing at Binghamton University’s School of Management. “In the wake of a data breach, we wanted to explore those different reactions and see if people acted to protect themselves or directed feelings toward those responsible.”

Chatterjee partnered with faculty across multiple disciplines within the School of Management. Working with Sumantra Sarkar, assistant professor of management information systems, Cihan Uzmanoglu, assistant professor of finance, and Xiang Gao, a Binghamton University PhD alumnus now at the Paseka School of Business at Minnesota State University, the group conducted three studies to get to their findings.

“So much business is now conducted online, and while that provides many conveniences, it opens up new threats. Data breaches are constantly in the news, and the scope of some of these breaches are huge,” Sarkar said. “When you hear that millions of people may be impacted, how do you react?”

Two of the studies surveyed how consumers reacted to the scope of a data breach. They found that only the customers who felt fear after a breach were sensitive to the size and scope of the breach, while scope didn’t matter to angry consumers.

“Fearful consumers were sensitive to knowing, for example, if the breach only affected 100 customers or 10 million customers, and we found that the larger the scope, the larger the reaction,” said Chatterjee. “Meanwhile, angry consumers didn’t care if it was 10 customers or 10 million customers. Their focus wasn’t on the scope. They were directing their focus and anger on the perpetrator.”

The findings suggest that among consumers who are fearful, the larger the breach the more likely they are to think that they are at risk. And the threat becomes more vivid to them as the scope of the breach increases.

“Consumers may often find themselves imaging the worst-case scenario when these large-scale data breaches happen. Is my information safe? Is my credit card information being used by the hackers? These images will help determine whether they’ll ever make a purchase from that company again,” said Chatterjee.

A third study examined 12,000 news stories about data breaches. Testing for keywords that suggested either a fearful or angry response in the coverage, the researchers then compared the findings to stock prices for affected companies at the time of the coverage.

They found that the stock market reacts similarly to how consumers react: Fear makes the stock market sensitive to the scope of a data breach, while anger makes the stock market insensitive to the scope of a data breach.

“The intuition is that changes in stock prices should reveal the underlying consumer reactions to news of data breaches,” said Uzmanoglu. “Using this approach, we show that data breaches that affect more customers are associated with more negative stock returns, and that this effect primarily comes from data breaches that trigger emotions of fear rather than anger.”

Easing fears in the wake of a data breach should be a priority, the researchers said.

“From day one, you need to let your customers know that you are on top of this and move to ease those fears they may have. You don’t want them picturing that worst-case scenario,” said Chatterjee.

Researchers say this could mean clarifying your company’s disaster recovery plans, training customers on the basics of data security, or offering free services such as credit monitoring or fraud protection services.

The researchers also recommend being extra careful about how you communicate the scope of the data breach, as fearful customers will be very sensitive to the size of breaches.

“If you have 500 million customers that were affected by a breach, but it only represents around 16 percent of your customer base, you may want to focus on that smaller number in your communications to minimize the threat to fearful customers,” Chatterjee said.

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Mining 25 years of data uncovers a new predictor of age of onset for Huntington disease

Investigators at the University of British Columbia (UBC)/Centre for Molecular Medicine & Therapeutics (CMMT) and BC Children’s Hospital have examined more than 25 years of data to reveal new insights into predicting the age of onset for Huntington disease.

“This discovery may enable us to provide families with additional information,” said lead author Galen Wright, a research associate in the UBC faculty of medicine, CMMT and BC Children’s. “It could also potentially improve disease management by providing genetic counsellors with valuable data in the future.”

Huntington disease is an inherited disorder that affects one in approximately 7,000 Canadians. For every affected person, there are four to five individuals that carry the gene mutation that causes the disease, but are not yet ill. The disease often begins around age 40. Symptoms include motor, cognitive and psychiatric changes.

Huntington disease is caused by a single mutation in the huntingtin gene, where patients carry an expanded stretch of repetitive DNA. While the length of this mutation has long been regarded as the greatest indicator of when (and whether) an individual will exhibit symptoms of the disease, researchers at UBC have uncovered a genetic variant that also significantly influences age of onset in patients.

“Our study reveals that age of onset in Huntington disease is influenced not only by the length of the expansion mutation, but also by the DNA sequence directly adjacent to this repetitive sequence,” said senior author Dr. Michael Hayden, a Killam professor of medical genetics and director emeritus for the CMMT, which is part of the faculty of medicine at UBC and located at BC Children’s.

This is the key finding in a new study published today in the American Journal of Human Genetics. While previous studies of the huntingtin gene have focused on the length of the string of glutamine building blocks in the DNA of the gene, this study examined variants in the DNA sequence encoding for these glutamine building blocks and the relationship between these variants and the age of onset of the disease.

The DNA sequence that causes Huntington disease is primarily made up of repeats of three letters of DNA, CAG, which encode the protein building block, glutamine. But UBC researchers have shown that the presence of another glutamine building block, CAA, significantly impacts the disease. In individuals where the CAA sequence is replaced with a CAG sequence, patients were found to present with the disorder decades earlier than expected, despite carrying an identical number of glutamine amino acids.

“Now we know that the age of onset in Huntington disease is significantly impacted by the length of uninterrupted CAG sequence,” said Hayden.

The length of uninterrupted CAG sequence also appears to contribute to somatic instability.

The researchers screened samples from patients in the UBC Huntington disease biobank for the variant in the huntingtin gene, to examine age of onset and whether the mutation was more likely to expand to longer repeat lengths in the blood. Hayden established this bank — which now contains approximately 8,000 specimens — in 1986 in an effort to conduct such studies.

Hayden’s team hopes to screen additional DNA samples to further refine age of onset prediction models for people from families with Huntington disease with this variant, and to look at how these variants express themselves in brain tissue.

Story Source:

Materials provided by University of British Columbia. Note: Content may be edited for style and length.

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Health24.com | Scientists are developing a hearing aid that will separate the voices you want to hear from those you don’t

Chances are if you’re over 60 it’s already happened to you: You’re in a crowded room and finding it tough to understand what your partner is saying a couple of feet away.

It’s a longstanding hearing-loss issue known as the “cocktail party” problem. Conventional hearing aids still aren’t able to fix it – to separate out the talk you do want to hear from the background chatter you don’t.

But scientists may be developing a device that can do just that.

The device would rely on an emerging technology called “auditory attention decoding” (AAD). AAD cracks the cocktail party problem by simultaneously monitoring a person’s brainwaves and the sound around them.

With that data in place, the new hearing device would triangulate which voice or sound the person is focused on – and then give it an extra sonic boost.

“The cocktail party problem refers to a hearing condition where there is more than one speaker talking at the same time,” explained Nima Mesgarani, who led a group that published their new findings May 15 in Science Advances.

“Because hearing-impaired listeners have reduced sensitivity to different frequencies, they are not able to pick out the right voice,” explained Mesgarani. He’s associate professor of electrical engineering with the Zuckerman Mind Brain Behavior Institute, part of Columbia University in New York City.

Conventional hearing aids – which simply raise overall sound levels – don’t help much in a crowded room.

“Increasing the volume doesn’t help hearing-impaired listeners, because it amplifies everyone, and not just the ‘target speaker,'” Mesgarani said.

AAD works differently.

Versatility

“[It] works by first automatically separating the sound sources in the acoustic environment,” he said. “The separated sounds are then compared to the brain waves of a listener. And the source that is most similar is chosen and amplified relative to other speakers to assist the listener.”

But this research is still in its early stages, so crowd-addled seniors shouldn’t expect to order the technology anytime soon.

For the moment, the technology requires an invasive surgical procedure and isn’t portable. Any practical application is at least five-to-10 years off, Mesgarani said.

Still, the research illustrates yet again the amazing versatility of the human brain. As Mesgarani noted, neural networks in the brain’s hearing center are remarkably adept at pinpointing which voice a person wants to pay attention to, even with lots of competing noise.

Digging deeper into that phenomenon, the Columbia team enlisted a group of people with epilepsy (who were already undergoing surgical care) to listen to a massed group of several speakers. None of the patients had hearing difficulties.

By means of electrodes directly implanted into their brains, researchers were then able to monitor how brain waves responded to the various sounds. That data was fed into a computer, which quickly learned to automatically raise the volume of the “target” speaker’s voice.

Preliminary results suggest that the technology does work as intended. But to date, testing has been confined to a controlled indoor setting, and it remains to be seen whether it would work as well among those with actual hearing impairment, the researchers said.

And, of course, it will take time to convert the technology into something that could be worn as an external hearing aid.

Promising

Tricia Ashby-Scabis is director of audiology practices with the American Speech-Language-Hearing Association, in Rockville, Maryland. She reviewed the new study and said the work “sounds highly promising”.

“Artificial intelligence certainly sounds like a great option in terms of focused listening and setting precedence on which speaker the listener wants to hear,” Ashby-Scabis said.

But questions remain.

“The difficulty is, communication is dynamic,” said Ashby-Scabis. “It is ever-changing. People jump in and out of conversations, and that is a lot of processing for a device to do, and a lot of knowledge it needs to have.

“I am surprised if this is something we are close to having researchers solving [or] developing, but it is certainly a promising area to be studying.”

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Health24.com | Injured lungs can be regenerated for transplant

People who suffer from COPD may need a single or a double lung transplant if their lung health cannot be improved through other treatments.

A transplant is the only lifesaving treatment for people with end-stage lung disease, but donor organs are in short supply.

Potentially reversible injuries

Lungs for transplantation are normally obtained from a deceased donor and need to be in a suitable condition for the operation to be successful.  

However, severely damaged lungs can now be regenerated to be suitable for transplantation, researchers say.

Up to 80% of donor lungs are rejected due to serious but potentially reversible injuries. Researchers hope to increase the supply of lungs available for transplant by recovering lungs that are now unsuitable for clinical use.

“For seven years, we have diligently worked to develop new technologies for the maintenance and recovery of donor organs,” said study co-leader Gordana Vunjak-Novakovic. She’s a professor of biomedical engineering and medical sciences at Columbia University in New York City.

“This paper represents a culmination of … studies of lung bioengineering that have converged into a system capable to recover severely damaged lungs,” Vunjak-Novakovic said in a university news release.

New, non-invasive evaluation

Current methods of donor lung support are limited to six to eight hours – too little time to regenerate an injured lung and improve its function.

In the new study, researchers created a cross-circulation platform that maintained viability and function of the donor lung and the recipient’s stability for 36 to 56 hours.

The team also developed new, non-invasive ways to evaluate the regenerating lung, according to the study published online in the journal Nature Communications.

Researchers tested their platform – along with conventional therapies and new diagnostics – on lungs affected by gastric aspiration, the most common injury leading to rejection of donor lungs.

It occurs when stomach material gets into the respiratory tract, causing severe damage that makes the lung unacceptable for transplant.

Cross-circulation platform

This new study suggests that lungs injured by gastric aspiration can be maintained outside the body for several days, undergo repeated treatment, and show evidence of cellular regeneration and improved function.

Lungs regenerated on this platform met all criteria for transplantation, according to the researchers.

“We now have the team and technology to bring this research to the patients, by making more donor lungs available for transplant,” Vunjak-Novakovic said.

The next step is to assess functioning of regenerated lungs after transplantation, as well as safety, in a study with large animals.

Researchers said this cross-circulation platform may be used to investigate regeneration of other damaged organs, such as hearts, kidneys and livers, in order to increase the number available for transplant.

Image credit: iStock

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Ultra-processed foods ‘make you eat more’

The first trial of ultra-processed foods suggests they lead people to eat more and put on weight.

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Health24.com | The virus that gave you chicken pox as a child could sneak up on you in old age, and potentially blind you

The virus that gave you chickenpox as a kid can rise again after decades of inactivity and inflict a painful, even blinding, eye infection in old age.

New research reveals that cases of eye-based “shingles” have tripled since 2004.

Exactly what is driving the increase remains unclear. What is clear, however, is that either of two vaccines could prevent many cases of shingles.

The problem? Relatively few Americans have been vaccinated.

“Shingles is a recurrence of pre-existing varicella zoster virus (VZV) infection, which patients likely first got when they had chickenpox earlier in life,” said study lead author Dr Nakul Shekhawat, an ophthalmologist with Kellogg Eye Center at the University of Michigan in Ann Arbor.

“VZV never completely goes away… but lies ‘dormant’ in some of the deeper nerves of the body, and can reactivate years or even decades later within the territory of those same nerves to cause shingles,” he explained.

In fact, roughly 20% of shingles cases strike nerves around the eye. Because the eye has “numerous highly sensitive nerves,” it’s particularly painful, Shekhawat said, and a rash, swelling, inflammation and pink eye can go along with it. In some cases, corneal scarring and blistering can result in permanent vision loss.

Peril of old age

For their study, he and his colleagues analysed health records for 21 million patients. They found that from 2004 to 2016, the rate of eye shingles infections rose from under 10 cases for every 100 000 people to more than 30 per 100 000.

Patients in the study were enrolled in the same healthcare plan, allowing investigators to compare treatment records over the 12-year period.

Although shingles infection rates did triple, the researchers found that those over age 75 were at highest risk. Among that population, there were 53 cases per 100 000, according to the study. Whites and women also had a higher risk.

Though shingles can strike younger adults, it is considered a peril of old age, Shekhawat said. Nationwide, it strikes about 4 in every 1 000 Americans – but 10 in 1 000 of those over 60.

While Shekhawat said America’s aging population is probably a factor, it’s clear that “there’s something else going on”. What that might be is still unknown.

But getting more people vaccinated would likely make a big difference, he noted, adding: “From a public health and prevention standpoint, we can do much better.”

A two-dose vaccine called Shingrix, approved in 2017, can prevent 97% of shingles cases, and an older vaccine (Zostavax) can cut risk by half.

Get vaccinated

What’s more, even people who have had shingles can gain future protection by getting vaccinated, according to the US Centers for Disease Control and Protection (CDC). It recommends Shingrix for anyone over 50.

Although vaccination patterns for Shingrix have yet to be analyzed, Shekhawat said only 10% to 30% of eligible patients have gotten the Zostavax vaccine.

Dr Thomas Steinemann is a clinical spokesperson for the American Academy of Ophthalmology.

He pointed out that the vaccine can’t cure shingles or relieve symptoms once they develop, so people should plan to get the shot as a preventive measure, before problems begin.

Treatment can range from eye drops and compresses in manageable cases to surgery in more advanced cases, he said.

The researchers presented their findings last week at a meeting for the Association for Research in Vision and Ophthalmology in Vancouver. Research presented at meetings is typically considered preliminary until published in a peer-reviewed journal.

Image credit: iStock

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