Health24.com | Govt to introduce warning labels on junk food

Packaged food that is high in salt, sugar and fat may soon have to carry warning labels, according to a top health official.

“We hope to introduce regulations about front-of-pack warning labels by late this year or early next year,” said Lynn Moeng, Chief Director of Nutrition in the Department of Health.

“This will assist people to know what is in packaged food because most people don’t know what they are eating,” said Moeng.“The problem will then be how to deal with the food that isn’t packaged. People are excited to buy those combos – the chicken, chips and a fizzy drink – without knowing what is in them.”

She was speaking at the launch of the #Whatsinmyfood campaign on Thursday, organised by the Healthy Living Alliance (HEALA), which aims to educate ordinary people about the unhealthy ingredients lurking in processed food.

Poor diet is driving obesity in South Africa, which is the fattest nation in sub-Saharan Africa with soaring rates of diabetes, 240 people have strokes every day and a high rate of  heart attacks – mostly linked to poor diet and being overweight.

HEALA Executive Director Sibongile Nkosi welcomed Moeng’s announcement, saying that the current ingredient labels on processed food were confusing.“The food industry uses many different words for sugar and salt to conceal what is in their products, so clear warning labels will make it easy for people to identify unhealthy food,” said Nkosi. 

“We have launched our campaign because people have the right to know what is in the food they eat. 

Identify unhealthy food

Think of the mother in a squatter camp preparing a lunchbox for her child. She just goes to the nearest shop and buys polony. She doesn’t have time to read what’s in it. We want to help her to identify unhealthy food, but also get shops to stock the healthy food grown by local small scale farmers.

”HEALA’s campaign comprises of advertisements to be flighted on TV and radio warning people about high levels of salt, sugar and fat in cereal, fruit drinks, polony and white bread. Also speaking at the launch, Professor Sue Goldstein from Wits University’s School of Public Health warned of the “corporate determinants of health”.

“The tobacco, alcohol and food industries all use similar tactics to keep information about their products from people,” said Goldstein. In 2016, Chile ruled that food high in added sugar, saturated fat, kilojoules and added salt had to display a black stop sign on the front of their packages. 

Any food with these warning signs also cannot be sold in schools or advertised to children under the age of 14.  

A study published two weeks ago to evaluate how mothers of young children had responded to the new policy found that it was changing what mothers were buying.

“Many mothers described that their children requested healthier food and used the stop signs as shortcuts to distinguish healthy from unhealthy food choices. As a result, many mothers said that they have changed the foods they purchase for their children,” said the study’s lead author, Dr Teresa Correa, from Diego Portales University in Santiago. 

Moeng said government was using both regulation and engagement with the food industry to address obesity.

– Health-e.

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Three years into soda tax, sugary drink consumption down more than 50 percent in Berkeley

Consumption of sugary drinks in Berkeley’s diverse and low-income neighborhoods dropped precipitously in 2015, just months after the city levied the nation’s first soda tax on sugar-sweetened beverages.

Three years later, residents in these neighborhoods reported drinking 52 percent fewer servings of sugary drinks than they did before the tax was passed in November 2014, shows a new report from the University of California, Berkeley. This drop more than doubles the 21 percent decline found in 2015. Water consumption also saw a bump, going up 29 percent over the three-year period.

The study, which is the first to document the long-term impacts of a soda tax on drinking habits in the United States, provides strong evidence that soda taxes are an effective tool for encouraging healthier drinking habits, with the potential to reduce sugar-linked diseases like diabetes, heart disease and tooth decay.

“This just drives home the message that soda taxes work,” said Kristine Madsen, faculty director of the Berkeley Food Institute in UC Berkeley’s School of Public Health. “Importantly, our evidence comes from low-income and diverse neighborhoods, which have the highest burden of diabetes and cardiovascular disease, not to mention a higher prevalence of advertising promoting unhealthy diets.”

The study, which appears Feb. 21 in the American Journal of Public Health, comes at a critical time for jurisdictions considering soda taxes. While a number of cities, including Philadelphia and Seattle, now have soda taxes on the books, both California and Washington state passed bills in 2018 that ban municipalities from putting future soda taxes in place.

The bulk of Berkeley’s soda tax revenue is dedicated to supporting nutrition education and gardening programs in schools and to local organizations working to encourage healthier behaviors in the community.

“Sugar-sweetened beverages, which are linked to obesity, diabetes and cardiovascular disease, cost our nation billions of dollars each year, but they are super-cheap. They’d cost much more if the health care costs were actually included in the price of the soda,” Madsen said. “Taxes are one way of taking those costs into account.”

Madsen is leading a team that has been tracking the drinking habits of residents of low-income and diverse neighborhoods in Berkeley since 2014, when 76 percent of voters came out in favor of levying a penny-per-ounce tax on all sugar-sweetened beverages.

While the excise tax is levied on distributors, rather than directly on consumers, subsequent studies have shown that retailers incorporated the higher costs into the shelf price of the drinks.

To find out about residents’ drinking habits, the team polls around 2,500 people each year in high foot traffic intersections in racially and demographically diverse neighborhoods across Berkeley, Oakland and San Francisco.

The so-called street intercept surveys revealed a steep drop in sugar-sweetened beverage consumption in Berkeley between 2014 and 2017. The decrease was seen overall for sugary drinks, and specifically for soft drinks like Coke and Pepsi, sports drinks like Gatorade and Powerade, and sweetened teas and coffees.

Residents of neighboring Oakland and San Francisco drank about the same number of sugary beverages in 2017 as they did in 2014, suggesting that these changes were unique to Berkeley and not signs of a regional trend in drinking habits unrelated to the tax.

Oakland and San Francisco have since enacted their own soda taxes, which went into effect in mid-2017 and 2018, respectively.

The study does have its limitations, Madsen cautions. Street intercept surveys do not provide a random sample of residents, and Berkeley is a relatively small and highly-educated city.

And price hikes may not be the only driving factor behind the change, Madsen says. Taxes also send a message about societal values, which can have a big impact on consumer behavior.

“There are some earlier studies out of Berkeley that suggest that the messaging alone is effective at reducing consumption,” Madsen said. “But people are still very much affected by what hits their pocketbooks.”

However, the similarity between these results and other long-term results in Mexico, which also saw increased effects of its soda tax over time, suggest that these measures can be a powerful tool in the fight against diabetes, cardiovascular disease and obesity.

“I really want to push back against this idea that taxes are the sign of a nanny state,” Madsen said. “They are one of many ways to make really clear what we value as a country. We want to end this epidemic of diabetes and obesity, and taxes are a form of counter-messaging, to balance corporate advertising. We need consistent messaging and interventions that make healthier foods desirable, accessible and affordable.”

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Chemical added to consumer products impairs response to antibiotic treatment

Grocery store aisles are stocked with products that promise to kill bacteria. People snap up those items to protect themselves from the germs that make them sick. However, new research from Washington University in St. Louis finds that a chemical that is supposed to kill bacteria is actually making them stronger and more capable of surviving antibiotic treatment.

The study, available online Feb. 19 in the journal Antimicrobial Agents & Chemotherapy, suggests that triclosan exposure may inadvertently drive bacteria into a state in which they are able to tolerate normally lethal concentrations of antibiotics — including those antibiotics that are commonly used to treat urinary tract infections (UTIs).

Triclosan is the active ingredient responsible for the “antibacterial” property marketed on many consumer products. It is added to toothpaste, mouthwash, cosmetics and even to clothing, baby toys and credit cards with the intention of reducing or preventing bacterial growth.

“In order to effectively kill bacterial cells, triclosan is added to products at high concentrations,” said Petra Levin, professor of biology in Arts & Sciences.

In 2017, the U.S. Food and Drug Administration cited both safety concerns and lack of efficacy when it recommended against adding triclosan to consumer soaps, but these guidelines have not discouraged companies from adding it to other products. What’s more, Levin said, “Triclosan is very stable. It lingers in the body and in the environment for a long time.”

The new study in mice uncovers the extent to which triclosan exposure limits the body’s ability to respond to antibiotic treatment for urinary tract infection. It also sheds new light on the cellular mechanism that allows triclosan to interfere with antibiotic treatment.

Escaping death

Some antibiotics kill bacterial cells, while others keep them from growing.

Levin and her colleagues were particularly interested in bactericidal antibiotics — those that can kill bacterial cells and are typically prescribed by doctors to treat bacterial infections. They wanted to know whether triclosan could protect bacteria from death in the presence of killing antibiotics.

Corey Westfall, postdoctoral scholar in the Levin lab, treated bacterial cells with bactericidal antibiotics and tracked their ability to survive over time. In one group, the bacteria were exposed to triclosan prior to being given the bactericidal antibiotic. In the other group, they were not.

“Triclosan increased the number of surviving bacterial cells substantially,” Levin said. “Normally, one in a million cells survive antibiotics, and a functioning immune system can control them. But triclosan was shifting the number of cells. Instead of only one in a million bacteria surviving, one in 10 organisms survived after 20 hours. Now, the immune system is overwhelmed.”

Triclosan exposure allowed the bacteria to escape death by antibiotics. And the protective property was not limited to any single family of antibiotics. In fact, multiple antibiotics that are considered unique in how they kill cells were less effective at killing bacteria exposed to triclosan.

“Triclosan increased tolerance to a wide breadth of antibiotics,” Westfall said. “Ciprofloxacin (also known as Cipro) was the most interesting one to us because it is a fluoroquinolone that interferes with DNA replication and is the most common antibiotic used to treat UTIs.”

Antibiotics can’t do their job with triclosan around

UTIs occur when bacteria, primarily Escherichia coli (E. coli), enter and infect the urinary tract. Antibiotics such as Cipro are commonly used to kill the bacteria and treat the infection.

UTIs are common; so is exposure to triclosan. A shocking percentage — about 75 percent — of adults in the United States have detectable levels of triclosan in their urine. About 10 percent of adults have levels high enough to prevent E. coli from growing. Could triclosan’s presence in the body interfere with treating UTIs?

Westfall and Levin worked with collaborators at Washington University School of Medicine in St. Louis to answer this question.

Ana Flores-Mireles, an assistant professor at the University of Notre Dame, worked on this study as a postdoctoral scholar in the lab of Scott Hultgren, the Helen L. Stoever Professor of Molecular Microbiology at the School of Medicine. With the help of Jeffrey Henderson, associate professor of medicine and molecular biology, she figured out that mice which drink triclosan-spiked water have urine triclosan levels similar to those reported in humans.

“This result meant we could actually test the impact that human urine levels of triclosan have during antibiotic treatment of UTIs in mice,” Levin said.

All of the mice with the infection received Cipro to treat the UTI. Only some of the mice drank triclosan-spiked water. After antibiotic treatment, mice with triclosan exposure had a large number of bacteria in their urine and stuck to the bladder; mice without exposure had significantly lower bacterial counts.

“The magnitude of the difference in bacterial load between the mice that drank triclosan-spiked water and those that didn’t is striking,” Levin said.

“If the difference in the number of bacteria between the groups was less than tenfold, it would be difficult to make a strong case that the triclosan was the culprit,” Levin added. “We found 100 times more bacteria in the urine of triclosan-treated mice — that is a lot.”

This striking result has an equally striking message — antibiotics are less effective at treating UTIs when triclosan is around, at least in mice.

Triclosan’s dirty weapon: ppGpp

Triclosan is interfering with antibiotic treatment, but how?

Levin and her colleagues found that triclosan works with a cell growth inhibitor, a small molecule nicknamed ppGpp, to render cells less sensitive to antibiotics.

During times of stress, ppGpp responds by shutting down the biosynthetic pathways that make the building blocks — DNA, RNA, protein and fat — that ultimately become new cells. This response helps divert resources away from growth and towards survival.

“There is a rule in medicine that you don’t give drugs that slow cell growth before drugs that kill cells,” Levin said.

Bactericidal antibiotics kill by targeting specific biosynthetic pathways. Ampicillin targets the enzymes that make the bacterial cell wall, for example, while Cipro targets DNA synthesis. When these pathways are shut down, bactericidal antibiotics have trouble doing their job.

If triclosan triggers ppGpp, biosynthesis is curtailed and bactericidal antibiotics would become ineffective at killing cells. Biosynthesis continues in bacteria lacking ppGpp, however, and these cells would be expected to die.

Levin and colleagues tested their hypothesis by engineering E. coli mutants unable to make ppGpp and compared them to E. coli able to make ppGpp. The absence of ppGpp in the mutant E. coli removed triclosan’s ability to protect the cells from bactericidal antibiotics.

While clinical studies would be required to definitely prove that triclosan is interfering with antibiotic treatments in humans, Levin said, “My hope is that this study will serve as a warning that will help us rethink the importance of antimicrobials in consumer products.”

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With nanopore sensing, physics researchers detect subtle changes in single particles

Researchers in Virginia Commonwealth University’s Department of Physics have discovered that a technique known as nanopore sensing can be used to detect subtle changes in clusters, or extremely small chunks of matter that are bigger than a molecule but smaller than a solid.

“Nanopores act as extremely small volume sensors that are on the order of a few nanometers a side,” said Joseph Reiner, Ph.D., an associate professor of experimental biophysics and nanoscience in the College of Humanities and Sciences. “This size scale allows us to observe when the cluster changes size by a single ligand molecule. The ability to detect these changes in real time — as they happen — to a single cluster particle is the new and exciting thing here.”

The discovery is described in a paper, “Ligand-induced Structural Changes of Thiolate-capped Gold Nanoclusters Observed with Resistive-pulse Nanopore Sensing,” by Reiner and physics professor Massimo F. Bertino, Ph.D., along with VCU students Bobby Cox, Peter Wilkerson and Patrick Woodworth, published in the Journal of the American Chemical Society.

“This is new because there really aren’t many ways to detect these changes on a single particle in real time,” Reiner said. “This opens the door to observe all kinds of interesting phenomenon on nanosurfaces, which is an area of great interest to many chemists in both applied and pure research areas.”

The research sheds new light on the activity of clusters, which are extremely reactive objects and are considered to be interesting for catalysis, or the acceleration of a chemical reaction by a catalyst.

“Understanding how molecules behave on a nanocluster helps [our] understanding of their catalytic properties,” Bertino said. “To date, people thought that molecules were kind of stationary on cluster surfaces. Our experiments show that molecules, instead, change their configuration and position at a very fast pace. This opens new perspectives for the chemistry of these things.”

The team’s findings could lead to exciting new discoveries, Bertino said.

“There are several possible alleys that open now. One is to look at cluster growth. Nobody has a good grasp on how these things come into existence. Another one is to help tune their properties,” he said. “To date, people grow these things and make them reactive, but it’s not always clear how this happens. Essentially, darts are thrown at the problem and one hopes that one of them sticks. This work allows us to look at a single cluster of a well-defined size and lets us mess with it by varying one parameter at a time.”

By getting a better look at these clusters and how they behave, the researchers hope to gain a better understanding of how catalysts could be improved for more efficient drug discovery and synthesis.

Story Source:

Materials provided by Virginia Commonwealth University. Note: Content may be edited for style and length.

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Sepsis campaigner takes son’s ashes to Buckingham Palace

Melissa Mead takes the ashes of her son William in a teddy bear to Buckingham Palace to collect an MBE.

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Health24.com | CT surgeon performs emergency procedure with pocket knife to save injured biker

After being involved in a road accident in Port Elizabeth, a biker in his 40s had a Cape Town surgeon to thank for his survival.

The biker had sustained life-threatening injuries, and Cape Town surgeon, Dr Wimpie Odendaal, on holiday in the city along with his wife, jumped in to attend to his injuries.

In a statement, Netcare said that Dr Odendaal, who was first to arrive on the scene, recognised that the motorcyclist had sustained serious chest injuries and was able to perform a life-saving emergency procedure with only rudimentary tools while waiting for emergency medical services to arrive. 

Seconds after the accident

“My wife, general practitioner Dr Christa de Wit, and I were on holiday in Port Elizabeth and were driving with my sister-in-law Louise, who is a nursing sister, on a quiet, leafy back road when we happened upon the scene of a road accident,” Dr Odendaal, who practises at Netcare Blaauwberg Hospital, recalls. 

“Clearly, the accident had happened just seconds before we arrived. My wife immediately asked Louise to call emergency medical services. 

“An injured man was sitting upright in the middle of the road, and a woman, clearly very distressed, was standing next to her damaged car. While he was visibly in pain, it was not initially obvious that he had sustained severe injuries. 

“Within seconds, however, the man’s condition deteriorated. He became very short of breath, lost consciousness and no pulse could be discerned.”

Saving a life… with a pocket knife

Dr Odendaal and his wife immediately began performing cardiopulmonary resuscitation (CPR) on the man. 

“The veins in the patient’s neck were distended and his trachea had shifted. It became evident that he had developed a tension pneumothorax, which is a life-threatening condition where air becomes trapped between the membranes surrounding the lungs. 

“Not only does tension pneumothorax compress the lung, making breathing difficult, if not impossible, it also decreases the flow of blood to the heart and can very quickly lead to cardiopulmonary arrest. I knew that something would need to be done immediately to relieve the tension pneumothorax, or the man would have little chance of survival. 

“By this time, a few bystanders had gathered at the scene and, as I had no medical equipment in my car save for a plastic mouthpiece for mouth to mouth resuscitation, I shouted to ask if anybody had a sharp object I could use.

“I was offered a pocket knife, and had no other choice than to use this to open the fifth intercostal space anterior to the midaxillary line, which is a specific area between the ribs on the side, to relieve the pressure. If it weren’t for this emergency intervention, the man would most likely have died within minutes.”

Small, vital improvements

After Dr Odendaal’s intervention the patient’s condition briefly improved, and a basting needle was fetched from a nearby house, which he used to keep the hole in the patient’s side open.

An ambulance soon arrived at the scene and the emergency personnel assisted with resuscitating the man. 

“We used an endotracheal tube and bowl of water to devise a makeshift underwater drain to restore negative pressure to the pleural cavity and prevent the space from refilling with air. A large bore drip needle was used to relieve a second tension pneumothorax,” Dr Odendaal explains. 

“The patient was intubated and adrenaline was administered intravenously, and soon he was stable enough that we could transport him to the emergency department at a nearby hospital.”

According to Dr Odendaal, the man spent several weeks in hospital recuperating from his injuries, which included 14 rib fractures, cardiac and pulmonary contusions, a broken pelvis and a broken foot – and has since been discharged, and is continuing his recovery at home.

Image credit: iStock

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Health24.com | Animal study suggests Ritalin won’t harm the heart

Ritalin, a widely used stimulant drug to treat attention-deficit/hyperactivity disorder (ADHD), likely poses no risk of heart damage in children, new research in monkeys suggests.

The findings are “very reassuring,” said the study’s principal investigator, Dr Steven Lipshultz.

Sudden cardiac death

Each year, more than 1.8 million children in the US take drugs to treat ADHD. Concerns have been raised that Ritalin, Concerta and other forms of methylphenidate could harm children’s hearts.

Some studies have reported an increase in sudden cardiac death among children taking methylphenidate or other stimulant drugs for ADHD.

But this new study found that five years of high doses of methylphenidate did not damage the hearts of 30 rhesus monkeys. That length of time is similar to how long children and adults would use the drugs.

“Even high-dose chronic [methylphenidate] stimulant therapy did not result in any evidence of abnormal structures or function in the hearts of the monkeys,” said Lipshultz, chair of paediatrics at the University at Buffalo School of Medicine and Biomedical Sciences, in New York.

However, his team cautioned that the results of animal research are not automatically applicable to humans.

One ADHD specialist unconnected to the study agreed.

Man vs. Monkey

“The [animal] study cannot be automatically applicable to humans,” said Dr Victor Fornari, who directs child and adolescent psychiatry at Zucker Hillside Hospital in Glen Oaks, New York.

Still, the findings “provide compelling evidence of the cardiac safety of this important evidence-based treatment for ADHD,” Fornari said.

About 10% of US children have been diagnosed with ADHD and related disorders. Up to 70% of them take prescription stimulant drugs, so possible heart risks associated with the drugs are a major concern, study author Lipshultz said in a university news release.

The US Food and Drug Administration has ordered some prescription stimulants to carry black box warnings stating that children with underlying heart disease should use these medications with caution.

In Canada, a stimulant drug was removed from the market after it was linked to a small number of sudden cardiac deaths. Sales of the drug later resumed.

“This controversy has persisted without answer,” Lipshultz said. “Yet the number of prescriptions for these medications for children with ADHD continues to expand.”

Another expert said the new findings should help ease concerns.

Each case is unique

The study results “are overall re-assuring in terms of cardiac safety and long-term use of stimulants for ADHD in otherwise healthy individuals,” said Dr. Andrew Adesman, chief of developmental and behavioral paediatrics at Cohen Children’s Medical Center in New Hyde Park, New York.

However, he added that the study “does not address clinical concerns about the safety of stimulants in individuals with certain types of heart disease.”

Therefore, “health care providers need to continue to screen children for cardiac problems prior to prescribing stimulant medications like Ritalin, Concerta or Adderall, since there are some individuals who may still be at increased risk for potentially serious heart problems if treated with stimulant medication,” Adesman said.

Lipshultz noted that the findings are good news for another type of pediatric patient: young cancer survivors.

“I have cared for children and adolescents who have survived childhood cancer, who now are experiencing severe learning disabilities as a result of their cancer therapies. They become my patients because their hearts have been damaged, an unfortunate effect of the successful treatment of their childhood cancer,” he said.

“Current recommendations state that children such as these, with underlying heart disease, should avoid chronic stimulant therapy because of the concern that it could further damage their hearts,” he explained. “However, these prescription stimulants often allow these children to do much better with their learning progress.”

The new findings suggest that, in many cases, these medications can be prescribed to these children as well, Lipshultz said.

The study was funded by the US National Institutes of Health. It was recently published in the journal Pediatric Research.

Image credit: iStock

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Health24.com | You never get used to it, diabetic double amputee tells of life without legs

Joel Mnisi (52) was born without any disabilities, but after suffering from sugar diabetes he has had to have both legs amputated and is now wheelchair bound.

Three years after being diagnosed with diabetes, and a year after his second foot was surgically removed, Mnisi is struggling to adjust to life as a double amputee.

Wounds heal slowly

Mnisi has type 1 diabetes, a genetic condition that runs in the family. He lives in a house without wheelchair ramps in Bridgeway Village outside Tzaneen.

He lost his left leg in 2017 after being diagnosed with sugar diabetes a previous year. His right leg was amputated in March 2018 after it starting to swell and got painful, exactly like his left foot.

“It felt like my foot was burnt. There was a blister on my left toe, and because I slept around a fire at a funeral the previous night, I thought I burned myself. I went to the clinic and they gave me medication to treat the wound, but it didn’t heal. So I went to the hospital and that’s when they confirmed the wound was because of diabetes,” he said.

Diabetes is known to cause wounds to heal slowly. According to the Journal of Clinical Investigation, diabetic foot ulcers are a leading cause of amputations and affect 15% of people with diabetes.

Mnisi stays alone in a one bedroom house which he describes as a mountain to climb as he is unable to get in or out without assistance.

Supportive relatives

“It’s very difficult to stay alone, especially when you are a person living with a disability. My house does not accommodate my special needs. It doesn’t have ramps – even for the toilet. My son-in-law is the one who is helping me, but he is leaving to study soon,” said the 52-year-old.

Greater Tzaneen Municipality (GTM) has agreed to assist Mnisi so he can easily manoeuvre around his yard while waiting for an emergency house.

“The Municipality will in meantime organise a ramp for the gentleman so that he can get into his house, and also to the toilet. His name will also be included in the list of emergency houses,” said GTM communication officer Patricia Muchabi.

Mnisi said it has been difficult to accept his disability, although his family has been supportive.

“It has not been a simple to accept the condition. You don’t get used to being without legs, especially when you were born with two good legs. However, my relatives support me and they have also accepted my condition. That also gives me strength to accept, and to realise it’s not all over.”

Image credit: Health-e News

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