Health24.com | ‘Extreme’ exercise no danger to middle-aged hearts

Middle-aged men who partake in extreme exercise are not putting their heart health at risk, a new study contends.

Ageing athletes who do eight or more hours a week of vigorous exercise have no greater risk of early death than people who work out less often, researchers found.

Protective and not injurious

Extreme exercise included activities such as fast running or biking, as well as competitive sports such as basketball or tennis.

In fact, middle-aged men who didn’t already have hardening of the arteries saw their odds for early death fall by half if they regularly engaged in vigorous activity, noted senior researcher Dr Benjamin Levine. He’s director of the Institute for Exercise and Environmental Medicine, a collaboration of University of Texas Southwestern Medical Center and Texas Health Presbyterian Hospital Dallas.

“Being a high-level athlete was clearly protective and not injurious” for those with lower levels of arterial plaques, Levine said.

Previous studies had questioned whether extreme exercise could be harmful, because some very active athletes tended to have higher levels of coronary artery calcification (CAC), researchers said in background notes.

Heart doctors use imaging tests to check for CAC as a means of assessing risk for heart attack, stroke or heart disease. Coronary calcium is a footprint of atherosclerosis, in which plaques accumulate in the blood vessels that supply the heart.

Closer examination

“Particularly the male athletes tended to have more coronary plaques, and the plaques they did have were virtually all calcified,” Levine said.

But no study had ever taken the next logical step, he added.

“No one actually ever determined whether that made them at higher risk of death or not, and that’s really the whole question,” Levine said. “Who cares if they have more calcium if they don’t die [prematurely]?”

To examine this more closely, Levine and his colleagues studied data gathered on nearly 22 000 generally healthy men, aged 40 to 80, during the years from 1998 through 2013.

The men reported their activity levels and underwent coronary calcium scanning. Most were runners, but some were cyclists, swimmers, rowers or triathletes.

Extreme exercise was defined as eight or more hours a week of activity at an average of 10 metabolic equivalents, or METS, Levine said. METS are a measure of the energy spent in activity.

Levels of physical activity

Vigorous exercise at 6 METS or higher can include jogging at 6 mph (9.6kph) or faster, bicycling at 14 mph (22.5kph) or faster, carrying heavy loads, or playing competitive basketball, soccer or tennis, according to the Harvard T.H. Chan School of Public Health.

“People don’t typically do that for recreational fitness,” Levine said of these exercise levels. “They’re more likely to do that for competitive fitness.”

The athletes were split into two groups based on their CAC scores, and researchers compared them based on their levels of physical activity. The investigators tracked participants’ rate of death for any cause and specifically for heart disease.

During the study period, extremely active athletes with low CAC scores died half as often as the least-active men with similar CAC scores, the findings showed. They also were 61% less likely to die of heart disease.

Those with high CAC scores also appeared to do well. Extreme athletes with high arterial calcium were about 23% less likely to die compared with less active men, but there were so few deaths that the result was not statistically significant, Levine said.

“Rather than saying they have a lower risk of death, we say they had no greater risk of death,” Levine said of extreme athletes with high CAC scores.

Women not included

The study did not include women because their lower rates of death in middle age made a valid statistical comparison impossible. “The trend seems to be similar in men and women, but we can’t say anything convincingly because the death rates were so low” in women, Levine said.

Cardiologist Dr Nieca Goldberg said these findings support the advice she regularly provides.

“A really important message that I try to get across to my patients is you can have plaque present but if you lead a healthy lifestyle, it helps prevent dying of a heart attack,” said Goldberg. She is medical director of the Center for Women’s Health and Women’s Heart Program at NYU Langone Health in New York City.

However, Goldberg hesitated to say these results would apply to women the same as men.

“I would have to see a study done to see what the results are,” Goldberg said.

Levine pointed out that there are several potential reasons why extreme exercise might aid heart health rather than harm it.

“Exercise, particularly over a long time, causes increased flexibility and youthfulness of the heart and blood vessels,” he said. “Blood vessels are better able to flex and send blood where it needs to go.”

No upper age limit

It also appears that plaques in arteries of extreme athletes tend to be more calcified and harder, making them less prone to rupture and cause a blood vessel blockage, Levine said.

So how old might be too old to engage in extreme exercise?

“I don’t think there’s an upper age limit beyond which the benefit diminishes,” Levine said. “The trick is to sustain a meaningful amount of exercise across your lifespan.”

While extreme amounts of exercise don’t appear to harm your heart, you don’t need to do that much working out to keep yourself healthy, he noted.

“The biggest bang for your buck comes with the conversion from a sedentary to an active lifestyle,” Levine said. “Most of the benefit for cardiovascular mortality tends to plateau at about the three- to five-hour-a-week mark.”

The study was published online in JAMA Cardiology.

Image credit: iStock

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Women’s brains appear three years younger than men’s

Time wears differently on women’s and men’s brains. While the brain tends to shrink with age, men’s diminish faster than women’s. The brain’s metabolism slows as people grow older, and this, too, may differ between men and women.

A new study from Washington University School of Medicine in St. Louis finds that women’s brains appear to be about three years younger than men’s of the same chronological age, metabolically speaking. The findings, available online the week of Feb. 4 in Proceedings of the National Academy of Sciences, could be one clue to why women tend to stay mentally sharp longer than men.

“We’re just starting to understand how various sex-related factors might affect the trajectory of brain aging and how that might influence the vulnerability of the brain to neurodegenerative diseases,” said senior author Manu Goyal, MD, an assistant professor of radiology at the university’s Mallinckrodt Institute of Radiology. “Brain metabolism might help us understand some of the differences we see between men and women as they age.”

The brain runs on sugar, but how the brain uses sugar changes as people grow and age. Babies and children use some of their brain fuel in a process called aerobic glycolysis that sustains brain development and maturation. The rest of the sugar is burned to power the day-to-day tasks of thinking and doing. In adolescents and young adults, a considerable portion of brain sugar also is devoted to aerobic glycolysis, but the fraction drops steadily with age, leveling off at very low amounts by the time people are in their 60s.

But researchers have understood little about how brain metabolism differs between men and women. So Goyal and colleagues, including Marcus Raichle, MD, the Alan A. and Edith L. Wolff Distinguished Professor of Medicine and a professor of radiology, and Andrei Vlassenko, MD, PhD, an associate professor of radiology, studied 205 people to figure out how their brains use sugar.

The study participants — 121 women and 84 men, ranging in age from 20 to 82 years — underwent PET scans to measure the flow of oxygen and glucose in their brains. For each person, the researchers determined the fraction of sugar committed to aerobic glycolysis in various regions of the brain. They trained a machine-learning algorithm to find a relationship between age and brain metabolism by feeding it the men’s ages and brain metabolism data. Then, the researchers entered women’s brain metabolism data into the algorithm and directed the program to calculate each woman’s brain age from its metabolism. The algorithm yielded brain ages an average of 3.8 years younger than the women’s chronological ages.

The researchers also performed the analysis in reverse: They trained the algorithm on women’s data and applied it to men’s. This time, the algorithm reported that men’s brains were 2.4 years older than their true ages.

“The average difference in calculated brain age between men and women is significant and reproducible, but it is only a fraction of the difference between any two individuals,” Goyal said. “It is stronger than many sex differences that have been reported, but it’s nowhere near as big a difference as some sex differences, such as height.”

The relative youthfulness of women’s brains was detectable even among the youngest participants, who were in their 20s.

“It’s not that men’s brains age faster — they start adulthood about three years older than women, and that persists throughout life,” said Goyal, who is also an assistant professor of neurology and of neuroscience. “What we don’t know is what it means. I think this could mean that the reason women don’t experience as much cognitive decline in later years is because their brains are effectively younger, and we’re currently working on a study to confirm that.”

Older women tend to score better than men of the same age on tests of reason, memory and problem solving. Goyal, Raichle, Vlassenko and colleagues are now following a cohort of adults over time to see whether people with younger-looking brains are less likely to develop cognitive problems.

Story Source:

Materials provided by Washington University School of Medicine. Original written by Tamara Bhandari. Note: Content may be edited for style and length.

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New method to reduce quantum noise

In a recent issue of Physical Review A, Argonne researchers reported a new method for alleviating the effects of “noise” in quantum information systems, a challenge scientists around the globe are working to meet in the race toward a new era of quantum technologies. The new method has implications for the future of quantum information science, including quantum computing and quantum sensing.

Many current quantum information applications, such as carrying out an algorithm on a quantum computer, suffer from “decoherence” — a loss of information due to “noise,” which is inherent to quantum hardware. Matthew Otten, a Maria Goeppert Mayer Fellow at Argonne, and Stephen Gray, group leader of Theory and Modeling at the Center for Nanoscale Materials, a U.S. Department of Energy Office of Science User Facility, have developed a new technique that recovers this lost information by repeating the quantum process or experiment many times, with slightly different noise characteristics, and then analyzing the results.

After gathering results by running the process many times in sequence or parallel, the researchers construct a hypersurface where one axis represents the result of a measurement and the other two (or more) axes represent different noise parameters. This hypersurface yields an estimate of the noise-free observable and gives information about the effect of each noise rate.

“It’s like taking a series of flawed photographs,” said Otten. “Each photo has a flaw, but in a different place in the picture. When we compile all the clear pieces from the flawed photos together, we get one clear picture.”

Applying this technique effectively reduces quantum noise without the need for additional quantum hardware.

“This is a versatile technique that can be done with separate quantum systems undergoing the same process at the same time,” said Otten.

“One could create several small quantum devices and run them in parallel,” said Gray. “Using our method, one would combine the results on the hypersurface and generate approximate noise-free observables. The results would help extend the usefulness of the quantum devices before decoherence sets in.”

“We successfully performed a simple demonstration of our method on the Rigetti 8Q-Agave quantum computer,” said Otten. “This class of methods will likely see much use in near-term quantum devices.”

The researchers’ work described above appears in Physical Review A and is entitled “Recovering noise-free quantum observables.”

Otten and Gray have also developed a similar and somewhat less computationally complex process to achieve noise-reduction results based on correcting one qubit at a time to approximate the result for all qubits being simultaneously corrected. A qubit, or quantum bit, is the equivalent in quantum computing to the binary digit or bit used in classical computing.

“In this approach, we assume that the noise can be reduced on each qubit individually, which, while experimentally challenging, leads to a much simpler data processing problem and results in an estimate of the noise-free result,” noted Otten.

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Materials provided by DOE/Argonne National Laboratory. Note: Content may be edited for style and length.

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Laughter may be best medicine — for brain surgery

Neuroscientists at Emory University School of Medicine have discovered a focal pathway in the brain that when electrically stimulated causes immediate laughter, followed by a sense of calm and happiness, even during awake brain surgery. The effects of stimulation were observed in an epilepsy patient undergoing diagnostic monitoring for seizure diagnosis. These effects were then harnessed to help her complete a separate awake brain surgery two days later.

The behavioral effects of direct electrical stimulation of the cingulum bundle, a white matter tract in the brain, were confirmed in two other epilepsy patients undergoing diagnostic monitoring. The findings are scheduled for publication in the Journal of Clinical Investigation. Videos of the effects of cingulum bundle stimulation are available, with the patient’s identity obscured.

Emory neurosurgeons see the technique as a “potentially transformative” way to calm some patients during awake brain surgery, even for people who are not especially anxious. For optimal protection of critical brain functions during surgery, patients may need to be awake and not sedated, so that doctors can talk with them, assess their language skills, and detect impairments that may arise from resection.

“Even well-prepared patients may panic during awake surgery, which can be dangerous,” says lead author Kelly Bijanki, PhD, assistant professor of neurosurgery. “This particular patient was especially prone to it because of moderate baseline anxiety. And upon waking from global anesthesia, she did indeed begin to panic. When we turned on her cingulum stimulation, she immediately reported feeling happy and relaxed, told jokes about her family, and was able to tolerate the awake procedure successfully.”

Outside of use during awake surgery, understanding how cingulum bundle stimulation works could also inform efforts to better treat depression, anxiety disorders, or chronic pain via deep brain stimulation.

Previous investigators have reported that direct electrical stimulation of other parts of the brain can trigger laughter, but the demonstration that anti-anxiety effects observed with cingulum bundle stimulation can provide meaningful clinical benefits make this study distinct, says senior author Jon T, Willie, MD, PhD, who performed the surgeries reported in the paper. He is assistant professor of neurosurgery and neurology at Emory University School of Medicine.

Additional Emory authors include Joseph Manns, PhD, Cory Inman, PhD, graduate student Sahar Harati , Nigel Pedersen, MD, Daniel Drane, PhD, and Rebecca Fasano, MD. Authors who are now at Mount Sinai in New York City are Ki Sueng Choi, PhD, Allison Waters, PhD and Helen Mayberg, MD, all previously at Emory.

Lying under the cortex and curving around the midbrain, the cingulum bundle has a shape resembling a girdle or belt — hence its Latin name. The area that was a key to laughter and relaxation lies at the top and front of the bundle. The bundle is a logical target because of its many connections among brain regions coordinating complex emotional responses, Willie says.

The location of cingulum bundle stimulation is distinct from other brain locations that process reward, such as ventral striatum, which has been targeted for the treatment of depression and addiction. Because the cingulum bundle is a crossroads for white matter connecting several lobes, Willie and his team may be affecting widespread networks throughout the brain.

Willie says the locations of initial electrode placement were chosen in order to record brain activity and locate the onset of the first patient’s seizures. The electrode initially used to stimulate the cingulum bundle was inserted into the brain in a way that was different than standard, he says. The unique trajectory was necessary because of the first patient’s previous surgeries; the approach was from the rear (see illustration), leading to a broader extent of cingulum bundle being sampled and therefore accessible for electrical stimulation.

The JCI paper says that cingulum bundle stimulation “immediately elicited mirthful behavior, including smiling and laughing, and reports of positive emotional experience.”

“The patient described the experience as pleasant and relaxing and completely unlike any component of her typical seizure or aura,” the authors write. “She reported an involuntary urge to laugh that began at the onset of stimulation and evolved into a pleasant, relaxed feeling over the course of a few seconds of stimulation.”

As a test of her mood and thought processes, the researchers tested how the first patient viewed faces and whether she interpreted them as happy, sad or neutral. Cingulum bundle stimulation shifted her view of faces so that they were interpreted as happier. This effect, called “affective bias” is known to correspond with the reduction of depressive symptoms, and suggests a potential use of cingulum stimulation in treating depression.

The two other patients that underwent cingulum stimulation and behavioral testing did not undergo awake surgery for epilepsy treatment. Upon stimulation, they both also smiled and reported mood elevation and pain relief, and at higher levels of current, experienced laughter. During stimulation, one of the later patients took tests of attention, memory and language and performed normally, except for delayed verbal recall on a list-learning task.

The researchers envision cingulum bundle stimulation as potentially applicable to surgery for brain tumors, as well as epilepsy.

“We could be surer of safe boundaries for removal of pathological tissue and preservation of tissue encoding critical human functions such as language, emotional, or sensory functions, which can’t be evaluated with the patient sedated,” Bijanki says. “In addition, although substantial further study is necessary in this area, the cingulum bundle could become a new target for chronic deep brain stimulation therapies for anxiety, mood, and pain disorders.”

The research was supported by the American Foundation for Suicide Prevention (YIG-727 0-015-13), the National Center for Advancing Translational Sciences (UL1TR002378, KL2TR002381), the National Institute of Neurological Disease and Stroke (R21NS104953, K08NS105929, R01NS088748, K02NS070960) and the National Institute of Mental Health (K01MH116364).

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Health24.com | Cape Town boy suffers from ‘popcorn lung’

Travonne Rhoda, 4, from Kraaifontein, Cape Town, has spent almost all of his four years on earth in hospital.

Travonne was only six months old when he developed a bad, persistent cough. Since then, he’s spent most of his life in hospital and was eventually diagnosed in 2018 with bronchiolitis obliterans — an incurable lung disease commonly known as popcorn lung.

The condition causes the smallest airways of the lungs to be obstructed due to chronic inflammation.

It’s possible that the condition was triggered when Travonne suffered pneumonia as a baby.

The damage to his lungs is irreversible, says the little boy’s mom, 35-year-old Simone Rhoda.

Simone spoke to YOU this week in the Melomed Belville Hospital. The little boy – who considers entertainer Emo Adams his bestie and thinks of the hospital as home — is on a ventilator.

“He’s been on the machines since last week after he had another setback. For months he was doing better,” Simone tells us. She adds the nursing staff have become like family to them.

Travonne has had to spend the past two Christmases and New Years in hospital. Last year in June he was discharged, only to be readmitted a day later.

In September he spent a few days at home before his family had to take him back to hospital. He’s been on a ventilator four times since then.

“It takes its toll. It’s especially stressful and hard on me when I’m at work and he’s at home. The longest he’s been home, was a month and a half,” Simone says.

Doctors prefer to have Travonne in hospital where he can get the best possible care. She says she and her husband, Clement, 37, can’t thank the hospital staff enough for everything they’re doing for the family. During the crisis times, she and her husband are there day and night, she adds. “They give us a place to sleep and three meals a day.”

Travonne Rhoda

She gets emotional when she talks about how Travonne nearly died on September 29 last year. They were at home when the hospital called to say his organs had started failing. Upon their arrival, the nurses were in a circle around the little boy’s bed, holding hands and praying.

“People’s prayers are the only thing that’s keeping us standing,” Simone says.

To help cover medical costs, various fundraisers have been organised in the past four years, including an annual golf day and the Travonne Rhoda Sevens Rugby Tournament. Last year Emo Adams visited Travonne at the behest of the Reach for a Dream Foundation. “Since then Travonne thinks of Emo as his bestie.”

Travonne Rhoda

The little boy is also a huge fan of South African performer Early B. “He loves watching YouTube videos — Early B’s Ben 10 is his favourite.”

When Travonne was discharged in September, he’d asked to go back to hospital. “The hospital is home to him.”

Simone says there’s no cure for her son. “All we’re asking is that people pray for him.”

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Health24.com | You’ve been diagnosed with cancer – now what?

“You have cancer” are words no one wants to hear. The reality is that many people receive that exact diagnosis every year. 

Fortunately the news is not that bad anymore — nowadays many cancers, when detected early, have a much better prognosis and aren’t terminal.

Yet, it remains gut-wrenching and life-changing when you hear those words after what you thought would be a routine examination.

Even with the focus on early detection, we realise that no cancer diagnosis, no matter how early or late, is easy for a patient to bear. We spoke to Dr Charleen Muller, a radiation oncologist from Cancercare on what to do and what to expect when you are diagnosed with cancer.

1. Get all the medical information as soon as possible

Dr Muller says that every cancer patient they see, will have an hour-long consultation with an oncologist. Here, the prognosis and treatment options are discussed.

“It is important to get as much information as possible from an accredited oncologist,” she says. “We usually send a patient home with enough printed material to read in their own time as we know that the information can often be overwhelming, especially when you receive bad news.” The best advice is to receive realistic information and to be as proactive as possible. You might want to read up on your illness from every source you can find, but focus on what your oncologist is saying to you right now.

Doctor and patient

2. Find a support network

Dr Muller says that they make use of in-house social workers to offer additional emotional support to their patients. “It is vital to make use of a support structure as early as possible, whether it’s family, friends or a community support group. They can lend an ear when you want to talk about your feelings, but they can also give advice and positive reinforcement,” she says.

Therapist and patient

3. Consider your lifestyle, but don’t make drastic changes

While there is sufficient evidence to prove that quitting smoking, a healthy body mass index, a balanced diet and enough physical exercise can reduce the risk of cancer mortality, it’s important to remember that the early stages after a cancer diagnosis are stressful and that it’s important to go easy on yourself.  

A cancer diagnosis doesn’t mean you should pressurise yourself and make drastic lifestyle changes then and there, says Dr Muller. “It is an emotionally rough time, and while a healthy lifestyle is never a bad idea, any changes in your lifestyle should be incorporated gently,” says Dr Muller.

It’s important to note that any drastic weight loss or other changes due to a change in your lifestyle may mask weight loss that may be a result of the cancer. It’s important for your doctor to keep track of what’s happening, and any drastic changes you make may cloud this process.

woman trying healthy recipes

4. Prepare for treatment

“Invest in a notebook and pen and write things down in point-form as it might be hard to remember everything during appointments,” says Dr Muller. “Also note that each cancer treatment and its side-effects, be it radiation or chemotherapy, will differ from patient to patient, but I usually tell patients to reduce the stress and pressure in their lives and to reach out to their support system.”

Ask your doctor what possible side-effects you can expect and make practical preparations — including stocking up on lotion if your skin might be affected by chemotherapy, or simply having ice-lollies or ginger tea at hand for possible nausea — anything to relieve discomfort.

“It’s also imperative to keep your brain stimulated during a round of chemotherapy, as the impact of the medication may alter your memory. We call this chemo brain,” says Dr Muller. Do things that you enjoy that will also stimulate your mind, such as reading, completing crossword puzzles, or playing Sudoku.

Chemotherapy

5. Maintain your normal life

Note that the biggest burden during the early stages of cancer will not be necessarily physical, but emotional. Dr Muller states that it’s vital to maintain a normal pattern. “If you are someone who’s used to going out with friends, don’t stop doing that. It’s easy to want to isolate yourself, but it’s important to keep a support network close.”

Don’t hesitate to tell people how you want them to react. Family and friends may treat you with kid gloves or might not know what to do or say, and tend to shy away from the topic. On the other end of the spectrum, they might overload you with opinions, platitudes and advice. This doesn’t come from a bad place, so communicate clearly how you feel.

Two friends exercising

Do you have personal experience of a cancer diagnosis? Share your experience by emailing marelize.wilke@24.com and should you wish to remain anonymous, please let us know.

Image credits: iStock

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