Snowpack declines may stunt tree growth and forests’ ability to store carbon emissions

Researchers conducting a 5-year-long study examining snow cover in a northern hardwood forest region found that projected changes in climate could lead to a 95 percent reduction of deep-insulating snowpack in forest areas across the northeastern United States by the end of the 21st century. The loss of snowpack would likely result in a steep reduction of forests’ ability to store climate-changing carbon dioxide and filter pollutants from the air and water.

The new findings, out today in Global Change Biology, highlight a growing understanding of the broad impact of climate change across seasons on forest ecosystems, according to scientists who leveraged six decades of data showing declining winter snowpack at Hubbard Brook’s forest. The 7,800-acre research forest in New Hampshire is heavily populated by sugar maple and yellow birch trees, and has been used for over 60 years to study changes in northern hardwood forests — an ecosystem covering over 54 million acres and stretching from Minnesota to southeastern Canada.

“We know global warming is causing the winter snowpack to develop later and melt earlier,” said the paper’s first author Andrew Reinmann, an assistant professor and researcher with the Environmental Science Initiative at the Advanced Science Research Center (ASRC) at The Graduate Center, CUNY, and with Hunter College’s Department of Geography. “Our study advances our understanding of the long-term effects of this trend on northern hardwood forests — which are critical to North America’s environmental health and several industries. The experiments we conducted suggest snowpack declines result in more severe soil freezing that damages and kills tree roots, increases losses of nutrients from the forest and significantly reduces growth of the iconic sugar maple trees.”

The researchers’ 5-year-long experiment consisted of removing snowpack from designated plots during the first 4-6 weeks of winter each year between 2008 and 2012, and then comparing the resulting condition of the soil and trees (all sugar maples) in those plots to the soil and trees in adjacent plots with natural snowpack. Their analysis found that soil frost depth reached over 30 centimeters in areas where snow cover had been removed compared to roughly 5 centimeters at control plots. The severe frost caused damage to tree roots that triggered a cascade of responses, including reduced nutrient uptake by trees, shorter branch growth, loss of nitrogen from soils into nearby waterways, and decreases in soil insect diversity and abundance. Scientists collected sample cores from sugar maple trees on their research plots and measured the width of the cores’ rings to reconstruct growth rates. They found that growth declined by more than 40 percent in response to snow removal and increased soil freezing. The trees also were unable to rebound even after snowpack removal ceased.

“These experiments demonstrate the significant impact that changes in winter climate have on a variety of environmental factors, including forest growth, carbon sequestration, soil nutrients and air and water quality,” Reinmann said. “Left unabated, these changes in climate could have a detrimental impact on the forests of the region and the livelihoods of the people who rely on them for recreation and industries such as tourism, skiing, snowmobiling, timber and maple syrup production.”

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Health24.com | 5 ridiculous things some people still believe about HIV/Aids

HIV has become completely manageable, but it is surprising how many people still believe some of the misconceptions about the condition. 

The theme of 2018 is “Know your status”, which emphasises the importance of getting tested.

Here are a couple of misconceptions that need to be cleared up. Some are harsh and ignorant untruths while others are just absolute myths.

1. Only ‘high-risk people such as homosexuals and promiscuous people’ should be tested for HIV.

First, what defines “high risk”? Being with one long-term partner does not mean that you will never contract HIV.

“HIV can happen to anyone. It’s not a disease of the promiscuous. Think about survivors of rape or someone born with HIV,” says Barbara Kingsley, an HIV activist who was diagnosed in 2000.

And regardless of that, no-one should be shamed for their sexual choices and lifestyle.

It’s important to know your status as symptoms may not manifest for years and people can be completely unaware that they have HIV. The earlier you know your status, the earlier you can start taking antiretrovirals (ARVs) to combat the virus and take control of your status. You will also need to know your status to reduce the risk of infecting other possible sexual partners.

Regular testing will also help you raise awareness and break the stigma surrounding HIV/Aids by improving the negative attitudes and perceptions in your own family and circle of friends, even if you are with a long-term partner or not having sex at all.

2. You will get very sick and die if you are HIV positive.

Yes, HIV can lead to Aids. Yes, Aids can be fatal. Does this mean that you are immediately doomed as soon as you are tested positive? Certainly not. Nowadays, HIV is well controlled through ARVs, and many HIV positive people live completely healthy, happy lives.

It may take years for the immune system to deteriorate to such an extent that someone living with HIV becomes ill and is diagnosed with Aids.

According to the World Health Organization (WHO), HIV will progress to Aids if not treated with ARVs. This will usually happen after about 10 to 15 years, and before it happens, people with HIV may look and feel perfectly well and can continue life to the fullest.

HIV is no longer a death sentence and the sooner you are tested, the sooner you can start the proper treatment.

3. ‘I will never contract HIV/Aids. It’s a disease that only poor people get.’

This statement is so harsh that you cannot imagine anyone saying it out loud. The truth is, HIV is blind to colour or economic status.

According to a paper published in the journal AIDS, stigma surrounding HIV/Aids is a big factor in the limitation of proper treatment.

You as an individual might feel helpless in the face of the quest to find a cure for HIV, or to ensure that everyone has access to medicine and medical care. But what you can do is to start changing the views and perceptions of people in your immediate circle, which can have a wider effect on society.

4. ‘He/she is very skinny. They must have HIV/Aids.’

Progressive Aids in its end stages can cause weight loss and an impaired immune system. Untreated HIV can lead to Aids. However, there is no way of telling someone’s status by simply looking at them.

Physical signs and symptoms can take years to manifest or may never do so, especially when an HIV positive person is taking ARVs and has a healthy, active lifestyle.

5. It’s impossible to marry/have a sexual relationship if you are HIV positive.

Unprotected sex is the most common way of spreading HIV. But with protection, there is no reason why an HIV positive person can’t have a fulfilling relationship with an HIV negative person.

With proper treatment and management through ARVs, there is a chance that the viral load (the presence of HIV in your blood) may be undetectable. Research has shown that having an undetectable viral load can lead to little to no risk of spreading the virus to other people.

However, Barbara Kingsley says that it remains important always to use protection, no matter what your viral load:

“The goal of ARVs is for the virus to eventually become undetectable. This means that if you have an undetectable viral load for a period of six months or longer you cannot pass the virus on to others. It is very important to understand that this doesn’t protect you against pregnancy or any other STD, and that you can still practise irresponsible sex — you should ideally be in a monogamous, long-term relationship. An undetectable state can ONLY be achieved with ARVs, something that has been scientifically proven and internationally accepted. (It, however, doesn’t mean that you can have unprotected sex as you wish.)”

Health24 previously told the story of Quinton Jonck, a South African living with HIV. He said the following: 

“My wife is wonderful – I tried to break it off with her early on in our relationship because I believed we had no future. She wanted to hear nothing about that and two years later we got married. 

“Five years after we got married we had our first child. He was conceived using a procedure called sperm washing and insemination. When we had the next two children, I was on medication to take my viral load down to zero and we took a chance just at the right time. Now we have three children – two boys and a girl [all HIV negative].  

“We are very happy and my wife is still HIV negative after almost 14 years of marriage. Although we only found out about my status after we met, we have always used condoms.

Get tested

It’s important to know your status. You can get tested at any of the following institutions, in both the public and private sectors:

  • Hospitals
  • Clinics
  • Pharmacies who offer clinic services
  • Community health centres
  • Family planning clinics
  • STD clinics
  • Pathological laboratories

Make sure that these institutions offer HIV/Aids counselling to help you process the result and to answer any further questions.

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Health24.com | Are you better at remembering faces or names?

Don’t be surprised at holiday parties if you can remember someone’s name but not their face.

Despite what many believe, people are better at remembering names than faces, researchers found.

In a series of tests, volunteers were able to recall up to 83% of names but only 64% of faces.

A different picture

“Our study suggests that, while many people may be bad at remembering names, they are likely to be even worse at remembering faces,” said Rob Jenkins, a reader in the Department of Psychology at the University of York, in Great Britain.

“Our life experiences with names and faces have misled us about how our minds work, but if we eliminate the double standards we are placing on memory, we start to see a different picture,” he added in a university news release.

Remembering a person’s face relies on recognition, while their name is a matter of recall. People are much better at the former than the latter, according to the researchers.

An everyday phenomenon

They noted that people only realize they’ve forgotten someone’s name when they’ve already recognized the face.

“Knowing someone’s face, but not remembering their name is an everyday phenomenon,” Jenkins said.

“Our knee-jerk reaction to it is to say that names must be harder to memorize than faces, but researchers have never been able to come up with a convincing explanation as to why that might be. This study suggests a resolution to that problem by showing that it is actually a red herring in the first place.”

The study was published recently in the Quarterly Journal of Experimental Psychology.

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Health24.com | World Aids Day: You never know what tomorrow holds for you

As the globe marks World Aids Day on December 1, the call has again gone out for people to join the fight against HIV and Aids, with the event being used as an opportunity to educate people and to remember those who have passed away.

As the first ever global health day, World Aids Day was held for the first time in 1988. Since then it has become an important annual reminder that HIV has not gone away and that there is still a vital need to increase awareness, fight prejudice and improve education.

Disclosure key to long life

This year’s theme for the 30th anniversary of World Aids Day is, “Know your status”. Communities are encouraged to care for their health by getting tested, practising safe sex and taking treatment.

Nomsa Tyali, 40, who has been living with HIV since 2001, has appealed to South Africans with the virus to speak out about their infection. “People die because of the lack of information. Disclosure is key to a long life,” she said.

She explained that it was important for people to disclose their status and be open about it because it was helpful to others in many ways.

People living with HIV gain strength from knowing that there are others also living with the virus, that they are not alone and that there are many others living with the same condition.

Words of support

Disclosure also offered hope as people can see clearly that the disease does not discriminate and affects rich and poor, young and old, saints and heathens.

“Disclosure also gives people reassurance because they know where to find help or find acceptance in times of isolation,” Tyali said.

Offering words of support, Tyali said “You can be positive, but that doesn’t make you different from others. You are a human, so you need to be accepted and loved. You are HIV positive. Not mad, not sick.”

She warned people to be brave and get tested for HIV.

“Don’t just sit back and be clueless about your health status. Go and test your blood so that you’ll stay aware of your health condition and get some assistance if you need it. Remember, the more you delay, the more the virus is taking charge of your body. Wise up, love your life, take care of HIV before it takes care of you.

“And never treat others with HIV badly. Understand that it just happened like any other disease. Never laugh at them and never judge. Be supportive,” Tyali urged. – Health-e News.

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Health24.com | A topic of heated debate: Should HIV testing be compulsory?

According to UNAIDS, 36.9 million people around the world are living with HIV. South Africa currently has the largest HIV epidemic in the world, with 7.2 million of its citizens affected by the virus.

Southern and Eastern Africa is home to 50% of the world’s HIV positive population. It’s no wonder the question of whether or not HIV testing should be compulsory keeps popping up.

Earlier this year two Ugandan ministers were backing the call for compulsory HIV testing. The ministers in question were Sarah Achieng Opendi, the State Minister of Health, and Janat Mukwaya, the Minister of Gender, Labour and Social Justice.

According to an article in The Guardian, Mukwaya believed that compulsory HIV testing would allow the stigma surrounding the epidemic to diminish and that through the Ugandan government’s test and treat initiative those affected would receive the help that they need.

In August, Zambian President Edgar Lungu announced that HIV testing was now compulsory in his country. According to News24 Lungu said, “I must admit that there were some colleagues who felt that this policy would infringe on human rights but there [is] no one [who] has the right to take away somebody’s life. Just the same way we don’t consult you for consent when we are testing for malaria, we will go ahead and test you for HIV and we will counsel you and if you are positive; we will commence you on treatment.”

Both announcements by these countries were met with stark opposition and the comments and decisions made were quickly retracted. However, the question about whether or not HIV testing should be compulsory still lingers.

Public debate

Researchers investigating the pros and cons of compulsory HIV testing for pregnant women found that women, children and society as a whole would benefit from mandatory testing.

However, they felt that it should not be something used by governments simply for the sake of testing but as a means to stop the spread of infection and to treat those infected.

A debate between Médicins sans Frontières (Doctors without Borders, MSF) and the University of Cape Town’s Students’ Health and Welfare Centres Organisation (SHAWCO) highlighted the different viewpoints of those in favour and those against compulsory HIV testing.

According to Dr Gilles van Cutsem from MSF, mandatory testing could slow down the rate of new infections and help those who were unaware of their HIV status.

Professor Leslie London, director of the School of Public Health at UCT argued that compulsory testing was an abuse of human rights and that there were other methods available to encourage people to get tested.

In an interview Health-e news, labour lawyer Marlene Potgieter notes that “HIV/Aids is mired in folklore, suspicion and mistrust and the fact that it is a disease that comes from having sex (mostly). It is something that is not spoken about openly… People simply disappear quietly from the workplace and die in silence.”

Confidential HIV testing is considered as a human right. The UN’s International Covenant on Political and Social Rights states that one’s human rights may be limited if it’s a matter of public interest. This limitation may only be initiated if it serves an objective purpose and there are no other alternatives to solving the problem. 

Know your status

Because we live in a country with such high HIV rates, South Africans are regularly encouraged to get themselves tested. Knowing your status can save the lives of those around you, from your partner to your unborn child. Various clinics and health centres around the country offer free, confidential HIV testing. Last year BIOSURE, the HIV self-test, was legally approved, making it that much easier for people to get tested in private. 

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Health24.com | Be thankful for cranberries’ health benefits all year long

No respectable Thanksgiving plate is without some form of cranberry, but the fruit’s popularity seems to plummet the other 364 days of the year.

That’s a shame, nutrition experts say, because cranberries deliver a bundle of health benefits. And they’re quite efficient: A cup of raw cranberries has just 50 calories.

Bias toward sweetness

So why aren’t they more of an everyday food? It may come down to taste.

“They’re a little bit more bitter than blueberries or other berries that have those phytochemicals and a little bit crunchier,” said Maya Vadiveloo, an assistant professor in the Department of Nutrition and Food Sciences at the University of Rhode Island.

“I think you can start to get used to almost any flavour over time, but I think we may have this bias that all fruit needs to be sweet,” she said. “It might just be that people have not really thought that much about cranberries, unless it’s around Thanksgiving.”

Among the health benefits associated with cranberries:

  • The vitamins and minerals they contain boost the body’s digestive health and antioxidant system and promote good heart health even possibly improving blood pressure and cholesterol.
  • They are high in fibre. But contrary to common perception, the most recent research has not definitively shown that cranberry products help prevent or treat urinary tract infections.
  • In laboratory studies, they’ve been linked to a lower risk of certain types of cancer.
  • They contain chemicals that may combat norovirus and other food-borne illnesses.

“Cranberries may be a little underutilized,” Vadiveloo said. “They’re not nearly as expensive as many other berries, and at Thanksgiving, the greater variety of fruits and vegetables that you have around things like stuffing, mashed potatoes, gravy if you’re balancing your plate with a little bit of everything, you tend to eat less of all the things and still feel very satisfied.”

Closer to candy than fruit

One popular way to work cranberries into a daily diet all year long is by adding dried cranberries to a salad. And while cranberries may taste better when they’re dried than when they’re raw, that sweetness comes at a high cost.

Nutritionally speaking, dried cranberries may be closer to candy than they are to fruit. A 1/3-cup serving of dried cranberries has 123 calories. Worse, most of the nutrients found in raw cranberries are nowhere to be found in the dried version.

One cup of chopped raw cranberries, for example, contains 14.6 mg of vitamin C per serving, while one cup of dried cranberries contains 0.3 mg.

“If you start to think that one of the snack-size Halloween candies is 60 to 110 calories, you could have two cups of raw cranberries for that amount and feel fuller, and have a lot of the beneficial effects,” Vadiveloo said.

Similarly, sweetened cranberry sauce, a Thanksgiving staple, contains 418 calories with just 5.5 mg of vitamin C per one-cup serving.

Interaction with medications

“For almost any food, the preparation matters,” Vadiveloo said. “Most foods can be healthy, especially in their raw form. But when we start doing things to them, we need to be more concerned about the health effects. If you’re trying to start eating more cranberries, even if you’re planning to add sweetener, doing it yourself versus buying something that’s already pre-processed is better.

“People tend to add far less of their own sweetener than what’s in commercially prepared food.”

Another popular way people may try to add cranberries to the diet is by drinking them. Cranberry juice is often combined with other fruit juices, such as grape or apple, for a better flavour.

As with any juice, it’s important to consider the amount of sweetener that’s added. Unsweetened cranberry juice contains 116 calories and 23.5 mg of vitamin C per one-cup serving. Also, it’s worth noting that cranberry juice may interact with certain medications.

And of course, cranberries are popular in muffins. But depending on how they are made, muffins aren’t necessarily a nutritionist’s favourite choice, Vadiveloo said: “We don’t want to see a muffin claim health benefits just because it has cranberries, you know?”

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Namibia’s success in the fight against HIV

Namibia’s data-driven approach to HIV has helped it become successful in tackling its spread.

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New approach to assess sustainability of reef fish

A new study helping to improve how sustainability is measured for popular reef fish could help better assess the eco-friendly seafood options at the dinner table.

A team of researchers at the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science and NOAA Fisheries tested their newly developed fishery risk assessment method on groupers and snappers in the Florida Keys to determine if these tropical reef fish are being managed sustainability.

The new approach developed by UM Rosenstiel School Professor Jerald Ault and colleagues uses fish size-structured abundance data to evaluate fisheries sustainability status, instead of the traditional “catch-per-unit effort” method that requires long-term information collected by fishers to assess the health of a fishery.

The researchers then applied the length-based assessment to six key species in the Florida Keys region — black grouper, red grouper, coney, mutton snapper, yellowtail snapper and hog snapper — to evaluate the sustainability status of the fisheries.

They found that only one species — coney — was within the sustainable range with a less than a 35 percent risk score. The other five species had estimated sustainability risks of greater than 95 percent.

While the focus of this study was to develop a general length-based risk analysis methodology appropriate for data-limited fisheries worldwide, says the researchers, the results of the sustainability risk assessment for the species evaluated were in line with previous analyses for reef fishes in the Florida Keys and surrounding regions.

“The ecological and economic importance of tropical reef fish makes their sustainability a key conservation concern,” said Ault, the lead author of the study. “The next challenge will be to evaluate the sustainability status of the over 50 principal exploited species in the Florida reef-fish community.”

The new risk analysis framework can evaluate the sustainability status of tropical reef fish stocks when traditional catch data are not reliable or available and provide a frame of reference to help balance sustainability risks with management decisions.

In a separate but related study, Ault and colleagues developed a new fisheries-independent ecosystem monitoring survey to estimate biomass of deepwater snappers in the Hawaiian Islands. This new survey provides critical data for the risk analysis framework to assess fisheries sustainability in Hawaii.

“Our results help to improve the science and decision-making capacity for fisheries managers, and promotes the sustainability of coral reef fisheries subject to fishing and environmental changes,” said Ault. “These combined methods will greatly improve the capacity and efficacy of fishery management for shallow and deep water coral reef fisheries in Florida, the U.S. Caribbean, and the U.S. Pacific Islands.”

The new methods developed are designed to ensure the quality of commercial and recreational fishing today and into the future, said Ault.

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The future of fighting cancer: Zapping tumors in less than a second

New accelerator-based technology being developed by the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University aims to reduce the side effects of cancer radiation therapy by shrinking its duration from minutes to under a second. Built into future compact medical devices, technology developed for high-energy physics could also help make radiation therapy more accessible around the world.

Now, the SLAC/Stanford team has received crucial funding to proceed with two projects to develop possible treatments for tumors — one using X-rays, the other using protons. The idea behind both is to blast cancer cells so quickly that organs and other tissues don’t have time to move during the exposure — much like taking a single freeze frame from a video. This reduces the chance that radiation will hit and damage healthy tissue around tumors, making radiation therapy more precise.

“Delivering the radiation dose of an entire therapy session with a single flash lasting less than a second would be the ultimate way of managing the constant motion of organs and tissues, and a major advance compared with methods we’re using today,” said Billy Loo, an associate professor of radiation oncology at the Stanford School of Medicine.

Sami Tantawi, a professor of particle physics and astrophysics and the chief scientist for the RF Accelerator Research Division in SLAC’s Technology Innovation Directorate, who works with Loo on both projects, said, “In order to deliver high-intensity radiation efficiently enough, we need accelerator structures that are hundreds of times more powerful than today’s technology. The funding we received will help us build these structures.”

Blasting cancer with X-rays

The project called PHASER will develop a flash delivery system for X-rays.

In today’s medical devices, electrons fly through a tube-like accelerator structure that’s about a meter long, gaining energy from a radiofrequency field that travels through the tube at the same time and in the same direction. The energy of the electrons then gets converted into X-rays. Over the past few years, the PHASER team has developed and tested accelerator prototypes with special shapes and new ways of feeding radiofrequency fields into the tube. These components are already performing as predicted by simulations and pave the way for accelerator designs that support more power in a compact size.

“Next, we’ll build the accelerator structure and test the risks of the technology, which, in three to five years, could lead to a first actual device that can eventually be used in clinical trials,” Tantawi said.

The Stanford Department of Radiation Oncology will provide about $1 million over the next year for these efforts and support a campaign to raise more research funding. The Department of Radiation Oncology, in collaboration with the School of Medicine, has also established the Radiation Science Center focusing on precision radiation treatment. Its PHASER division, co-led by Loo and Tantawi, aims to turn the PHASER concept into a functional device.

Making proton therapy more agile

In principle, protons are less harmful to healthy tissue than X-rays because they deposit their tumor-killing energy in a more confined volume inside the body. However, proton therapy requires large facilities to accelerate protons and adjust their energy. It also uses magnets weighing hundreds of tons that slowly move around a patient’s body to guide the beam into the target.

“We want to come up with innovative ways to manipulate the proton beam that will make future devices simpler, more compact and much faster,” said Emilio Nanni, a staff scientist at SLAC, who leads the project with Tantawi and Loo.

That goal could soon be within reach, thanks to a recent $1.7 million grant from the DOE Office of Science Accelerator Stewardship program to develop the technology over the next three years.

“We can now move forward with designing, fabricating and testing an accelerator structure similar to the one in the PHASER project that will be capable of steering the proton beam, tuning its energy and delivering high radiation doses practically instantaneously,” Nanni said.

Quick, effective and accessible

In addition to making cancer therapy more precise, flash delivery of radiation also appears to have other benefits.

“We’ve seen in mice that healthy cells suffer less damage when we apply the radiation dose very quickly, and yet the tumor-killing effect is equal to or even a little bit better than that of a conventional longer exposure,” Loo said. “If the result holds for humans, it would be a whole new paradigm for the field of radiation therapy.”

Another key objective of the projects is to make radiation therapy more accessible for patients worldwide.

Today, millions of patients around the world receive only palliative care because they don’t have access to cancer therapy, Loo said. “We hope that our work will contribute to making the best possible treatment available to more patients in more places.”

That’s why the team is focusing on designing systems that are compact, power-efficient, economical, efficient to use in the clinical setting, and compatible with existing infrastructure around the world, Tantawi said: “The first broadly used medical linear accelerator design was invented and built at Stanford in the years leading up to the building of SLAC. The next generation could be a real game changer — in medicine and in other areas, such as accelerators for X-ray lasers, particle colliders and national security.”

Peter Maxim at Stanford (now director of radiation oncology physics at Indiana University) is a co-inventor of PHASER and made key contributions to both projects. Additional members on the proton therapy team are Reinhard Schulte at Loma Linda University and Matthew Murphy at Varian Medical Systems.

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In vitro cell culture findings could lead to novel interventions for Schizophrenia

A study recently published in Translational Psychiatry, a Nature journal, has shown how using cultured cells from patients with psychotic disorders, such as schizophrenia, to investigate abnormalities in nerve connections in the brain could lead to new treatments. Strong correlations were observed between the findings in the cells in culture — grown outside the body in a controlled environment — and findings from brain imaging performed on the very same human participants.

“The findings are important, because if the health of cells in culture reflects the health of the same cells in a human brain, we may be able to create a better model for studying psychotic disorders,” said the study’s senior author, Bruce M. Cohen, MD, PhD, director of McLean Hospital’s Program for Neuropsychiatric Research (PNPR). Cohen said such a model could give researchers a greater capacity to find genetic and biochemical targets in the brain. Using these targets, he said, “could enable us to develop novel and more effective interventions for psychotic disorders.”

For their work, Cohen and his colleagues, including first author Donna L. McPhie, PhD, director of the Cellular Neuropsychiatry Laboratory in the PNPR, drew on studies showing that altered pathways of brain development can be found across most cases of schizophrenia and that inaccurate connections and “leaks” in signaling between nerve cells are a feature of many psychotic disorders. A substance called myelin, produced by cells called oligodendrocytes, serves as a kind of insulation to prevent these leaks. In studies at McLean Hospital by co-author Dost Öngür, MD, PhD, chief of the Psychotic Disorders Division at McLean, and his colleagues, myelin was measured and found to be reduced in the brain in patients with schizophrenias.

Based on this prior research, Cohen and his colleagues drew on a repository of cell lines they had obtained from patients with psychiatric disorders. These samples were reprogrammed from skin cells into brain-like cells in the laboratory. The reprogrammed cell lines, taken from both ill and healthy patients, produced nerve cells and support cells called glia, including oligodendrocytes, in laboratory cultures. Investigations into these cells revealed significant abnormalities in the development of oligodendrocytes grown from subjects with psychotic disorders.

The research also revealed a strong correlation between the number of oligodendrocytes in culture and the amount of myelin made by these cells in the brains of the same subjects who provided the cells. This finding, Cohen explained, “means that we can now study the causes of the abnormality of myelin that we have observed in living brain tissue in a laboratory setting.”

For Cohen and his colleagues, the prospect of using lab cultures to examine differences in the brains of individuals with psychotic illnesses is “an exciting development.” For example, Cohen said, researchers have observed that not all genes and proteins necessary to make oligodendrocytes are affected in these cells, and they can now begin to identify exactly what genes and proteins are different in these cells. It would be impossible, he said, to do these detailed studies in living brain tissue.

Such studies, the researchers believe, could lead to better treatment approaches for individuals with psychotic conditions. “Using in vitro cell cultures to study these abnormalities could help us identify specific genetic and biochemical targets that might be addressed by novel drug treatments, cell transplantation, or other interventions,” Cohen said.

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