Noel Conway said he was “extremely disappointed” as his court battle for assisted dying ends.
Category Archives: Mind Building
Danger at Your Doctor’s Office

In 1999, Susan Sheridans husband, Pat, went in for surgery to remove a tumor in his neck. After the surgery, the neurosurgeon gave the Eagle, Idaho, couple great news: The mass was benigna fact the neurosurgeon confirmed after looking at the pathology report two weeks later.
“Little did we know that the pathologist had been conducting ongoing stains on the tumor and had released a final pathology report 21 days after the surgery,” says Susan, now 48. “It said ‘malignant sarcoma.” Cancer. But the Sheridans never got this critical update because it was mistakenly filed away at Pats doctors office without the physician or patient ever seeing it.
Within six months, Pats cancer had spread dramatically; he died of it in 2002, at the age of 45, leaving behind two school-age children. Had Pats malignancy been aggressively treated after that first surgery, he would likely be alive today. “There was no system in place to make sure a life-or-death document was read,” explains Susan, who discovered the error after requesting Pats medical records.
The mistake that cost Pat Sheridan his life took just seconds. Even if most errors dont have such tragic consequences, the circumstances that prompt them are everywhereand screwups happen often. In fact, 95% of physicians report having witnessed a serious medical mistake, and 56% say theyve personally been involved in a serious preventable error, says Sanjaya Kumar, MD, author of Fatal Care: Survive in the U.S. Health System. And these mistakes kill. "To Err is Human: Building a Safer Health System," the Institute of Medicines 1999 seminal report that first brought to light the problem of medical mistakes, noted that up to 98,000 preventable deaths happen each year in hospitals. But deaths in other settings, including doctors offices, were about three times that.
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Why the doctor's office is so risky
Simply put, “Medicine is more complicated today. Its a lot more daunting,” says Pamela Gallin, MD, author of How to Survive Your Doctors Care: Get the Right Diagnosis, the Right Treatment, and the Right Experts for You. “There are so many more treatment choices, often for diseases that once couldnt be treated. There are more moving parts.” Here, four key factors that are making a trip to the doc more dangerous than ever.
Appointments are shorter
The average doctors visit lasts seven minutes. Blink-and-youll-miss-it appointments conspire against safe care, says Dr. Gallin, who is also a clinical professor at New York Presbyterian–Columbia University Medical Center in New York City. She likens medical care today to the famous I Love Lucy episode in which Lucy cant keep up with the chocolates coming down the candy-factory conveyor belt. “The system has sped everybody up, and everybodys multitasking more. If I have more time to think about a patient or a diagnosis, Im going to be more attentive,” she says. “When doctors are forced to go faster, their judgments have to be formulated more quickly.” That pressure-cooker environment makes every decision ripe for error.
There arent enough primary-care physicians
By 2025, we will be down 200,000 MDs. Fewer students want to go into family medicine, internal medicine, and pediatricsthe areas in need of those workhorse docs who provide the great majority of year-in, year-out care. “Family care has become one of those jobs Americans wont do, like picking grapes,” says Phil Miller, vice president of communications at Merritt Hawkins and Associates, the countrys largest physician-recruiting firm. If youve tried to get a last-minute appointment (or, in many places, any appointment) you know that the MD shortage has already arrived in some parts of the country. This means you may not be able to choose your doctor so easily, which might result in your inability to pick the safest ones.
People are playing “musical doctors”
Maybe youre a patient in a practice with several doctors who rotate in and out of your appointments; half of all physicians today are in these plus-size practices (with three or more MDs). Maybe youve moved around a lot. Or maybe youre seeing a revolving door of specialists. Whatever the reason, “you rarely go to just one doctor,” Dr. Gallin says. “The system mandates that you go to an internist to check your blood, a radiologist for a mammogram, a gynecologist for your Pap smear, and a pathologist is reading your Pap smear. Youre up to four doctors and nothing is wrong with you. Four peopleany one of whom can mess up.”
A critical test result may go missing or not get to the office in time for a patient to schedule a follow-up appointment, or different specialists could be prescribing drugs that cause dangerous interactions. Whats more, safety experts know that any transition in careas happens when a patient sees different doctors in a medical groupraises the risk for experiencing a slipup.
Safety isnt on the radar of many practices
Safety is becoming more and more of a buzzword in hospitals. But doctors in stand-alone practices are on their own to educate themselves about medical errors and put in place protections (including costly technology) that could safeguard patients. “Theres also a lack of feedbackan error can occur, like a missed diagnosis, and the [physician] who missed it may never know,” says Tejal Gandhi, MD, executive director of quality and safety at Brigham and Womens Hospital in Boston. “The patient may be [correctly] diagnosed a year later by a different doctor,” but this means the stand-alone doctor may not even grasp the size of the problem in her own practice.
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Misdiagnosis
Misdiagnosesand missed diagnosesare perhaps the most-feared of all the kinds of doctor errors. And for good reason: “In about half of cases where a diagnosis is never made or delayed significantly, the result is real harm to the patient,” says Jerome Groopman, MD, author of How Doctors Think and the Dina and Raphael Recanati chair of medicine at Harvard Medical School.
How do well-trained MDs blow the call?
There are three main thinking traps physicians fall into, leading them to the wrong diagnosis, Dr. Groopman explains. The first happens when “the doctor makes a snap judgment by seizing on the first symptom or finding.” The second: sticking only to the diagnosis foremost in her mind. For instance, when a doctor has just seen 15 consecutive flu cases, “thats whats most likely to come to mind when he sees a 16th person,” Dr. Groopman says, even though patient number 16 may have something else. The last type has to do with negative stereotypes. “For example, if a woman in the middle of menopause has hot flashes and headaches and feels jittery, her doctor may attribute any of her complaints to menopause,” he says.
These assumptions can add up to a lot of wrong calls: About 15% to 20% of all diagnoses are missed or flat-out incorrect. One study of settled malpractice claims found that 59% of outpatient claims were for a diagnostic screwup. The most common errors? Incorrect reading of a test result; wrong or inadequate follow-up care; and missed or delayed cancer diagnosis. Breast cancer accounted for about 42% of missed cancer cases.
Thats what happened to Maureen Thiel. The 40-year-old Pennsylvania mother of two first found a lump in her left breast during a self-exam in late 1994. She followed up immediately with a mammogram and ultrasound and was told she had fibrocystic breasts. Although the lump didnt wax and wane, as is usually the case with this condition, her initial doctor and two subsequent ones she saw failed to advise her to get a biopsy. By February 1997, Maureen had found a new lumpthis time under her arm. She then saw a different doctor, who ordered not only a mammogram and ultrasound but a biopsy; the tests turned up stage III metastatic breast cancer. “She was positive [for cancer] in all 47 lymph nodes,” Maureens husband, William, says. “She lived 15 months.”
Communication breakdown
Many errors stem from a communication lapse. “These errors go to everything,” says Nancy C. Elder, MD, an associate professor of family medicine at the University of Cincinnati and one of the few researchers to study mistakes in doctors offices. In a 2004 study of 75 errors reported anonymously by family physicians, 47 were triggered by miscommunication.
So what is a communication error, exactly? Its the rushed doctor who doesnt listen and brushes off your concernsor even your symptoms or pain; the lost medical record or referral that delays diagnosis or treatment; the rude office manager or nurse who makes it impossible to get information or an appointment when its really needed; or the phone that never rings with word about that lab result youve been losing sleep over. “Anytime you undergo a test, you should always get the result back,” Dr. Elder says. “‘Well call you if anything is bad isnt an acceptable response.”
Medication mistakes
If you take even one prescription med, youre at risk for an error. Your doctor could give you the wrong drug, wrong dose, wrong type (pill versus liquid), wrong timing (morning versus evening)or you could even be the wrong person (i.e., you dont need the drug). And the more meds youre on, the more likely it is youll experience dangerous interactions. (A side effect shouldnt be confused with an error, though.)
As tempting as it may be, bypass free drug samples, advises Allen J. Vaida, PharmD, executive vice president of the Institute for Safe Medication Practices, in Horsham, Pa. Theres a debate about whether physicians should dispense samples in the first place, because theres no way for pharmacists and other providers to know youre on that drug. “Sometimes labeling is really inadequate,” he adds, citing an example of an arthritis-pain-med sample that came in a blister pack of three capsules: “The box said to take 200 milligrams, but it never said that each capsule was 200 milligrams, so people were taking all three.”
Drugs can expire without a doctor or patient realizing it, too. "Pharmaceutical reps leave samples in the doctors drug cabinetin front of their competitors,” Vaida explains. That means some drugs languish on the shelf for months before they make it to you. Finally, when you get a drug off the record, youre less likely to hear about a recall because theres no log of who got what sample and lot number.
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Testing blunders
Chances are good that, at least once, youve had some sort of medical test and then waited…and waited…and waited…to get your result back. Maybe the doctors office finally got in touch (after youd driven yourself mad with worry), or maybe they never did. If you never got the resultgood or badthats an error. If you got a result saying you had a disease or condition when you didnt, or that you didnt have a disease when you really did, or that you had a disease but it turned out to be another disease, those are testing mistakes too, as is a lost lab result and mixing up your specimen with someone elses. When you consider that the average family physician sees about 100 patients a week and orders tests for 39 of those, its not hard to imagine the opportunity for blunders.
In 2006 Darrie Eason, a then-33-year-old single mother from Long Island, N.Y., was one of those unlucky few. Shed gotten the news every woman dreads: She had breast cancer, and it was aggressive. Her doctor recommended a double mastectomy, so Eason went for a second opinion and brought along the test results her first doctor had used to make his recommendation. The second doctor gave her the same advice, and she decided to have both breasts removed. “I was told I had lobular breast cancer, which everyone said would come back,” Eason told the Today show last fall. But after her double mastectomy, she learned she had never had cancer: The lab had mixed up her biopsy results with those of another woman.
What goes wrong most often?
A 2008 study found that many mistakes happened in the doing of the testit wasnt done, the specimen was lost or improperly stored, or the wrong test was performed or scheduled. Most common, though, were glitches in getting test results to the doctor in a timely way (or at all). In fact, 39% of the time, one mistake led to another, and 60% of the errors took place in an MDs office, not in a lab.
And 1 out of 10 times, the mistakes in the study resulted in pain and suffering, as in the tragic mix-up that cost Eason her healthy breasts. A doctor can also fail to get enough of a tissue, blood, or urine sample or take a sample from the wrong place, perhaps giving a false-negative result when disease is present, explains David S. Wilkinson, MD, PhD, professor and chair of the department of pathology at Virginia Commonwealth University, in Richmond, Va., and chair of the quality-practice committee for the College of American Pathologists, which accredits U.S. and foreign labs. Or, he adds, a pathologist can simply write the wrong thing in a report. “It can be a subtle error, writing ‘malignant cells seen instead of ‘no malignant cells seen.”
It gets even dicier when a test is complicated to interpret. Tests that require analyzing a tissue sample are particularly prone to error, because theres often no clear-cut interpretation. “Looking at a biopsy and deciding if its cancer and what kind is not as precise as measuring glucose in a test tube. Even knowledgeable, conscientious, well-trained people may have differences of opinion,” Dr. Wilkinson says. Hence the need for the all-important second (or third) opinion to interpret pathology results for biopsies.
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Take action now
There are simple steps you can take to guard against mistakes. First, choose your physician very carefully. Be sure shes affiliated with a top hospital. Remember: Youre not just picking an MD for an annual checkup; you may one day need her for something more serious. “A doctor affiliated with a top-notch hospital extends to you the high-quality care of all the specialists and support staff she knows there,” Dr. Gallin says.
Once youve found an MD you trust, stay loyal. Jumping from physician to physicianor popping in and out of in-store and after-hours clinics ups your odds that a key piece of information, like a test result or potential drug interaction, will slip through the cracks. If youre seeing several specialists, consider it your job to make sure all parts of your medical story are filled in on all your records, kept updated, and, most important, consolidated with all records from your different care providers. Keep your own copy, too.
It also helps to be a good (read: organized) patient. Before you land in an exam room, “know all the details of your family history and how long youve had symptoms,” Dr. Gandhi says. Also bring a list of all medications and supplements youre taking, because this can avert a medication disaster.
The time for a passive, blinders-on approach to our medical care has passed. “A lot of people are worried about alienating or insulting their doctor by asking questionswhen I was a patient I felt the same waybut a good doctor welcomes that kind of input and questioning,” Harvards Dr. Groopman says.
This approach can go a long way toward protecting you, Susan Sheridan believes. In addition to losing her husband to a delayed cancer diagnosis, her son, Cal, now 13, was the victim of lack of treatment for too-high bilirubin levels as a newborn, which resulted in kernicterus, or brain damage from severe jaundice.
“Dont be afraid to be demanding,” says Sheridan, who now works as a patient-safety advocate. “Dont be afraid to ask too many questions. Women are the number-one health-care purchasers for our families, so we can be very influential in safety. And maybe were better wired to be, because were mothers, were wives, were caretakers. We have a huge opportunity to keep ourselves and our families safer.”
Could Your Glass Cleaner Make You Sick?
The other day, my sweet husband, Frank, decided to give our kitchen a major scrub down. Unasked. I know, I know. Im a very lucky woman, and, no, you cant have his phone number.
He was well into the project when he emerged from the kitchen, pale, nauseated, sweaty, and dizzy. One glance and I knew he was in some kind of trouble. Instinctively, I suspected the cleaning supplies.
I asked him what hed been using and he named two products: Murphys Oil Soap, which we keep in a spray bottle diluted with water to use on our wooden kitchen table and cabinets, and a non-brand-name window cleaner in a blue bottle, clearly a famous brands copycat.
I didnt think Murphys was the problem, because its made from natural plant oils. The 99-cent-store glass cleaner was another story. Its label listed that its active ingredient is a chemical called 2-butoxyethanol (111-76-2). I Googled the stuff, and the very first hit absolutely shocked me. Now I was feeling dizzy.
Thats because the manufacturers product sheet said this, in capital letters: “Danger! Harmful if swallowed, inhaled, or absorbed through the skin. Causes eye irritation. Affects central nervous system, blood and blood-forming organs, kidneys, liver, and lymphoid system.”
There was more. On a “health rating” scale with 1 being “slight” and 3 being “severe”, the manufacturer rated 2-butoxyethanol a 2. The chemical also appears on the National Institutes of Health Household Products website. More products than I could count contain the stuff. Although our product didnt make the list, several other glass cleaners did; one contained a 50% concentration of 2-butoxyethanol, for example.
But heres what really made me crazy: the Centers for Disease Control says that the principal effect of 2-butoxyethanol is hematotoxicity. That means that its poisonous to the blood. My husband has chronic myeloid leukemia.
Now, not to worry. Hes fine, just fine. His condition is totally under control thanks to a miracle drug called Gleevec. Hes been fine for more than three years now and his doctor tells us hell live a long, normal life as long as he doesnt walk in front of a bus.
Or, I wonder, use products containing 2-butoxyethanol?
Luckily, as soon as Frank got into fresh air and rested for a little while, he was totally back to normal.
I know better than to use chemical cleanersespecially in enclosed, unventilated spaces; Ive written about their dangers and healthier alternatives many times. But somehow, window cleaners didnt worry me, and so I didnt yelp when Frank, the households penny-pincher, brought home his bargain brand.
Well still be penny-wise: From now on, our exclusive window cleaner will be white vinegar and water, 50/50. For more ideas on safe home-cleaning supplies, check out this slideshow.
Health24.com | How long will you live? Personality as a teen might tell
Could your teenager’s personality predict how long he or she will live?
Yes, claims new research that finds high school students who tend to be calm, empathetic and intellectually curious are more likely to still be alive 50 years later than their peers who are less so.
The finding does not prove that certain traits in adolescence actually cause people to live longer; it only reveals an association between the two.
But the conclusion stems from an in-depth analysis of personality surveys conducted in 1960, involving nearly 27 000 high school students across the United States. Those results were then stacked up against participant deaths due to all causes over nearly 50 years.
Personality characteristics
“Essentially, we find that high school students who report adaptive personality characteristics – things like high levels of calmness and low levels of impulsivity – have a lower risk of death over the ensuing half century,” said study author Benjamin Chapman. He is an associate professor in the departments of psychiatry and public health sciences at the University of Rochester Medical Center in New York.
In addition to calmness and impulsivity, the initial survey gauged teenage levels of social sensitivity; leadership; energetic disposition; self-confidence; tidiness; sociability; intellectual curiosity; and maturity.
Chapman said his team “looked initially at each trait one by one”. That meant that calmness was linked to a reduced risk of early death, whether or not the same teen also possessed other protective or risky traits.
Still, “adolescents who are more sociable tended also to be more self-confident, and so forth,” he observed, suggesting that some traits tend to group together in the same person.
Chapman also noted that personality traits were assessed on a spectrum, so that each teen was characterised as having relatively high or low levels of a particular trait. And that meant that the degree to which a teenage trait was associated with a lower premature death risk also fell across a continuum.
For example, highly mature teens saw their long-term risk for an early death fall by about 6% for every statistically significant move up along the maturity spectrum; it fell by 8% for every notable bump in calmness and energetic disposition.
Bigger trait differences would likely produce even more dramatic protective benefits, the study authors suggested.
The findings were published online in the Journal of Epidemiology & Community Health.
The initial personality survey asked more than 377 000 high schoolers to complete a battery of psychological tests back in 1960.
Death records dating up to 2009 were obtained for nearly 27 000 of them. By that point, 13% had died. The team did not assess specific causes of death.
Empathy and calmness
And regardless of a teen’s ethnic or family background, those who scored higher in terms of energy, empathy, calmness, tidiness, intellectual curiosity and maturity – as well as lower for impulsivity – faced a lower risk of death over the 48-year period.
“The insight of this work is that characteristics that we think are not particularly helpful in teens for immediate outcomes – like getting good grades, getting into college, adjusting socially and emotionally to everyday life – actually can have very long-term health consequences,” said Chapman.
“The good news is that people can and often do change,” he added. “There are many points in life between high school and a half-century later where chains of negative events can be halted or reversed in a sense.”
Kit Yarrow is professor emeritus of psychology at Golden Gate University in San Francisco. She suggested the findings make intuitive sense.
“Human connection is strongly correlated with health and happiness, so it’s no surprise that those with more empathy – our social glue – would fare better,” she said.
“Meanwhile, impulsivity is dangerous,” Yarrow added. “[And] people with stronger personal control are more likely to avoid substances and reckless behaviour which are detrimental to health.”
By contrast, “a calmer, more mature person will make better lifestyle choices that have long-reaching consequences,” she said.
William Chopik, an assistant professor of psychology at Michigan State University, agreed that personality drives the everyday health decisions that ultimately impact longevity.
“Personality is pervasive in predicting everything about us,” he said. “Who we think we are, what we achieve, the type of job we have, how we deal with stress, whether our relationships last. And now, thanks to this and other research projects, how long we live.”
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Health24.com | Can antidepressants treat your IBS?
The gut is considered the body’s second brain. This complex ecosystem might not be a thinking brain, but it does contain an extensive neural system.
The intricacies of your gut have an effect on your mood and all-round well-being. It is no wonder many doctors recommend antidepressants to patients suffering from irritable bowel syndrome (IBS).
IBS is a chronic condition that occurs in the large intestine, but its exact causes and cure are still unknown. There are various factors that are considered as possible causes of IBS.
Irregular muscle contractions in the large intestines can cause bloating, constipation, diarrhoea and excessive gas. Miscommunication and irregularities in your gut’s nervous system can result in abdominal pain and drastic changes to your bowel movements. Inflammation and infection in the intestines can also cause IBS symptoms.
Studies have shown that antidepressants in low doses can be effective in treating the symptoms of IBS. Using antidepressants for IBS is considered an off-label approach to treating the symptoms of IBS as these medications were neither manufactured nor medically approved for treating IBS.
There are three different kinds of antidepressants that are used to treat IBS. These include:
Tricyclic antidepressants
Tricyclic antidepressants act on the gut’s neurotransmitters. Some of these neurotransmitters then act on the muscle walls of the large intestine. This type of antidepressant is great for those who suffer from IBS with diarrhoea (IBS-D). Studies have shown that tricyclic antidepressants result in a reduction of loose stools in patients.
Selective Serotonin Reuptake Inhibitors
Selective Serotonin Reuptake Inhibitors are antidepressants used to combat the pain experienced with IBS. These antidepressants improve a patient’s general well-being as well as symptoms experienced in the bowel.
Serotonin-Norepinephrine Reuptake Inhibitors
Serotonin-Norepinephrine Reuptake Inhibitors, much like Selective Serotonin Reuptake Inhibitors, are used to treat gut pain symptoms.
Researchers have noted that stress can result in the onset and aggravation of IBS symptoms. Depression and anxiety have also been found to be common symptoms of those suffering from IBS. Using antidepressants can help to ease and treat these symptoms as well.
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Health24.com | Expecting a baby? You might be at risk for anaemia
Being pregnant and giving birth can be a beautiful experience; it does, however, come with its fair share of complications.
Your body goes through various changes and adjustments to accommodate the growth and development of your baby.
According to the American Society of Haematology the blood supply in your body increases by 20 to 30%.
In order to create healthy red blood cells your body needs an adequate supply of iron and vitamins.
Red blood cells
Red blood cells help to transport the oxygen in the lungs to the rest of the body. Without enough red blood cells you are at risk for anaemia.
Most pregnant women experience slight anaemia due to their increase in blood. Having mild anaemia may present symptoms like shortness of breath, dizziness and weakness.
Pregnant women may encounter three different kinds of anaemia. These are iron-deficiency, folate-deficiency and vitamin B12 deficiency anaemia. Iron, folate and vitamin B12 are absorbed by the body through foods rich in these vitamins and minerals.
Should the anaemia progress and become more severe, the lives of both mother and child may be at risk. During the pregnancy the baby may be at risk of having neural tube defects. The baby may also be pre-term and have a low birth weight. The mother may also have to undergo a blood transfusion after the birth as a result of blood loss. Growing up, the baby may experience developmental defects and delays, as well as suffering from anaemia.
How to combat anaemia
Here are some ways you can combat anaemia during pregnancy:
1. Eat foods high in folic acid
When pregnant, your baby absorbs most of your folic acid and this can lead to a folate deficiency. To improve your folic-acid levels you should eat foods that are high in this vitamin. These include green, leafy vegetables, beans, bananas and pasta.
2. Take your prenatal multi-vitamins
Taking prenatal vitamins can help to combat anaemia as well as other deficiencies experienced during pregnancy. Because your baby is absorbing most of your nutrients and minerals, you need to make sure that you have enough to sustain both of you.
3. Cooking with cast-iron pots
Cooking with cast-iron pots adds a significant amount of iron to your food. These pots and pans require less oil and are safer than modern cookware, thereby making them healthier for you and your baby.
4. Eat foods high in vitamin C
These include different citrus fruits, tomatoes, broccoli and kiwis. However, it is not recommended that you take too much. High doses of vitamin C may put your baby at risk of preterm birth.
5. Avoid foods that inhibit iron absorption
If you are anaemic, you need to increase the amount of iron in your blood stream. Eating and drinking foods like cocoa, coffee, herbal teas and foods that are rich in calcium inhibits your body’s ability to absorb enough iron. Try and reduce your intake of these foods.
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Cancer care: England still lagging behind the best
Experts say 10,000 lives a year could be saved if England was as good as the best-performing nations on cancer.
Citrate-based biomaterial fuels bone healing with less rejection
A material based on a natural product of bones and citrus fruit, called citrate, provides the extra energy that stem cells need to form new bone tissue, according to a team of Penn State bioengineers. Their new understanding of the mechanism that allows citrate to aid in bone regeneration will help the researchers develop slow-release, biodegradable, citrate-releasing scaffolds to act as bone-growth templates to speed up healing in the body.
“In our lab, we have been working with citrate for over a decade,” said Jian Yang, professor of biomedical engineering, Penn State. “We knew that in the human body, 90 percent of organic citrate is located in skeletal tissue. But no one had really tried to use citrate as a building block to make bone biomaterials. Our new paper tries to understand how citrate helps in bone healing and uses the understanding to guide the design of new biomimetic biomaterials for better bone repair.”
The team’s paper publishes today (Nov. 26) in the Proceedings of the National Academy of Sciences.
Autografting — taking bone from another part of the patient’s body and grafting it to the wound — is the method used most for bone regeneration in a hospital setting. This is not always a suitable method, especially in the case of large wounds or bone tissue removed during cancer treatment.
Synthetic biomaterials would be a welcome replacement and many labs are working on developing them. But current synthetic materials cause significant inflammation, and the bone healing rate is slow and healing quality is poor. The body encapsulates the implant with fibrotic tissues that keep the implant from integrating with surrounding bone. With Yang’s material, the researchers do not see encapsulation, and chronic inflammation is minimal.
Chuying Ma, a doctoral student in Yang’s lab, is lead author on the paper. Ma was given the problem of uncovering the poorly known mechanism underlying the body’s use of citrate to regenerate bone. She found that the stem cell membrane has a transporter that is used to transport citrate into the cell to elevate the cellular energy level. When the bone stem cells differentiate to make new bone cells, they require more energy as support for active bone formation. The timing and dosage of citrate supply to stem cells are also critical. Yang and Ma coined the newly identified citrate effect on stem cell differentiation as “metabonegenic regulation” in the paper.
The team also identified a second factor involved in energy production, an amino acid called phosphoserine. With their new understanding of the mechanism for bone regrowth, they developed a biomaterial incorporating both citrate and phosphoserine and tested it on rat models.
“Using our new material, we see the early deposition of new bone at one month,” Ma said. “This is much earlier than the biomaterials widely used in FDA-approved devices. In this study we tested two models, the femoral condyle bone and cranial bone defects.”
In both animal models we see the new biomaterial is better than the commercial materials in inducing early bone formation and also promoting bone maturation, according to Ma. “To me, this is an important finding,” said Yang, who is a faculty member in Penn State’s Materials Research Institute and the Huck Institutes of the Life Sciences. “Citrate is now recognized as a central linker between stem cell metabolism and differentiation. We are uncovering the mechanism whereby citrate influences stem cell activity, not only in bone, but by implication extending to other types of cells and tissues. For instance, there is a high concentration of citrate in the cerebrospinal fluid surrounding the brain. People can now use this understanding to start looking at citrate as a metabolism regulator to further regulate stem cells for other types of tissues and organs throughout the body.”
Along with Yang and Ma, other authors on the paper, “Citrate-based Materials Fuel Human Stem Cells by Metabonegenic Regulation,” are Jimin Kim, Dingying Shan, QiaolingLin and Maria Hudock, all current or former students in Yang’s lab; and Xinggui Tian, Denghui Xie, Xiang Ao and Xiaochun Bai, all of Southern Medical University, China. The National Institutes of Health, a Cystic Fibrosis Foundation Research Award, and the National Natural Sciences Foundation of China supported this research.
Story Source:
Materials provided by Penn State. Original written by Walt Mills. Note: Content may be edited for style and length.

Effort clarifies major branch of insect tree of life
The insects known as Hemiptera are not a particularly glamorous bunch. This group includes stink bugs, bed bugs, litter bugs, scale insects and aphids. Their closest relatives are thrips, bark lice and parasitic lice. But with a massive number of species, two-thirds of which are still unknown to science, these insects together make up one of the twiggiest branches of the tree of life.
A new study published in the Proceedings of the National Academy of Sciences collected a vast amount of molecular data on these insects and used the information to help tease out their family relationships and evolutionary history. The findings — and the data, which are now publicly available — will aid future research into some of the most abundant and economically important insects on the planet, the researchers said.
“There are 120,000 known species in this group, which is maybe a third of what’s actually out there,” said Illinois Natural History Survey entomologist Christopher Dietrich, who led the study with INHS ornithologist Kevin Johnson. “To put that in perspective, that’s more than all the vertebrates combined. It’s a massively diverse group. They cover the planet. They’re in every habitat.”
Many of these insects feed on plants and animals and can be seen as pests, Dietrich said. But they also provide food for birds, insectivorous mammals, reptiles, amphibians and other predacious insects.
“Many of them form the first link of the food chain, converting plant material into protein that can be used by other animals,” he said.
Among this group are many, like aphids and planthoppers, that afflict crops; others, such as body lice and certain assassin bugs, transmit disease, Dietrich said.
To sort out these insects’ family relationships and history, the researchers analyzed nearly 2,400 protein-coding genes, their expression in the form of messenger RNA and the resulting amino-acid sequences. It was a massive effort involving collaborators in China, Europe, Japan and across the United States.
“We wanted to use newer sequencing technologies to address how all these major groups of hemipteroid insects related to each other,” Johnson said. “This is probably one of the largest data sets in existence for insects.”
The effort yielded several key findings. The most interesting of these had to do with the development of special mouthparts in some members of this group, the researchers said.
“The earliest, most primitive insects just had a pair of mandibles to chew, like ants do,” Dietrich said. “But some groups went off in a different direction.”
For those, the mandibles gradually evolved into sturdy narrow tubes that could pierce things and suck out the juices. “It was a major shift in feeding strategy,” Dietrich said. “All the insects to this point had just been chomping on things.”
The team’s molecular divergence estimate revealed that the evolution of piercing and sucking mouthparts likely occurred more than 350 million years ago. Similar mouthparts evolved independently in parasitic lice and other insects with the trait, such as mosquitoes.
“According to the fossil record, this group became the dominant group of insects on Earth in the Permian, 300 million years ago to 250 million years ago,” Dietrich said. “But at the end of the Permian they underwent a mass extinction, which was worse than the one that killed off the dinosaurs a couple hundred million years later.”
Eventually, the Hemiptera, along with the orders representing thrips and lice, were eclipsed by another group of insects, the Holometabola, which undergo complete metamorphosis and are even more diverse. Holometabola include butterflies, moths, ants, bees, flies and beetles.
Though more robust than other genetic studies of this group of insects, the new analysis has not fully resolved the relationship between the order that includes bark lice and parasitic lice, and the hemiptera and thrips, which likely belong to the same superorder, the researchers said. But the study sets the stage for future work, and an improved understanding of how some of the less charismatic, but ecologically essential, insects evolved.
The INHS is a division of the Prairie Research Institute at the University of Illinois at Urbana-Champaign.
The U.S. National Science Foundation supported this research.

NASA InSight lander arrives on Martian surface to learn what lies beneath
Mars has just received its newest robotic resident. NASA’s Interior Exploration using Seismic Investigations, Geodesy and Heat Transport (InSight) lander successfully touched down on the Red Planet after an almost seven-month, 300-million-mile (458-million-kilometer) journey from Earth.
InSight’s two-year mission will be to study the deep interior of Mars to learn how all celestial bodies with rocky surfaces, including Earth and the Moon, formed.
InSight launched from Vandenberg Air Force Base in California May 5. The lander touched down Monday, Nov. 26, near Mars’ equator on the western side of a flat, smooth expanse of lava called Elysium Planitia, with a signal affirming a completed landing sequence at 11:52:59 a.m. PST (2:52:59 p.m. EST).
“Today, we successfully landed on Mars for the eighth time in human history,” said NASA Administrator Jim Bridenstine. “InSight will study the interior of Mars and will teach us valuable science as we prepare to send astronauts to the Moon and later to Mars. This accomplishment represents the ingenuity of America and our international partners, and it serves as a testament to the dedication and perseverance of our team. The best of NASA is yet to come, and it is coming soon.”
The landing signal was relayed to NASA’s Jet Propulsion Laboratory (JPL) in Pasadena, California, via NASA’s two small experimental Mars Cube One (MarCO) CubeSats, which launched on the same rocket as InSight and followed the lander to Mars. They are the first CubeSats sent into deep space. After successfully carrying out a number of communications and in-flight navigation experiments, the twin MarCOs were set in position to receive transmissions during InSight’s entry, descent and landing.
From Fast to Slow
“We hit the Martian atmosphere at 12,300 mph (19,800 kilometers per hour), and the whole sequence to touching down on the surface took only six-and-a-half minutes,” said InSight project manager Tom Hoffman at JPL. “During that short span of time, InSight had to autonomously perform dozens of operations and do them flawlessly — and by all indications that is exactly what our spacecraft did.”
Confirmation of a successful touchdown is not the end of the challenges of landing on the Red Planet. InSight’s surface-operations phase began a minute after touchdown. One of its first tasks is to deploy its two decagonal solar arrays, which will provide power. That process begins 16 minutes after landing and takes another 16 minutes to complete.
The InSight team expects a confirmation later Monday that the spacecraft’s solar panels successfully deployed. Verification will come from NASA’s Odyssey spacecraft, currently orbiting Mars. That signal is expected to reach InSight’s mission control at JPL about five-and-a-half hours after landing.
“We are solar powered, so getting the arrays out and operating is a big deal,” said Tom Hoffman at JPL. “With the arrays providing the energy we need to start the cool science operations, we are well on our way to thoroughly investigate what’s inside of Mars for the very first time.”
InSight will begin to collect science data within the first week after landing, though the teams will focus mainly on preparing to set InSight’s instruments on the Martian ground. At least two days after touchdown, the engineering team will begin to deploy InSight’s 5.9-foot-long (1.8-meter-long) robotic arm so that it can take images of the landscape.
“Landing was thrilling, but I’m looking forward to the drilling,” said InSight principal investigator Bruce Banerdt of JPL. “When the first images come down, our engineering and science teams will hit the ground running, beginning to plan where to deploy our science instruments. Within two or three months, the arm will deploy the mission’s main science instruments, the Seismic Experiment for Interior Structure (SEIS) and Heat Flow and Physical Properties Package(HP3) instruments.”
InSight will operate on the surface for one Martian year, plus 40 Martian days, or sols, until Nov. 24, 2020. The mission objectives of the two small MarCOs which relayed InSight’s telemetry was completed after their Martian flyby.
“That’s one giant leap for our intrepid, briefcase-sized robotic explorers,” said Joel Krajewski, MarCO project manager at JPL. “I think CubeSats have a big future beyond Earth’s orbit, and the MarCO team is happy to trailblaze the way.”
With InSight’s landing at Elysium Planitia, NASA has successfully soft-landed a vehicle on the Red Planet eight times.
“Every Mars landing is daunting, but now with InSight safely on the surface we get to do a unique kind of science on Mars,” said JPL director Michael Watkins. “The experimental MarCO CubeSats have also opened a new door to smaller planetary spacecraft. The success of these two unique missions is a tribute to the hundreds of talented engineers and scientists who put their genius and labor into making this a great day[BA(1].”
JPL manages InSight for NASA’s Science Mission Directorate. InSight is part of NASA’s Discovery Program, managed by the agency’s Marshall Space Flight Center in Huntsville, Alabama. The MarCO CubeSats were built and managed by JPL. Lockheed Martin Space in Denver built the InSight spacecraft, including its cruise stage and lander, and supports spacecraft operations for the mission.
A number of European partners, including France’s Centre National d’Études Spatiales (CNES) and the German Aerospace Center (DLR), are supporting the InSight mission. CNES, and the Institut de Physique du Globe de Paris (IPGP), provided the SEIS instrument, with significant contributions from the Max Planck Institute for Solar System Research (MPS) in Germany, the Swiss Institute of Technology (ETH) in Switzerland, Imperial College and Oxford University in the United Kingdom, and JPL. DLR provided the HP3 instrument, with significant contributions from the Space Research Center (CBK) of the Polish Academy of Sciences and Astronika in Poland. Spain’s Centro de Astrobiología (CAB) supplied the wind sensors.
For more information about InSight, visit:
For more information about MarCO, visit:
https://www.jpl.nasa.gov/cubesat/missions/marco.php
For more information about NASA’s Mars missions, go to:









