Health24.com | What’s the low-FODMAP diet?

If you suffer from IBS, you may have come across suggestions to give a low-FODMAP diet a go. But what exactly does it entail? Can it be described as a “diet”? And could it drastically improve your symptoms? We break down the basics.

What is FODMAP?

The abbreviation FODMAP stands for:

  • Fermentable,
  • Oligosaccharides,
  • Disaccharides,
  • Monosaccharides, and
  • Polyols

These are carbohydrates (sugars) found in many common foods. When poorly absorbed, they cause IBS symptoms. Research has found that limiting FODMAPs in your diet could have a favourable effect on those with IBS. In an Australian study, 75% of IBS patients showed improvements in their symptoms on the low-FODMAP diet.

Why do FODMAPs trigger symptoms of IBS?

According to About IBS, the small FODMAP molecules cause an osmotic effect in the small and large intestine – this means that more fluid is attracted to the bowel, which ultimately causes discomfort and bloating. These FODMAPs also ferment rapidly when the colonic microflora produce gas. When gas increases, this additionally causes discomfort and bloating. It also affects how the muscles in the bowel contract, causing increased peristalsis (movement of the digestive tract), which leads to diarrhoea.

Normal digestive systems also respond to the malabsorption of FODMAPs in food, but in people with IBS, the effect of FODMAPs may be amplified because of the following reasons:

  • The muscles of the bowel respond more rapidly, meaning that this could either cause faster or slower movement through the gut, leading to either diarrhoea or constipation.
  • The gut of someone with IBS is hypersensitive to any changes and people with IBS may feel abdominal pain much more quickly than someone without IBS, even though the same process occurs.
  • The type of bacteria also plays a role – they may produce a larger amount of gas, or there may be an overgrowth of gut bacteria (small intestinal bacterial overgrowth, also referred to as SIBO). 

Why the FODMAP diet doesn’t always work

Criticism of a low-FODMAP diet includes that it could be very limiting and cause over-restriction and a lack of crucial nutrition. However, experts agree that the focus should be on “low” FODMAP and not “no” FODMAP.

According to the Harvard Medical School, someone who suffers from IBS and wants to benefit from a low-FODMAP diet should not restrict all foods on the FODMAP list but should only limit problematic foods in a category.

It is also important to understand that the low-FODMAP diet is a process of elimination based on foods which an individual does not respond well to, and not a list of foods that someone with IBS should avoid as a whole.

“In my practice I find some people are not good candidates for an elimination diet, particularly those at risk for eating disorders, those with little control over their food (such as people living in community situations), and those whose diet history reveals that they are already following an instinctively-determined low-FODMAP diet,” says Patsy Catsos, a registered dietitian.  

High-FODMAP foods include: Onions, garlic, vegetables, such as asparagus, cauliflower, fresh beetroot, mushrooms, fermented foods, such as sauerkraut, a broad variety of legumes, such as kidney beans and black beans, fruits, such as apples, blueberries, pomegranates, avocado and dates, processed meats and refined starch, such as biscuits and cereals, processed condiments, such as tomato sauce, and dairy products, such as cheese and full-fat milk.

Low-FODMAP foods include: Vegetables, such as carrots, bell peppers, aubergine and leafy greens, fruits, such as grapes, papaya, unripe bananas, strawberries and kiwifruit, unprocessed sources of protein, such as lean beef, chicken and seafood, and grain-free, gluten-free breads and cereals. 

*For a comprehensive list of high- and low-FODMAP foods, see this link.

Important to know

Speak to your doctor or a registered dietitian before diagnosing yourself with IBS.

Always have realistic expectations on the low-FODMAP diet – many people with IBS expect to be symptom-free after avoiding all the foods on the list. It doesn’t work like that.

“Learning more about how your body reacts to FODMAPs can empower you to manage your IBS more effectively,” says Catsos. 

You should also be aware of your fibre intake. One mistake that IBS patients often make is to eliminate all sources of fibre – fibre is crucial for the proper functioning of the digestive system.

Ensure that you get plenty of fibre by including fruits, vegetables, grains, legumes, nuts and seeds from the low-FODMAP list. These fibres are fermented slowly and are less likely to lead to more fluid in the gut, according to the International Foundation for Functional Gastrointestinal Disorders (IFFGD).

The solution is to deliberately increase your intake of fibre from low-FODMAP foods: Eat a wide variety of low-FODMAP fruits and vegetables, low-FODMAP grains and legumes, and small servings of low-FODMAP nuts and seeds.

*Disclaimer: The foods mentioned in this article form part of an extremely condensed list – those who wish to follow a low-FODMAP diet should work in conjunction with their doctors and/or nutritionists. 

Image credit: iStock

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Oldest weapons ever discovered in North America pre-date Clovis

Texas A&M University researchers have discovered what are believed to be the oldest weapons ever found in North America: ancient spear points that are 15,500 years old. The findings raise new questions about the settlement of early peoples on the continent.

Michael Waters, distinguished professor of anthropology and director of the Center for the Study of the First Americans at Texas A&M, and colleagues from Baylor University and the University of Texas have had their work published in the current issue of Science Advances.

The team found the numerous weapons — about 3-4 inches long — while digging at what has been termed the Debra L. Friedkin site, named for the family who owns the land about 40 miles northwest of Austin in Central Texas. The site has undergone extensive archaeological work for the past 12 years.

Spear points made of chert and other tools were discovered under several feet of sediment that dating revealed to be 15,500 years old, and pre-date Clovis, who for decades were believed to be the first people to enter the Americas.

“There is no doubt these weapons were used for hunting game in the area at that time,” Waters said. “The discovery is significant because almost all pre-Clovis sites have stone tools, but spear points have yet to be found. These points were found under a layer with Clovis and Folsom projectile points. Clovis is dated to 13,000 to 12,700 years ago and Folsom after that. The dream has always been to find diagnostic artifacts — such as projectile points — that can be recognized as older than Clovis and this is what we have at the Friedkin site.”

Clovis is the name given to the distinctive tools made by people starting around 13,000 years ago. The Clovis people invented the “Clovis point,” a spear-shaped weapon made of stone that is found in Texas and parts of the United States and northern Mexico and the weapons were made to hunt animals, including mammoths and mastodons, from 13,000 to 12,700 years ago.

“The findings expand our understanding of the earliest people to explore and settle North America,” Waters said. “The peopling of the Americas during the end of the last Ice Age was a complex process and this complexity is seen in their genetic record. Now we are starting to see this complexity mirrored in the archaeological record.”

The project was funded by The North Star Archaeological Research Program and the Elfrieda Frank Foundation.

Story Source:

Materials provided by Texas A & M University. Original written by Keith Randall. Note: Content may be edited for style and length.

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Small flying robots haul heavy loads

A closed door is just one of many obstacles that poses no barrier to a new type of flying, micro, tugging robot called a FlyCroTug. Outfitted with advanced gripping technologies and the ability to move and pull on objects around it, two FlyCroTugs can jointly lasso the door handle and heave the door open.

Developed in the labs of Mark Cutkosky, the Fletcher Jones Chair in the School of Engineering at Stanford University, and Dario Floreano at the École Polytechnique Fédérale de Lausanne in Switzerland, FlyCroTugs are micro air vehicles that the researchers have modified so the vehicles can anchor themselves to various surfaces using adhesives inspired by the feet of geckos and insects, previously developed in Cutkosky’s lab.

With these attachment mechanisms, FlyCroTugs can pull objects up to 40 times their weight, like door handles in one scenario, or cameras and water bottles in a rescue situation. Similar vehicles can only lift objects about twice their own weight using aerodynamic forces.

“When you’re a small robot, the world is full of large obstacles,” said Matthew Estrada, a graduate student at Stanford and lead author of a paper on FlyCroTugs, published Oct. 25 in Science Robotics. “Combining the aerodynamic forces of our aerial vehicle along with interaction forces that we generate with the attachment mechanisms resulted in something that was very mobile, very forceful and micro as well.”

The researchers say the FlyCroTugs’ small size means they can navigate through snug spaces and fairly close to people, making them useful for search and rescue. Holding tightly to surfaces as they tug, the tiny robots could potentially move pieces of debris or position a camera to evaluate a treacherous area.

Taking a cue from nature

As with most projects in Cutkosky’s lab, the FlyCroTugs were inspired by the natural world. Hoping to have an air vehicle that was fast, small and highly maneuverable but also able to move large loads, the researchers looked to wasps.

“Wasps can fly rapidly to a piece of food, and then if the thing’s too heavy to take off with, they drag it along the ground. So this was sort of the beginning inspiration for the approach we took,” said Cutkosky, who is a co-author of the paper.

The researchers read studies on wasp prey capture and transport, which identify the ratio of flight-related muscle to total mass that determines whether a wasp flies with its prey or drags it. They also followed the lead of the wasp in having different attachment options depending on where the FlyCroTugs land.

For smooth surfaces, the robots have gecko grippers, non-sticky adhesives that mimic a gecko’s intricate toe structures and hold on by creating intermolecular forces between the adhesive and the surface. For rough surfaces, these robots are equipped with 32 microspines, a series of fishhook-like metal spines that can individually latch onto small pits in a surface.

Each FlyCroTug has a winch with a cable and either microspines or gecko adhesive in order to tug. Beyond those fixed features they are otherwise highly modifiable. The location of the grippers can vary depending on the surface where they will be landing, and the researchers can also add parts for ground-based movement, such as wheels. Getting all of these features onto a small air vehicle with twice the weight of a golf ball was no small feat, according to the researchers.

“People tend to think of drones as machines that fly and observe the world, but flying insects do many other things — such as walking, climbing, grasping, building — and social insects can even cooperate to multiply forces,” said Floreano, who was senior author on the paper. “With this work, we show that small drones capable of anchoring to the environment and collaborating with fellow drones can perform tasks typically assigned to humanoid robots or much larger machines.”

Interacting with the world

Drones and other small flying robots may seem like all the rage these days but the FlyCroTugs — with their ability to navigate to remote locations, anchor and pull — fall into a more specific niche, according to Cutkosky.

“There are many laboratories around the world that are starting to work with small drones or air vehicles, but if you look at the ones that are also thinking about how these little vehicles can interact physically with the world, it’s a much smaller set,” he said.

The researchers can successfully open a door with two FlyCroTugs. They also had one fly atop a crumbling structure and haul up a camera to see inside. Next, they hope to work on autonomous control and the logistics of flying several vehicles at once.

“The tools to create vehicles like this are becoming more accessible,” said Estrada. “I’m excited at the prospect of increasingly incorporating these attachment mechanisms into the designer’s tool belt, enabling robots to take advantage of interaction forces with their environment and put these to useful ends.”

Additional co-authors of this paper are Stefano Mintchev of EPFL and David Christensen, who was at Stanford at the time of the research. This work was funded by the Swiss National Science Foundation, the National Science Foundation, a Swiss Government Excellence Scholarship and the United States Army Research Laboratory MAST program.

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New CRISPR tool opens up more of the genome for editing

The genome editing system CRISPR has become a hugely important tool in medical research, and could ultimately have a significant impact in fields such as agriculture, bioenergy, and food security.

The targeting system can travel to different points on the genome, guided by a short sequence of RNA, where a DNA-cutting enzyme known as Cas9 then makes the desired edits.

However, despite the gene-editing tool’s considerable success, CRISPR-Cas9 remains limited in the number of locations it can visit on the genome.

That is because CRISPR needs a specific sequence flanking the target location on the genome, known as a protospacer adjacent motif, or PAM, to allow it to recognize the site.

For example, the most widely used Cas9 enzyme, Streptococcus pyogenes Cas9 (SpCas9), requires two G nucleotides as its PAM sequence, significantly restricting the number of locations it can target, to around 9.9 percent of sites on the genome.

As yet, there are only a handful of CRISPR enzymes with minimal PAM requirements, meaning they are able to target a wider range of locations.

Now researchers at the MIT Media Lab, led by Joseph Jacobson, a professor of media arts and sciences and head of the Molecular Machines research group, have discovered a Cas9 enzyme that can target almost half of the locations on the genome, significantly widening its potential use. They report their findings in the Science Advances.

“CRISPR is like a very accurate and efficient postal system, that can reach anywhere you want to go very precisely, but only if the ZIP code ends in a zero,” Jacobson says. “So it is very accurate and specific, but it limits you greatly in the number of locations you can go to.”

To develop a more general CRISPR system, the researchers implemented computational algorithms to conduct a bioinformatics search of bacterial sequences, to determine if there were any similar enzymes with less restrictive PAM requirements.

To carry out the search, the researchers developed a data analysis software tool, which they called SPAMALOT (Search for PAMs by Alignment of Targets).

This revealed a number of interesting possible enzymes, but no clear winner. So the team then built synthetic versions of the CRISPRs in the laboratory, to evaluate their performance.

They found that the most successful enzyme, a Cas9 from Streptococcus canis (ScCas9), was strikingly similar to the Cas9 enzyme already widely used, according to co-lead author Pranam Chatterjee, a graduate student in the Media Lab, who carried out the research alongside fellow graduate student Noah Jakimo.

“The enzyme looks almost identical to the one that was originally discovered … but it is able to target DNA sequences that the commonly used enzyme cannot,” Chatterjee says.

Rather than two G nucleotides as its PAM sequence, the new enzyme needs just one G, opening up far more locations on the genome.

This should allow CRISPR to target many disease-specific mutations that have previously been out of reach of the system.

For example, a typical gene is around 1,000 bases in length, giving researchers a number of different locations to target if their aim is to simply knock out the entire gene, Jacobson says.

However, many diseases, such as sickle cell anemia, are caused by the mutation of a single base, making them much more difficult to target.

“Base editing is not just a matter of hitting that gene anywhere over the 1,000 bases and knocking it out; it is a matter of going in and correcting, in a very precise way, that one base that you want to change,” Jacobson says.

“You need to be able to go to that very exact location, put your piece of CRISPR machinery right next to it, and then with a base editor — another protein that’s attached to the CRISPR — go in and repair or change the base,” he says.

The new CRISPR tool could be particularly helpful in such applications.

“We are excited to get ScCas9 into the hands of the genome editing community and receive their feedback for future development,” Chatterjee says.

The researchers are now hoping to use their technique to find other enzymes that could expand the targeting range of the CRISPR system even further, without reducing its accuracy, according to Jacobson.

“We feel confident of being able to go after every address on the genome,” he says.

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Health24.com | Govt’s free sanitary pads projects earmarked to start in November

South Africans who menstruate are a step closer to free sanitary pads as government scraps the Value Added Tax (VAT) on sanitary pads from April 2019. 

Finance minister Tito Mboweni made the announcement during his Medium Term Budget Policy Statement (MTBPS) on Wednesday‚ which outlines how government will spend money in the next three years.

Bread and cake flour will also be exempt from VAT. 

The announcement to do away with the VAT on sanitary pads comes after years of activism and campaigns from civil society and ordinary South Africans. 

“It may have taken years to get to this point but the hard work, frustrations and run-arounds made it all worth it. Just to know that millions of people particularly from disadvantaged groups will benefit from this makes all the hard work worth it. Thank you, Minister,” says Sheilan Clarke who was part of Livity Africa’s #FreeToBleed campaign.

Mboweni also announced funds will be allocated to provinces to provide free sanitary pads to poor learners who menstruate.

“We will ensure that female learners in schools have access to sanitary pads.

“Several provinces have already taken the lead in rolling out the provision of free sanitary pads in schools. Funds will be added to the provincial equitable share to enable provinces to progressively further this objective,” he said in his speech. 

According to a 2014 study published in the British Journal of Medicine & Medical Research, the average person who menstruates will use up to 17 000 sanitary pads or tampons in their lifetime.

If a packet of disposable pads typically costs R45.00, one pad is about R2.80. A person could spend close to R48 000 in their lifetime. But zero-rating sanitary pads could equate to a saving of about R5 per packet — or R5000 in a lifetime.  

Zero-rating sanitary pads doesn’t make a difference for those who cannot afford them, says economist Thabi Leoka.

“What is important is not the zero-rating, but that government intend to allocate money for free sanitary pads for school-going learners who make up a large proportion of those who need sanitary pads. ”

In July 2017, the Department of Women in the Presidency hosted a stakeholders meeting where together with civil society and other governmental departments deliberated how the South African government would provide free sanitary pads to poor people who menstruation.

Delegates were presented with the department’s Sanitary Dignity Policy Framework which outlined the proposed roll-out plan for free sanitary pads. 

“We presented the framework to Cabinet in October 2017. Cabinet recommended the policy framework  developed further  that can be implemented and piloted to see how much it would cost government,” says Reshoketswe Tshabalala, the department’s Acting Director General. 

Cabinet selected Mpumalanga, Eastern Cape and KwaZulu Natal and the department will oversee the pilot projects which are earmarked to begin in November.

 “It’s not just about providing sanitary pads. We need to ensure that there adequate disposal facilities, availability of water and proper sanitation to ensure that menstrual health is managed” says the department.

– Health-e

Image credit: iStock

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Health24.com | ‘I’m a man and I survived breast cancer – this is my story’

In June 2013, the National Director at Legal Resources Centre, Nersan Govender’s life changed when he was diagnosed with breast cancer. 

Speaking to DRUM, the 56-year-old said that there’s a stigma around breast cancer which is that it’s a women’s disease, but in reality, men also have breast tissues and can get breast cancer too.

This is his story:

“It was about five years ago and I discovered a pimple under my left nipple. I had no pain, nothing at all. I was energetic so you wouldn’t tell. That’s the thing about breast cancer even with women, you don’t really know it.

“So, what I discovered was a pimple and I thought it would go away. I went to the chemist and got an ointment, but the pimple never went away. It just started growing and eventually I went to an outpatient health facility and I was told that I have to go have a biopsy done.

“I had a biopsy done and that’s when I discovered I had breast cancer, and that it was spreading rapidly. With breast cancer for men, there are not many survivors simply because they don’t know and they don’t check.

Treatment challenges

“So, I went for the surgery, I went for the radiation, then I went through chemotherapy – it was a difficult time for my family and me. The treatment was for about 10 months. It was very hard — the treatment is actually harder than the cancer itself.

“Sometimes you just want to give up. This is when I discovered support groups. Wings of Hope was a group I discovered and it was still new. They helped me through difficult times and as I started to heal, I joined them as a volunteer.

“Today I head the organisation. I re-positioned it because support is not only about talking about treatment, but it’s about quality of life. 

A new kind of normal

“We try to teach people to have the quality of life and to value every single day, but also try to extend it to the families, because the families need to understand that they add stress when they say you need to be normal, but you can’t be normal. You will be a new normal.

“There were some days where I prayed to die, because during the treatment you’re alive, but you feel dead. I’ve watched some people die in less then a week from chemo. 

“Today I can proudly say that I am a breast cancer survivor. I have two birthdays now — the day I was biologically born and the day I got given a new life.”

This year Nersan celebrates his first remission. He lives by the motto, “Live your life every day.”

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