Over 70% of patients with ovarian cancer are diagnosed at an advanced stage, often presenting with large volumes of ascites. This ascites fluid not only supports the spread of cancer throughout the abdominal cavity but also significantly impairs the body’s immune defences. Understanding how ascites affects the immune system is important for developing better treatments that use the immune system to fight cancer.

In this recent study, researchers from Trinity College Dublin and University College Dublin explored how ascites disrupts immune cell function, with a particular focus on natural killer (NK) cells and T cells, which are key players in the body’s ability to eliminate tumours.

By analysing the contents of ascites fluid from ovarian cancer patients, the team identified a group of fat molecules called phospholipids as key drivers of this immune dysfunction.

Dr Karen Slattery, Research Fellow in the Trinity Translational Medicine Institute, is the first author of the research article just published in leading international journal Science Immunology. She said: “We found that these lipids interfere with NK cell metabolism and suppress their ability to kill cancer cells. Crucially, we also discovered that blocking the uptake of these phospholipids into NK cells using a specific receptor blocker can restore their anti-tumour activity, which offers a compelling new target for therapeutic intervention.”

“This work adds a critical piece to the puzzle of why ovarian cancer is so aggressive and has such poor outcomes. While the immune system is naturally equipped to detect and destroy cancer cells, this function is switched off in many individuals with ovarian cancer, and we now know that this is in part due to the fat-rich environment created by ascites.”

Prof. Lydia Lynch, formerly based in Trinity and now in Princeton University, is the senior author of the research article. She said: “This study marks a significant advancement in ovarian cancer research, identifying a new mechanism underpinning immune failure and laying the foundation for new therapies that could restore immune function in these patients. By targeting the fat-induced suppression of immune cells, future treatments could empower the body’s own immune defences to fight back and in doing so, improve outcomes for ovarian cancer patients.”

Humans are the only species on earth known to use language. They do this by combining sounds into words and words into sentences, creating infinite meanings. This process is based on linguistic rules that define how the meaning of calls is understood in different sentence structures. For example, the word “ape” can be combined with other words to form compositional sentences that add meaning: “the ape eats” or append meaning: “big ape,” and non-compositional idiomatic sentences that create a completely new meaning: “go ape.” A key component of language is syntax, which determines how the order of words affects meaning, for instance how “go ape” and “ape goes” convey different meanings.

One fundamental question in science is to understand where this extraordinary capacity for language originates from. Researchers often use the comparative approach to trace the evolutionary origins of human language by comparing the vocal production of other animals, particularly primates, with that of humans. Unlike humans, other primates typically rely on single calls (referred to as call types), and while some species combine calls, these combinations are only a few per species and mostly serve to alert others to the presence of predators. This suggests that their communication systems may be too restricted to be a precursor to the complex, open-ended combinatorial system that is human language. However, we may not have a full picture of the linguistic capacities of our closest living relatives, particularly how they might use call combinations to significantly expand their meaning.

Studying the meaning of chimpanzee vocalisations

Researchers from the Max Planck Institutes for Evolutionary Anthropology and for Cognitive and Brain Sciences in Leipzig, Germany, and from the Cognitive Neuroscience Center Marc Jeannerod (CNRS/Université Claude Bernard Lyon 1) and Neuroscience Research Center (CNRS/Inserm/Université Claude Bernard Lyon 1) in Lyon, France recorded thousands of vocalisations from three groups of wild chimpanzees in the Taï National Park in Ivory Coast. They examined how the meanings of 12 different chimpanzee calls changed when they were combined into two-call combinations. “Generating new or combined meanings by combining words is a hallmark of human language, and it is crucial to investigate whether a similar capacity exists in our closest living relatives, chimpanzees and bonobos, in order to decipher the origins of human language,” says Catherine Crockford, senior author of the study. “Recording chimpanzee vocalisations over several years in their natural environment is essential in order to document their full communicative capabilities, a task that is becoming increasingly challenging due to growing human threats to wild chimpanzee populations,” says Roman Wittig, co-author of the study and director of the Taï Chimpanzee Project.

Chimpanzees’ complex communication system

The study reveals four ways in which chimpanzees alter meanings when combining single calls into 16 different two-call combinations, analogous to the key linguistic principles in human language. Chimpanzees used compositional combinations that added meaning (e.g., A = feeding, B = resting, AB = feeding + resting) and clarified meaning (e.g., A = feeding or travelling, B = aggression, AB = travelling). They also used non-compositional idiomatic combinations that created entirely new meanings (e.g., A = resting, B = affiliation, AB = nesting). Crucially, unlike previous studies which have mostly reported call combinations in limited situations such as predator encounters, the chimpanzees in this study expanded their meanings through the versatile combination of most of their single calls into a large diversity of call combinations used in a wide range of contexts.

“Our findings suggest a highly generative vocal communication system, unprecedented in the animal kingdom, which echoes recent findings in bonobos suggesting that complex combinatorial capacities were already present in the common ancestor of humans and these two great ape species,” says Cédric Girard-Buttoz, first author on the study. He adds: “This changes the views of the last century which considered communication in the great apes to be fixed and linked to emotional states, and therefore unable to tell us anything about the evolution of language. Instead, we see clear indications here that most call types in the repertoire can shift or combine their meaning when combined with other call types. The complexity of this system suggests either that there is indeed something special about hominid communication — that complex communication was already emerging in our last common ancestor, shared with our closest living relatives — or that we have underestimated the complexity of communication in other animals as well, which requires further study.”

The research team published their findings in the American Journal of Botany.

The fossils, at least two million years old, represent the first direct evidence of an endangered tropical tree species in the fossil record. The research study, conducted in collaboration with the University of Brunei among other international partners, identified fossilized leaves of Dryobalanops rappa, known locally as the Kapur Paya. It is a towering dipterocarp tree that still exists today but is endangered and found in the carbon-rich peatlands of Borneo, including Brunei.

“This discovery provides a rare window into the ancient history of Asia’s wet tropical forests,” said Tengxiang Wang, a doctoral student in the College of Earth and Mineral Sciences at Penn State and lead author on the paper. “We now have fossil proof that this magnificent tree species has been a dominant part of Borneo’s forests for millions of years, emphasizing its ecological importance and the need to protect its remaining habitats.”

Until now, the fossil record of Asia’s wet tropical forests has been surprisingly scarce compared to the Amazon and Africa, said Peter Wilf, professor of geosciences at Penn State and co-author.

The team identified the fossils by analyzing microscopic features of the preserved leaf cuticles, which revealed a perfect match with modern Dryobalanops rappa, down to the last cellular detail.

“Our findings highlight that these forests are not just rich in biodiversity today but have been home to iconic tree species for millions of years,” Wang said. “Conserving them is not only about protecting present-day species but also about preserving a legacy of ecological resilience that has withstood millions of years.”

Dipterocarps, the dominant tree family in Asia’s rainforests, are critical for carbon storage and biodiversity. However, the researchers said, they are increasingly threatened by deforestation and habitat destruction. By revealing the deep historical roots of these trees, this discovery adds an important new perspective to conservation efforts.

“The findings add a new dimension to conservation; we are not only protecting modern species but ancient survivors that have been key components of their unique ecosystems for millions of years,” Wang said. “This historical perspective makes both the endangered trees and their habitats even more valuable for conservation. Our study also shows how fossil evidence can strengthen conservation strategies for threatened species and ecosystems based on their historical significance.”

Understanding the history of tropical forests is essential for their conservation, especially as many key species face rapid decline, Wilf said.

“Penn State’s paleobotany group is making exciting fossil discoveries with our international partners in several Southeast Asian countries, illuminating the poorly known history of the region’s magnificent and severely threatened tropical forests,” Wilf said. “Our finding fossils of living, endangered, giant tree species provides a vital historical foundation for conserving tropical Asia’s keystone trees, the rapidly disappearing dipterocarps.”

Two collaborators on the paper are Penn State alumni: Michael Donovan, The Field Museum; and Xiaoyu Zou, University of California San Diego. Additionally, collaborators from other institutions include Antonino Briguglio, Università degli Studi di Genova; László Kocsis, University of Lausanne; and Ferry Silk, Universiti Brunei Darussalam.

The research was supported by the U.S. National Science Foundation, Universiti Brunei Darussalam research grants and a Penn State Institute of Energy and the Environment seed grant.

Hydrogels are gels composed of polymers that can absorb and retain large amounts of water. They are widely used in wound dressings, drug delivery, tissue engineering, soft robotics, soft contact lenses and more.

Gel formation within minutes

Traditional hydrogel manufacturing relies on chemical initiators, some of which can be harmful, particularly in medical applications. Initiators are the chemicals used to trigger chemical chain reactions. The McGill research team, led by Mechanical Engineering Professor Jianyu Li, has developed an alternative method using ultrasound. When applied to a liquid precursor, sound waves create microscopic bubbles that collapse with immense energy, triggering gel formation within minutes.

“The problem we aimed to solve was the reliance on toxic chemical initiators,” said Li. “Our method eliminates these substances, making the process safer for the body and better for the environment.”

This ultrasound-driven technique is dubbed “sonogel.”

“Typical hydrogel synthesis can take hours or even overnight under UV light,” said Li. “With ultrasound, it happens in just five minutes.”

Revolutionizing biomedical applications

One of the most exciting possibilities for this technology is in non-invasive medical treatments. Because ultrasound waves can penetrate deep into tissues, this method could enable in-body hydrogel formation without surgery.

“Imagine injecting a liquid precursor and using ultrasound to solidify it precisely where needed,” said Li. “This could be a game-changer for treating tissue damage and regenerative medicine. Further refinement, we can unlock new possibilities for safer, greener material production.”

The technique also opens the door to ultrasound-based 3D bioprinting. Instead of relying on light or heat, researchers could use sound waves to precisely “print” hydrogel structures.

“By leveraging high-intensity focused ultrasound, we can shape and build hydrogels with remarkable precision,” said Jean Provost, one of co-authors of the study and assistant professor of engineering physics at Polytechnique Montréal.

Published in PNAS Nexus, the study is the first to estimate the scale of global river contamination from human antibiotics use. Researchers calculated that about 8,500 tonnes of antibiotics — nearly one-third of what people consume annually — end up in river systems around the world each year even after in many cases passing through wastewater systems.

“While the amounts of residues from individual antibiotics translate into only very small concentrations in most rivers, which makes them very difficult to detect, the chronic and cumulative environmental exposure to these substances can still pose a risk to human health and aquatic ecosystems,” said Heloisa Ehalt Macedo, a postdoctoral fellow in geography at McGill and lead author of the study.

The research team used a global model validated by field data from nearly 900 river locations. They found that amoxicillin, the world’s most-used antibiotic, is the most likely to be present at risky levels, especially in Southeast Asia, where rising use and limited wastewater treatment amplify the problem.

“This study is not intended to warn about the use of antibiotics — we need antibiotics for global health treatments — but our results indicate that there may be unintended effects on aquatic environments and antibiotic resistance, which calls for mitigation and management strategies to avoid or reduce their implications,” said Bernhard Lehner, a professor in global hydrology in McGill’s Department of Geography and co-author of the study.

The findings are especially notable because the study did not consider antibiotics from livestock or pharmaceutical factories, both of which are major contributors to environmental contamination.

“Our results show that antibiotic pollution in rivers arising from human consumption alone is a critical issue, which would likely be exacerbated by veterinarian or industry sources of related compounds” said Jim Nicell, an environmental engineering professor at McGill and co-author of the study. “Monitoring programs to detect antibiotic or other chemical contamination of waterways are therefore needed, especially in areas that our model predicts to be at risk.”