The earthquake, which killed more than 23,000 people and left about 1.5 million people homeless, took place along the Motagua Fault, at the boundary between the North American and Caribbean tectonic plate boundary.

Severe ground shaking from the 1976 earthquake caused landslides and sediment-laden turbidity currents that can be seen clearly in cores taken from the lakebeds. Normally, researchers might expect that this shaking would produce the thinnest sediment deposits in lakes furthest away from an earthquake, since seismic waves weaken as they travel away from an earthquake epicenter.

But in the Guatemalan lakes, the cores with the thickest sediment traces of the earthquake occur at the end of the fault rupture, said Jonathan Obrist-Farner, a geologist at Missouri University of Science and Technology. “What we see is lakes that are actually the closest to the epicenter but just away from the rupture path have very thin deposits.”

Jeremy Maurer, a geophysicist also at Missouri University, suggested that the unusual pattern had in this case recorded the directivity of the 1976 shaking.

It’s not unusual for scientists to find evidence of past earthquakes in lake sediment cores, Maurer added, noting examples from New Zealand to Turkey that offer a glimpse at how far away a particular earthquake could have an impact.

“What hasn’t been done as much is looking at where these lakes are located in relationship to the fault,” said Maurer. “Are they off-axis or on-axis? Does the direction of the rupture have an effect on sediment deposits?”

When the U.S. Geological Survey collected field data after the 1976 earthquake, “they found, for example, adobe houses that were 10 kilometers south of the main rupture path that were still standing, yet those that were actually on the fault trace and towards the propagation direction all collapsed,” said Maurer. “I think there’s a lot of evidence that points to the directivity of the rupture and now we’re just looking at it sedimentologically from the lakes.”

The researchers began recovering and analyzing cores from the lakes in 2022. “We thought it would be a very interesting opportunity to not just look at the 1976 earthquake, but actually learn a little bit more about the paleoseismic history of the plate boundary, which we know very little of,” said Obrist-Farner, who is originally from Guatemala.

Although there was a brief rush of seismologists to the region after the 1976 earthquake, the impacts of a 36-year civil war and sparse instrumentation have left the plate boundary poorly monitored. Paleoseismic data like the lake records are important for building a more complete picture of the country’s seismic risk.

Last year Obrist-Farner’s team retrieved their largest cores yet from the lakes, with lengths of sediment that may represent up to four thousand years of lake history. Their initial analysis shows evidence of the 1816 earthquake of at least magnitude 7.5 that is known mostly from historical documents.

Using data compiled from single earthquakes across the world, Christie Rowe of the Nevada Seismological Laboratory at the University of Nevada, Reno and Alex Hatem of the U.S. Geological Survey sought a more comprehensive answer, one that considers both surface and deep traces of seismic rupture and creep.

By compiling observations of recent earthquakes, Rowe and Hatem conclude that from Turkey to California, it’s not just a single strand of a fault but quite often a branching network of fault strands involved in an earthquake, making the fault zone hundreds of meters wide.

“So that suggests that significant parts of the broad array of fractures that develops over many earthquakes can be activated in a single earthquake,” said Rowe, who noted that this width sometimes roughly corresponds to the width of Alquist-Priolo zones established for safe building in California.

“We want to know how this might change things like the shaking patterns that you would expect, or how much radiated energy you get from an earthquake,” Rowe explained. “Because it’s not the same if you have slip distributed on many strands as when it is all on one strand of the fault.”

At the same time, the researchers found that the width of creep zones at these earthquakes are much narrower, both near the surface and 10-25 kilometers deep in the earth. The creep zones, between 2 and 10 meters wide, “may be the most localized behavior a fault does,” Rowe said.

The study emphasizes the importance of thinking of faults in a more three-dimensional manner, said Rowe.

“As a geologist, it’s always kind of been a cognitive disconnect for me when I talk to earthquake modelers who have these two-dimensional features that they model earthquakes on,” she said. “Because the sheer resistance, the strength or the friction, comes from a volume of rock that’s deforming during an earthquake or in between earthquakes. So the size of that volume controls the strength of the fault in some really tangible ways.”

The researchers used a variety of data in their study, including rupture maps, creeping zone width from surveys of slowly shifting monuments along faults and satellite observations, the locations of earthquake aftershocks, low velocity damage zone widths, and the zones delineated by certain types of rock such as pseudotachylyte, ultramylonite and mylonite that are a signature of creep and deformation.

The findings also have implications for how scientists study past earthquakes to calculate earthquake recurrence intervals on faults, Rowe noted.

Slip rates and recurrence intervals can be constrained using localized measurements, but it can be difficult to disentangle the slip that occurred during an earthquake and aseismic slip that occurred after the event. The 2014 Napa, California earthquake is a good example of this phenomenon, said Rowe, noting that almost half of the slip measured after that event occurred slowly after the earthquake.

But if the Napa earthquake occurred thousands of years ago and researchers came across its traces in the rock record, “you would just see a bigger earthquake. You might lump all of that slip as a single event,” Rowe said.

Creep isn’t always accounted for in calculating recurrence intervals, “so finding out that creep zones are quite narrow means that we should be aware that we could be convolving creep with seismic slip when we look at those paleoseismic records,” she added.

And that’s why planetary scientists are also interested in finding deltas on Saturn’s moon Titan. Titan is the only planetary body in the solar system besides Earth that has liquid currently flowing across its surface, so its deltas could be a scientific treasure trove.

One problem: Titan appears to be largely devoid of deltas, a new study finds, despite its large rivers of liquid methane and ethane.

“It’s kind of disappointing as a geomorphologist because deltas should preserve so much of Titan’s history,” said Sam Birch, an assistant professor in Brown University’s Department of Earth, Environmental and Planetary Sciences who led the work.

But the absence of deltas raises a host of new questions.

“We take it for granted that if you have rivers and sediments, you get deltas,” Birch said. “But Titan is weird. It’s a playground for studying processes we thought we understood.”

Titan is the largest of Saturn’s 274 confirmed moons. Its thick nitrogen and methane atmosphere gives rise to a host of Earth-like climate and weather features. Titan has clouds, wind and rain as well as rivers, lakes and seas. But instead of water, Titan’s fluid bodies contain methane and ethane, which are liquid at Titan’s chilly surface temperatures.

Scientists learned of Titan’s liquid bodies when the Cassini spacecraft flew by in 2006. Peering through Titan’s thick atmosphere with Cassini’s synthetic aperture radar (SAR), the spacecraft revealed spidering channels and large flat areas consistent with large bodies of liquid.

Largely missing from Cassini’s SAR images, however, were deltas — even at the mouths of large rivers. It wasn’t clear, however, whether the deltas were truly absent, or whether they just didn’t show up in Cassini’s SAR data. That’s the question Birch and his colleagues tried to answer with this new study, published in the Journal of Geophysical Research: Planets.

The problem with Cassini’s SAR data is that shallow liquid methane is largely transparent in any images. So while the SAR images could see the broad seas and river channels, it’s harder to confidently make out coastal features because it’s difficult to see where the coast ends and where the sea floor begins.

For the study, Birch developed a numerical model to simulate what Cassini’s SAR would see if it looked at a landscape scientists understand well: Earth. In the model, the water in Earth’s rivers and oceans was replaced by Titan’s methane liquid, which has different radar absorption properties compared to water.

“We basically made synthetic SAR images of Earth that assume properties of Titan’s liquid instead of Earth’s,” Birch said. “Once we see SAR images of a landscape we know very well, we can go back to Titan and understand a bit better what we’re looking at.”

The research found that the synthetic SAR images of Earth clearly resolved large deltas and many other large coastal landscapes.

“If there are deltas the size of the one at the mouth of the Mississippi River, we should be able to see it,” Birch said. “If there are large barrier islands and similar coastal landscapes like those we see all along the U.S. Gulf Coast, we should be able to see those.”

But when Birch and his colleagues combed over the Titan images in light of their new analysis, they came up mostly empty. Aside from two probable deltas near Titan’s south pole, the rest of the moon’s rivers were entirely delta-free. The researchers found that only about 1.3% of Titan’s large rivers that terminate at coastlines have deltas. On Earth, in contrast, nearly every river of similar size has a delta.

It’s not entirely clear why Titan generally lacks deltas, Birch says. The fluid properties of Titan’s rivers should make them perfectly capable of carrying and depositing sediment. It could be, the researchers say, that sea levels on Titan rise and fall so rapidly that deltas are smeared across the landscape more quickly than they can be built up in a single spot. Winds and tidal currents along Titan’s coasts may also play an equally large role in preventing delta formation.

And missing deltas aren’t the only mystery raised by the new research. The new analysis of Cassini SAR data of Titan’s coasts revealed pits of unknown origin deep within lakes and seas. The study also found deep channels on the floors of the seas that seem to have been carved by river flows, but it’s not clear how they got there.

All of these surprises will require more research to fully understand, Birch says.

“This is really not what we expected,” Birch said. “But Titan does this to us a lot. I think that’s what makes it such an engaging place to study.”

Constructed using 22 small pressure sensors and fueled by small solar panels on the tops of shoes, the system offers real-time health tracking based on how a person walks, a biomechanical process that is as unique as a human fingerprint.

This complex personal health data can then be transmitted via Bluetooth to a smartphone for quick and detailed analysis, said Jinghua Li, co-author of the study and an assistant professor of materials science and engineering at The Ohio State University.

“Our bodies carry lots of useful information that we’re not even aware of,” said Li. “These statuses also change over time, so it’s our goal to use electronics to extract and decode those signals to encourage better self health care checks.”

It’s estimated that at least 7% of Americans suffer from ambulatory difficulties, activities that include walking, running or climbing stairs. While efforts to manufacture a wearable insole-based pressure system have risen in popularity in recent years, many previous prototypes were met with low energy limitations and unstable performances.

To overcome the challenges of their precursors, Li and Qi Wang, the lead author of the study and a current PhD student in materials science and engineering at Ohio State, sought to ensure that their wearable is durable, has a high degree of precision when collecting and analyzing data, and can provide consistent and reliable power, said Li.

“Our device is innovative in terms of high resolution, spatial sensing, self-powering capability, and its ability to combine with machine learning algorithms,” she said. “So we feel like this research can go further based on the pioneering successes of this field.”

The study was recently published in the journal Science Advances.

This team’s system is also made unique through its use of AI. Using an advanced machine learning model, the wearable can recognize eight different motion states, including static ones like sitting and standing to more dynamic movements such as running and squatting.

Additionally, since the materials the insoles are made of are flexible and safe, the device, much like a smartwatch, is low-risk and safe for continuous use. For instance, after the solar cells convert sunlight to energy, that power is stored in tiny lithium batteries that don’t harm the user or affect daily activities.

Because of the distribution of sensors from toe to heel, the researchers could see how the pressure on parts of the foot is different in activities such as walking versus running.

During walking, pressure is applied sequentially from the heel to the toes, whereas during running, almost all sensors are subjected to pressure simultaneously. In addition, during walking, the pressure application time accounts for about half of the total time, while during running, it accounts for only about a quarter.

In health care, the smart insoles could support gait analysis to detect early abnormalities associated with foot pressure-related conditions (such as diabetic foot ulcers), musculoskeletal disorders (such as plantar fasciitis) and neurological conditions (such as Parkinson’s disease).

The new system also used machine learning to learn and classify different types of motion. That offers opportunities for personalized health management, including real-time posture correction, injury prevention and rehabilitation monitoring. Customized fitness training may also be a future use, the researchers said.

According to the study, these smart insoles showed no notable deterioration in performance after 180,000 cycles of compression and decompression, showing their long-term durability.

“The interface is flexible and quite thin, so even during repetitive deformation, it can remain functional,” said Li. “The combination of the software and hardware means it isn’t as limited.”

Researchers expect the technology will likely be available commercially within the next three to five years. Next steps to advance the work will be aimed at improving the system’s gesture recognition abilities, which, according to Li, will likely be helped with further testing on more diverse populations.

“We have so many variations among individuals, so demonstrating and training these fantastic capabilities on different populations is something we need to give further attention to,” said Li.

Other co-authors include Hui Guan, Chen Wang, Peiming Lei, Hongwei Sheng, Huasheng Bi, Jinkun Hu, Chenhui Guo, Yichuan Mao, Jiao Yuan, Mingjiao Shao, Zhiwen Jin and Wei Lan from Lanzhou University in China.

Of course, wood has often been passed over in favor of other materials because it is easily damaged by sunlight and moisture when used outdoors. Wood coatings have been designed to protect wood surfaces for this reason, but coating damage often starts before it becomes visible. Once the deterioration can be seen with the naked eye, it is already too late.

To solve this problem, a team of researchers at Kyoto University is working to create a simple but effective method of diagnosing this nearly invisible deterioration before the damage becomes irreparable.

“If we can ‘see’ what the eye cannot, we can extend the life of wooden structures and improve sustainability in the building industry,” says corresponding author Yoshikuni Teramoto.

The team is endeavoring to bring data-driven tools into traditional wood maintenance by combining mid-infrared spectroscopy with machine learning. They’ve started by testing artificially weathered wood coatings along with coatings containing cellulose nanofiber, a plant-derived additive that can improve the durability of these coatings.

Their machine learning component uses a technique called partial least square, which they employed to build a model to predict the extent of deterioration. They also used a genetic algorithm to identify the most informative infrared signals, improving both accuracy and interpretability.

“We were surprised to find that very subtle chemical changes — far too small to detect visually — could be captured by infrared spectroscopy and predicted by the model,” says Teramoto.

This approach allows the researchers to detect subtle chemical changes and estimate the level of deterioration with high accuracy. By making it possible to diagnose early coating deterioration quickly and without damaging the wood, their method could also reduce the need for costly visual inspections by detecting early warning signs of deterioration and preventing further decay.

With their study, the researchers have also demonstrated how chemistry and data-driven modeling techniques can work together to support smarter maintenance of sustainable buildings. “We hope this technology will help bridge the gap between traditional craftsmanship and modern data science,” continues Teramoto.

The research team is now conducting tests on real wooden buildings, with plans to improve their model for application in new paint and coating product development.

Beyond wood, the team’s method may also be applied to materials like concrete or metal to unlock new possibilities for diagnosing other kinds of early material failure, improving the sustainability of other applications and industries in the process.

Using data from the James Webb Space Telescope (JWST), the astronomers, led by the University of Cambridge, have detected the chemical fingerprints of dimethyl sulfide (DMS) and/or dimethyl disulfide (DMDS), in the atmosphere of the exoplanet K2-18b, which orbits its star in the habitable zone.

On Earth, DMS and DMDS are only produced by life, primarily microbial life such as marine phytoplankton. While an unknown chemical process may be the source of these molecules in K2-18b’s atmosphere, the results are the strongest evidence yet that life may exist on a planet outside our solar system.

The observations have reached the ‘three-sigma’ level of statistical significance — meaning there is a 0.3% probability that they occurred by chance. To reach the accepted classification for scientific discovery, the observations would have to cross the five-sigma threshold, meaning there would be below a 0.00006% probability they occurred by chance.

The researchers say between 16 and 24 hours of follow-up observation time with JWST may help them reach the all-important five-sigma significance. Their results are reported in The Astrophysical Journal Letters.

Earlier observations of K2-18b — which is 8.6 times as massive and 2.6 times as large as Earth, and lies 124 light years away in the constellation of Leo — identified methane and carbon dioxide in its atmosphere. This was the first time that carbon-based molecules were discovered in the atmosphere of an exoplanet in the habitable zone. Those results were consistent with predictions for a ‘Hycean’ planet: a habitable ocean-covered world underneath a hydrogen-rich atmosphere.

However, another, weaker signal hinted at the possibility of something else happening on K2-18b. “We didn’t know for sure whether the signal we saw last time was due to DMS, but just the hint of it was exciting enough for us to have another look with JWST using a different instrument,” said Professor Nikku Madhusudhan from Cambridge’s Institute of Astronomy, who led the research.

To determine the chemical composition of the atmospheres of faraway planets, astronomers analyse the light from its parent star as the planet transits, or passes in front of the star as seen from the Earth. As K2-18b transits, JWST can detect a drop in stellar brightness, and a tiny fraction of starlight passes through the planet’s atmosphere before reaching Earth. The absorption of some of the starlight in the planet’s atmosphere leaves imprints in the stellar spectrum that astronomers can piece together to determine the constituent gases of the exoplanet’s atmosphere.

The earlier, tentative, inference of DMS was made using JWST’s NIRISS (Near-Infrared Imager and Slitless Spectrograph) and NIRSpec (Near-Infrared Spectrograph) instruments, which together cover the near-infrared (0.8-5 micron) range of wavelengths. The new, independent observation used JWST’s MIRI (Mid-Infrared Instrument) in the mid-infrared (6-12 micron) range.

“This is an independent line of evidence, using a different instrument than we did before and a different wavelength range of light, where there is no overlap with the previous observations,” said Madhusudhan. “The signal came through strong and clear.”

“It was an incredible realisation seeing the results emerge and remain consistent throughout the extensive independent analyses and robustness tests,” said co-author Måns Holmberg, a researcher at the Space Telescope Science Institute in Baltimore, USA.

DMS and DMDS are molecules from the same chemical family, and both are predicted to be biosignatures. Both molecules have overlapping spectral features in the observed wavelength range, although further observations will help differentiate between the two molecules.

However, the concentrations of DMS and DMDS in K2-18b’s atmosphere are very different than on Earth, where they are generally below one part per billion by volume. On K2-18b, they are estimated to be thousands of times stronger — over ten parts per million.

“Earlier theoretical work had predicted that high levels of sulfur-based gases like DMS and DMDS are possible on Hycean worlds,” said Madhusudhan. “And now we’ve observed it, in line with what was predicted. Given everything we know about this planet, a Hycean world with an ocean that is teeming with life is the scenario that best fits the data we have.”

Madhusudhan says that while the results are exciting, it’s vital to obtain more data before claiming that life has been found on another world. He says that while he is cautiously optimistic, there could be previously unknown chemical processes at work on K2-18b that may account for the observations. Working with colleagues, he is hoping to conduct further theoretical and experimental work to determine whether DMS and DMDS can be produced non-biologically at the level currently inferred.

“The inference of these biosignature molecules poses profound questions concerning the processes that might be producing them” said co-author Subhajit Sarkar of Cardiff University.

“Our work is the starting point for all the investigations that are now needed to confirm and understand the implications of these exciting findings,” said co-author Savvas Constantinou, also from Cambridge’s Institute of Astronomy.

“It’s important that we’re deeply sceptical of our own results, because it’s only by testing and testing again that we will be able to reach the point where we’re confident in them,” Madhusudhan said. “That’s how science has to work.”

While he is not yet claiming a definitive discovery, Madhusudhan says that with powerful tools like JWST and future planned telescopes, humanity is taking new steps toward answering that most essential of questions: are we alone?

“Decades from now, we may look back at this point in time and recognise it was when the living universe came within reach,” said Madhusudhan. “This could be the tipping point, where suddenly the fundamental question of whether we’re alone in the universe is one we’re capable of answering.”

The James Webb Space Telescope is a collaboration between NASA, ESA and the Canadian Space Agency (CSA). The research is supported by a UK Research and Innovation (UKRI) Frontier Research Grant.

In a study published in the journal ACS Nano and supported by the National Institutes of Health, the research team showed that nanoparticles injected into the retina can successfully stimulate the visual system and restore vision in mice with retinal disorders. The findings suggest that a new type of visual prosthesis system in which nanoparticles, used in combination with a small laser device worn in a pair of glasses or goggles, might one day help people with retinal disorders to see again.

“This is a new type of retinal prosthesis that has the potential to restore vision lost to retinal degeneration without requiring any kind of complicated surgery or genetic modification,” said Jiarui Nie, a postdoctoral researcher at the National Institutes of Health who led the research while completing her Ph.D. at Brown. “We believe this technique could potentially transform treatment paradigms for retinal degenerative conditions.”

Nie performed the work while working in the lab of Jonghwan Lee, an associate professor in Brown’s School of Engineering and a faculty affiliate at Brown’s Carney Institute for Brain Science, who oversaw the work and served as the study’s senior author.

Retinal disorders like macular degeneration and retinitis pigmentosa affect millions of people in the U.S. and around the world. These conditions damage light-sensitive cells in the retina called photoreceptors — the “rods” and “cones” that convert light into tiny electric pulses. Those pulses stimulate other types of cells further up the visual chain called bipolar and ganglion cells, which process the photoreceptor signals and send them along to the brain.

This new approach uses nanoparticles injected directly into the retina to bypass damaged photoreceptors. When infrared light is focused on the nanoparticles, they generate a tiny amount of heat that activates bipolar and ganglion cells in much the same way that photoreceptor pulses do. Because disorders like macular degeneration affect mostly photoreceptors while leaving bipolar and ganglion cells intact, the strategy has the potential to restore lost vision.

In this new study, the research team tested the nanoparticle approach in mouse retinas and in living mice with retinal disorders. After injecting a liquid nanoparticle solution, the researchers used patterned near-infrared laser light to project shapes onto the retinas. Using a calcium signal to detect cellular activity, the team confirmed that the nanoparticles were exciting bipolar and ganglion cells in patterns matched the shapes projected by the laser.

The experiments showed that neither the nanoparticle solution nor the laser stimulation caused detectable adverse side effects, as indicated by metabolic markers for inflammation and toxicity. Using probes, the researchers confirmed that laser stimulation of the nanoparticles caused increased activity in the visual cortices of the mice — an indication that previously absent visual signals were being transmitted and processed by the brain. That, the researchers say, is a sign that vision had been at least partially restored, a good sign for potentially translating a similar technology to humans.

For human use, the researchers envision a system that combines the nanoparticles with a laser system mounted in a pair of glasses or goggles. Cameras in the goggles would gather image data from the outside world and use it to drive the patterning of an infrared laser. The laser pulses would then stimulate the nanoparticles in people’s retinas, enabling them to see.

The approach is similar to one that was approved by the Food and Drug Administration for human use a few years ago. The older approach combined a camera system with a small electrode array that was surgically implanted in the eye. The nanoparticle approach has several key advantages, according to Nie.

For starters, it’s far less invasive. As opposed to surgery, “an intravitreal injection is one of the simplest procedures in ophthalmology,” Nie said.

There are functional advantages as well. The resolution of the previous approach was limited by the size of the electrode array — about 60 square pixels. Because the nanoparticle solution covers the whole retina, the new approach could potentially cover someone’s full field of vision. And because the nanoparticles respond to near-infrared light as opposed to visual light, the system doesn’t necessarily interfere with any residual vision a person may retain.

More work needs to be done before the approach can be tried in a clinical setting, Nie said, but this early research suggests that it’s possible.

“We showed that the nanoparticles can stay in the retina for months with no major toxicity,” Nie said of the research. “And we showed that they can successfully stimulate the visual system. That’s very encouraging for future applications.”

The research was funded by the National Institutes of Health’s National Eye Institute (R01EY030569), the China Scholarship Council scholarship, the Saudi Arabian Cultural Mission scholarship, and South Korea’s Alchemist Project Program (RS-2024-00422269). Co-authors also include Professor Kyungsik Eom from Pusan National University, Brown Professor Tao Lui, as well as Brown students Hafithe M. Al Ghosain, Alexander Neifert, Aaron Cherian, Gaia Marie Gerbaka, and Kristine Y. Ma.

“Blood tests that detect biomarkers for Alzheimer’s disease and other dementias are emerging and as these tests are further developed, they are becoming important tools for understanding and diagnosing these conditions,” said study author Hannah Stocker, PhD, MPH, of Heidelberg University in Germany. “Our findings provide valuable insights into how age, sex, genetics and hormonal changes during menopause are linked to three biomarkers believed to influence a person’s risk of dementia.”

Researchers analyzed data from a larger 17-year study, comparing 513 people who developed dementia during the study to 513 people who remained free of dementia during that time. The participants had an average age of 64 at the start of the study.

Researchers took blood samples from participants three times during the study to measure levels of three biomarkers: neurofilament light chain proteins, glial acidic proteins and phosphorylated tau 181. Neurofilament light chain proteins are found in the blood when nerve cells are injured or die. Glial acidic proteins are released when cells work to repair injury. Phosphorylated tau 181 is linked to the buildup of amyloid proteins in the body, which occurs in Alzheimer’s disease.

Researchers then compared levels of the biomarkers in people with and without dementia in the following ways: over time as people aged; in male and female participants; in people with and without a gene linked to Alzheimer’s; and in female participants before and after menopause.

After adjusting for age, sex, and APOEe4, a genetic biomarker that indicates a strong risk of Alzheimer’s disease, researchers found that an older age was tied to higher levels of all three markers.

For neurofilament light chain proteins, people age 75 had an average of 25 picograms per milliliter (pg/ml) compared to people age 50 with an average of 10 pg/ml. For glial acidic proteins, people age 75 had an average of 140 pg/ml compared to people age 50 with an average of 45 pg/ml. For phosphorylated tau 181, people age 75 had an average of two to three pg/ml compared to people age 50 with an average of 0.5 to 1.5 pg/ml.

Researchers also found that female participants had higher levels of glial acidic proteins, while male participants had higher levels of neurofilament light chain proteins.

In addition, they found people who had the APOEe4 gene had higher levels of tau and glial acidic proteins.

Lastly, the study found that female participants who had not yet gone through menopause had higher levels of glial acidic proteins, which Stocker noted may be due to having higher levels of sex hormones. Stocker said previous studies have found a link between sex hormones and neuroinflammation.

“Gaining a better understanding of these biomarkers will help improve our ability to test for dementia in the future with simple blood tests,” said Stocker. “Our research underscores the need to further explore these biomarkers, including during menopause, in the development of dementia.”

A limitation of the study was that participants were of European descent, so the results may not be the same for other populations.

The study was supported by the German Alzheimer Forschung Initiative.