Traditionally, synthesizing solid-state materials has been a time-consuming and energy-intensive process, often accompanied by the production of harmful byproducts. But FWF enables gram-scale production of diverse compounds in seconds while reducing energy, water consumption and greenhouse gas emissions by more than 50%, setting a new standard for sustainable manufacturing.

The innovative research builds on Tour’s 2020 development of waste disposal and upcycling applications using flash Joule heating, a technique that passes a current through a moderately resistive material to quickly heat it to over 3,000 degrees Celsius (over 5,000 degrees Fahrenheit) and transform it into other substances.

“The key is that formerly we were flashing carbon and a few other compounds that could be conductive,” said Tour, the T.T. and W.F. Chao Professor of Chemistry and professor of materials science and nanoengineering. “Now we can flash synthesize the rest of the periodic table. It is a big advance.”

FWF’s success lies in its ability to overcome the conductivity limitations of conventional flash Joule heating methods. The team — including Ph.D. student Chi Hun “Will” Choi and corresponding author Yimo Han , assistant professor of chemistry, materials science and nanoengineering — incorporated an outer flash heating vessel filled with metallurgical coke and a semiclosed inner reactor containing the target reagents. FWF generates intense heat of about 2,000 degrees Celsius, which rapidly converts the reagents into high-quality materials through heat conduction.

This novel approach allows for the synthesis of more than 20 unique, phase-selective materials with high purity and consistency, according to the study. FWF’s versatility and scalability is ideal for the production of next-generation semiconductor materials such as molybdenum diselenide (MoSe2), tungsten diselenide and alpha phase indium selenide, which are notoriously difficult to synthesize using conventional techniques.

“Unlike traditional methods, FWF does not require the addition of conductive agents, reducing the formation of impurities and byproducts,” Choi said.

This advancement creates new opportunities in electronics, catalysis, energy and fundamental research. It also offers a sustainable solution for manufacturing a wide range of materials. Moreover, FWF has the potential to revolutionize industries such as aerospace, where materials like FWF-made MoSe2 demonstrate superior performance as solid-state lubricants.

“FWF represents a transformative shift in material synthesis,” Han said. “By providing a scalable and sustainable method for producing high-quality solid-state materials, it addresses barriers in manufacturing while paving the way for a cleaner and more efficient future.”

The study examined genes that cause inborn errors of metabolism (disorders of the processes that cells use to convert food to energy) and inborn errors of immunity (disorders that affect immune system function). These rare and complex diseases are not fully understood.

“There had previously been only a small number of genes that were on both lists of diseases, but we found that many more have overlap,” said Andrew Patterson, PhD, who led the study as a postdoctoral fellow working with Jeffrey Rathmell, PhD, at Vanderbilt University Medical Center. “Our study showed that a large number of genes associated with inborn errors of metabolism can also potentially affect T cell function when they are mutated.”

The findings suggest that patients with an inborn error of metabolism may also have immune defects that could impact their care, and conversely that metabolic defects may contribute to symptoms in patients with inborn errors of immunity.

“There’s a lot more that will have to be learned, but these connections might point to different therapies,” said Rathmell, Cornelius Vanderbilt Professor of Immunobiology and director of the Vanderbilt Center for Immunobiology. “Rather than different categories, these diseases are part of a continuum; there’s a gray zone between them and a potential new class of inborn errors of immunometabolism that intersects the two.”

Patterson and the research team used a gene-editing CRISPR approach to screen the inborn errors of metabolism genes for immune defects and the inborn errors of immunity genes for metabolic defects. They further analyzed one example from each set — one metabolic gene that had an immune defect; one immunity gene that had a metabolic defect — to more carefully examine the mechanistic impact.

Overall, Rathmell’s team is interested in discovering how metabolic pathways regulate T cell function, with the goal of developing targeted therapies for immune-mediated disorders.

“What we’ve done is lay the foundation for further investigation,” Patterson said. “The two examples we studied in detail point to new biology and new mechanisms, and there are hundreds of other genes we identified to analyze for their roles in T cell function.”

The findings are available on the Functional ImmunoGenomices reSource (FIGS) website for other researchers to use.

“If you’re trying to understand the connections between metabolism and immunity, this is a great place to start,” Rathmell said.

Patterson recently joined the faculty of the University of Louisville as an assistant professor of Biochemistry and Molecular Genetics. Vanderbilt collaborators Vivian Gama, PhD, associate professor of Cell and Developmental Biology, and Janet Markle, PhD, assistant professor of Pathology, Microbiology and Immunology, were important contributors to the study.

The research is published in Science Advances.

Vikas Sonwalkar, a professor emeritus, and Amani Reddy, an assistant professor, discovered the new type of wave. The wave carries lightning energy, which enters the ionosphere at low latitudes, to the magnetosphere. The energy is reflected upward by the ionosphere’s lower boundary, at about 55 miles altitude, in the opposite hemisphere.

It was previously believed, the authors write, that lightning energy entering the ionosphere at low latitudes remained trapped in the ionosphere and therefore was not reaching the radiation belts. The belts are two layers of charged particles surrounding the planet and held in place by Earth’s magnetic field.

“We as a society are dependent on space technology,” Sonwalkar said. “Modern communication and navigation systems, satellites, and spacecraft with astronauts aboard encounter harmful energetic particles of the radiation belts, which can damage electronics and cause cancer.

“Having a better understanding of radiation belts and the variety of electromagnetic waves, including those originating in terrestrial lightning, that impact them is vital for human operations in space,” he said.

Sonwalkar and Reddy’s discovery is a type of whistler wave they call a “specularly reflected whistler.” Whistlers produce a whistling sound when played through a speaker.

Lightning energy entering the ionosphere at higher latitudes reaches the magnetosphere as a different type of whistler called a magnetospherically reflected whistler, which undergoes one or more reflections within the magnetosphere.

The ionosphere is a layer of Earth’s upper atmosphere characterized by a high concentration of ions and free electrons. It is ionized by solar radiation and cosmic rays, making it conductive and crucial for radio communication because it reflects and modifies radio waves.

Earth’s magnetosphere is a region of space surrounding the planet and created by Earth’s magnetic field. It provides a protective barrier that prevents most of the solar wind’s particles from reaching the atmosphere and harming life and technology.

Sonwalkar and Reddy’s research shows that both types of whistlers — specularly reflected whistlers and magnetospherically reflected whistlers — coexist in the magnetosphere.

In their research, the authors used plasma wave data from NASA’s Van Allen Probes, which launched in 2012 and operated until 2019, and lightning data from the World Wide Lightning Detection Network.

They developed a wave propagation model that, when considering specularly reflected whistlers, showed the doubling of lightning energy reaching the magnetosphere.

Review of plasma wave data from the Van Allen Probes showed that specularly reflected whistlers are a common magnetospheric phenomenon.

A majority of lightning occurs at the low latitudes, which are tropical and subtropical regions prone to thunderstorm development.

“This implies that specularly reflected whistlers probably carry a greater part of lightning energy to the magnetosphere relative to that carried by magnetospherically reflected whistlers,” Sonwalkar said.

The impact of lightning-generated whistler waves on radiation belt physics and their use in remote sensing of magnetospheric plasma have been researched since the 1950s.

These compounds are essential in the pharmaceutical industry but have been challenging to synthesize with the required stereochemical accuracy. The innovative reagent t-BuSF uses strain-release reactivity to achieve a level of efficiency and selectivity previously unattainable, paving the way for more effective drug development and broader applications in medical research.

“Sulfur-based compounds, including those developed using the new methods, are known to have favorable physiochemical properties that make them ideal candidates for drug development,” said Justin M. Lopchuk, Ph.D., lead author and associate member of the Drug Discovery Department at Moffitt. “The ability to synthesize these compounds rapidly and stereochemical control open new possibilities for designing targeted therapies that combat cancer cells more effectively while minimizing side effects.”

By leveraging the unique properties of the t-BuSF reagent, researchers were able to explore previously inaccessible chemical space within the sulfur family, particularly in the S(IV) and S(VI) oxidation states. This advancement has resulted in the creation of over 70 new chemical compounds, many of which have immediate applications in medicinal chemistry and the development of new pharmaceutical agents.

Lopchuk adds that this research has already been used to significantly improve the scalable synthesis of DFV890, an investigational compound from Novartis currently in clinical trials at Moffitt and other locations for myeloid diseases.

According to a widely accepted theory, the mass extinction at the Cretaceous-Paleogene boundary was triggered by the impact of an asteroid at least 10 kilometres in diameter near Chicxulub on the Yucatán Peninsula in Mexico. On impact, the asteroid and large quantities of earth rock vaporized. Fine dust particles spread into the stratosphere and obscured the sun. This led to dramatic changes in the living conditions on the planet and brought photosynthetic activity to a halt for several years.

The dust particles released by the impact formed a layer of sediment around the entire globe. This is why the Cretaceous-Paleogene boundary can be identified and sampled in many places on Earth. It contains high concentrations of platinum-group metals, which come from the asteroid and are otherwise extremely rare in the rock that forms the Earth’s crust.

By analysing the isotopic composition of the platinum metal ruthenium in the cleanroom laboratory of the University of Cologne’s Institute of Geology and Mineralogy, the scientists discovered that the asteroid originally came from the outer solar system. “The asteroid’s composition is consistent with that of carbonaceous asteroids that formed outside of Jupiter’s orbit during the formation of the solar system,” said Dr Mario Fischer-Gödde, first author of the study.

The ruthenium isotope compositions were also determined for other craters and impact structures of different ages on Earth for comparison. This data shows that within the last 500 million years, almost exclusively fragments of S-type asteroids have hit the Earth. In contrast to the impact at the Cretaceous-Paleogene boundary, these asteroids originate from the inner solar system. Well over 80 percent of all asteroid fragments that hit the Earth in the form of meteorites come from the inner solar system. Professor Dr Carsten Münker, co-author of the study, added: “We found that the impact of an asteroid like the one at Chicxulub is a very rare and unique event in geological time. The fate of the dinosaurs and many other species was sealed by this projectile from the outer reaches of the solar system.”

Special recordings made by Flinders University ecologists in Australia show this chaotic mixture of soundscapes can be a measure of the diversity of tiny living animals in the soil, which create sounds as they move and interact with their environment.

With 75% of the world’s soils degraded, the future of the teeming community of living species that live underground face a dire future without restoration, says microbial ecologist Dr Jake Robinson, from the Frontiers of Restoration Ecology Lab in the College of Science and Engineering at Flinders University.

This new field of research aims to investigate the vast, teeming hidden ecosystems where almost 60% of the Earth’s species live, he says.

“Restoring and monitoring soil biodiversity has never been more important.

“Although still in its early stages, ‘eco-acoustics’ is emerging as a promising tool to detect and monitor soil biodiversity and has now been used in Australian bushland and other ecosystems in the UK.

“The acoustic complexity and diversity are significantly higher in revegetated and remnant plots than in cleared plots, both in-situ and in sound attenuation chambers.

“The acoustic complexity and diversity are also significantly associated with soil invertebrate abundance and richness.”

The latest study, including Flinders University expert Associate Professor Martin Breed and Professor Xin Sun from the Chinese Academy of Sciences, compared results from acoustic monitoring of remnant vegetation to degraded plots and land that was revegetated 15 years ago.

The passive acoustic monitoring used various tools and indices to measure soil biodiversity over five days in the Mount Bold region in the Adelaide Hills in South Australia. A below-ground sampling device and sound attenuation chamber were used to record soil invertebrate communities, which were also manually counted.

“It’s clear acoustic complexity and diversity of our samples are associated with soil invertebrate abundance — from earthworms, beetles to ants and spiders — and it seems to be a clear reflection of soil health,” says Dr Robinson.

“All living organisms produce sounds, and our preliminary results suggest different soil organisms make different sound profiles depending on their activity, shape, appendages and size.

“This technology holds promise in addressing the global need for more effective soil biodiversity monitoring methods to protect our planet’s most diverse ecosystems.”

Dr Joshua Soderholm, an Honorary Senior Research Fellow from UQ’s School of the Environment, and lead researcher PhD candidate Yuzhu Lin from Penn State in the US, have found storm modelling outcomes change significantly when using real hailstones.

Key points:

• Researchers are measuring and scanning samples for a global ‘hailstone library’
• Storm simulations using 3-D modelling of real hailstones show it behaves differently than spherical hail shapes
• Data from the hail library could lead to more accurate storm forecasts

“People tend to think of a hailstone as a perfect sphere, like a golf ball or cricket ball,” Dr Soderholm said.

“But hail can be all sorts of weird shapes, from oblong to a flat disc or have spikes coming out — no two pieces of hail are the same.

“Conventional scientific modelling of hail assumes spherical hailstones, and we wanted to know if that changed when non-spherical, natural hail shapes are used.”

Ms Lin said they found the differences were dramatic.

“Modelling of the more naturally shaped hail showed it took different pathways through the storm, experienced different growth and landed in different places,” Ms Lin said.

“It also affected the speed and impact the hail had on the ground.

“This way of modelling had never been done before, so it’s exciting science.”

Dr Soderholm said building a ‘hailstone library’ was critical to further fine-tuning hailstorm simulations.

“This is effectively a dataset to represent the many and varied shapes of hailstones, to make weather modelling more accurate,” he said.

“Our study used data from 217 hail samples, which were 3-D scanned and the sliced in half, to tell us more about how the hailstone formed.

“This data is now part of a global library, as we try and get a really clear picture of hailstone shape and structure.”

Dr Soderholm said the research has significant potential.

“At the moment, the modelling is specifically for scientists studying storms, but the end game is to be able to predict in real-time how big hail will be, and where it will fall,” he said.

“More accurate forecasts would of course warn the public so they can stay safe during hailstorms and mitigate damage.

“But it could also significantly benefit industries such as insurance, agriculture and solar farming which are all sensitive to hail.”

The research paper was published in the Journal of the Atmospheric Sciences.

Dr Soderholm is also a Research Scientist at the Australian Bureau of Meteorology.

Some hail samples for the UQ data set were provided by Higgins Storm Chasing.