Buckling does the trick

A team of researchers from the University of Amsterdam has now found a way to create materials that are stiff, but still good at absorbing vibrations — and equally importantly, that can be kept very light-weight. David Dykstra, lead author of the publication, explains: “We discovered that the trick was to use materials that buckle, like thin metal sheets. When put together in a clever way, constructions made out of such buckled sheets become great absorbers of vibrations — but at the same time, they preserve a lot of the stiffness of the material they are made out of. Moreover, the sheets do not need to be very thick, and so the material can be kept relatively light.” The image shows an example of a material that uses this buckling of metal sheets to combine all of these desired properties.

A host of applications

The researchers thoroughly investigated the properties of these buckled materials, and found that they all showed this magical combination of stiffness and ability to dissipate vibrations. As known materials do not have this desired combination of properties, the new lab-made materials (or metamaterials) have a very wide range of potential applications, and at a very wide range of scales. Possible uses range from meter-sized (think of aerospace, automotive applications and many other civil designs) to the microscale (applications such as microscopes or nanolithography). Dykstra: “Humans like to build things — small things and big things — and we almost always want these structures to be light. If that can be done with materials that are both stiff and good at shock-absorbing, many existing designs can be improved and many new designs become possible. There really is no end to the possible applications!”

Some patients were more responsive to ropinirole treatment than others, and the researchers were able to predict clinical responsiveness in vitro using motor neurons derived from patient stem cells.

“ALS is totally incurable, and it’s a very difficult disease to treat,” says senior author and physiologist Hideyuki Okano of the Keio University School of Medicine in Tokyo. “We previously identified ropinirole as a potential anti-ALS drug in vitro by iPSC drug discovery, and with this trial, we have shown that it is safe to use in ALS patients and that it potentially has some therapeutic effect, but to confirm its effectiveness we need more studies, and we are now planning a phase 3 trial for the near future.”

To test ropinirole’s safety and effectiveness in patients with sporadic (i.e., non-familial) ALS, the team recruited 20 patients receiving care at Keio University Hospital in Japan. None of the patients carried genes predisposing to the disease, and, on average, they had been living with ALS for 20 months.

The trial was double blinded for the first 24 weeks, meaning that the patients and doctors did not know which patients were receiving ropinirole and which were receiving a placebo. Then, for the following 24 weeks, all patients who wished to continue were knowingly administered ropinirole. Many patients dropped out along the way — partially due to the COVID-19 pandemic — so only 7/13 ropinirole-treated and 1/7 placebo-followed-by-ropinirole-treated patients were monitored for the full year. However, no patients dropped out due to safety reasons.

To determine whether the drug was effective at slowing the progression of ALS, the team monitored a variety of different measures throughout the trial and for 4 weeks after treatment concluded. These included changes in the patients’ self-reported physical activity and ability to eat and drink independently, activity data from wearable devices, and physician-measured changes in mobility, muscle strength, and lung function.

“We found that ropinirole is safe and tolerable for ALS patients and shows therapeutic promise at helping them sustain daily activity and muscle strength,” says first author Satoru Morimoto, a neurologist at the Keio University School of Medicine in Tokyo.

Patients who received ropinirole during both phases of the trial were more physically active than patients in the placebo group. They also showed slower rates of decline in mobility, muscle strength, and lung function, and they were more likely to survive.

The benefits of ropinirole relative to the placebo became increasingly pronounced as the trial progressed. However, placebo group patients who began taking ropinirole halfway through the trial did not experience these improvements, which suggests that ropinirole treatment may only be useful if treatment is started earlier and administered over a longer duration.

Next, the researchers investigated the mechanisms behind ropinirole’s effects and looked for molecular markers of the disease. To do this, they generated induced pluripotent stem cells from the patients’ blood and grew these cells into motor neurons in the lab. Compared to healthy motor neurons, they found that motor neurons from ALS patients showed distinct differences in structure, gene expression, and metabolite concentrations, but ropinirole treatment reduced these differences.

Specifically, motor neurons grown from ALS patients had shorter neurites compared to healthy motor neurons, but these axons grew to a more normal length when the cells were treated with ropinirole. The team also identified 29 genes related to cholesterol synthesis that tended to be upregulated in motor neurons from ALS patients, but ropinirole treatment suppressed their gene expressions over time. They also identified lipid peroxide as a good surrogate marker for estimating the effect of ropinirole both in vitro and clinically.

“We found a very striking correlation between a patient’s clinical response and the response of their motor neurons in vitro,” says Morimoto. “Patients whose motor neurons responded robustly to ropinirole in vitro had a much slower clinical disease progression with ropinirole treatment, while suboptimal responders showed much more rapid disease progression despite taking ropinirole.”

The researchers say that this suggests that this method — of growing and testing motor neurons from patient-derived induced pluripotent stem cells — could be used clinically to predict how effective the drug would be for a given patient. It’s unclear why some patients are more responsive to ropinirole than others, but the researchers think that it’s probably due to genetic differences that they hope to pinpoint in future studies.

House-owners the world over consider ‘knocking through’ walls to achieve more open-plan living or changing layouts to accommodate new arrivals or circumstances. The results may be impressive, but they come at a sizeable financial and environmental cost. But what if it wasn’t necessary to demolish internal brick and/or plaster walls and build new ones?

Researchers at Cambridge’s Centre for Natural Material Innovation and partners PLP Architecture have just unveiled Ephemeral, an innovative alternative using engineered wood, at the London Design Biennale at London’s Somerset House (1st — 25th June 2023).

The project, led by Cambridge researcher Ana Gatóo, invites visitors to step into a home constructed around principles of affordability, sustainability, flexibility and adaptation. The flexible wooden partition walls — developed by Gatóo as part of her Cambridge PhD research — are made using kerfing, which allows wood to bend without breaking, the same technique employed in the construction of guitars and other stringed instruments.

The resulting wooden walls are simple, resilient, foldable and movable, meaning they can respond to the changing needs of residents, for instance, as children are born or leave the nest; as age or mobility bring changing requirements; or as homeworking patterns change.

Gatóo says: “Self-assembly and modular furniture have improved so many people’s lives. We’ve developed something similar but for walls so people can take total control of their interior spaces.”

“If you have lots of money, you can hire a designer and alter the interiors of your house, but if you don’t, you’re stuck with very rigid systems that could be decades out-of-date. You might be stuck with more rooms than you need, or too few. We want to empower people to make their spaces their own.”

The team’s ‘rooms of requirement’ provide elegant, affordable solutions which can be built into the fabric of the building from its first design, or seamlessly retrofitted — avoiding the mountains of carbon associated with demolition and reconstruction.

Gatóo says: “We’re using engineered timber, which is affordable and sustainable. It’s a natural material which stores carbon, and when you don’t need it anymore, you can make something else with it. So you are creating minimal waste.”

Gatóo and her colleagues are based in the University of Cambridge’s Centre for Natural Material Innovation, a world leader in research into innovative and sustainable uses of timber in construction.

The team emphasises that their system could be used anywhere in the world, in workplaces as well as in homes, and the researchers have already had encouraging conversations with industry, including with affordable housing developers in India.

Gatóo says: “I’ve worked in development and post-disaster housing with NGOs in many countries around the world, always using sustainable materials. When I started my PhD, I wanted to merge making housing more affordable and social with technical innovation and sustainability. This is what our cities of the future need — caring for people and the environment at the same time.”

Implemented at scale, this innovation could change the construction industry for the better, empowering people to adapt their spaces to their needs while slashing housing costs and overcoming some of the hurdles which the construction industry must tackle to be part of a sustainable future.

Working with Cambridge Enterprise, the research team is seeking industry and policy partners to further advance product feasibility for industry-wide adoption.

The project is supported by PLP Architecture, The Laudes Foundation, the Future Observatory and the AHRC Design Accelerator.

“Mountain building is a fundamental process of how Earth behaves,” said Sean Gallen, lead author and CSU assistant professor of geosciences, “and this study suggests that we may not understand that as well as we thought we did.”

Gallen and his team generated new data sets and techniques to use landscapes to reconstruct long-term histories of mountain building in southern Italy. Their novel approach yielded some “confounding” results, according to Gallen.

In subduction zones, like the one in Calabria in southern Italy, one tectonic plate dives beneath another plate. Mountains in these settings are believed to have formed through the crumpling and thickening of Earth’s crust.

The team combined measurements that recorded geologically short and long timescales, from thousands of years to tens of millions of years. Like a “geologic tape recorder” of the tectonic history, the landscape filled in the rest.

“In southern Italy, the landscape actually is the bridge between these different methods that we typically use,” Gallen said.

The flat, high-elevation patches of the landscape along the “toe” of the Italian peninsula represent a time when mountain formation was slow, and a steep transition below marks a rapid acceleration. These clues in the landscape allowed the researchers to produce a long-term, continuous record of rock uplift, the longest and most complete record of its kind.

“We would expect to see a correlation between the rate at which the plate is diving down beneath the other plate through time and our rock uplift history, and we don’t see that,” Gallen said.

Crumpling and thickening of the crust appears to be secondary to another process in the formation of the Calabrian mountains. Data points to descension of the lower plate through the Earth’s mantle and its alteration of the mantle flow field as the primary factor controlling rock uplift.

“The results suggest that the typical way we view mountain building doesn’t hold for southern Italy,” Gallen said. “It appears to be controlled by things that are much deeper within the Earth system. This behavior has been seen in models but never in nature. This is the first time we think we’ve observed it.”

Gallen cautioned that more data is needed to confirm whether their interpretation is correct, but it is backed by existing numerical models. Scientists have previously connected mountain height to tectonic plate interactions within Earth’s plastically flowing mantle, but this research indicates for the first time that this mechanism is the dominant force in mountain building in subduction zones.

“The records we have produced imply that deep earth signals appear to dominate what’s happening at the surface,” Gallen said. “I’ve been working in the Mediterranean for 15 years, and this result has profoundly changed the way I think about these subduction zones.”

Transformative, transparent research

The new techniques developed for this study offer a breakthrough in constructing long-term rock uplift histories.

The team created a unified framework based on a collection of standard geomorphology measurements — thermochronology, cosmogenic nuclides, bedrock river profiles and the record of past sea levels found in marine terraces. The novel approach goes back further in time than other methods and uses different data sets to constrain modeling in a unique way.

The method is best applied to active systems, where the modern landscape offers clues to its history. The further back in geologic time a system was active, the harder it is to reconstruct its history with confidence.

Software developed for the study, published in Nature Geoscience, is freely available for other researchers to use. Gallen hopes the new techniques will stimulate research and discoveries in other areas.

Co-authors on the study are Nikki M. Seymour, Christoph Glotzbach, Daniel F. Stockli and Paul O’Sullivan. The Department of Geosciences is in the Warner College of Natural Resources.

The key breakthrough lies in the construction of this novel electrode. The researchers developed a uniform carbon coating technique on anodic aluminum oxide (AAO) formed on an aluminum substrate, with the barrier layer eliminated. The resulting conformally carbon-coated layer exhibits vertically aligned gCNTs with nanopores ranging from 10 to 200 nm in diameter and 2 μm to 90 μm in length, covering small electrolyte molecules to bio-related large matters such as enzymes and exosomes. Unlike traditional composite electrodes, this self-standing model electrode eliminates inter-particle contact, ensuring minimal contact resistance — something essential for interpreting the corresponding electrochemical behaviors.

“The potential of this model electrode is immense,” stated Dr. Zheng-Ze Pan, one of the corresponding authors of the study. “By employing the model membrane electrode with its extensive range of nanopore dimensions, we can attain profound insights into the intricate electrochemical processes transpiring within porous carbon electrodes, along with their inherent correlations to the nanopore dimensions.”

Moreover, the gCNTs are composed of low-crystalline stacked graphene sheets, offering unparalleled access to the electrical conductivity within low-crystalline carbon walls. Through experimental measurements and the utilization of an in-house temperature-programmed desorption system, the researchers constructed an atomic-scale structural model of the low-crystalline carbon walls, enabling detailed theoretical simulations. Dr. Alex Aziz, who carried out the simulation part for this research, points out, “Our advanced simulations provide a unique lens to estimate electron transitions within amorphous carbons, shedding light on the intricate mechanisms governing their electrical behavior.”

This project was led by Prof. Dr. Hirotomo Nishihara, the Principal Investigator of the Device/System Group at Advanced Institute for Materials Research (WPI-AIMR). The findings are detailed in one of materials science’s top-level journal, ” Advanced Functional Materials.

Ultimately, the study represents a significant step forward in our understanding of amorphous-based porous carbon materials and their applications in probing various electrochemical systems.

Using a clever combination of quantum physics and Einstein’s theory of gravity, Stephen Hawking argued that the spontaneous creation and annihilation of pairs of particles must occur near the event horizon (the point beyond which there is no escape from the gravitational force of a black hole). A particle and its anti-particle are created very briefly from the quantum field, after which they immediately annihilate. But sometimes a particle falls into the black hole, and then the other particle can escape: Hawking radiation. According to Hawking, this would eventually result in the evaporation of black holes.

Spiral

In this new study the researchers at Radboud University revisited this process and investigated whether or not the presence of an event horizon is indeed crucial. They combined techniques from physics, astronomy and mathematics to examine what happens if such pairs of particles are created in the surroundings of black holes. The study showed that new particles can also be created far beyond this horizon. Michael Wondrak: ‘We demonstrate that, in addition to the well-known Hawking radiation, there is also a new form of radiation.’

Everything evaporates

Van Suijlekom: ‘We show that far beyond a black hole the curvature of spacetime plays a big role in creating radiation. The particles are already separated there by the tidal forces of the gravitational field.’ Whereas it was previously thought that no radiation was possible without the event horizon, this study shows that this horizon is not necessary.

Falcke: ‘That means that objects without an event horizon, such as the remnants of dead stars and other large objects in the universe, also have this sort of radiation. And, after a very long period, that would lead to everything in the universe eventually evaporating, just like black holes. This changes not only our understanding of Hawking radiation but also our view of the universe and its future.’

The study was published on 2 June in the journal Physical Review Letters of the American Physical Society (APS). Michael Wondrak is excellence fellow at Radboud University and an expert in quantum field theory. Walter van Suijlekom is a Professor of Mathematics at Radboud University and works on the mathematical formulation of physics problems. Heino Falcke is an award-winning Professor of Radio Astronomy and Astroparticle Physics at Radboud University and known for his work on predicting and making the first picture of a black hole.

Primates show great genetic diversity that varies between species and geographic regions. “Studying this diversity is crucial also for understanding human evolution, the causes of human diseases, and for preserving our closest relatives,” says Christian Roos, a scientist in the Primate Genetics Laboratory at the German Primate Center and one of the authors. Led by researchers from Universitat Pompeu Fabra, Spain, Baylor College of Medicine, USA, and Illumina Inc, USA, the genomes of 809 individuals from 233 primate species have been sequenced. This covers nearly half of the extant primate species and increases the number of available primate genomes fourfold.

New insights into primate evolution and the uniqueness of humans

The comparative analyses provide fundamental information on the genetic diversity and evolutionary history of primates and important insights into what distinguishes humans from other primates. The genomic data have halved the number of genomic variants thought to occur exclusively in humans. “This makes it easier to look for mutations that we do not share with other primates and that could therefore be the basis for the traits that make us human,” says Dietmar Zinner, a scientist in the Cognitive Ethology Laboratory at the German Primate Center and also one of the authors. One of the studies looks more closely at baboon evolution and finds that there have been several, previously unknown episodes of hybridization and gene flow between baboon species. “We found that baboons from western Tanzania are the first nonhuman primates to have received input from three genetic lineages,” said Liye Zhang, a doctoral student at the German Primate Center and one of the lead authors of the baboon study. “These results suggest that the genetic structure of the baboon population and its history of genetic exchange between species is more complex than previously thought and show that baboons make a good model for similar processes in the evolution of early human lineages in and outside Africa,” says Dietmar Zinner.

Species conservation with the help of genome data

High genetic diversity enables species to better adapt to changing environmental conditions and pathogens. Especially in small populations, there is a risk of inbreeding and thus a reduction in genetic diversity. Already, 63 percent of all primate species are threatened with extinction, and the analysis of genetic diversity provides information which species most urgently need to be protected, at least from a genetic point of view. “We found particularly low genetic diversity in the golden snub-nosed monkey of China and the aye-aye in Madagascar,” says Christian Roos.

Rare mutations can increase disease risk

One of the limitations in human and clinical genetics is that it is currently not possible to identify among hundreds of thousands of mutations those that cause disease. To date, the genetic causes of many common diseases, such as diabetes and heart disease, are unknown, due either to a lack of genetic information or to the large number of genetic and other factors involved. By comparing the primate genomes, 4.3 million mutations have now been identified that may alter protein function and thus lead to disease in humans. Six percent of the 4.3 million mutations identified are, however, common in primates and are therefore considered to potentially have little impact on human disease because they are tolerated in these animals. Thanks to the PrimateAI-3D deep-learning algorithm developed by Illumina Inc, disease-causing mutations can now be better identified. “It’s a kind of ChatGPT for genetics that uses genome sequences instead of human language,” explains Kyle Farh, vice director of the AI group at Illumina Inc, the global leader in DNA sequencing.

In the early 1980s, Northwestern University’s Farhad Yusef-Zadeh discovered gigantic, one-dimensional filaments dangling vertically near Sagittarius A*, our galaxy’s central supermassive black hole. Now, Yusef-Zadeh and his collaborators have discovered a new population of filaments — but these threads are much shorter and lie horizontally or radially, spreading out like spokes on a wheel from the black hole.

Although the two populations of filaments share several similarities, Yusef-Zadeh assumes they have different origins. While the vertical filaments sweep through the galaxy, towering up to 150 light-years high, the horizontal filaments look more like the dots and dashes of Morse code, punctuating only one side of Sagittarius A*.

The study will be published on Friday (June 2) in The Astrophysical Journal Letters.

“It was a surprise to suddenly find a new population of structures that seem to be pointing in the direction of the black hole,” Yusef-Zadeh said. “I was actually stunned when I saw these. We had to do a lot of work to establish that we weren’t fooling ourselves. And we found that these filaments are not random but appear to be tied to the outflow of our black hole. By studying them, we could learn more about the black hole’s spin and accretion disk orientation. It is satisfying when one finds order in a middle of a chaotic field of the nucleus of our galaxy.”

An expert in radio astronomy, Yusef-Zadeh is a professor of physics and astronomy at Northwestern’s Weinberg College of Arts and Sciences and member of CIERA.

Decades in the making

The new discovery may come as a surprise, but Yusef-Zadeh is no stranger to uncovering mysteries at the center of our galaxy, located 25,000 light-years from Earth. The latest study builds on four decades of his research. After first discovering the vertical filaments in 1984 with Mark Morris and Don Chance, Yusef-Zadeh along with Ian Heywood and their collaborators later uncovered two gigantic radio-emitting bubbles near Sagittarius A*. Then, in a series of publications in 2022, Yusef-Zadeh (in collaborations with Heywood, Richard Arent and Mark Wardle) revealed nearly 1,000 vertical filaments, which appeared in pairs and clusters, often stacked equally spaced or side by side like strings on a harp.

Yusef-Zadeh credits the flood of new discoveries to enhanced radio astronomy technology, particularly the South African Radio Astronomy Observatory’s (SARAO) MeerKAT telescope. To pinpoint the filaments, Yusef-Zadeh’s team used a technique to remove the background and smooth the noise from MeerKAT images in order to isolate the filaments from surrounding structures.

“The new MeerKAT observations have been a game changer,” he said. “The advancement of technology and dedicated observing time have given us new information. It’s really a technical achievement from radio astronomers.”

Horizontal vs. vertical

After studying the vertical filaments for decades, Yusef-Zadeh was shocked to uncover their horizontal counterparts, which he estimates are about 6 million years old. “We have always been thinking about vertical filaments and their origin,” he said. “I’m used to them being vertical. I never considered there might be others along the plane.”

While both populations comprise one-dimensional filaments that can be viewed with radio waves and appear to be tied to activities in the galactic center, the similarities end there.

The vertical filaments are perpendicular to the galactic plane; the horizontal filaments are parallel to the plane but point radially toward the center of the galaxy where the black hole lies. The vertical filaments are magnetic and relativistic; the horizontal filaments appear to emit thermal radiation. The vertical filaments encompass particles moving at speeds near the speed of light; the horizontal filaments appear to accelerate thermal material in a molecular cloud. There are several hundred vertical filaments and just a few hundred horizontal filaments. And the vertical filaments, which measure up to 150 light-years high, far surpass the size of the horizontal filaments, which measure just 5 to 10 light-years in length. The vertical filaments also adorn space around the nucleus of the galaxy; the horizontal filaments appear to spread out to only one side, pointing toward the black hole.

“One of the most important implications of radial outflow that we have detected is the orientation of the accretion disk and the jet-driven outflow from Sagittarius A* along the galactic plane,” Yusef-Zadeh said.

‘Our work is never complete’

The new discovery is filled with unknowns, and Yusef-Zadeh’s work to unravel its mysteries has just begun. For now, he can only consider a plausible explanation about the new population’s mechanisms and origins.

“We think they must have originated with some kind of outflow from an activity that happened a few million years ago,” Yusef-Zadeh said. “It seems to be the result of an interaction of that outflowing material with objects near it. Our work is never complete. We always need to make new observations and continually challenge our ideas and tighten up our analysis.”

The study, “The population of the galactic center filaments: Position angle distribution reveal a degree-scale collimated outflow from Sgr A* along the galactic plane,” was supported by NASA (award number 80GSFC21M0002). The SARAO is a facility of the National Research Foundation, an agency of the Department of Science and Innovation.