To understand what drives people to overeat, scientists are looking more closely at a brain structure involved in motivation, called the nucleus accumbens. This small region drives reward-seeking behaviors underlying the pursuit of sex, recreational drugs like nicotine and alcohol, and food.

“These brain motivation centers evolved to help us survive; finding food and having sex are essential to the survival of an individual and of a species,” said Carrie Ferrario, Ph.D., associate professor in the Department of Pharmacology at U-M Medical School.

“What was advantageous when food was hard to find has become a disadvantage and unhealthy in the current food dense environment. This is compounded by the over-abundance of over-processed, low nutrition foods that may satisfy our taste but leave our bodies unnourished. People don’t tend to find it difficult to turn down an extra serving of broccoli, but just one more french-fry or making room for a bit of chocolate dessert…that’s a different story. The real challenge is overcoming these urges and changing our behavior when it comes to food,” Ferrario added.

Given the immense toll obesity takes on virtually all body systems, Ferrario, Peter Vollbrecht, Ph.D., of Western Michigan University, and their colleagues are using rat models to understand potential brain differences between animals who are prone to over-eating and obesity and those who are not.

Previous research from Ferrario’s lab pinpointed differences in the nucleus accumbens in obesity-prone and obesity-resistant rats. Their latest study, published in the Journal of Neurochemistry, tracked what was happening in real time in the brain when these animals were presented with glucose, a type of sugar, labeled with a tracer. The tracer allowed the researchers to measure this new sugar in the brain.

Sugar is the brain’s main fuel source and once there, the molecule is broken down and used to create new molecules such as glutamine, glutamate, and GABA, each with an important role in influencing the activation of neurons in the brain and nervous system.

“Glucose that is consumed gets broken down and then its carbons get incorporated into neurotransmitters. We see those labelled carbons showing up in those molecules — glutamate, glutamine, and GABA — over time,” explained Vollbrecht.

They found that glucose was taking longer to get into the nucleus accumbens of obesity-prone animals.

Furthermore, when measuring the concentration of the glutamate, glutamine, and GABA, they discovered excess levels of glutamate, an excitatory neurotransmitter. This, said the team, implied a defect in a neurotransmitter recycling process, typically maintained in the nervous system by star-shaped cells called astrocytes.

Normally, astrocytes will pull glutamate out of the space between neurons, called the synapse, convert it into glutamine, and then shuttle it back to cells that produce GABA or glutamate. This sequence is crucial for turning neurons off and on. “The findings suggest that we’re getting too much glutamate and it’s not being taken out of the synapse,” said Vollbrecht.

Ferrario added, “The balance between glutamate and GABA (the main inhibitory transmitter) is really important for brain function and will influence activity of the neurons in the nucleus accumbens.”

This balance, and therefore brain activity, is different in obesity-prone vs. obesity-resistant rats.

The fact that these rats are either prone to obesity or not is important for disentangling cause and effect, says Vollbrecht. “It allows us to remove diet as one of the variables.”

The team hopes to next study the role of inflammation in the development of obesity, and how differences in brain function contribute to susceptibility and resistance to obesity.

The new form of ice is amorphous. Unlike ordinary crystalline ice where the molecules arrange themselves in a regular pattern, in amorphous ice the molecules are in a disorganised form that resembles a liquid.

In this paper, published in Science, the team created a new form of amorphous ice in experiment and achieved an atomic-scale model of it in computer simulation. The experiments used a technique called ball-milling, which grinds crystalline ice into small particles using metal balls in a steel jar. Ball-milling is regularly used to make amorphous materials, but it had never been applied to ice.

The team found that ball-milling created a novel amorphous form of ice, which unlike all other known ices, had a density similar to that of liquid water and whose state resembled water in solid form. They named the new ice medium-density amorphous ice (MDA).

To understand the process at the molecular scale the team employed computational simulation. By mimicking the ball-milling procedure via repeated random shearing of crystalline ice, the team successfully created a computational model of MDA.

“Our discovery of MDA raises many questions on the very nature of liquid water and so understanding MDA’s precise atomic structure is very important” comments co-author Dr. Michael Davies, who carried out the computational modelling. “We found remarkable similarities between MDA and liquid water.”

A happy medium

Amorphous ices have been suggested to be models for liquid water. Until now, there have been two main types of amorphous ice: high-density and low-density amorphous ice.

As the names suggest, there is a large density gap between them. This density gap, combined with the fact that the density of liquid water lies in the middle, has been a cornerstone of our understanding of liquid water. It has led in part to the suggestion that water consists of two liquids: one high- and one low-density liquid.

Senior author Professor Christoph Salzmann said: “The accepted wisdom has been that no ice exists within that density gap. Our study shows that the density of MDA is precisely within this density gap and this finding may have far-reaching consequences for our understanding of liquid water and its many anomalies.”

A high-energy geophysical material

The discovery of MDA gives rise to the question: where might it exist in nature? Shear forces were discovered to be key to creating MDA in this study. The team suggests ordinary ice could undergo similar shear forces in the ice moons due to the tidal forces exerted by gas giants such as Jupiter.

Moreover, MDA displays one remarkable property that is not found in other forms of ice. Using calorimetry, they found that when MDA recrystallises to ordinary ice it releases an extraordinary amount of heat. The heat released from the recrystallization of MDA could play a role in activating tectonic motions. More broadly, this discovery shows water can be a high-energy geophysical material.

Prof. Angelos Michaelides, lead author from Cambridge, said: “Amorphous ice in general is said to be the most abundant form of water in the universe. The race is now on to understand how much of it is MDA and how geophysically active MDA is.”

A team of researchers from the Keck School of Medicine of USC have now begun to document the actual impact of electric vehicle adoption in the first study to use real-world data to link electric cars, air pollution and health. Leveraging publicly available datasets, the researchers analyzed a “natural experiment” occurring in California as residents in the state rapidly transitioned to electric cars, or light-duty zero emissions vehicles (ZEVs). The results were just published in the journal Science of the Total Environment.

The team compared data on total ZEV registration, air pollution levels and asthma-related emergency room visits across the state between 2013 to 2019. As ZEV adoption increased within a given zip code, local air pollution levels and emergency room visits dropped.

“When we think about the actions related to climate change, often it’s on a global level,” said Erika Garcia, PhD, MPH, an assistant professor of population and public health sciences at the Keck School of Medicine and the study’s lead author. “But the idea that changes being made at the local level can improve the health of your own community could be a powerful message to the public and to policy makers.”

The researchers also found that while total ZEVs increased over time, adoption was considerably slower in low-resource zip codes — what the researchers refer to as the “adoption gap.” That disparity points to an opportunity to restore environmental justice in communities that are disproportionately affected by pollution and related health problems.

“The impacts of climate change on health can be challenging to talk about because they can feel very scary,” said Sandrah Eckel, PhD, an associate professor of population and public health sciences at the Keck School of Medicine and the study’s senior author. “We’re excited about shifting the conversation towards climate change mitigation and adaptation, and these results suggest that transitioning to ZEVs is a key piece of that.”

Benefits for health and the climate

To study the effects of electric vehicle adoption, the research team analyzed and compared four different datasets. First, they obtained data on ZEVs (which includes battery electric, plug-in hybrid, and hydrogen fuel cell cars) from the California Department of Motor Vehicles and tabulated the total number registered in each zip code for every year between 2013 and 2019.

They also obtained data from U.S. Environmental Protection Agency air monitoring sites on levels of nitrogen dioxide (NO₂), an air pollutant related to traffic, and zip code level asthma-related visits to the emergency room. Asthma is one of the health concerns long linked with air pollutants such as NO₂, which can also cause and exacerbate other respiratory diseases, as well as problems with the heart, brain and other organ systems.

Finally, the researchers calculated the percentage of adults in each zip code who held bachelor’s degrees. Educational attainment levels are frequently used as an indicator of a neighborhood’s socioeconomic status.

At the zip code level, for every additional 20 ZEVs per 1,000 people, there was a 3.2% drop in the rate of asthma-related emergency visits and a small suggestive reduction in NO₂ levels. On average across zip codes in the state, ZEVs increased from 1.4 to 14.6 per 1,000 people between 2013 and 2019. ZEV adoption was significantly lower in zip codes with lower levels of educational attainment. For example, a zip code with 17% of the population having a bachelor’s degree had, on average, an annual increase of 0.70 ZEVs per 1,000 people compared to an annual increase of 3.6 ZEVs per 1,000 people for a zip code with 47% of the population having a bachelor’s degree.

Past research has shown that underserved communities, such as lower-income neighborhoods, tend to face worse pollution and associated respiratory problems than more affluent areas. If ZEVs replace gas-powered cars in those neighborhoods, they could stand to benefit substantially.

“Should continuing research support our findings, we want to make sure that those communities that are overburdened with the traffic-related air pollution are truly benefiting from this climate mitigation effort,” Garcia said.

More to learn

While climate change is a massive health threat, mitigating it offers a massive public health opportunity, Eckel said. As one of the first studies to quantify the real-world environmental and health benefits of ZEVs, the research can help demonstrate the power of this mitigation measure, including possibly reduced health care utilization and expenditures.

The findings are promising, Garcia said, but many questions remain. Future studies should consider additional impacts of ZEVs, including emissions related to brake and tire wear, mining of materials for their manufacture, and disposal of old cars. The researchers also hope to study additional types of pollutants and other classes of vehicles, in addition to conducting a follow-up study of the effects of the ever-growing share of ZEVs in the state.

Moving forward, transitioning to ZEVs is just one part of the solution, Eckel said. Shifting to public transport and active transport, including walking and biking, are other key ways to boost environmental and public health.

This work was supported by the University of Southern California Office of Research Strategic Directions for Research Award and the National Institute of Environmental Health Sciences [P30ES007048, P2CES033433].

The authors of the study are Rut Sánchez-Bragado and Josep Lluís Araus-Ortega, from the UB Faculty of Biology and Agrotecnio-UdL; Gustavo A. Slafer, ICREA researcher at the UdL School of Agrifood and Forestry Science and Engineering, and Gemma Molero, from the International Maize and Wheat Improvement Center in Mexico, currently a researcher at KWS Seeds Inc.

A cereal that changed human history

The cultivation of wheat — a grass that became basic food — represented a turning point in the progress of human civilisation. Today it is the world’s most important crop in terms of food security, but EU data warn that the impact of climate change could significantly increase its price and modify its production process in certain areas of the world.

Throughout the domestication process of wheat, the plant phenotype has undergone both rapid (within a few hundred years) and slow (thousands of years) changes, such as the weakening of the rachis, the increase in seed size, and the reduction or disappearance of the awns. In particular, awned and awnless wheat varieties are found all over the world, although the latter tend to be abundant in regions with arid climates, especially during the final stages of cultivation in late spring, a condition typical of Mediterranean environments.

“It is important to conduct studies that show which wheat varieties are best adapted to different environmental growing conditions, especially in a context of climate change. Studying the past retrospectively can give us an idea of the evolution of wheat cultivation over the millennia since agriculture appeared in ancient Mesopotamia,” says Rut Sánchez-Bragado, first author of the study, who got a PhD at the UB.

“Awns are organs of the spike that have traditionally been associated with the plant’s adaptations to drought conditions,” says Josep Lluís Araus, professor at the Department of Evolutionary Biology, Ecology and Environmental Sciences of the Faculty of Biology.

“However, archaeological and historical records show that the wheat spike has existed predominantly with awns for more than ten millennia after the domestication of wheat. It is not until the last millennium that evidence shows in many cases the absence of awns, indicating a selection by farmers — probably in an undirected way — against this organ,” stresses Araus, one of the most cited authors in the world according to Clarivate Analytics’ Highly Cited Researchers (2022).

“The role of wheat awns in their performance remains controversial despite decades of studies,” says researcher Gustavo A. Slafer, corresponding author of the study.

Spike awns: beneficial for the plant?

Is the presence of awns on the spike beneficial for the plant and the crops? Although there is no scientific consensus, “everything suggests that in conditions where the plant does not suffer from water stress, the extra photosynthetic capacity of the awns does not compensate for other potential negative effects (reduced susceptibility to fungal diseases, limitation in the total number of large ones that an ear supports, etc.),” says Araus.

“However, in wetter climates the awns accumulate moisture and can promote the spread of diseases,” says Rut Sánchez-Bragado. “So, as the world’s population is continuously growing, it is necessary to investigate the role of the awned spikes in the changing conditions of our climate in order to meet the world’s demand for a primary food commodity such as wheat.”

In arid conditions, the spikes — including the awns — “have better physiological characteristics than the leaves. In addition, the awns allow the light captured by the crop to be more diffused, which facilitates a better distribution of light energy and allows the crop to photosynthesise more. Therefore, in arid conditions, the awns can still be beneficial for the crop, or at most, neutral,” concludes Professor Josep Lluís Araus.

Platform for building quantum networks

The two quantum systems were set up in in two laboratories, one in the building that houses the Department of Experimental Physics and one in the building that houses the Institute of Quantum Optics and Quantum Information of the Austrian Academy of Sciences. “Until now, trapped ions were only entangled with each other over a few meters in the same laboratory. Those results were also achieved using shared control systems and photons (light particles) with wavelengths that aren’t suitable for travelling over much longer distances,” Ben Lanyon explains. After years of research and development, the Innsbruck physicists have now managed to entangle two ions across campus. “To do this, we sent individual photons entangled with the ions over a 500-meter fiber optic cable and superimposed them on each other, swapping the entanglement to the two remote ions,” says Tracy Northup, describing the experiment. “Our results show that trapped ions are a promising platform for realizing future distributed networks of quantum computers, quantum sensors and atomic clocks.”

Ben Lanyon’s and Tracy Northup’s teams are part of the Quantum Internet Alliance, an international project under the European Union’s Quantum Flagship. The latest results have been published in Physical Review Letters. The research was financially supported by the Austrian Science Fund FWF and the European Union, among others.

These are among the results of a new study co-authored by University of Kansas professor of Communication Studies and friendship expert Jeffrey Hall.

“Quality Conversation Can Increase Daily Well-Being” was published in the journal Communication Research by Hall and co-authors Amanda Holmstrom, Natalie Pennington, Evan Perrault and Daniel Totzkay. The study was informed by and provides further support for Hall’s Communicate Bond Belong (CBB) theory of relationships. Hall is the director of KU’s Relationships and Technology Lab.

“This paper was an attempt to define quality communication in the context of relationships,” Hall said.”The types of communication we chose to study were ones shown in past research to make people feel more bonded through conversation.”

There were seven:

• Catching up
• Meaningful talk
• Joking around
• Showing care
• Listening
• Valuing others and their opinions
• Offering sincere compliments

Over 900 study participants from five university campuses — before, during and after pandemic lockdowns — were directed to engage in one of the seven communication behaviors on a single day, and then reported back that night about their feelings of stress, connection, anxiety, well-being, loneliness and the quality of their day.

As it turned out, Hall said, it didn’t matter which of these quality conversations someone had. The very act of intentionally reaching out to a friend in one of these ways was what mattered most.

“One of the take-home messages of this study is that there are many paths toward the same goal,” Hall said.

He said the study was also designed to explore the impact of both the quality and quantity of daily communications.

“There’s a lot of good research that says the number of interactions you have as well as the quality of interactions are both associated with being a less lonely, happier and more connected person,” said Hall. This study found that once is enough, but more is better. Participants who chose to have more quality conversations had better days.

“This means the more that you listened to your friends, the more that you showed care, the more that you took time to value others’ opinions, the better you felt at the end of the day,” he said.

“The experimental design means that it’s not just people who are already having fulfilling lives who have higher-quality conversations,” Hall said. “This study suggests that anyone who makes time for high-quality conversation can improve their well-being. We can change how we feel on any given day through communication. Just once is all it takes.”

The study also brought in Hall’s past research on different ways to connect in the era of social and mobile media. The study found high quality face-to-face communication was more closely associated with well-being than electronic or social media contact.

“If at least one of their quality conversations was face-to-face, that mattered,” Hall said.

The paper also explains why quality communication makes people feel better. CBB theory claims that people use conversations with friends to help get their need to belong met.

“Across these three studies, quality conversation mattered most for connection and stress,” Hall said. “This supports the idea that we use communication to get our need to belong met, and, in doing so, it helps us manage our stress.”

What is exciting about this research, Hall said, is that it shows there are a host of good things that come along with just one good conversation with a friend. This drives home the point that making time for quality conversation makes our days better.