Lead author of the study published in MNRAS, Dr Cristina Martínez-Lombilla from the School of Physics at UNSW Science, said “We know almost nothing about intra-group light.

“The brightest parts of the intra-group light are ~50 times fainter than the darkest night sky on Earth. It is extremely hard to detect, even with the largest telescopes on Earth — or in space.”

Using their sensitive technique, which eliminates light from all objects except that from the intra-group light, the researchers not only detected the intra-group light but were able to study and tell the story of the stars that populate it.

“We analysed the properties of the intra-group stars — those stray stars between the galaxy groups. We looked at the age and abundance of the elements that composed them and then we compared those features with the stars still belonging to galaxy groups,” Dr Martínez-Lombilla said.

“We found that the intra-group light is younger and less metal-rich than the surrounding galaxies.”

Rebuilding the story of intra-group light

Not only were the orphan stars in the intra-group light ‘anachronistic’ but they appeared to be of a different origin to their closest neighbours. The researchers found the character of the intra-group stars appeared similar to the nebulous ‘tail’ of a further away galaxy.

The combination of these clues allowed the researchers to rebuild the history — the story — of the intra-group light and how its stars came to be gathered in their own stellar orphanage.

“We think these individual stars were at some points stripped from their home galaxies and now they float freely, following the gravity of the group,” said Dr Martínez-Lombilla. “The stripping, called tidal stripping, is caused by the passage of massive satellite galaxies — similar to the Milky Way — that pull stars in their wake.”

This is the first time the intra-group light of these galaxies has been observed.

“Unveiling the quantity and origin of the intra-group light provides a fossil record of all the interactions a group of galaxies has undergone and provides a holistic view of the system’s interaction history,” Dr Martínez-Lombilla said.

“Also, these events occurred a long time ago. The galaxies [we’re looking at] are so far away, that we’re observing them as they were 2.5 billion years ago. That is how long it takes for their light to reach us.”

By observing events from a long time ago, in galaxies so far away, the researchers are contributing vital datapoints to the slow-burning evolution of cosmic events.

Tailored image treatment procedure

The researchers pioneered a unique technique to achieve this penetrating view.

“We have developed a tailored image treatment procedure that allows us to analyse the faintest structures in the Universe,” said Dr Martínez-Lombilla.

“It follows the standard steps for the study of faint structures in astronomical images — which implies 2D modelling and the removal of all light except that coming from the intra-group light. This includes all the bright stars in the images, the galaxies obscuring the intra-group light and a subtraction of the continuum emission from the sky.

“What makes our technique different is that it is fully Python-based so it is very modular and easily applicable to different sets of data from different telescopes rather than being just useful for these images.

“The most important outcome is that when studying very faint structures around galaxies, every step in the process counts and every undesirable light should be accounted for and removed. Otherwise, your measurements will be wrong.

The techniques presented in this study are a pilot, encouraging future analyses of intra-group light, Dr Martínez-Lombilla said.

“Our main long-term goal is to extend these results to a large sample of group of galaxies. Then we can look at statistics and find out the typical properties regarding the formation and evolution of the intra-group light and these extremely common systems of groups of galaxies.

“This is key work for preparing the next generation of deep all-sky surveys such as those to be performed with the Euclid space telescope and the LSST with the Vera C. Rubin Observatory.”

Previous research has demonstrated that the smell and texture of food can affect how it tastes for picky eaters, but little is known about other senses.

A team from the University of Portsmouth has discovered the colour of the bowl in which food is served also influences taste perception.

The experiment comprised nearly 50 people to measure their food neophobia, which is a reluctance to eat or try new food. The participants, who were divided into picky and non-picky eaters, then tasted the same snacks served in red, white and blue bowls.

Results revealed that both the perceived saltiness and desirability of the foods were influenced by colour in the picky group, but not the non-picky group.

Specifically, the snack was rated as higher in saltiness in the red and blue versus white bowl, and least desirable when served in the red bowl. In the UK, salty snacks are often sold in blue packaging, and the team believe that this might explain some of the saltiness findings.

Dr Lorenzo Stafford, an olfactory (sense of smell) researcher in the Department of Psychology at the University of Portsmouth, said: “Having restricted diets can lead to nutritional deficiencies as well as health problems like heart disease, poor bone health and dental issues. There is also a social cost because normally enjoyable moments between family members can easily turn into stressful, anxious, and conflict-causing situations when picky eaters feel ashamed or pressured to eat food.

“That is why it’s important to understand the factors that act to ‘push and pull’ this behaviour.”

Picky eating behaviour is usually categorised as having a limited diet, specific food preparation, strong dislikes and difficulty accepting new foods. Across a lifespan, a picky eater will generally consume fewer than 20 different food items.

The paper, published in the Food Quality and Preference journal, says this study is believed to be the first to provide insight into the interaction between colour and taste perception in adult picky and non-picky eaters and reveal a difference in the way that colour affects the perception of food in picky eaters.

It recommends further research to see if these findings extend beyond the food and colours tested here.

“This knowledge could be useful for those trying to expand the repertoire of foods,” added Dr Stafford.

“For example, if you wanted to encourage a picky eater to try more vegetables well known to be viewed as bitter, you could attempt to serve them on a plate or bowl that is known to increase sweetness.

“Through further research we could determine ways to help positively affect a person’s diet, and as a result their mental and physical health.”

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“Most reactions involving free radicals take place at the site of the unpaired electron,” explained Brookhaven Lab chemist Matthew Bird, one of the co-corresponding authors on the paper. The Princeton team had become experts in using free radicals for a range of synthetic applications, such as polymer upcycling. But they’ve wondered whether free radicals might influence reactivity on other parts of the molecule as well, by pulling electrons away from those more distant locations.

“Our measurements show that these radicals can exert powerful ‘electron-withdrawing’ effects that make other parts of the molecule more reactive,” Bird said.

The Princeton team demonstrated how that long-distance pull can overcome energy barriers and bring together otherwise unreactive molecules, potentially leading to a new approach to organic molecule synthesis.

Combining capabilities

The research relied on the combined resources of a Princeton-led DOE Energy Frontier Research Center (EFRC) focused on Bio-Inspired Light Escalated Chemistry (BioLEC). The collaboration brings together leading synthetic chemists with groups having advanced spectroscopic techniques for studying reactions. Its funding was recently renewed for another four years.

Robert Knowles, who led Princeton’s role in this research, said, “This project is an example of how BioLEC’s combined expertise enabled the team to quantify an important physical property of these radical species, that in turn allowed us to design the resulting synthetic methodology.”

The Brookhaven team’s major contribution is a technique called pulse radiolysis — available only at Brookhaven and one other location in the U.S.

“We use the Laser Electron Accelerator Facility (LEAF) — part of the Accelerator Center for Energy Research (ACER) in Brookhaven’s Chemistry Division — to generate intense high-energy electron pulses,” Bird explained. “These pulses allow us to add or subtract electrons from molecules to make reactive species that might be difficult to make using other techniques, including short-lived reaction intermediates. With this technique, we can step into one part of a reaction and monitor what happens.”

For the current study, the team used pulse radiolysis to generate molecules with oxygen-centered radicals, and then measured the “electron-withdrawing” effects on the other side of the molecule. They measured the electron pull by tracking how much the oxygen at the opposite side attracts protons, positively charged ions sloshing around in solution. The stronger the pull from the radical, the more acidic the solution has to be for protons to bind to the molecule, Bird explained.

The Brookhaven scientists found the acidity had to be high to enable proton capture, meaning the oxygen radical was a very strong electron withdrawing group. That was good news for the Princeton team. They then demonstrated that it’s possible to exploit the “electron-withdrawing” effect of oxygen radicals by making parts of molecules that are generally inert more chemically reactive.

“The oxygen radical induces a transient ‘polarity reversal’ within the molecule — causing electrons that normally want to remain on that distant side to move toward the radical to make the ‘far’ side more reactive,” Bird explained.

These findings enabled a novel substitution reaction on phenol based starting materials to make more complex phenol products.

“This is a great example of how our technique of pulse radiolysis can be applied to cutting-edge science problems,” said Bird. “We were delighted to host an excellent graduate student, Nick Shin, from the Knowles group for this collaboration. We look forward to more collaborative projects in this second phase of BioLEC and seeing what new problems we can explore using pulse radiolysis.”

Brookhaven Lab’s role in this work and the EFRC at Princeton were funded by the DOE Office of Science (BES). Princeton received additional funding for the synthesis work from the National Institutes of Health.

Numerous prior studies conducted around the world have documented people’s beliefs in witchcraft — the idea that certain individuals have supernatural abilities to inflict harm. Understanding people’s witchcraft beliefs can be important for policymaking and other community engagement efforts. However, due to a lack of data, global-scale statistical analyses of witchcraft beliefs have been lacking.

To deepen understanding of witchcraft beliefs, Gershman compiled a new dataset that captures such beliefs among more than 140,000 people from 95 countries and territories. The data come from face-to-face and telephone surveys conducted by the Pew Research Center and professional survey organizations between 2008 and 2017, which included questions about religious beliefs and belief in witchcraft.

According to the dataset, over 40 percent of survey participants said they believe that “certain people can cast curses or spells that cause bad things to happen to someone.”Witchcraft beliefs appear to exist around the world but vary substantially between countries and within world regions. For instance, 9 percent of participants in Sweden reported belief in witchcraft, compared to 90 percent in Tunisia.

Using this dataset, Gershman then conducted an investigation of various individual-level factors associated with witchcraft beliefs. This analysis suggests that, while beliefs cut across socio-demographic groups, people with higher levels of education and economic security are less likely to believe in witchcraft.

Gershman also combined this dataset with other country-level data, finding that witchcraft beliefs differ between countries according to various cultural, institutional, psychological, and socioeconomic factors. For instance, witchcraft beliefs are linked to weak institutions, low levels of social trust, and low innovation, as well as conformist culture and higher levels of in-group bias — the tendency for people to favor others who are similar to them”

These findings, as well as future research using the new dataset, could be applied to help optimize policies and development projects by accounting for local witchcraft beliefs.

The author adds: “The study documents that witchcraft beliefs are still widespread around the world. Moreover, their prevalence is systematically related to a number of cultural, institutional, psychological, and socioeconomic characteristics.”

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Now, a new animal study points to a gene that is important for the earliest development of basic social behaviors.

The work also suggests that exposure to certain drugs and environmental risk factors during embryonic development can cause changes to this gene, leading to alterations in social behavior that are similar to those found in individuals who have autism. Much to their surprise, the researchers also found they could reverse some of the effects using an experimental drug.

“This study helps us understand at the molecular level why sociability is disrupted during the very earliest stages of life,” says Randall T. Peterson, Ph.D., the corresponding author of the study and dean of the University of Utah College of Pharmacy. “It also gives us an opportunity to explore potential treatments that could restore sociability in these animals and, perhaps in time, eventually in humans as well.”

More broadly, their findings suggest that the gene — TOP2a — controls a large network of genes that are known to increase the risk of autism. It also may serve as a link between genetic and environmental factors that contribute to onset of disorder, Peterson adds.

The study, conducted by University of Utah Health researchers and colleagues nationwide, appears in the Nov. 23 issue of Science Advances.

Anti-social animals

Scientists suspect many social traits are determined before birth. But the precise mechanisms involved in this process remain murky. One promising area of research suggests that social behavior and other characteristics and traits are influenced not only by our genetic makeup but also how and where we live.

To test this model, the scientists evaluated whether environmental exposures during embryonic development could influence social behavior. Peterson and his colleagues exposed zebrafish embryos to more than 1,100 known drugs — one drug per 20 embryos — for 72 hours beginning three days after conception.

The researchers determined that four of the 1,120 tested drugs significantly reduced sociability among the zebrafish. Fish exposed to these drugs were less likely to interact with other fish. It turned out that the four medications all belonged to the same class of antibiotics, called fluoroquinolones. These drugs are used to treat upper and lower respiratory tract infections in people.

When the scientists gave a related drug to pregnant mice, the offspring behaved differently when they became adults. Even though they appeared normal, they communicated less with other mice and engaged in more repetitive acts — like repeatedly poking their head in the same hole — than other rodents.

A basis for sociability

Digging deeper, the researchers found that the drugs suppressed a gene called TOP2a, which, in turn, acted on a cluster of genes that are known to be involved in autism in humans.

They also found that the cluster of autism-associated genes shared another thing in common — a higher than usual tendency to bind a group of proteins called the PRC2. The researchers hypothesized that Top2a and the PRC2 work together to control the production of many autism-associated genes.

To determine whether the anti-social behaviors could be reversed, the research team gave embryonic and young zebrafish an experimental drug called UNC1999, which is known to inhibit the PRC2. After treatment with the drug, fish exposed to fluoroquinolones were more likely to swim closer to other fish, demonstrating that the drug helped restore sociability. They saw similar results with other drugs known to inhibit the same key gene, TOP2a.

“That really surprised me because I would’ve thought disrupting brain development when you’re an embryo would be irreversible,” Peterson says. “If you don’t develop sociality as an embryo, you’ve missed the window. But this study suggests that even in those individuals later in life, you can still come in and inhibit this pathway and restore sociality.”

Moving forward, the researchers plan to explore how and why this drug had this effect.

Although the scientists only found four compounds that are Top2a inhibitors, evidence suggests hundreds of other drugs and naturally occurring compounds in our environment can inhibit its activity.

“It’s possible that these four compounds are just the tip of the iceberg in terms of substances that could be problematic for embryonic exposure,” Peterson says.

However, Peterson notes that this study was conducted in animals, and more research needs to be done before any of its results can be confirmed in humans. Therefore, he cautions against drawing conclusions about real-world applications.

“We have no evidence that fluroquinolones or any other antibiotic causes autism in humans,” Peterson says. “So, there is no reason to stop using antibiotics. What this paper does identify is a new molecular pathway that appears to control social development and is worthy of further exploration.”

In addition to Dr. Peterson, U of U Health scientists Yijie Geng, Tejia Zhang, Ivy G. Alonzo, Sean C. Godar, Christopher Yates, Brock Plummer, and Marco Bortolato contributed to this study. Other participating institutions include the University of Chicago; Beth Israel Deaconess Medical Center in Boston; Massachusetts General Hospital and Harvard Medical School; the Broad Institute, Cambridge, Massachusetts; and MDI Biological Laboratory, Bar Harbor, Maine.

The study, “Top2a promotes the development of social behavior via PRC2 and H3K27me3,” appears in the Nov. 23, 2022, issue of Science Advances. This research was supported by the L. S. Skaggs Presidential Endowed Chair and the National Institute of Environmental Health Sciences at the National Institutes of Health.

In this new study, an international team, led by Bristol’s Professor Christiane Schaffitzel, scrutinised the spike glycoproteins decorating all coronaviruses. They reveal that a tailor-made pocket feature in the SARS-CoV-2 spike protein, first discovered in 2020, is present in all deadly coronaviruses, including MERS and Omicron. In striking contrast, the pocket feature is not present in coronaviruses which cause mild infection with cold-like symptoms.

The team say their findings suggest that the pocket, which binds a small molecule, linoleic acid—an essential fatty acid indispensable for many cellular functions including inflammation and maintaining cell membranes in the lungs so that we can breathe properly—could now be exploited to treat all deadly coronaviruses, at the same time rendering them vulnerable to a linoleic acid-based treatment targeting this pocket.   

COVID-19, caused by SARS-CoV-2, is the third deadliest coronavirus outbreak following SARS-CoV in 2002 and MERS-CoV in 2012. The much more infectious SARS-CoV-2 continues to infect people and damage communities and economies worldwide, with new variants of concern emerging successively, and Omicron evading vaccination and immune response.

Professor Schaffitzel from Bristol’s School of Biochemistry, explained: “In our earlier work we identified the presence of a small molecule, linoleic acid, buried in a tailor-made pocket within the SARS-Cov-2 glycoprotein, known as the ‘Spike protein’, which binds to the human cell surface, allowing the virus to penetrate the cells and start replicating, causing widespread damage.

“We showed that binding linoleic acid in the pocket could stop virus infectivity, suggesting an anti-viral treatment. This was in the original Wuhan strain that started the pandemic. Since then, a whole range of dangerous SARS-CoV-2 variants have emerged, including Omicron, the currently dominating variant of concern. We scrutinised every new variant of concern and asked whether the pocket function is still present.”

Omicron has undergone many mutations, enabling it to escape immune protection offered by vaccination or antibody treatments that lag behind this rapidly evolving virus.  Intriguingly, while everything else may have changed, the researchers found that the pocket remained virtually unaltered, also in Omicron.

Christine Toelzer, Research Associate in the School of Biochemistry and lead author of the study, added: “When we realised that the pocket we had discovered remained unchanged, we looked back and asked whether SARS-CoV and MERS-CoV, two other deadly coronaviruses causing previous outbreaks years ago, also contained this linoleic acid binding pocket feature.”  

The team applied high-resolution electron cryo-microscopy, cutting-edge computational approaches and cloud computing. Their results showed that SARS-CoV and MERS-CoV also had the pocket, and could bind the ligand, linoleic acid, by a virtually identical mechanism.  

Professor Schaffitzel concluded: “In our current study, we provide evidence that the pocket remained the same in all deadly coronaviruses, from the first SARS-CoV outbreak 20 years ago to Omicron today. We have shown previously that linoleic acid binding to this pocket induces a locked spike, abrogating viral infectivity. We also show now that linoleic acid supplementation suppresses virus replication inside cells. We anticipate that future variants will also contain the pocket, which we can exploit to defeat the virus.”

Halo Therapeutics, a recent University of Bristol spin-out Professor Schaffitzel co-founded, is using these findings to develop pocket-binding pan-coronavirus antivirals.

The team included experts from the Bristol UNCOVER Group, Max Planck Bristol Centre for Minimal Biology, Bristol University spin-out Halo Therapeutics Ltd, and collaborators in Sweden and France. The studies have been supported by funds from Max Planck Gesellschaft, Wellcome Trust and European Research Council, with additional support from Oracle for Research for high-performance cloud computing resources.