As the world battles the ills of disease and war, it is especially important to remember the universal desire for happiness and the capacity of individuals to rally to each other’s support in times of great need, say the authors of the report. This year marks the 10^th anniversary of the World Happiness Report, which uses global survey data to report on how people evaluate their own lives in more than 150 countries around the world reaching over 9 million people in 2021.

“COVID-19 is the biggest health crisis we’ve seen in more than a century,” says Professor John Helliwell of the University of British Columbia. “Now that we have two years of evidence, we are able to assess not just the importance of benevolence and trust, but to see how they have contributed to well-being during the pandemic.”

Growth in acts of kindness

Helliwell adds “We found during 2021 remarkable worldwide growth in all three acts of kindness monitored in the Gallup World Poll. Helping strangers, volunteering, and donations in 2021 were strongly up in every part of the world, reaching levels almost 25% above their pre-pandemic prevalence. This surge of benevolence, which was especially great for the helping of strangers, provides powerful evidence that people respond to help others in need, creating in the process more happiness for the beneficiaries, good examples for others to follow, and better lives for themselves.”

Finland takes the top spot while Canada drops to 15^th place

For the fifth year in a row Finland takes the top spot as the happiest in the world. This year its score was significantly ahead of other countries in the top ten. Denmark continues to occupy second place, with Iceland up from 4^th place last year to 3^rd this year. Switzerland is 4^th, followed by the Netherlands and Luxembourg. The top ten are rounded out by Sweden, Norway, Israel and New Zealand. The next five are Austria, Australia, Ireland, Germany and Canada, in that order. This marks a substantial fall for Canada, which was 5^th ten years ago.

“The downward trend for Canada is significant and has been going on steadily for years. While Canada once ranked beside the Scandinavian countries, it now ranks closer to the United States in people’s overall evaluation of how good their lives felt,” says Professor Christopher Barrington-Leigh of McGill University.

The rest of the top 20 include the United States at 16^th (up from 19^th last year), the UK and the Czechia still in 17^th and 18^th, followed by Belgium at 19^th and France at 20^th, its highest ranking yet. Overall, the three biggest gains were in Serbia, Bulgaria, and Romania. The biggest losses were in Lebanon, Venezuela, and Afghanistan.

1. Finland
2. Denmark
3. Iceland
4. Switzerland
5. Netherlands
6. Luxembourg
7. Sweden
8. Norway
9. Israel
10. New Zealand
11. Austria
12. Australia
13. Ireland
14. Germany
15. Canada

Conflict in Afghanistan takes a toll

Jan-Emmanuel De Neve, the Director of the Wellbeing Research Centre at the University of Oxford notes that “At the very bottom of the ranking we find societies that suffer from conflict and extreme poverty, notably we find that people in Afghanistan evaluate the quality of their own lives as merely 2.4 out of 10. This presents a stark reminder of the material and immaterial damage that war does to its many victims and the fundamental importance of peace and stability for human wellbeing.”

Progress marked by measures of happiness

“The World Happiness Report is changing the conversation about progress and wellbeing. It provides important snapshots of how people around the world feel about the overall quality of their lives,” says McGill University Professor Christopher Barrington-Leigh. According to the researchers, this information can in turn help countries to craft policies aimed at achieving happier societies.

Past reports have looked at the links between people’s trust in government and institutions with happiness. The findings demonstrate that communities with high levels of trust are happier and more resilient in the face of a wide range of crises.

About the report

The World Happiness Report is a publication of the Sustainable Development Solutions Network, powered by the Gallup World Poll data.

Read: https://worldhappiness.report/

In the study, published today in The ISME Journal, researchers say that even a low level of one type of microbe in the airways can have a profound effect on the way other microbes respond to antibiotics.

The results highlight the need to consider the interaction between different species of microbe when treating infections with antibiotics — and to adjust dosage accordingly.

“People with chronic infections often have co-infection with several pathogens, but the problem is we don’t take that into account in deciding how much of a particular antibiotic to treat them with. Our results might help explain why, in these people, the antibiotics just don’t work as well as they should,” said Thomas O’Brien, who carried out the research for his PhD in the University of Cambridge’s Department of Biochemistry and is joint first author of the paper.

Chronic bacterial infections such as those in the human airways are very difficult to cure using antibiotics. Although these types of infection are often associated with a single pathogenic species, the infection site is frequently co-colonised by a number of other microbes, most of which are not usually pathogenic in their own right.

Treatment options usually revolve around targeting the pathogen, and take little account of the co-habiting species. However, these treatments often fail to resolve the infection. Until now scientists have had little insight into why this is.

To get their results the team developed a simplified model of the human airways, containing artificial sputum (‘phlegm’) designed to chemically resemble the real phlegm coughed up during an infection, packed with bacteria.

The model allowed them to grow a mixture of different microbes, including pathogens, in a stable way for weeks at a time. This is novel, because usually one pathogen will outgrow the others very quickly and spoil the experiment. It enabled the researchers to replicate and study infections with multiple species of microbe, called ‘poly-microbial infections’, in the laboratory.

The three microbes used in the experiment were the bacteria Pseudomonas aeruginosa and Staphylococcus aureus, and the fungus Candida albicans — a combination commonly present in the airways of people with cystic fibrosis.

The researchers treated this microbial mix with an antibiotic called colistin, which is very effective in killing Pseudomonas aeruginosa. But when the other pathogens were present alongside Pseudomonas aeruginosa, the antibiotic didn’t work.

“We were surprised to find that an antibiotic that we know should clear an infection of Pseudomonas effectively just didn’t work in our lab model when other bugs were present,” said Wendy Figueroa-Chavez in the University of Cambridge’s Department of Biochemistry, joint first author of the paper.

The same effect happened when the microbial mix was treated with fusidic acid — an antibiotic that specifically targets Staphylococcus aureus, and with fluconazole -an antibiotic that specifically targets Candida albicans.

The researchers found that significantly higher doses of each antibiotic were needed to kill bacteria when it was part of poly-microbial infection, compared to when no other pathogens were present.

“All three species-specific antibiotics were less effective against their target when three pathogens were present together,” said Martin Welch, Professor of Microbial Physiology and Metabolism in the University of Cambridge’s Department of Biochemistry and senior author of the paper.

At present antibiotics are usually only laboratory tested against the main pathogen they are designed to target, to determine the lowest effective dose. But when the same dose is used to treat infection in a person it often doesn’t work, and this study helps to explain why. The new model system will enable the effectiveness of potential new antibiotics to be tested against a mixture of microbe species together.

Poly-microbial infections are common in the airways of people with cystic fibrosis. Despite treatment with strong doses of antibiotics, these infections often persist long-term. Chronic infections of the airways in people with asthma and chronic obstructive pulmonary disorder (COPD) are also often poly-microbial.

By looking at the genetic code of the Pseudomonas bacteria in their lab-grown mix, the researchers were able to pinpoint specific mutations that give rise to this antibiotic resistance. The mutations were found to arise more frequently when other pathogens were also present.

Comparison with the genetic code of 800 samples of Pseudomonas from around the world revealed that these mutations have also occurred in human patients who had been infected with Pseudomonas and treated with colistin.

“The problem is that as soon as you use an antibiotic to treat a microbial infection, the microbe will start to evolve resistance to that antibiotic. That’s what has happened since colistin started to be used in the early 1990’s. This is another reminder of the vital need to find new antibiotics to treat human infections,” said Welch.

That may soon change, thanks to the work of an international team of scientists — including UNLV astrophysicist Bing Zhang — which tracked hundreds of the bursts from five different sources and found clues in FRB polarization patterns that may reveal their origin. The team’s findings were reported in the March 17 issue of the journal Science.

FRBs produce electromagnetic radio waves, which are essentially oscillations of electric and magnetic fields in space and time. The direction of the oscillating electric field is described as the direction of polarization. By analyzing the frequency of polarization in FRBs observed from various sources, scientists revealed similarities in repeating FRBs that point to a complex environment near the source of the bursts.

“This is a major step towards understanding the physical origin of FRBs,” said Zhang, a UNLV distinguished professor of astrophysics who coauthored the paper and contributed to the theoretical interpretation of the phenomena.

To make the connection between the bursts, an international research team, led by Yi Feng and Di Li of the National Astronomical Observatories of the Chinese Academy of Sciences, analyzed the polarization properties of five repeating FRB sources using the massive Five-hundred-meter Aperture Spherical radio Telescope (FAST) and the Robert C. Byrd Green Bank Telescope (GBT). Since FRBs were first discovered in 2007, astronomers worldwide have turned to powerful radio telescopes like FAST and GBT to trace the bursts and to look for clues on where they come from and how they’re produced.

Though still considered mysterious, the source of most FRBs is widely believed to be magnetars, incredibly dense, city-sized neutron stars that possess the strongest magnetic fields in the universe. They typically have nearly 100% polarization. Conversely, in many astrophysical sources that involve hot randomized plasmas, such as the Sun and other stars, the observed emission is unpolarized because the oscillating electric fields have random orientations.

That’s where the cosmic detective work kicks in.

In a study the team originally published last year in Nature, FAST detected 1,652 pulses from the active repeater FRB 121102. Even though the bursts from the source were discovered to be highly polarized with other telescopes using higher frequencies — consistent with magnetars — none of the bursts detected with FAST in its frequency band were polarized, despite FAST being the largest single-dish radio telescope in the world.

“We were very puzzled by the lack of polarization,” said Feng, first author on the newly released Science paper. “Later, when we systematically looked into other repeating FRBs with other telescopes in different frequency bands — particularly those higher than that of FAST, a unified picture emerged.”

According to Zhang, the unified picture is that every repeating FRB source is surrounded by a highly magnetized dense plasma. This plasma produces different rotation of the polarization angle as a function of frequency, and the received radio waves come from multiple paths due to scattering of the waves by the plasma.

When the team accounted for just a single adjustable parameter, Zhang says, the multiple observations revealed a systematic frequency evolution, namely depolarization toward lower frequencies.

“Such a simple explanation, with only one free parameter, could represent a major step toward a physical understanding of the origin of repeating FRBs,” he says.

Di Li, a corresponding author of the study, agrees that the analysis could represent a corner piece in completing the cosmic puzzle of FRBs. “For example, the extremely active FRBs could be a distinct population,” he says. “Alternatively, we’re starting to see the evolutionary trend in FRBs, with more active sources in more complex environments being younger explosions.”

The study, “Frequency-dependent polarization of repeating fast radio bursts — implications for their origin,” appeared March 17 in the journal Science. It includes 25 co-authors from 11 institutions and is part of long-running collaboration among institutions. In addition to UNLV and NAOC, collaborating institutions also include Yunnan University, Princeton University, Western Sidney University, Peking University and Green Bank Observatory, USA.

Dr. Ted Price BS’97, Ashbel Smith Professor of neuroscience in the School of Behavioral and Brain Sciences (BBS) and CAPS director, leads a team that is analyzing the origins of how pain is generated by nociceptors — pain-sensing nerve cells — in human dorsal root ganglia (DRG) neurons. Price is co-corresponding author of a study, featured on the cover of the Feb. 16 issue of Science Translational Medicine, that charts the full range of messenger RNA (mRNA) strands — a grouping called the transcriptome — produced in these cells.

Because mRNA is a single-stranded copy of a gene that can be translated into protein, the findings provide neuroscientists with a much better understanding of which genes are expressed in DRG neurons. The study also reinforces the value of studying human tissue — as opposed to animal cells — in the search for pain treatments.

DRG neurons are specialized nerve cells clustered near the base of the spine. Very little work has been done previously with these cells from humans due to the scarcity of their availability for research.

“We’re one of the few groups in the country with access to human donor DRG tissue acquired specifically for research,” said Stephanie Shiers PhD’19, neuroscience research scientist and a joint first author of the paper.

Shiers’ prior research made the case in broad terms that significant differences exist between the nociceptors in mice and humans. That work explained why proposed pain treatments that succeed in mice fail in humans.

“This paper is the next step, clearly demonstrating the profound scale of those differences,” Price said. “An entire set of nociceptors that many people study in mice just aren’t found in humans. There are subtypes in humans that don’t exist even in nonhuman primates.

“It’s not that we should abandon all existing nonhuman models of pain. But some are really good, while others aren’t, depending on what you want to study. When it comes to this aspect of pain, our work shows which is which.”

To profile all the gene activity in a DRG tissue sample, the research team used an advanced technique called spatial transcriptomics, which has enhanced capabilities compared with single-cell RNA sequencing.

“It’s rare to have access to both the human tissue we used and to the technology,” said Dr. Diana Tavares-Ferreira, also a co-first and co-corresponding author of the study and a CAPS fellow. “Spatial transcriptomics allows us to overcome the large size of these neurons and to see with a degree of certainty where and how a gene is expressed in human nociceptors.

“Our main goal was to fully characterize the whole transcriptome of human DRG neurons because so much of the work that’s been done to find new pain therapeutic targets has been in mice. Our results help clarify why those efforts struggle to produce results.”

By describing the neuron types present in human DRG and detailing their gene expression, the team has a much better picture of what the physiological functions are for each gene, Price said.

“With that knowledge, not only can anybody use our data to seek drug targets that they couldn’t have sought before, but in some cases we also don’t need to use the mice at all now. We can use the human information,” he said.

Price called removing that reliance on animal models “a fundamental change,” because it allows scientists to explore how any cell type might interact with any neuron in the human peripheral nervous system.

“We’re now able to approach developing pain therapeutics in a more specific way and to think about how chronic pain happens in people in a different way,” Price said. “My hope is that our findings can change the way people do research in our field. It’s a road map that we will use, and others are welcome to follow.”

Story Source:

Materials provided by University of Texas at Dallas. Original written by Stephen Fontenot. Note: Content may be edited for style and length.

Solid water, or ice, is like many other materials in that it can form different solid materials based on variable temperature and pressure conditions, like carbon forming diamond or graphite. However, water is exceptional in this aspect as there are at least 20 solid forms of ice known to us.

A team of scientists working in UNLV’s Nevada Extreme Conditions Lab pioneered a new method for measuring the properties of water under high pressure. The water sample was first squeezed between the tips of two opposite-facing diamonds — freezing into several jumbled ice crystals. The ice was then subjected to a laser-heating technique that temporarily melted it before it quickly re-formed into a powder-like collection of tiny crystals.

By incrementally raising the pressure, and periodically blasting it with the laser beam, the team observed the water ice make the transition from a known cubic phase, Ice-VII, to the newly discovered intermediate, and tetragonal, phase, Ice-VIIt, before settling into another known phase, Ice-X.

Zach Grande, a UNLV Ph.D. student, led the work which also demonstrated that the transition to Ice-X, when water stiffens aggressively, occurs at much lower pressures than previously thought.

While it’s unlikely we’ll find this new phase of ice anywhere on the surface of Earth, it is likely a common ingredient within the mantle of Earth as well as in large moons and water-rich planets outside of our solar system.

The team’s findings were reported in the March 17 issue of the journal Physical Review B.

Takeaways

The research team had been working to understand the behavior of high-pressure water that may be present in the interior of distant planets.

To do so, Grande and UNLV physicist Ashkan Salamat placed a sample of water between the tips of two round-cut diamonds known as diamond anvil cells, a standard feature in the field of high pressure physics. Applying a little bit of force to the diamonds enabled the researchers to recreate pressures as high as those found at the center of the Earth.

By squeezing the water sample between these diamonds, scientists drove the oxygen and hydrogen atoms into a variety of different arrangements, including the newly discovered arrangement, Ice-VIIt.

Not only did the first-of-its-kind laser-heating technique allow scientists to observe a new phase of water ice, but the team also found that the transition to Ice-X occurred at pressures nearly three times lower than previously thought — at 300,000 atmospheres instead of 1 million. This transition has been a highly debated topic in the community for several decades.

“Zach’s work has demonstrated that this transformation to an ionic state occurs at much, much lower pressures than ever thought before,” Salamat said. “It’s the missing piece, and the most precise measurements ever on water at these conditions.”

The work also recalibrates our understanding of the composition of exoplanets, Salamat added. Researchers hypothesize that the Ice-VIIt phase of ice could exist in abundance in the crust and upper mantle of expected water-rich planets outside of our solar system, meaning they could have conditions habitable for life.

Story Source:

Materials provided by University of Nevada, Las Vegas. Original written by Natalie Bruzda. Note: Content may be edited for style and length.