In a paper published in Nature Ecology and Evolution on June 11, researchers from the University of Birmingham and University of Bristol have used a new method of geographical analysis to infer how these ancestral reptiles, known as archosauromorphs, dispersed following one of the most impactful climate events the Earth has ever seen, the end-Permian mass extinction.

The first archosauromorphs, some resembling modern reptiles and many times smaller than familiar dinosaurs, were previously believed to only survive in certain parts of the globe due to extreme heat across the tropics, viewed by many paleontologists as a dead zone, in the earliest Triassic.

By developing a new modelling technique based on landscape reconstructions and evolutionary trees, the team of researchers have been able to discover clues about how these reptiles moved around the world during the Triassic period, following the mass extinction where more than half of land-based animals and 81% of marine life died.

The archosauromorphs that survived the extinction event rose to prominence in Earth’s ecosystems in the Triassic, leading to the evolution of dinosaurs. The team now suggest that their later success was in part due to their ability to migrate up to 10,000 miles across the tropical dead zone to access new ecosystems.

Dr Joseph Flannery-Sutherland from the University of Birmingham and corresponding author of the study said:

“Amid the worst climatic event in Earth’s history, where more species died than at any period since, life still survived. We know that archosauromorphs as a group managed to come out of this event and over the Triassic period became one of the main players in shaping life thereafter.

“Gaps in their fossil record have increasingly begun to tell us something about what we weren’t seeing when it comes to these reptiles. Using our modelling system, we have been able to build a picture of what was happening to the archosauromorphs in these gaps and how they dispersed across the ancient world. This is what led us to call our method TARDIS, as we were looking at terrains and routes directed in space-time.

“Our results suggest that these reptiles were much hardier to the extreme climate of the Pangaean tropical dead zone, able to endure these hellish conditions to reach the other side of the world. It’s likely that this ability to survive the inhospitable tropics may have conferred an advantage that saw them thrive in the Triassic world.”

“The evolution of life has been controlled at times by the environment,” says Professor Michael Benton from the University of Bristol, senior author of the study, “but it is difficult to integrate our limited and uncertain knowledge about the ancient landscape with our limited and uncertain knowledge about the ecology of extinct organisms. But by combining the fossils with reconstructed maps of the ancient world, in the context of evolutionary trees, we provide a way of overcoming these challenges.”

Results show that teens who got up to two more hours of sleep on weekends than on weekdays exhibited fewer anxiety symptoms compared with those who did not sleep longer on weekends. However, longer durations of catch-up sleep on weekends were associated with slightly more internalizing symptoms.

“The results show that both sleeping less on weekends than weekdays and sleeping substantially more on weekends were associated with higher anxiety symptoms,” said lead author Sojeong Kim, a doctoral candidate in the department of clinical psychology and psychology graduate advisor at the University of Oregon in Eugene. “In contrast, moderate catch-up sleep — defined as less than two hours — was associated with lower anxiety symptoms, suggesting that some weekend recovery sleep may be beneficial.”

The American Academy of Sleep Medicine recommends that teenagers 13 to 18 years of age should sleep 8 to 10 hours on a regular basis to promote optimal health. However, CDC data show that only 23% of high school students get sufficient sleep on an average school night.

“Many teens try to make up for lost sleep by sleeping in on weekends,” Kim said.

Consistently getting sufficient sleep is associated with better health outcomes including improved attention, behavior, learning, memory, emotional regulation, quality of life, and mental and physical health. In contrast, insufficient sleep in teenagers is associated with increased risks of problems such as depression and suicidal thoughts.

The study involved 1,877 adolescents with a mean age of 13.5 years. Sleep duration was estimated using Fitbit devices, while internalizing symptoms were assessed using the Child Behavior Checklist survey. Weekend catch-up sleep was calculated as the difference between weekend and weekday sleep duration.

Kim noted that it is important to identify the right amount of catch-up sleep that is beneficial to teens who restrict their sleep during the week.

“Too little or too much sleep variability from weekday to weekend may contribute to the symptoms someone is trying to combat, like physical or mental fatigue and feelings of anxiety,” she said.

The research abstract was published recently in an online supplement of the journal Sleep and will be presented Wednesday, June 11, during SLEEP 2025 in Seattle. SLEEP is the annual meeting of the Associated Professional Sleep Societies, a joint venture of the American Academy of Sleep Medicine and the Sleep Research Society.

Abstract Title: The Sweet Spot of Weekend Catch-Up Sleep: A Protective Factor Against Depressive Symptoms?

Abstract ID: 0263

The study, partly funded by the National Institutes of Health, was published May 22 in Cancer Discovery.

Investigators were surprised they could detect cancer-derived mutations in the blood so much earlier, says lead study author Yuxuan Wang, M.D., Ph.D., an assistant professor of oncology at the Johns Hopkins University School of Medicine. “Three years earlier provides time for intervention. The tumors are likely to be much less advanced and more likely to be curable.”

To determine how early cancers could be detected prior to clinical signs or symptoms, Wang and colleagues assessed plasma samples that were collected for the Atherosclerosis Risk in Communities (ARIC) study, a large National Institutes of Health-funded study to investigate risk factors for heart attack, stroke, heart failure and other cardiovascular diseases. They used highly accurate and sensitive sequencing techniques to analyze blood samples from 26 participants in the ARIC study who were diagnosed with cancer within six months after sample collection, and 26 from similar participants who were not diagnosed with cancer.

At the time of blood sample collection, eight of these 52 participants scored positively on a multicancer early detection (MCED) laboratory test. All eight were diagnosed within four months following blood collection. For six of the eight individuals, investigators also were able to assess additional blood samples collected 3.1-3.5 years prior to diagnosis, and in four of these cases, tumor-derived mutations could also be identified in samples taken at the earlier timepoint.

“This study shows the promise of MCED tests in detecting cancers very early, and sets the benchmark sensitivities required for their success,” says Bert Vogelstein, M.D., Clayton Professor of Oncology, co-director of the Ludwig Center at Johns Hopkins and a senior author on the study.

“Detecting cancers years before their clinical diagnosis could help provide management with a more favorable outcome,” adds Nickolas Papadopoulos, Ph.D., professor of oncology, Ludwig Center investigator and senior author of the study. “Of course, we need to determine the appropriate clinical follow-up after a positive test for such cancers.”

The study was supported in part by National Institutes of Health grant #s R21NS113016, RA37CA230400, U01CA230691, P30 CA 06973, DRP 80057309, and U01 CA164975. Additional funding was provided by the Virginia and D.K. Ludwig Fund for Cancer Research, the Commonwealth Fund, the Thomas M Hohman Memorial Cancer Research Fund, The Sol Goldman Sequencing Facility at Johns Hopkins, The Conrad R. Hilton Foundation, the Benjamin Baker Endowment, Swim Across America, Burroughs Wellcome Career Award for Medical Scientists, Conquer Cancer — Fred J. Ansfield, MD, Endowed Young Investigator Award, and The V Foundation for Cancer Research. The Atherosclerosis Risk in Communities study has been funded in whole or in part with federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under contract numbers 75N92022D00001, 75N92022D00002, 75N92022D00003, 75N92022D00004, and 75N92022D00005.

The findings, led by scientists at the University of Bristol and the cover story of the journal Nature, mean plants and shallow soil layers are likely removing around one gigatonne more CO2 each year from the atmosphere to counteract this, emphasising their pivotal and greater part in combating climate change.

Lead author Dr Josh Dean, Associate Professor in Biogeochemistry and UKRI Future Leaders Fellow at the University of Bristol, said: “The results took us by surprise because it turns out that old carbon stores are leaking out much more into the atmosphere then previous estimates suggested.

“The implications are potentially huge for our understanding of global carbon emissions. Plants and trees take up CO₂ from the atmosphere and can then lock this carbon away in soils for thousands of years.

“Our findings show some of this old carbon, as well as ancient carbon from rocks, is leaking sideways into rivers and making its way back to the atmosphere. We don’t yet know how humans are affecting this flow of ancient carbon, but we do know plants and trees must be taking up more carbon from the atmosphere today to account for this unrecognised release of old carbon.”

Rivers transport and release methane and carbon dioxide as part of the global carbon cycle. Until now, scientists believed the majority of this was a quick turnover derived from the recycling of recent plant growth – organic material broken down and carried into the river system in the past 70 years or so. This new study indicates the opposite, with more than half – some 60% – of emissions being attributed to long-term carbon stores accumulated over hundreds to thousands of years ago, or even longer.

The international research team, led by scientists at the University of Bristol, University of Oxford and the UK Centre for Ecology and Hydrology, studied more than 700 river reaches from 26 different countries across the world.

They took detailed radiocarbon measurements of carbon dioxide and methane from the rivers. By comparing the levels of carbon-14 in the river samples with a standard reference for modern atmospheric CO₂, the team was able to date the river carbon.

Co-author Prof Bob Hilton, Professor of Sedimentary Geography at the University of Oxford, explained: “We discovered that around half of the emissions are young, while the other half are much older, released from deep soil layers and rock weathering that were formed thousands and even millions of years ago.”

The research was supported by funding from UK Research and Innovation (UKRI) Natural Environment Research Council (NERC).

Co-author Dr Gemma Coxon, Associate Professor in Hydrology and UKRI Future Leaders Fellow at the University of Bristol, said: “Rivers globally release about two gigatonnes of carbon each year, compared to human activity that results in between 10-15 gigatonnes of carbon emissions. These river emissions are significant at a global scale, and we’re showing that over half of these emissions may be coming from carbon stores we considered relatively stable. This means we need to re-evaluate these crucial parts of the global carbon cycle.”

Further building on these findings, the researchers plan to explore how the age of river carbon emissions varies across rivers the study was not able to capture, as well as investigating how the age of these emissions may have changed through time.

The development, published today (June 11) in Nature, represents a major leap toward the realization of thinner, faster and more energy-efficient electronics, the researchers said. They created a complementary metal-oxide semiconductor (CMOS) computer — technology at the heart of nearly every modern electronic device — without relying on silicon. Instead, they used two different 2D materials to develop both types of transistors needed to control the electric current flow in CMOS computers: molybdenum disulfide for n-type transistors and tungsten diselenide for p-type transistors.

“Silicon has driven remarkable advances in electronics for decades by enabling continuous miniaturization of field-effect transistors (FETs),” said Saptarshi Das, the Ackley Professor of Engineering and professor of engineering science and mechanics at Penn State, who led the research. FETs control current flow using an electric field, which is produced when a voltage is applied. “However, as silicon devices shrink, their performance begins to degrade. Two-dimensional materials, by contrast, maintain their exceptional electronic properties at atomic thickness, offering a promising path forward.”

Das explained that CMOS technology requires both n-type and p-type semiconductors working together to achieve high performance at low power consumption — a key challenge that has stymied efforts to move beyond silicon. Although previous studies demonstrated small circuits based on 2D materials, scaling to complex, functional computers had remained elusive, Das said.

“That’s the key advancement of our work,” Das said. “We have demonstrated, for the first time, a CMOS computer built entirely from 2D materials, combining large area grown molybdenum disulfide and tungsten diselenide transistors.”

The team used metal-organic chemical vapor deposition (MOCVD) — a fabrication process that involves vaporizing ingredients, forcing a chemical reaction and depositing the products onto a substrate — to grow large sheets of molybdenum disulfide and tungsten diselenide and fabricate over 1,000 of each type of transistor. By carefully tuning the device fabrication and post-processing steps, they were able to adjust the threshold voltages of both n- and p-type transistors, enabling the construction of fully functional CMOS logic circuits.

“Our 2D CMOS computer operates at low-supply voltages with minimal power consumption and can perform simple logic operations at frequencies up to 25 kilohertz,” said first author Subir Ghosh, a doctoral student pursuing a degree in engineering science and mechanics under Das’s mentorship.

Ghosh noted that the operating frequency is low compared to conventional silicon CMOS circuits, but their computer — known as a one instruction set computer — can still perform simple logic operations.

“We also developed a computational model, calibrated using experimental data and incorporating variations between devices, to project the performance of our 2D CMOS computer and benchmark it against state-of-the-art silicon technology,” Ghosh said. “Although there remains scope for further optimization, this work marks a significant milestone in harnessing 2D materials to advance the field of electronics.”

Das agreed, explaining that more work is needed to further develop the 2D CMOS computer approach for broad use, but also emphasizing that the field is moving quickly when compared to the development of silicon technology.

“Silicon technology has been under development for about 80 years, but research into 2D materials is relatively recent, only really arising around 2010,” Das said. “We expect that the development of 2D material computers is going to be a gradual process, too, but this is a leap forward compared to the trajectory of silicon.”

Ghosh and Das credited the 2D Crystal Consortium Materials Innovation Platform (2DCC-MIP) at Penn State with providing the facilities and tools needed to demonstrate their approach. Das is also affiliated with the Materials Research Institute, the 2DCC-MIP and the Departments of Electrical Engineering and of Materials Science and Engineering, all at Penn State. Other contributors from the Penn State Department of Engineering Science and Mechanics include graduate students Yikai Zheng, Najam U. Sakib, Harikrishnan Ravichandran, Yongwen Sun, Andrew L. Pannone, Muhtasim Ul Karim Sadaf and Samriddha Ray; and Yang Yang, assistant professor. Yang is also affiliated with the Materials Research Institute and the Ken and Mary Alice Lindquist Department of Nuclear Engineering at Penn State. Joan Redwing, director of the 2DCC-MIP and distinguished professor of materials science and engineering and of electrical engineering, and Chen Chen, assistant research professor, also co-authored the paper. Other contributors include Musaib Rafiq and Subham Sahay, Indian Institute of Technology; and Mrinmoy Goswami, Jadavpur University.

The U.S. National Science Foundation, the Army Research Office and the Office of Naval Research supported this work in part.