Physician associate law may confuse patients – BMA

Plans for the doctors’ regulator to license less-qualified health workers are under attack.

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Junior doctors strike for 10th time over pay

NHS bosses warn of significant disruption to services in England during the five-day walkout.

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Germany legalises cannabis, but makes it hard to buy

Under the law backed by MPs, possession will be legal, but strict rules mean it will be complicated.

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Barriers against Antarctic ice melt disappearing at the double

Undersea anchors of ice that help prevent Antarctica’s land ice from slipping into the ocean are shrinking at more than twice the rate compared with 50 years ago, research shows.

More than a third of these frozen moorings, known as pinning points, have decreased in size since the turn of the century, experts say.

Further deterioration of pinning points, which hold in place the floating ice sheets that fortify Antarctica’s land ice, would accelerate the continent’s contribution to rising sea levels, scientists warn.

Floating ice sheets fringe 75 per cent of Antarctica’s coastline and cover an area equivalent to the size of Greenland.

The findings are part of the first ever study of changes in the thickness of Antarctic ice shelves — extensions of land ice that float on the ocean — stretching back to 1973. Previous observations only date from 1992.

Researchers from the University of Edinburgh used satellite imagery from the NASA/United States Geological Survey (USGS) Landsat program’s fifty-year-old archive to track variations in the appearances pinning points on the ice’s surface.

Pinning points form when part of a floating ice sheet anchors itself to an elevation on the ocean floor, creating a visible bump on the otherwise smooth ice shelf surface.

Using changes in pinning points as a reliable proxy for variations in the thickness of ice shelves, the team measured changes in these features during three periods: from 1973 to 1989, 1990 to 2000 and from 2000 to 2022.

The scientists found that only 15 per cent of pinning points reduced in size from 1973 to 1989, leading to small localised pockets of thinning ice shelves.

However, a widespread acceleration and unanchoring of ice shelves from pinning points began in the 1990s in the western Antarctic Peninsula and the Amundsen Sea.

The number of pinning points that shrank increased to 25 per cent from 1990 to 2000 and 37 per cent from 2000 to 2022.

The paper, published in Nature, was funded by the Leverhulme Trust.

Lead author, Dr Bertie Miles, Leverhulme Early Career Fellow, School of GeoSciences, University of Edinburgh, said: “The switch over the past 50 years from relatively limited and regionally concentrated ice shelf melt, to much more widespread unanchoring, is striking. The ongoing concern is how many more of these vitally important pinning points will begin to melt away in the coming 50 years.”

Co-lead author, Professor Robert Bingham, Professor of Glaciology and Geophysics, School of GeoSciences, University of Edinburgh, said: “What we are seeing around Antarctica is a sustained attack by climate warming to the buttresses, that slow the conversion of ice melting, into global sea-level rise. This reinforces the need for us to take action where we can to reduce global carbon emissions.”

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Wetlands, parks and even botanical gardens among the best ways to cool cities during heatwaves

Botanical gardens are not just beautiful — they can cool the city air by 5°C during heatwaves, according to the most comprehensive review of its kind led by the University of Surrey.?Parks and wetlands have a similar effect.

The study analysed how green spaces and waterways cool down cities and towns.

Professor Prashant Kumar, Director of Surrey’s Global Centre for Clean Air Research (GCARE), said:

“We have known for some time that green spaces and water can cool cities down. However, this study provides us the most comprehensive picture yet. What’s more — we can explain why. From trees providing shade, to evaporating water cooling the air.”

They found that while success depends heavily on local factors — there were some general patterns. Among the key findings, the following green spaces and waterways cooled the air considerably:

  • Botanical gardens: -5°C avg (variation: -2.2°C to -10°C)

  • Wetlands: -4.7°C avg (variation: -1.2°C to -12°C)

  • Rain garden: -4.5°C avg (variation: -1.3°C to -7°C)

  • Green walls: -4.1°C avg (variation: -0.1°C to -18°C)

  • Street trees: -3.8°C avg (variation: -0.5°C to -12°C)

  • City farm: -3.5°C avg (variation -3°C to -3.9°C)

  • Parks: -3.2°C avg (variation -0.8°C to -10°C)

  • Reservoirs -2.9°C avg (variation -1.8°C to 5°C)

  • Playgrounds: -2.9°C avg (variation: -2.8°C to -3°C)

Up to a point, the bigger the park — the bigger the cooling effect. Cities can unlock greater benefits by connecting green spaces into ‘green corridors’.

Greening projects can also remove carbon emissions and even help prevent flooding.

Professor Kumar said:

“This will help town planners around the world confront the challenges of global heating. By implementing just some of the measures we describe, cities can become more resilient, and their citizens can be healthier and happier too.”

However — the team also found areas of the globe which were vulnerable to heat — but had not researched the best way to use green spaces to cool down.

Maria de Fatima Andrade, Professor at the Atmospheric Sciences Department at the University of Sao Paulo, Brazil, said:

“Our paper confirms just how many ways there are to keep cool. But it also reveals how much work is left to do. Institutions around the world need to invest in the right research — because what’s very clear from our study is that there is no one-size-fits-all solution. It depends on what works for your community.”

The study is published in the journal, The Innovation.

The study demonstrates the University of Surrey’s contribution towards the United Nations’ Sustainable Development Goals, especially Goal 11 (Sustainable Cities and Communities) and Goal 13 (Climate Action).

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Health workers still waiting for promised payments

Social enterprises say hardworking front-line staff have not received one-off payments agreed last May.

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Killer instinct drove evolution of mammals’ predatory ancestors

The evolutionary success of the first large predators on land was driven by their need to improve as killers, researchers at the University of Bristol and the Open University suggest.

The forerunners of mammals ruled the Earth for about 60 million years, long before the origin of the first dinosaurs. They diversified as the top predators on land between 315-251 million years ago.

Researchers studied the jaw anatomy and body size of carnivorous synapsids, using these traits to reconstruct the likely feeding habits of these ancient predators and chart their ecological evolution through time. They found a major shift in synapsid jaw function roughly 270 million years ago linked to a significant shift in predatory behaviour that has important implications for the evolution of our earliest ancestors.

As herbivores grew larger and faster, carnivores adapted to become bigger and better predators to survive.

“Earlier synapsid predators such as the famous sail backed Dimetrodon, had fairly long jaws with lots of teeth to ensure that once they ensnared their prey, it wouldn’t escape,” explained lead author Dr Suresh Singh based in Bristol’s School of Earth Sciences. “However, we saw a shift in jaw function toward shorter jaws with greater muscle efficiency and fewer teeth that were concentrated at the front of the jaw — these were jaws adapted to deliver deep, powerful bites.

“The change shows that later synapsid carnivores placed more emphasis on heavily injuring and so more quickly killing their prey. Among these later synapsids were the very first sabertoothed carnivores! This change highlights that predators were facing new selective pressures from their prey.”

This finding provides important context for a key step in synapsid evolution. “The reorganisation of synapsid jaws through this time has long been known as a big step towards the evolution of mammals,” added Dr Armin Elsler, a collaborator on the study. “These changes don’t just make the jaw more efficient; they also mark the very earliest redevelopment of the jaw that also created the complex ear found in mammals. What drove this first step? Our study suggests that it was partly driven by ecological pressures from their prey.”

Co-author Dr Tom Stubbs said: “The timing of the shift in jaw function corresponds with the evolution of new larger, faster herbivores that would have posed a greater challenge for predators to tackle.

“The risks to carnivores of getting injured or killed went up, so some synapsid carnivores became bigger, better killers to overcome these risks.”

This shift reflects a new dynamism in predator-prey interactions that shows that life on land was moving more quickly.

“The late Palaeozoic was the time when animals first began to live, eat and reproduce entirely on land,” said Professor Mike Benton, a co-supervisor on the study

“They became fully terrestrial, colonising new habitats and exploiting new resources further inland from the aquatic environments they’d previously relied on.

“Our findings show how the selective pressures on these early land animals changed as they became better adapted for life on land — catching another animal that can move fast and grow to larger sizes is much more difficult than catching a slippery little fish or amphibian.”

Professor Emily Rayfield also co-supervised the study. She added: “Predator-prey interactions are an important driver of animal behaviour today so it’s quite something to see that influence through anatomical evolution over millions of years, and find that they are potentially responsible for driving some big leaps in our own evolutionary history.

“It highlights how palaeontologists can use the relationship between form and function to explore how different prehistoric animals may have lived, which can tell us so much about the evolution of life on Earth.”

The researchers also found that synapsid carnivore morphological diversity increased following the shift, with the addition of new functional groups adapted for either faster biting speeds or even more powerful bites through the mid-late Permian — around 265-251 million years ago. By assessing how the sizes of these new carnivore species compared within different communities through time, they realised these communities may have begun to closely resemble those of modern carnivorous mammals.

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Climate change linked to rise in mental distress among teens, according to Drexel study

Worsening human-induced climate change may have effects beyond the widely reported rising sea levels, higher temperatures, and impacts on food supply and migration — and may also extend to influencing mental distress among high schoolers in the United States.

According to a representative survey of 38,616 high school students from 22 public school districts in 14 U.S. states, the quarter of those adolescents who had experienced the highest number of days in a climate disaster within the past two years and the past five years — such as hurricanes, floods, tornadoes, droughts, and wildfire — had 20% higher odds of developing mental distress than their peers who experienced few or no disaster events.

The paper is the first large scale research looking at mental health of adolescents following multiple disaster events — including the timing, frequency, and duration of the events — spanning 83 federally declared climate disasters occurring within 10 years before the survey was completed. The findings, using May 2019 data on sadness/hopelessness and short sleep from the U.S. Youth Risk Behavior Survey and disaster data from the Federal Emergency Management Agency, were published this month in the journal Preventive Medicine Reports.

“We know that climate change has and will have catastrophic impacts across the globe,” said lead author Amy Auchincloss, PhD, an associate professor of epidemiology in the Dornsife School of Public Health. “But we were alarmed to find that climate related disasters already were affecting so many teens in the U.S. For example, within the past 2 years, many school districts in our study were subject to climate disasters for over 20 days.”

Respondents reported mental health distress by responding affirmatively to persistent feelings of sadness or hopelessness and short sleep duration, two factors that previous studies strongly link to mental health disorders among adolescents. The group controlled for other factors that may influence mental health, such as age, race, gender, experience of bullying, concerns about school safety and household income.

A positive, but not statistically significant, link between experiencing climate disasters and mental distress was also found when spanning ten years before the U.S. Youth Risk Survey.

“We found the strongest effects on mental distress in the 2 years immediately following a climate disaster — with the effect gradually weakening 5 to 10 years after the disaster,” said co-author Josiah Kephart, PhD, an assistant professor in the Dornsife School of Public Health.

As the results cannot prove causation, the authors say they would like to see more studies into the range of effects of climate change on youth and methods to improve preparing for potential worsening mental health among this population.

Already, roughly half of adolescents have experienced a mental health disorder in their childhood or teen years, according to the U.S. Department of Health and Human Services.

“Resources for the youth mental health crisis already have difficulty meeting demand and demand will increase as disasters increase,” said co-author Esther Chernak, MD, a clinical professor and director of the Center for Public Health Readiness and Communication at Dornsife School of Public Health. “The current study is evidence that clinicians, policymakers, parents, and many others with a stake in youth mental health can point to when advocating for increasing adolescent-specific mental health resources — particularly in lower-income communities who will be hit hardest by disasters.”

Drexel’s Dornsife School of Public Health is home to significant ongoing work addressing health and climate change. Among other projects, the school’s Urban Health Collaborative recently received National Institutes of Health funding to support establishment of the Drexel Climate Change and Urban Health Research Center (CCUH), which with foster research on the effects of climate change on health across the Americas. The Urban Health in Latin America Project (SALURBAL-Climate), of which Dornsife School of Public Health is an institutional partner, funds research on climate change’s links to health and health inequity impacts across Latin America using data on as any as 400 cities in 11 countries. Additional work at the school, in collaboration with the World Resources Institute (WRI), WRI Brasil, SALURBAL, and WRI Mexico, seeks to deepen our understanding of the relationship between neighborhood-scale heat mortality and neighborhood social characteristics in two Brazilian cities; the findings of which aim to inform public policy.

In addition to Auchincloss, additional authors on the study includes Dominic A. Ruggiero, and Meghan T. Donnelly, who were graduate students at Drexel at the time of this work.

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Similarities and differences in human and insect vision formation

Researchers at the University of California, Irvine have discovered profound similarities and surprising differences between humans and insects in the production of the critical light-absorbing molecule of the retina, 11-cis-retinal, also known as the “visual chromophore.” The findings deepen understanding of how mutations in the RPE65 enzyme cause retinal diseases, especially Leber congenital amaurosis, a devastating childhood blinding disease.

For the study, recently published online in the journal Nature Chemical Biology, the team used X-ray crystallography to study NinaB, a protein found in insects that functions similarly to the RPE65 protein found in humans. Both are crucial for synthesis of 11-cis-retinal, and their absence results in severe visual impairment.

“Our study challenges traditional assumptions about the similarities and differences of human and insect vision,” said corresponding author Philip Kiser, UCI associate professor of physiology & biophysics as well as ophthalmology. “While these enzymes share a common evolutionary origin and three-dimensional architecture, we found that the process by which they produce 11-cis-retinal is distinct.”

Creation of 11-cis-retinal begins with the consumption of foods like carrots or pumpkins containing compounds used for vitamin A generation, such as beta-carotene. These nutrients are metabolized by carotenoid cleavage enzymes, including NinaB and RPE65. It was previously known that humans require two of these enzymes to produce 11-cis-retinal from beta-carotene, whereas insects can achieve the conversion with just NinaB. Gaining insight into how NinaB can couple the two steps into a single reaction along with the functional relationships between NinaB and RPE65 was a key motivation for the study.

“We found that structurally, these enzymes are very much alike, but the locations in which they perform their activity are different,” said lead author Yasmeen Solano, a graduate student in Kiser’s laboratory at the UCI Center for Translational Vision Research. “Understanding key features within the NinaB structure has led to an enhanced understanding of the catalytic machinery necessary to support the function of the retinal visual pigments. Through our study of NinaB, we were able to learn about the structure of a key portion of RPE65 that had not previously been resolved. This discovery is vital in understanding and addressing loss-of-function mutations in RPE65.”

Other team members included Michael Everett, a junior specialist in the Kiser lab, and Kelly Dang and Jude Abueg, biological sciences undergraduates at the time.

This work was supported by the National Science Foundation under grant CHE-2107713, the Department of Veterans Affairs under grant BX004939 and the National Institutes of Health under grant EY034519-01S1.

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Compound vital for all life likely played a role in life’s origin

A chemical compound essential to all living things has been synthesised in a lab in conditions that could have occurred on early Earth, suggesting it played a role at the outset of life, finds a new study led by UCL researchers.

The compound, pantetheine, is the active fragment of Coenzyme A. It is important for metabolism — the chemical processes that maintain life. Earlier studies failed to synthesise pantetheine effectively, leading to suggestions that it was absent at life’s origin.

In the new study, published in the journal Science, the research team created the compound in water at room temperature using molecules formed from hydrogen cyanide, which was likely abundant on early Earth.

Once formed, the researchers said, it is simple to envisage how pantetheine might have aided chemical reactions that led from simple forerunners of protein and RNA molecules to the first living organisms — a moment that is thought to have occurred 4 billion years ago.

The study challenges the view among some researchers in the field that water is too destructive for life to originate in it and that life more likely originated in pools that periodically dried out.

Driving the reactions that produced pantetheine were energy-rich molecules called aminonitriles, which are closely chemically related to amino acids, the building blocks of proteins and of life.

Members of the same team, led by Professor Matthew Powner (UCL Chemistry), have already used similar chemistry powered by aminonitriles to demonstrate how other key biological ingredients could be created at the origin of life, including peptides (protein-creating chains of amino acids) and nucleotides (the building blocks of RNA and DNA).

Professor Powner, senior author of the paper, said: “This new study is further evidence that the basic structures of biology, the primary molecules that biology is built from, are predisposed to form through nitrile chemistry.

“The ease with which different classes of biological molecules can be made using nitriles has convinced me that, rather than life being preceded by one molecule such as RNA, and there being an ‘RNA world’ before life began, the basic molecules of biology emerged alongside each other — a network of RNAs, proteins, enzymes and cofactors leading to the first living organisms.

“Our future work will look at how these molecules came together, how pantetheine chemistry talks to RNA, peptide and lipid chemistry for instance, to deliver chemistry that the individual classes of molecule could not deliver in isolation.”

A notable earlier attempt to synthesise pantetheine was made in 1995 by the late American chemist Stanley Miller, who had started the field of origin of life experiments three decades earlier, creating amino acids from four simple chemicals in glass tubes.

However, in the later 1995 experiment, the yields of pantetheine were very low and required extremely high concentrations of chemicals that had been dried out and sealed in an airtight tube before they were heated to 100 degrees Centigrade.

Dr Jasper Fairchild (UCL Chemistry), a lead author of the study, who conducted the work as part of his PhD, said: “The major difference between Miller’s study and ours is whereas Miller tried to use acid chemistry, we used nitriles. It’s the nitriles that bring the energy and the selectivity. Our reactions just run in water and produce high yields of pantetheine with relatively low concentrations of chemicals needed.”

Professor Powner added: “It had been assumed you should make these molecules from acids, because using acids appears to be biological, and that is what we are taught at school and at university. We are taught peptides are made from amino acids.

“Our work suggests this conventional view has ignored an essential ingredient, the energy required to forge new bonds. The reactions look a little different with nitriles but the end products — the basic units of biology — are indistinguishable whether formed through acid or nitrile chemistry.”

While the paper focuses solely on the chemistry, the research team said that the reactions they demonstrated could plausibly have taken place in pools or lakes of water on the early Earth (but not likely in the oceans as the concentrations of the chemicals would likely be too diluted).

The new study was supported by the Engineering and Physical Sciences Research Council, the Simons Foundation and the Volkswagen Foundation. As a result of his work on the origins of life, Professor Powner was named a finalist in the 2021 Blavatnik Awards for Young Scientists. The awards are for scientists aged 42 or younger whose research “is already transforming technology and our understanding of the world.”

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