Sensors made from ‘frozen smoke’ can detect toxic formaldehyde in homes and offices

Researchers have developed a sensor made from ‘frozen smoke’ that uses artificial intelligence techniques to detect formaldehyde in real time at concentrations as low as eight parts per billion, far beyond the sensitivity of most indoor air quality sensors.

The researchers, from the University of Cambridge, developed sensors made from highly porous materials known as aerogels. By precisely engineering the shape of the holes in the aerogels, the sensors were able to detect the fingerprint of formaldehyde, a common indoor air pollutant, at room temperature.

The proof-of-concept sensors, which require minimal power, could be adapted to detect a wide range of hazardous gases, and could also be miniaturised for wearable and healthcare applications. The results are reported in the journal Science Advances.

Volatile organic compounds (VOCs) are a major source of indoor air pollution, causing watery eyes, burning in the eyes and throat, and difficulty breathing at elevated levels. High concentrations can trigger attacks in people with asthma, and prolonged exposure may cause certain cancers.

Formaldehyde is a common VOC and is emitted by household items including pressed wood products (such as MDF), wallpapers and paints, and some synthetic fabrics. For the most part, the levels of formaldehyde emitted by these items are low, but levels can build up over time, especially in garages where paints and other formaldehyde-emitting products are more likely to be stored.

According to a 2019 report from the campaign group Clean Air Day, a fifth of households in the UK showed notable concentrations of formaldehyde, with 13% of residences surpassing the recommended limit set by the World Health Organization (WHO).

“VOCs such as formaldehyde can lead to serious health problems with prolonged exposure even at low concentrations, but current sensors don’t have the sensitivity or selectivity to distinguish between VOCs that have different impacts on health,” said Professor Tawfique Hasan from the Cambridge Graphene Centre, who led the research.

“We wanted to develop a sensor that is small and doesn’t use much power, but can selectively detect formaldehyde at low concentrations,” said Zhuo Chen, the paper’s first author.

The researchers based their sensors on aerogels: ultra-light materials sometimes referred to as ‘liquid smoke’, since they are more than 99% air by volume. The open structure of aerogels allows gases to easily move in and out. By precisely engineering the shape, or morphology, of the holes, the aerogels can act as highly effective sensors.

Working with colleagues at Warwick University, the Cambridge researchers optimised the composition and structure of the aerogels to increase their sensitivity to formaldehyde, making them into filaments about three times the width of a human hair. The researchers 3D printed lines of a paste made from graphene, a two-dimensional form of carbon, and then freeze-dried the graphene paste to form the holes in the final aerogel structure. The aerogels also incorporate tiny semiconductors known as quantum dots.

The sensors they developed were able to detect formaldehyde at concentrations as low as eight parts per billion, which is 0.4 percent of the level deemed safe in UK workplaces. The sensors also work at room temperature, consuming very low power.

“Traditional gas sensors need to be heated up, but because of the way we’ve engineered the materials, our sensors work incredibly well at room temperature, so they use between 10 and 100 times less power than other sensors,” said Chen.

To improve selectivity, the researchers then incorporated machine learning algorithms into the sensors. The algorithms were trained to detect the ‘fingerprint’ of different gases, so that the sensor was able to distinguish the fingerprint of formaldehyde from other VOCs.

“Existing VOC detectors are blunt instruments — you only get one number for the overall concentration in the air,” said Hasan. “By building a sensor that is able to detect specific VOCs at very low concentrations in real time, it can give home and business owners a more accurate picture of air quality and any potential health risks.”

The researchers say that the same technique could be used to develop sensors to detect other VOCs. In theory, a device the size of a standard household carbon monoxide detector could incorporate multiple different sensors within it, providing real-time information about a range of different hazardous gases. The team at Warwick are developing a low-cost multi-sensor platform that will incorporate these new aerogel materials and, coupled with AI algorithms, detect different VOCs.

“By using highly porous materials as the sensing element, we’re opening up whole new ways of detecting hazardous materials in our environment,” said Chen.

The research was supported in part by the Henry Royce Institute, and the Engineering and Physical Sciences Research Council (EPSRC), part of UK Research and Innovation (UKRI). Tawfique Hasan is a Fellow of Churchill College, Cambridge.

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‘There is no right or wrong way to have alopecia’

Gail Porter has shown people that bald is beautiful – but she can wear wigs too, says campaigner.

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Language barriers could contribute to higher aggression in people with dementia

Immigrants living with dementia were more likely to present with agitation and aggression compared with their non-immigrant counterparts, a new study by Edith Cowan University (ECU) in collaboration with The Dementia Centre, HammondCare, found.

Researchers from ECU’s Centre for Research in Aged Care and HammondCare’s The Dementia Centre noted that behaviours and psychological symptoms of dementia (BPSD), such as agitation and aggression, are common; however, its presentation may be influenced by the cultural background of the person.

A study investigated differences in clinical and demographics characteristics and BPSD between immigrants and non-immigrants living with dementia in residential aged care homes who were referred to Dementia Support Australia (DSA) programs. The study found that immigrants were more likely to present with agitation or aggression, while non-immigrants were more likely to present with hallucinations and delusions.

DSA, a free, Australian Government-funded dementia behaviour support program, has supported over 60,000 clients and 98 percent of aged care homes in every state and territory since 2016.

BPSD were common between the groups, with language barriers and cultural considerations frequently observed for immigrants, adding to the contributing factors.

“In Australia, over 400,000 people are living with dementia, a number projected to double by 2058, At least 54% of people living in residential aged care homes (RACHs) in 2019 — 2020 had a dementia diagnosis,” said lead researcher Pelden Chejor.

“Over 31% of aged care residents were also born overseas, and 9.2% of people using aged care preferred a language other than English. In 2019 — 2020, 21% of people living with dementia in RACHs were immigrants from non-English speaking countries. International studies have reported that immigrants experience a higher prevalence of dementia due to differing life experiences including those related to trauma, low literacy, and socioeconomic status.”

Chejor and his colleagues noted that loneliness, boredom, language barriers, and cultural considerations significantly contributed to BPSD for non-English-speaking immigrants compared with non-immigrants, with the largest significant differences being for language barriers and cultural considerations. There were no differences in the prevalence of contributing factors between English-speaking immigrants and non-immigrants.

“Our findings indicated a significantly lower rate of hallucinations for immigrants and non-English-speaking immigrants compared to non-immigrants. Additionally, non-English-speaking immigrants were significantly lower on delusions and disinhibition than non-immigrants.

“The higher severity of agitation or aggression is likely driven by communication difficulties as there was no difference for the English-speaking immigrants. Cognitive decline can impair both the ability to express and comprehend spoken language and people living with dementia who have English as their additional language may lose their ability to communicate in English and subsequently use their first language as the primary language of communication,” said Chejor.

“Our study calls for increased awareness and education on the impact of culture and language for people receiving residential care and exhibiting BPSD. Future research should explore related factors such as length of stay in Australia and English language proficiency to learn more about BPSD presentations for different immigrant groups. By doing so, we can better manage these symptoms.”

Head of DSA Marie Alford said the study reinforced the importance of understanding the person living with dementia, including their cultural background and experiences, likes, dislikes and routines when responding to BPSD.

“Communicating effectively with the person living with dementia, and taking the time to know them, including their language background and culture, is essential,” Alford said. “In many cases this can mean responding with support without the need for a pharmacological intervention.”

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Conversion process turns greenhouse gas into ethylene

Engineers at the University of Cincinnati created a more efficient way of converting carbon dioxide into valuable products while simultaneously addressing climate change.

In his chemical engineering lab in UC’s College of Engineering and Applied Science, Associate Professor Jingjie Wu and his team found that a modified copper catalyst improves the electrochemical conversion of carbon dioxide into ethylene, the key ingredient in plastic and a myriad of other uses.

Ethylene has been called “the world’s most important chemical.” It is certainly among the most commonly produced chemicals, used in everything from textiles to antifreeze to vinyl. The chemical industry generated 225 million metric tons of ethylene in 2022.

Wu said the process holds promise for one day producing ethylene through green energy instead of fossil fuels. It has the added benefit of removing carbon from the atmosphere.

“Ethylene is a pivotal platform chemical globally, but the conventional steam-cracking process for its production emits substantial carbon dioxide,” Wu said. “By utilizing carbon dioxide as a feedstock rather than depending on fossil fuels, we can effectively recycle carbon dioxide.”

The study was published in the journal Nature Chemical Engineering.

Wu’s students, including lead author and UC graduate Zhengyuan Li, collaborated with Rice University, Oak Ridge National Laboratory, Brookhaven National Laboratory, Stony Brook University and Arizona State University. Li received a prestigious graduate student award last year from the College of Engineering and Applied Science.

The electrocatalytic conversion of carbon dioxide produces two primary carbon products, ethylene and ethanol. Researchers found that using a modified copper catalyst produced more ethylene.

“Our research offers essential insights into the divergence between ethylene and ethanol during electrochemical CO2 reduction and proposes a viable approach to directing selectivity toward ethylene,” lead author Li said.

“This leads to an impressive 50% increase in ethylene selectivity,” Wu said. “Ideally, the goal is to produce a single product rather than multiple ones.”

Sponsored by the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy. Its Industrial Efficiency and Decarbonization Office is leading efforts to reduce fossil fuels and carbon emissions in industry wherever possible.

Li said the next step is refining the process to make it more commercially viable. The conversion system loses efficiency as byproducts of the reaction such as potassium hydroxide begin forming on the copper catalyst.

“The electrode stability must be improved for commercial deployment. Our next focus is to enhance stability and extend its operation from 1,000 to 100,000 hours,” Li said.

Wu said these new technologies will help make the chemical industry greener and more energy efficient.

“The overarching objective is to decarbonize chemical production by utilizing renewable electricity and sustainable feedstock,” Wu said. “Electrifying the conversion of carbon dioxide to ethylene marks a significant stride in decarbonizing the chemical sector.”

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Towards A Better Way of Releasing Hydrogen Stored in Hydrogen Boride Sheets

The looming threat of climate change has motivated scientists worldwide to look for cleaner alternatives to fossil fuels, and many believe hydrogen is our best bet. As an environmentally friendly energy resource, hydrogen (H2) can be used in vehicles and electric power plants without releasing carbon dioxide into the atmosphere.

However, storing and transporting H2 safely and efficiently remains a challenge. Compressed gaseous hydrogen poses a significant risk of explosion and leakage, whereas liquid hydrogen must be maintained at extremely low temperatures, which is costly. But what if we could store hydrogen directly in the molecular composition of other liquid or solid materials?

This was the focus of a team of scientists from Japan, who, in a recent study published in the journal Small, investigated the potential of hydrogen boride (HB) sheets as practical hydrogen carriers. Storing hydrogen in HB sheets is not an entirely new concept, and many aspects of their potential applications as hydrogen carriers have already been studied. However, getting the hydrogen out of the sheets is the tricky part. Heating at high temperatures or strong ultraviolet (UV) illumination is required to release hydrogen (H2) from HB sheets. However, both approaches have inherent disadvantages, such as high energy consumption or incomplete H2 release.

Thus, the team delved into a potential alternative: electrochemical release. Based on the mechanism of UV-induced H2 release from HB sheets, the team speculated that electron injection from a cathode electrode into HB nanosheets by an electric power supply could be a superior way to release H2 compared to UV irradiation or heating.

Based on this theory, the researchers dispersed HB sheets into acetonitrile — an organic solvent — and applied a controlled voltage to the dispersion. These experiments revealed that nearly all of the electrons injected into the electrochemical system were used to convert H+ ions from the HB sheets into H2 molecules. Notably, the Faradaic efficiency of this process, which measures how much electrical energy is converted into chemical energy, was over 90%.

The team also conducted isotope tracing experiments to confirm that the electrochemically released H2 originated from the HB sheets and not through some other chemical reaction. Moreover, they also employed scanning electron microscopy and X-ray photoelectron spectroscopy to characterize the sheets before and after H2 release, yielding further insights into the underlying mechanisms of the process.

These findings contribute to the development of safe and lightweight hydrogen carriers with low energy consumption. Although the team studied the dispersed form of the HB sheets in the published paper, the current findings are applicable to film or bulk-based HB sheet systems for H2 release. Moreover, the team will investigate the rechargeability of HB sheets after dehydrogenation in a future study.

With any luck, this line of research will help pave the way to cleaner energy sources and more sustainable societies!

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Junior doctors to strike over five days, BMA says

They will walk out on 24-28 February in a dispute with the government over pay.

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Technique could improve the sensitivity of quantum sensing devices

In quantum sensing, atomic-scale quantum systems are used to measure electromagnetic fields, as well as properties like rotation, acceleration, and distance, far more precisely than classical sensors can. The technology could enable devices that image the brain with unprecedented detail, for example, or air traffic control systems with precise positioning accuracy.

As many real-world quantum sensing devices are emerging, one promising direction is the use of microscopic defects inside diamonds to create “qubits” that can be used for quantum sensing. Qubits are the building blocks of quantum devices.

Researchers at MIT and elsewhere have developed a technique that enables them to identify and control a greater number of these microscopic defects. This could help them build a larger system of qubits that can perform quantum sensing with greater sensitivity.

Their method builds off a central defect inside a diamond, known as a nitrogen-vacancy (NV) center, which scientists can detect and excite using laser light and then control with microwave pulses. This new approach uses a specific protocol of microwave pulses to identify and extend that control to additional defects that can’t be seen with a laser, which are called dark spins.

The researchers seek to control larger numbers of dark spins by locating them through a network of connected spins. Starting from this central NV spin, the researchers build this chain by coupling the NV spin to a nearby dark spin, and then use this dark spin as a probe to find and control a more distant spin which can’t be sensed by the NV directly. The process can be repeated on these more distant spins to control longer chains.

“One lesson I learned from this work is that searching in the dark may be quite discouraging when you don’t see results, but we were able to take this risk. It is possible, with some courage, to search in places that people haven’t looked before and find potentially more advantageous qubits,” says Alex Ungar, a PhD student in electrical engineering and computer science and a member of the Quantum Engineering Group at MIT, who is lead author of a paper on this technique, which is published today in PRX Quantum.

His co-authors include his advisor and corresponding author, Paola Cappellaro, the Ford Professor of Engineering in the Department of Nuclear Science and Engineering and professor of physics; as well as Alexandre Cooper, a senior research scientist at the University of Waterloo’s Institute for Quantum Computing; and Won Kyu Calvin Sun, a former researcher in Cappellaro’s group who is now a postdoc at the University of Illinois at Urbana-Champaign.

Diamond defects

To create NV centers, scientists implant nitrogen into a sample of diamond.

But introducing nitrogen into the diamond creates other types of atomic defects in the surrounding environment. Some of these defects, including the NV center, can host what are known as electronic spins, which originate from the valence electrons around the site of the defect. Valence electrons are those in the outermost shell of an atom. A defect’s interaction with an external magnetic field can be used to form a qubit.

Researchers can harness these electronic spins from neighboring defects to create more qubits around a single NV center. This larger collection of qubits is known as a quantum register. Having a larger quantum register boosts the performance of a quantum sensor.

Some of these electronic spin defects are connected to the NV center through magnetic interaction. In past work, researchers used this interaction to identify and control nearby spins. However, this approach is limited because the NV center is only stable for a short amount of time, a principle called coherence. It can only be used to control the few spins that can be reached within this coherence limit.

In this new paper, the researchers use an electronic spin defect that is near the NV center as a probe to find and control an additional spin, creating a chain of three qubits.

They use a technique known as spin echo double resonance (SEDOR), which involves a series of microwave pulses that decouple an NV center from all electronic spins that are interacting with it. Then, they selectively apply another microwave pulse to pair the NV center with one nearby spin.

Unlike the NV, these neighboring dark spins can’t be excited, or polarized, with laser light. This polarization is a required step to control them with microwaves.

Once the researchers find and characterize a first-layer spin, they can transfer the NV’s polarization to this first-layer spin through the magnetic interaction by applying microwaves to both spins simultaneously. Then once the first-layer spin is polarized, they repeat the SEDOR process on the first-layer spin, using it as a probe to identify a second-layer spin that is interacting with it.

Controlling a chain of dark spins

This repeated SEDOR process allows the researchers to detect and characterize a new, distinct defect located outside the coherence limit of the NV center. To control this more distant spin, they carefully apply a specific series of microwave pulses that enable them to transfer the polarization from the NV center along the chain to this second-layer spin.

“This is setting the stage for building larger quantum registers to higher-layer spins or longer spin chains, and also showing that we can find these new defects that weren’t discovered before by scaling up this technique,” Ungar says.

To control a spin, the microwave pulses must be very close to the resonance frequency of that spin. Tiny drifts in the experimental setup, due to temperature or vibrations, can throw off the microwave pulses.

The researchers were able to optimize their protocol for sending precise microwave pulses, which enabled them to effectively identify and control second-layer spins, Ungar says.

“We are searching for something in the unknown, but at the same time, the environment might not be stable, so you don’t know if what you are finding is just noise. Once you start seeing promising things, you can put all your best effort in that one direction. But before you arrive there, it is a leap of faith,” Cappellaro says.

While they were able to effectively demonstrate a three-spin chain, the researchers estimate they could scale their method to a fifth layer using their current protocol, which could provide access to hundreds of potential qubits. With further optimization, they may be able to scale up to more than 10 layers.

In the future, they plan to continue enhancing their technique to efficiently characterize and probe other electronic spins in the environment and explore different types of defects that could be used to form qubits.

This research is supported, in part, by the U.S. National Science Foundation and the Canada First Research Excellence Fund.

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How one type of lung cancer can transform into another

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment. Researchers at Weill Cornell Medicine have developed a mouse model that illuminates this problematic process, known as histological transformation. The findings advance the understanding of how mutated genes can trigger cancer evolution and suggest targets for more effective treatments.

The researchers, whose results were published Feb. 8 in Science, discovered that during the transition from lung adenocarcinoma to small cell lung cancer (SCLC), the mutated cells appeared to undergo a change in cell identity through an intermediate, stem cell-like state, which facilitated the transformation.

“It is very difficult to study this process in human patients. So my aim was to uncover the mechanism underlying the transformation of lung adenocarcinoma to small cell lung cancer in a mouse model,” said study lead Dr. Eric Gardner, a postdoctoral fellow in the laboratory of Dr. Harold Varmus, the Lewis Thomas University Professor of Medicine and a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine. The complex mouse model took several years to develop and characterize but has allowed the researchers to crack this difficult problem.

This study was in collaboration with Dr. Ashley Laughney, assistant professor of physiology and biophysics and a member of the Meyer Cancer Center at Weill Cornell Medicine and Ethan Earlie, a graduate student in the Laughney lab and part of the Tri-Institutional Computational Biology and Medicine program.

“It is well known that cancer cells continue to evolve, especially to escape the pressure of effective treatments,” said Dr. Varmus. “This study shows how new technologies — including the detection of molecular features of single cancer cells, combined with computer-based analysis of the data — can portray dramatic, complex events in the evolution of lethal cancers, exposing new targets for therapeutic attack.”

Catching Transformation in the Act

SCLC most commonly occurs in heavy smokers, but this type of tumor also develops in a significant number of patients with lung adenocarcinomas, particularly after treatment with therapies that target a protein called Epidermal Growth Factor Receptor (EGFR), which promotes tumor growth. The new SCLC-type tumors are resistant to anti-EGFR therapy because their growth is fueled by a new cancer driver, high levels of Myc protein.

To unravel the interplay of these cancer pathways, the researchers engineered mice to develop a common form of lung adenocarcinoma, in which lung epithelial cells are driven by a mutated version of the EGFR gene. They then turned the adenocarcinoma tumors into SCLC-type tumors, which generally arise from neuroendocrine cells. They did this by shutting off EGFR in the presence of several other changes including losses of the tumor suppressor genes Rb1 and Trp53 as well as turning up the production of Myc,a known driver of SCLC.

Oncogenes, such as EGFR and Myc, are mutated forms of genes that normally control cell growth. They are known for their roles in driving the growth and spread of cancer. Tumor suppressor genes, on the other hand, normally inhibit cell proliferation and tumor development.

Context Matters

Surprisingly, this study showed that oncogenes act in a context-dependent manner. While most lung cells are resistant to becoming cancerous by Myc, neuroendocrine cells, are very sensitive to the oncogenic effects of Myc. Conversely, epithelial cells, which line the air sacs of the lungs and are the precursors to lung adenocarcinomas, grow excessively in response to mutated EGFR.

“This shows that an ‘oncogene’ in the wrong cell type doesn’t act like an oncogene anymore,” Dr. Laughney said. “So, it fundamentally changes how we think about oncogenes.”

The researchers also discovered a stem cell-like intermediate that was neither adenocarcinoma nor SCLC. Cells in this transitional state became neuroendocrine in nature only when mutations in the tumor suppressor genes RB1 and TP53 were present. They observed that loss of another tumor suppressor called Pten accelerated this process. At that stage, oncogenic Myc could drive these intermediate stem-like cells to form SCLC-type tumors.

This study further supports efforts seeking therapeutics that target Myc proteins, which are implicated in many types of cancers. The researchers now plan to use their new mouse model to further explore the adenocarcinoma-SCLC transition, detailing, for example, how the immune system normally responds to this transition.

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This common medication could save half a million children’s lives each year. So why is it underprescribed?

Health care providers in developing countries know that oral rehydration salts (ORS) are a lifesaving and inexpensive treatment for diarrheal disease, a leading cause of death for children worldwide — yet few prescribe it.

A new study published in Science suggests that closing the knowledge gap between what treatments health care providers think patients want and what treatments patients really want could help save half a million lives a year and reduce unnecessary use of antibiotics.

“Even when children seek care from a health care provider for their diarrhea, as most do, they often do not receive ORS, which costs only a few cents and has been recommended by the World Health Organization for decades,” said Neeraj Sood, senior author of the study, senior fellow at the USC Schaeffer Center for Health Policy & Economics and a professor at the USC Price School of Public Policy.

“This issue has puzzled experts for decades, and we wanted to get to the bottom of it,” said Sood, who also holds joint appointments at the Keck School of Medicine of USC and the USC Marshall School of Business.

A closer look at childhood illness in India

There are several popular explanations for the underprescription of ORS in India, which accounts for the most cases of child diarrhea of any country in the world:

  • Physicians assume their patients do not want oral rehydration salts, which come in a small packet and dissolve in water, because they taste bad or they aren’t “real” medicine like antibiotics.
  • The salts are out of stock because they aren’t as profitable as other treatments.
  • Physicians make more money prescribing antibiotics, even though they are ineffective against viral diarrhea.

To test these three hypotheses, Sood and his colleagues enrolled over 2,000 health care providers across 253 medium-size towns in the Indian states of Karnataka and Bihar. The researchers selected states with vastly different socioeconomic demographics and varied access to health care to ensure the results were representative of a broad population. Bihar is one of the poorest states in India with below-average ORS use, while Karnataka has above-average per capita income and above-average ORS use.

The researchers then hired staff who were trained to act as patients or caretakers. These “standardized patients” were given scripts to use in unannounced visits to doctors’ offices where they would present a case of viral diarrhea — for which antibiotics are not appropriate — in their 2-year-old child. (For ethical considerations, children did not attend these visits.) The standardized patients made approximately 2,000 visits in total.

Providers were randomly assigned to patient visits where patients expressed a preference for ORS, a preference for antibiotics or no treatment preference. During the visits, patients indicated their preference by showing the health care provider a photo of an ORS packet or antibiotics. The set of patients with no treatment preference simply asked the physician for a recommendation.

To control for profit-motivated prescribing, some of the standardized patients assigned as having no treatment preference informed the provider that they would purchase medicine elsewhere. Additionally, to estimate the effect of stockouts, the researchers randomly assigned all providers in half of the 253 towns to receive a six-week supply of ORS.

Provider misperceptions matter most when it comes to ORS underprescribing

Researchers found that provider perceptions of patient preferences are the biggest barrier to ORS prescribing — not because caretakers do not want ORS, but rather because providers assume most patients do not want the treatment. Health care providers’ perception that patients do not want ORS accounted for roughly 42% of underprescribing, while stockouts and financial incentives explained only 6% and 5%, respectively.

Patients expressing a preference for ORS increased prescribing of the treatment by 27 percentage points — a more effective intervention than eliminating stockouts (which increased ORS prescribing by 7 percentage points) or removing financial incentives (which only increased ORS prescribing at pharmacies).

“Despite decades of widespread knowledge that ORS is a lifesaving intervention that can save lives of children suffering from diarrhea, the rates of ORS use remain stubbornly low in many countries such as India,” said Manoj Mohanan, co-author of the study and professor of public policy, economics, and global health at the Sanford School of Public Policy at Duke University. “Changing provider behavior about ORS prescription remains a huge challenge.”

Study authors said these results can be used to design interventions that encourage patients and caretakers to express an ORS preference when seeking care, as well as efforts to raise awareness among providers about patients’ preferences.

“We need to find ways to change providers’ perceptions of patient preferences to increase ORS use and combat antibiotic resistance, which is a huge problem globally,” said Zachary Wagner, the study’s corresponding author, an economist at RAND Corporation and professor of policy analysis at Pardee RAND Graduate School. “How to reduce overprescribing of antibiotics and address antimicrobial resistance is a major global health question, and our study shows that changing provider perceptions of patient preferences is one way to work toward a solution.”

This research was funded by the National Institute of Diabetes and Digestive and Kidney Diseases (Grant 5R01DK126049).

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Why politics bring out the worst in us

Tap into any social media platform, turn on the television or cue up a podcast, and it is easy to find examples of hypocrisy or bad behavior in political discourse, and new research from University of Nebraska-Lincoln political scientists may explain why.

The findings from a large survey study, co-authored by Kyle Hull, Kevin Smith and Clarisse Warren, demonstrate the willingness of people to bend their morals — even behave unethically — when engaging in the political realm.

Results also suggest that hostility toward outgroups (i.e., opposing party) is the driving factor for the moral ambiguity exercised when respondents switch from the personal to the political arena.

And there is not just one guilty party.

“People, regardless of age or ideology, were more willing to engage in immoral behaviors and judgments if the behaviors were in the political realm,” said Hull, a visiting assistant professor in political science. “And a lot of it was just driven by genuine internal dislike of the ‘other’ side.”

The researchers developed a survey and engaged four different samples of adults, totaling 2,472 respondents. The survey included nonpolitical and political moral behavior scales and political and nonpolitical moral tolerance scales.

“Basically, we were taking the same person and asking them virtually the same questions,” said Smith, Leland J. and Dorothy H. Olson Professor of Political Science. “The only difference in the items is we changed ‘person’ to ‘politician.’ And that was enough to shift people’s moral judgment. It changes in a way that induces more flexibility in our moral assessments.”

That includes assessments of politicians’ bad behavior, as the co-authors found people are more morally tolerant of politicians they liked, similar to the behavior they were willing to tolerate from a friend.

In an increasingly polarized — and often toxic — political environment, the researchers said the results highlight the harm of outrage politics.

“I think there’s some reason for concern,” Hull said. “As long as there is some internalized dislike of the outgroup, there’s certainly a risk of behaviors that may be involved when people are willing to act less morally. Politics makes us do things that we just normally wouldn’t do and tolerate things we wouldn’t normally tolerate. It brings out, sometimes, the worst in us.

“The way some politicians and media speak about the other party fuels that fire in a way. The more we engage in pitting one party or the other as the bad guys, and the more you feel that way, the more you are willing to set your morals aside.”

The research builds on Smith’s work exploring how political engagement and ideology drive moral values and choices, not the other way around.

“If that’s true, then people will probably be using different standards for moral behavior or moral choices in their personal lives than they are in the political world,” Smith said. “And that’s what we found. It’s not like politics makes bastards of the left or the right, or the young or the old, or the rich or the poor. Politics seems to make bastards of us all.”

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