Could a fungal pandemic turn us all into zombies?

The apocalyptic plot of hit TV series The Last of Us has coincided with a real-life threat from fungi.

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US to make it easier for gay men to donate blood

The FDA will soon remove a three month abstinence policy for donations for men who have sex with men.

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Toxic slimming pill drug DNP to be declared poison

Families say the government has not acted quickly enough to prevent deaths from diet drug DNP.

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Volcano-like rupture could have caused magnetar slowdown

On Oct. 5, 2020, the rapidly rotating corpse of a long-dead star about 30,000 light years from Earth changed speeds. In a cosmic instant, its spinning slowed. And a few days later, it abruptly started emitting radio waves.

Thanks to timely measurements from specialized orbiting telescopes, Rice University astrophysicist Matthew Baring and colleagues were able to test a new theory about a possible cause for the rare slowdown, or “anti-glitch,” of SGR 1935+2154, a highly magnetic type of neutron star known as a magnetar.

In a study published this month in Nature Astronomy, Baring and co-authors used X-ray data from the European Space Agency’s X-ray Multi-Mirror Mission (XMM-Newton) and NASA’s Neutron Star Interior Composition Explorer (NICER) to analyze the magnetar’s rotation. They showed the sudden slowdown could have been caused by a volcano-like rupture on the surface of the star that spewed a “wind” of massive particles into space. The research identified how such a wind could alter the star’s magnetic fields, seeding conditions that would be likely to switch on the radio emissions that were subsequently measured by China’s Five-hundred-meter Aperture Spherical Telescope (FAST).

“People have speculated that neutron stars could have the equivalent of volcanoes on their surface,” said Baring, a professor of physics and astronomy. “Our findings suggest that could be the case and that on this occasion, the rupture was most likely at or near the star’s magnetic pole.”

SGR 1935+2154 and other magnetars are a type of neutron star, the compact remains of a dead star that collapsed under intense gravity. About a dozen miles wide and as dense as the nucleus of an atom, magnetars rotate once every few seconds and feature the most intense magnetic fields in the universe.

Magnetars emit intense radiation, including X-rays and occasional radio waves and gamma rays. Astronomers can decipher much about the unusual stars from those emissions. By counting pulses of X-rays, for example, physicists can calculate a magnetar’s rotational period, or the amount of time it takes to make one complete rotation, as the Earth does in one day. The rotational periods of magnetars typically change slowly, taking tens of thousands of years to slow by a single rotation per second.

Glitches are abrupt increases in rotational speed that are most often caused by sudden shifts deep within the star, Baring said.

“In most glitches, the pulsation period gets shorter, meaning the star spins a bit faster than it had been,” he said. “The textbook explanation is that over time, the outer, magnetized layers of the star slow down, but the inner, non-magnetized core does not. This leads to a buildup of stress at the boundary between these two regions, and a glitch signals a sudden transfer of rotational energy from the faster spinning core to the slower spinning crust.”

Abrupt rotational slowdowns of magnetars are very rare. Astronomers have only recorded three of the “anti-glitches,” including the October 2020 event.

While glitches can be routinely explained by changes inside the star, anti-glitches likely cannot. Baring’s theory is based on the assumption that they are caused by changes on the surface of the star and in the space around it. In the new paper, he and his co-authors constructed a volcano-driven wind model to explain the measured results from the October 2020 anti-glitch.

Baring said the model uses only standard physics, specifically changes in angular momentum and conservation of energy, to account for the rotational slowdown.

“A strong, massive particle wind emanating from the star for a few hours could establish the conditions for the drop in rotational period,” he said. “Our calculations showed such a wind would also have the power to change the geometry of the magnetic field outside the neutron star.”

The rupture could be a volcano-like formation, because “the general properties of the X-ray pulsation likely require the wind to be launched from a localized region on the surface,” he said.

“What makes the October 2020 event unique is that there was a fast radio burst from the magnetar just a few days after the anti-glitch, as well as a switch-on of pulsed, ephemeral radio emission shortly thereafter,” he said. “We’ve seen only a handful of transient pulsed radio magnetars, and this is the first time we’ve seen a radio switch-on of a magnetar almost contemporaneous with an anti-glitch.”

Baring argued this timing coincidence suggests the anti-glitch and radio emissions were caused by the same event, and he’s hopeful that additional studies of the volcanism model will provide more answers.

“The wind interpretation provides a path to understanding why the radio emission switches on,” he said. “It provides new insight we have not had before.”

The research was supported by the National Science Foundation (1813649), NASA (80NSSC22K0397), Japan’s RIKEN Advanced Science Institute and Taiwan’s Ministry of Science and Technology.

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New hybrid catalyst could help decarbonization and make ethylene production more sustainable

A new hybrid catalyst converts carbon dioxide into ethylene in one pot. The catalyst was developed by scientists from Ames National Laboratory, Iowa State University, University of Virginia, and Columbia University. This catalyst supports the world net-zero carbon initiative by using carbon dioxide (CO2) as a feedstock for efficient ethylene production powered by electricity.

Ethylene is a commodity chemical used to manufacture a wide range of products from plastics to antifreeze. The large-scale production of ethylene is energy intensive and relies heavily on fossil resources. Electrocatalytic production of ethylene from CO2 is emerging as a promising method. This new catalyst consists of only earth-abundant materials, such as nickel and copper, and requires less energy for chemical reaction.

Long Qi, a scientist at Ames Lab, explained how the catalyst works. Atomically dispersed nickel anchored on nitrogen assembly carbon (NAC) works to catalyze CO2 to CO at low voltage and high current. The catalyst is effective over a wide range of voltages and its effectiveness at higher currents means a higher rate of CO production.

“Since this catalyst remains active over a very wide voltage range, that allows easy coupling with a second catalyst,” Qi said. “So we use the second catalyst, which is a copper nanowire, and by combining these two we have a very selective process that has up to 60% efficiency going from CO2 to ethylene in one pot.”

Another important aspect of the catalyst is its structure. Wenyu Huang, an Ames Lab scientist and Iowa State University professor from the team, noted that the catalyst’s porous structure enhances its effectiveness. “Our catalyst has an ordered mesoporous structure that is beneficiary for mass transfer,” he said. “Because it’s highly porous, you have a very high surface area to expose a lot of nickel’s active sites, making our catalyst very effective in CO2 reduction to CO.”

For Huang, the most exciting aspect of this research was how the team combined the two catalysts to streamline the process. “We basically combine the two best catalysts on their own, and they work together so we can connect the CO2 to CO and the CO to ethylene reactions in one system,” he said.

Qi emphasized the importance of using CO2 as a feedstock for this reaction, because it addresses the global need to reduce the amount of CO2 released into the atmosphere. He explained that this process can use CO2 recovered from chemical or industrial processes, or from air capture. “And we can do this without any precious metal, simply the nickel, copper, carbon, and nitrogen, to permit large-scale industrial applications,” Qi said. “Also, we potentially eliminate the use of fossil resources to make ethylene.”

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Milk’s packaging influences its flavor

The dairy industry strives to preserve the quality and safety of milk products while maintaining the freshest possible taste for consumers. To date, the industry has largely focused on packaging milk in light-blocking containers to preserve freshness, but little has been understood about how the packaging itself influences milk flavor. However, a new study in the Journal of Dairy Science®, published by Elsevier, confirms that packaging affects taste — and paperboard cartons do not preserve milk freshness as well as glass and plastic containers.

Lead investigator MaryAnne Drake, PhD, of the North Carolina State University Department of Food, Bioprocessing and Nutrition Sciences, Raleigh, NC, USA, explained that “milk is more susceptible to packaging-related off-flavors than many other beverages because of its mild, delicate taste.” Besides light oxidation, “milk’s taste can be impacted by the exchange of the packaging’s compounds into the milk and by the packaging absorbing food flavors and aromas from the surrounding refrigeration environment.”

To quantify the flavor impacts of packaging, the researchers examined pasteurized whole and skim milk stored in six half pint containers: paperboard cartons, three plastic jugs (made from different plastics), a plastic bag, and glass as a control. The milk was stored in total darkness to control for light oxidation and kept cold at 4°C (39°F).

The samples were tested on the day of first processing, then again at 5, 10, and 15 days after. A trained panel examined the sensory properties of each sample, and the research team conducted a volatile compound analysis to understand how the packaging was intermingling with the milk. Finally, the samples underwent a blind consumer taste test on day 10 to see whether tasters could tell any difference between milk stored in the paperboard carton or the plastic jug compared with milk packaged in glass.

The results showed that package type doesinfluence milk flavor, and skim milk is more susceptible to flavor impacts than whole milk. Of the different packaging types, paperboard cartons and the plastic bag preserved milk freshness the least due to the paperboard’s absorption of milk flavor and the transfer of paperboard flavor into the milk. Milk packaged in paperboard cartons, in fact, showed distinct off-flavors as well as the presence of compounds from the paperboard. The final results show that, while glass remains an ideal container for preserving milk flavor, plastic containers provide additional benefits while also maintaining freshness in the absence of light exposure.

Paperboard cartons are the most widely used packaging type for school meal programs in the United States, so these findings are especially relevant for the consideration of how young children consume and enjoy milk.

“These findings suggest that industry and policymakers might want to consider seeking new package alternatives for milk served during school meals,” said Drake. Over time, the consequences of using milk packaging that contributes significant off-flavors may affect how young children perceive milk in both childhood and adulthood.

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UK substantially underestimates its methane emissions from oil and gas production — and many other countries probably do too

A newer, more accurate method for calculating methane emissions from offshore oil and gas production suggests that the United Kingdom severely underestimates its greenhouse gas emissions. Researchers conclude that as much as five times more methane is being leaked from oil and gas production than reported.

Methane is the second most important greenhouse gas after carbon dioxide, contributing about 1 degree Fahrenheit of present-day global warming relative to pre-industrial times. One major source of methane to the atmosphere is the extraction and transport of oil and gas. Countries are obligated to report their greenhouse gas emissions to international bodies such as the United Nations Framework Convention on Climate Change, but recent studies suggest that the current methods for calculating methane emissions rely on outdated and incomplete information and may not accurately represent actual emissions.

A recent study from researchers at Princeton University and Colorado State University finds that the current method for estimating methane emissions from offshore oil and gas production in the United Kingdom systematically and severely underestimates emissions. The study finds that as much as five times more methane is being emitted from oil and gas production in the UK than what the government has reported. The researchers reached this conclusion by critically evaluating the UK’s current method of calculating methane emissions, suggesting alternative, peer-review based methods and generating revised emission estimates.

Sincemany other countries use similar methodologies to calculate methane emissions from oil and gas production, this severe underestimation is likely not confined to the UK alone.

“It is critical to know when, where and how much methane is emitted from each of its sources in order to prioritize emission reductions,” said Denise Mauzerall, a co-author and core faculty member of the Center for Policy Research on Energy and the Environment at Princeton University. “We hope our work will facilitate improved emission estimates and reductions not only from the UK but also from other countries producing methane from oil and gas extraction,” Mauzerall said.

Due to its climate and indirect health impacts (methane is a precursor for ozone which is an air pollutant that damages human health and crops), methane mitigation has recently become a global policy priority. Its relatively short lifetime of about 12 years and high heat trapping ability per molecule makes reducing methane emissions among the most effective ways to slow the rate of climate warming. As a result, in 2021 countries signed the Global Methane Pledge, committing to reduce methane emissions by at least 30% of 2020 levels by 2030. To track progress, countries compile national emissions data into inventories, such as the UK’s National Atmospheric Emissions Inventory (NAEI), which are then reported to international monitoring bodies.

This study focuses on methane leakage associated with discovery, extraction, and production of oil and natural gas. These methane emissions are typically calculated by multiplying the activity level of various processes – namely venting, flaring, processing and combustion activities on production platforms, offshore oil loading, and gas transfer by high-pressure pipelines – by “emission factors,” which are standard estimates of the methane emissions associated with each activity.

The researchers found that the emissions factors used in the UK’s reporting are either outdated, rely on unpublished or publicly unavailable industry research, or use generic values recommended by the IPCC. Furthermore, these emission factors are usually “static,” meaning that they are not sensitive to factors such as environmental conditions and management practices which could affect emissions from various processes. In addition, leakage can occur when the off-shore rigs are idle – an “activity” that does not currently have an associated emission factor.

Noting these shortcomings, the researchers updated and revised estimation techniques for each process, and, wherever possible, used dynamic rather than static emission factor formulations that account for varying environmental conditions. They also incorporated direct boat-based measurements of methane concentrations around offshore gas platforms in the North Sea collected in summer 2017, documented in a study also led by the authors. These updates resulted in a total methane emission estimate more than five times larger than reported emissions.

“Methane emissions from offshore facilities are currently largely uncertain, and because sources on facilities only emit for a short time period, using direct survey methods such as satellite or drones will probably only capture about 25% of the actual emissions,” said Stuart Riddick, lead author and research scientist at Colorado State University. “To generate representative baseline emissions across the sector, we need to work with industry to develop practical, effective, and collaborative measurement strategies,” Riddick said.

Previous research has shown that reducing leakage across the oil and natural gas supply chain can advance climate and air quality goals while also being economically profitable – a win-win opportunity for industry and climate.

This study adds to a growing base of literature finding that current measurements of anthropogenic methane emission inventories are too low. With the world’s first “global stocktake” on progress implementing the Paris Agreement concluding in 2023, the researchers argue that improved measurement of emissions deserves urgent attention.

“We are hopeful that our work will facilitate more accurate emission inventory development and lead to critically important reductions of methane leakage – a win for both industry and the environment,” Mauzerall said.

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Qubits on strong stimulants

An international team of scientists have demonstrated a leap in preserving the quantum coherence of quantum dot spin qubits as part of the global push for practical quantum networks and quantum computers.

These technologies will be transformative to a broad range of industries and research efforts: from the security of information transfer, through the search for materials and chemicals with novel properties, to measurements of fundamental physical phenomena requiring precise time synchronisation among the sensors.

Spin-photon interfaces are elementary building blocks for quantum networks that allow converting stationary quantum information (such as the quantum state of an ion or a solid-state spin qubit) into light, namely photons, that can be distributed over large distances. A major challenge is to find an interface that is both good at storing quantum information and efficient at converting it into light. Optically active semiconductor quantum dots are the most efficient spin-photon interface known to date but extending their storage time beyond a few microseconds has puzzled physicists in spite of decade-long research efforts. Now, researchers at the University of Cambridge, the University of Linz and the University of Sheffield have shown that there is a simple material’s solution to this problem that improves the storage of quantum information beyond hundred microseconds.

Quantum Dots are crystalline structures made out of many thousands of atoms. Each of these atoms’ nuclei has a magnetic dipole moment that couples to the quantum dot electron and can cause the loss of quantum information stored in the electron qubit. The research team’s finding, reported in Nature Nanotechnology, is that in a device constructed with semiconductor materials that have the same lattice parameter, the nuclei ‘felt’ the same environment and behaved in unison. As a result, it is now possible to filter out this nuclear noise and achieve a near two-order magnitude improvement in storage time.

“This is a completely new regime for optically active quantum dots where we can switch off the interaction with nuclei and refocus the electron spin over and over again to keep its quantum state alive,” said Claire Le Gall from Cambridge’s Cavendish Laboratory, who led the project. “We demonstrated hundreds of microseconds in our work, but really, now we are in this regime, we know that much longer coherence times are within reach. For spins in quantum dots, short coherence times were the biggest roadblock to applications, and this finding offers a clear and simple solution to that.”

While exploring the hundred-microsecond timescales for the first time, the researchers were pleasantly surprised to find that the electron only sees noise from the nuclei as opposed to, say, electrical noise in the device. This is really a great position to be in because the nuclear ensemble is an isolated quantum system, and the coherent electron will be a gateway to quantum phenomena in large nuclear spin ensemble.

Another thing that surprised the researchers was the ‘sound’ that was picked up from the nuclei. It was not quite as harmonious as was initially anticipated, and there is room for further improvement in the system’s quantum coherence through further material engineering.

“When we started working with the lattice-matched material system employed in this work, getting quantum dots with well-defined properties and good optical quality wasn’t easy” — says Armando Rastelli, co-author of this paper at the University of Linz. “It is very rewarding to see that an initially curiosity-driven research line on a rather ´exotic´ system and the perseverance of skilled team members Santanu Manna and Saimon Covre da Silva led to the devices at the basis of these spectacular results. Now we know what our nanostructures are good for, and we are thrilled by the perspective of further engineering their properties together with our collaborators.”

“One of the most exciting things about this research is taming a complex quantum system: a hundred thousand nuclei coupling strongly to a well-controlled electron spin,” explains Cavendish PhD student, Leon Zaporski — the first author of the paper. “Most researchers approach the problem of isolating qubit from the noise by removing all the interactions. Their qubits become a bit like sedated Schrödinger’s cats, that can barely react to anyone pulling on their tail. Our ‘cat’ is on strong stimulants, which — in practice — means we can have more fun with it.”

“Quantum dots now combine high photonic quantum efficiency with long spin coherence times” explains Professor Mete Atatüre, co-author of this paper. “In the near future, we envisage these devices to enable the creation of entangled light states for all-photonic quantum computing and allow foundational quantum control experiments of the nuclear spin ensemble.”

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New test could detect Alzheimer’s disease 3.5 years before clinical diagnosis

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has established a blood-based test that could be used to predict the risk of Alzheimer’s disease up to 3.5 years before clinical diagnosis.

The study, published in the journal Brain, supports the idea that components in the human blood can modulate the formation of new brain cells, a process termed neurogenesis. Neurogenesis occurs in an important part of the brain called the hippocampus that is involved in learning and memory.

While Alzheimer’s disease affects the formation of new brain cells in the hippocampus during the early stages of the disease, previous studies have only been able to study neurogenesis in its later stages through autopsies.

To understand the early changes, researchers collected blood samples over several years from 56 individuals with Mild Cognitive Impairment (MCI), a condition where someone will begin to experience a worsening of their memory or cognitive ability. While not everyone experiencing MCI goes on to develop Alzheimer’s disease, those with the condition progress to a diagnosis at a much higher rate than the wider population. Of the 56 participants in the study, 36 went on to receive a diagnosis of Alzheimer’s disease.

Dr Aleksandra Maruszak, one of the study’s joint first authors from King’s IoPPN explains, “In our study, we treated brain cells with blood taken from people with MCI, exploring how those cells changed in response to blood as Alzheimer’s disease progressed.”

In studying how blood affected the brain cells, the researchers made several key discoveries. The blood samples collected from participants over the years who subsequently deterioratedand developed Alzheimer’s disease promoted a decrease in cell growth and division and an increase in apoptotic cell death (the process by which cells are programmed to die). However, the researchers noted that these samples also increased the conversion of immature brain cells to hippocampal neurons.

While the underlying reasons for the increased neurogenesis remain unclear, the researchers theorise that it may be an early compensating mechanism for the neurodegeneration (loss of brain cells) experienced by those developing Alzheimer’s disease.

Professor Sandrine Thuret, the study’s lead author from King’s IoPPN said, “Previous studies have shown that blood from young mice can have a rejuvenating effect on the cognition of older mice by improving hippocampal neurogenesis. This gave us the idea of modelling the process of neurogenesis in a dish using human brain cells and human blood. In our study, we aimed to use this model to understand the process of neurogenesis and to use changes in this process to predict Alzheimer’s disease and found the first evidence in humans that the body’s circulatory system can have an effect on the brain’s ability to form new cells.”

When the researchers used only the blood samples collected furthest away from when the participants were diagnosed with Alzheimer’s disease, they found that the changes in neurogenesis occurred 3.5 years prior to a clinical diagnosis.

Dr Edina Silajdži?, the study’s joint first author added, “Our findings are extremely important, potentially allowing us to predict onset of Alzheimer’s early in a non-invasive fashion. This could complement other blood-based biomarkers that reflect the classical signs of the disease, such as the accumulation of amyloid and tau (the ‘flagship’ proteins of Alzheimer’s disease).”

Dr Hyunah Lee, the study’s joint first author said, “It is now essential to validate these findings in a bigger and more diverse group of people. We are excited about the potential applications of the blood-based test we used. For example, it can help stratify individuals with memory problems for a clinical trial of disease-modifying drugs for Alzheimer’s.”

The researchers say that these findings could present an opportunity to further understand the changes the brain goes through at the earliest stages of Alzheimer’s disease.

This study was possible thanks to funding from the John and Lucille van Geest Foundation, the Medical Research Council UK, the Cohen Charitable Trust, the Galen and Hilary Weston Foundation and the Rhodes Trust.

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Starry tail tells the tale of dwarf galaxy evolution

A giant diffuse tail of stars has been discovered emanating from a large, faint dwarf galaxy. The presence of a tail indicates that the galaxy has experienced recent interaction with another galaxy. This is an important clue for understanding how so called “ultra-diffuse” galaxies are formed.

Astronomers using the Subaru Telescope and the Canada-France-Hawaii Telescope found a tail of stars stretching 200,000 light-years out away from a galaxy known as F8D1. This galaxy is a member of the M81 group located 12 million light-years away on the boundary between the constellations Ursa Major and Camelopardalis. F8D1 is one of the closest examples of an “ultra-diffuse” galaxy. The origin of these enigmatic galaxies has puzzled astronomers for several decades: are they born this diffuse or does some later event cause them to puff up in size?

The discovery of a huge tidal tail from F8D1 is compelling evidence that the galaxy has been strongly shaped by events in the past billion years. This is the first time that such a stellar stream has been discovered in a UDG. The team suggests F8D1 was disrupted by a recent close passage to the massive spiral M81, the dominant member of the group containing F8D1.

Since F8D1 lies at the edge of the survey area, only one tidal arm can be seen, extending to the northeast. The team will now search to see if there is a counterpart stream to the southwest.

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