Malawi finds Africa’s first wild polio case in five years

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Covid: NHS bosses call for free tests and isolation to remain

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Tamera: ‘Having synaesthesia means I see colours when I hear music’

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‘My child is in pain – but I’m helpless’

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U.S. coastline to see up to a foot of sea level rise by 2050

The United States is expected to experience as much sea level rise by the year 2050 as it witnessed in the previous hundred years. That’s according to a NOAA-led report updating sea level rise decision-support information for the U.S. released today in partnership with half a dozen other federal agencies.

The Sea Level Rise Technical Report provides the most up-to-date sea level rise projections for all U.S. states and territories by decade for the next 100 years and beyond, based on a combination of tide gauge and satellite observations and all the model ensembles from the Sixth Assessment Report of the Intergovernmental Panel on Climate Change (IPCC). The report projects sea levels along the coastline will rise an additional 10-12 inches by 2050 with specific amounts varying regionally, mainly due to land height changes.

The report updates the federal government’s 2017 sea level rise projections, and provides additional information on tide, wind, and storm-driven extreme water levels affecting current and future coastal flood risk. A suite of federal tools are using this data, including the NOAA Sea Level Rise Viewer, which are critical to the Administration’s commitment to tackle the climate crisis by making actionable climate data accessible to those who need it.

“For businesses along the coast, knowing what to expect and how to plan for the future is critical,” said U.S. Secretary of Commerce Gina M. Raimondo. “These updated projections will help businesses, and the communities they support, understand risks and make smart investments in the years ahead.”

“This new data on sea rise is the latest reconfirmation that our climate crisis ⁠ — as the President has said ⁠ — is blinking ‘code red,'” said Gina McCarthy, National Climate Advisor. “We must redouble our efforts to cut the greenhouse gases that cause climate change while, at the same time, help our coastal communities become more resilient in the face of rising seas.”

“This is a global wake-up call and gives Americans the information needed to act now to best position ourselves for the future,” said Rick Spinrad, Ph.D., NOAA Administrator. “As we build a Climate Ready Nation, these updated data can inform coastal communities and others about current and future vulnerabilities in the face of climate change and help them make smart decisions to keep people and property safe over the long run.”

The report also finds that the sea level rise expected by 2050 will create a profound increase in the frequency of coastal flooding, even in the absence of storms or heavy rainfall.

“By 2050, moderate flooding ⁠ — which is typically disruptive and damaging by today’s weather, sea level and infrastructure standards ⁠ — is expected to occur more than 10 times as often as it does today,” said Nicole LeBoeuf, NOAA National Ocean Service Director. “These numbers mean a change from a single event every 2-5 years to multiple events each year, in some places.”

“This report supports previous studies and confirms what we have long known: Sea levels are continuing to rise at an alarming rate, endangering communities around the world. Science is indisputable and urgent action is required to mitigate a climate crisis that is well underway,” said Bill Nelson, NASA Administrator. “NASA is steadfast in our commitment to protecting our home planet by expanding our monitoring capabilities and continuing to ensure our climate data is not only accessible but understandable.”

This multi-agency effort is a product of the Interagency Sea Level Rise and Coastal Flood Hazard and Tool Task Force, composed of NOAA, NASA, EPA, USGS, DoD, FEMA and the U.S. Army Corps of Engineers, as well as several academic institutes. The report leverages methods and insights from both the United Nations Intergovernmental Panel on Climate Change (IPCC) 6th Assessment Report and supporting research for the U.S. DoD Defense Regional Sea Level database offsite link.

Read the Sea Level Rise Technical Report: https://oceanservice.noaa.gov/hazards/sealevelrise/sealevelrise-tech-report.html

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Scientists reveal how Venus fly trap plants snap shut

Scientists at Scripps Research have revealed the three-dimensional structure of Flycatcher1, an aptly named protein channel that may enable Venus fly trap plants to snap shut in response to prey. The structure of Flycatcher1, published February 14 in Nature Communications, helps shed light on longstanding questions about the remarkably sensitive touch response of Venus fly traps. The structure also gives the researchers a better understanding of how similar proteins in organisms including plants and bacteria, as well as proteins in the human body with similar functions (called mechanosensitive ion channels), might operate.

“Despite how different Venus fly traps are from humans, studying the structure and function of these mechanosensitive channels gives us a broader framework for understanding the ways that cells and organisms respond to touch and pressure,” says co-senior author and Scripps Research professor Andrew Ward, PhD.

“Every new mechanosensitive channel that we study helps us make progress in understanding how these proteins can sense force and translate that to action and ultimately reveal more about human biology and health,” adds co-senior author Ardem Patapoutian, PhD, a Scripps Research professor who won the Nobel Prize in Physiology or Medicine for research on the mechanosensitive channels that allow the body to sense touch and temperature.

Mechanosensitive ion channels are like tunnels that span the membranes of cells. When jostled by movement, the channels open, letting charged molecules rush across. In response, cells then alter their behavior — a neuron might signal its neighbor, for instance. The ability for cells to sense pressure and movement is important for people’s senses of touch and hearing, but also for many internal body processes — from the ability of the bladder to sense that it’s full to the ability of lungs to sense how much air is being breathed.

Previously, scientists had homed in on three ion channels in Venus fly traps thought to be related to the ability of the carnivorous plant to snap its leaves shut when its sensitive trigger hairs get touched. One, Flycatcher1, caught researchers’ attention because its genetic sequence looked similar to a family of mechanosensitive channels, MscS, found in bacteria.

“The fact that variants of this channel are found throughout evolution tells us that it must have some fundamental, important functions that have been maintained in different types of organisms,” says co-first author Sebastian Jojoa-Cruz, a graduate student at Scripps Research.

In the new study, the researchers used cryo-electron microscopy — a cutting-edge technique that reveals the locations of atoms within a frozen protein sample — to analyze the precise arrangement of molecules that form the Flycatcher1 protein channel in Venus fly trap plants. They found that Flycatcher1 is, in many ways, similar to bacterial MscS proteins — seven groups of identical helices surrounding a central channel. But, unlike other MscS channels, Flycatcher1 has an unusual linker region extending outward from each group of helices. Like a switch, each linker can be flipped up or down. When the team determined the structure of Flycatcher1, they found six linkers in the down position, and just one flipped up.

“The architecture of Flycatcher1’s channel core was similar to other channels that have been studied for years, but these linker regions were surprising,” says Kei Saotome, PhD, a former postdoctoral research associate at Scripps Research and co-first author of the new paper.

To help elucidate the function of these switches, the researchers altered the linker to disrupt the up position. Flycatcher1, they found, no longer functioned as usual in response to pressure; the channel remained open for a longer duration when it would normally close upon removal of pressure.

“The profound effect of this mutation tells us that the conformations of these seven linkers is likely relevant for how the channel works,” says co-senior author Swetha Murthy, PhD, of Vollum Institute at Oregon Health and Science University, a former postdoctoral research associate at Scripps Research.

Now that they solved the molecular structure, the research team is planning future studies on the function of Flycatcher1 to understand how different conformations affect its function. More work is also needed to determine whether Flycatcher1 is solely responsible for the snapping shut of Venus fly trap leaves, or whether other suspected channels play complementary roles.

In addition to Jojoa-Cruz, Saotome, Murthy, Patapoutian and Ward, authors of the study, “Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1,” are Che Chun Alex Tsui and Wen-Hsin Lee of Scripps Research, and Mark Sansom of University of Oxford.

This work and the researchers involved were supported by funding from the National Institutes of Health (R01 HL143297, R01 HL143297), a Ray Thomas Edwards Foundation grant, the Wellcome Trust (grant 208361/Z/17/Z), the Biotechnology and Biological Sciences Research Council (grants BB/N000145/1 and BB/R00126X/1), the Engineering and Physical Sciences Research Council (grant EP/R004722/1), a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical Research, the Skaggs-Oxford Scholarship, the Croucher Foundation, and the Howard Hughes Medical Institute.

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Bionic eyes: Obsolete tech leaves patients in the dark

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Child Covid vaccinations: Your questions answered

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‘I lost my dad to prostate cancer, don’t lose yours’

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Exercise: Do you need it if you’re slim?

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