Floating gardens: More than just a pretty place

Floating gardens sound so idyllic. Now, a study proves that they are more than just a pretty place. The study, by researchers at Illinois State University, demonstrates that such constructed gardens can have a measurable, positive impact on water quality.

Floating gardens are essentially rafts built on a frame of plastic caging, wrapped in coconut husks, and filled in with native plantings. As plants grow, they extend their roots into the water, growing hydroponically. On Chicago’s North Branch of the Chicago River, non-profit Urban Rivers and partners are developing a mile-long, floating eco-park. Dubbed the Wild Mile, the re-development of this former industrial canal is Urban Rivers’ flagship project. As part of the park, floating gardens, attached to shore, are being installed.

The primary intent of the floating gardens is beautification. But the Illinois State team, from the University’s Department of Geology, Geography, and the Environment, saw an ideal setup for a controlled experiment. “We got involved because it’s the perfect opportunity to see if there’s an impact on water quality,” explains lead author Abigail Heath.

Heath will present the results of the study in an online talk on Tuesday during the Geological Society of America’s annual meeting.

The study is novel: previous studies have explored floating gardens’ impact on water quality over time, primarily in wastewater treatment ponds, but not over space, in moving water. The project also meshes well with Urban Rivers’ broader goals. “The city is interested in water quality,” says Phil Nicodemus, Urban Rivers Director of Research. “Happily, Illinois State got involved.”

Starting in spring 2018, Heath and co-authors have sampled water immediately upstream and downstream of a narrow 3 meter by 50 meter floating garden installed along the shoreline. Samples are collected weekly, at the surface and from 0.3 meters deep, the depth where roots reach from the garden’s base into the water. Although the garden is set at the edge of Chicago’s urban core, water quality is also impacted by upstream agriculture. Analyses are focused on nutrients including nitrate as nitrogen, chloride, sulfate, and phosphate.

Could this small slice of human-made paradise improve water quality? An average of data collected over the course of the study show modest but definitive improvement. For example, nitrate as nitrogen dropped from 4.69 milligrams per liter in surface water just upstream of the garden to 4.43 milligrams per liter just downstream, a drop of about 1 percent. Phosphate was also lower downstream of the garden.

“Despite how small this garden was there was measurable improvement in water quality from upstream to downstream, especially for nitrates,” notes Heath. She and colleagues see this as a scalable model for how larger floating gardens might help remediate water in similar settings. “Even this tiny garden makes a difference,” she says.

Story Source:

Materials provided by Geological Society of America. Note: Content may be edited for style and length.

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DrugCell: New experimental AI platform matches tumor to best drug combo

Only 4 percent of all cancer therapeutic drugs under development earn final approval by the U.S. Food and Drug Administration (FDA).

“That’s because right now we can’t match the right combination of drugs to the right patients in a smart way,” said Trey Ideker, PhD, professor at University of California San Diego School of Medicine and Moores Cancer Center. “And especially for cancer, where we can’t always predict which drugs will work best given the unique, complex inner workings of a person’s tumor cells.”

In a paper published October 20, 2020 in Cancer Cell, Ideker and Brent Kuenzi, PhD, and Jisoo Park, PhD, postdoctoral researchers in his lab, describe DrugCell, a new artificial intelligence (AI) system they created that not only matches tumors to the best drug combinations, but does so in a way that makes sense to humans.

“Most AI systems are ‘black boxes’ — they can be very predictive, but we don’t actually know all that much about how they work,” said Ideker, who is also co-director of the Cancer Cell Map Initiative and the National Resource for Network Biology.

He gave the example of the way an internet image search for “cat” works. AI systems working behind the scenes are trained on existing cat images, but how they actually label a new image as “cat” and not “rat” or something else is unknown.

For AI to be useful in health care, Ideker said, we have to be able to see inside the black box to understand how the system comes to its conclusions. “We need to know why that decision is made, what pathways those recommended drugs are targeting and the reasons for a positive drug response or for its rejection.”

The team’s work on DrugCell began several years ago in yeast. In a previous study , they built an AI system called DCell using information about a yeast cell’s genes and mutations. DCell predicted cellular behaviors, such as growth, all outside the “black box.”

DrugCell, a next-generation version of DCell, was trained on more than 1,200 tumor cell lines and their responses to nearly 700 FDA-approved and experimental therapeutic drugs — a total of more than 500,000 cell line/drug pairings. The researchers also validated some of DrugCell’s conclusions in laboratory experiments.

With DrugCell, the team can input data about a tumor and the system returns the best known drug, the biological pathways that control response to that drug, and combinations of drugs to best treat the malignancy.

Precision cancer therapy is already available at Moores Cancer Center at UC San Diego Health, where patients may have a biopsy of their tumor sequenced for mutations and assessed by the Molecular Tumor Board, an interdisciplinary group of experts. The board recommends personalized therapies based on the patient’s unique genomic alterations and other information. A recent study showed these patients have better outcomes. In a way, DrugCell simulates the human Molecular Tumor Board.

“We were surprised by how well DrugCell was able to translate from laboratory cell lines, which is what we trained the model on, to tumors in mice and patients, as well as clinical trial data,” Kuenzi said.

The team’s ultimate goal is to get DrugCell into clinics for the benefit of patients, but the study authors caution there’s still a lot of work to do.

“While 1,200 cell lines is a good start, it’s of course not representative of the full heterogeneity of cancer,” Park said. “Our team is now adding more single-cell data and trying different drug structures. We also hope to partner with existing clinical studies to embed DrugCell as a diagnostic tool, testing it prospectively in the real world.”

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Covid: Nottingham to move into tier 3

Some parts of the surrounding county will also face the toughest Covid rules.

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For the Experience

One framing that I find empowering is to do something for the experience.

If you choose not to do something, you don’t get the experience, which means you miss out on a lot of potential benefits.

When you lean into new experiences, you’re likely to gain some or all the following:

  • New lessons
  • More character growth
  • Perspective shifts and reframes
  • Insights
  • New friends
  • Maybe a whole new social circle
  • New income-generating ideas
  • New invitations
  • New opportunities
  • New memories
  • More knowledge
  • New skills
  • More emotional depth
  • More emotional resilience
  • A more optimistic attitude
  • More excitement and passion
  • Less boredom
  • A sharper, fitter, less fragile brain

New experiences make you smarter and enrich your life in so many ways. Even a relatively short one-time experience like going to a lecture or a concert can change the direction of your life or give you a strong memory you’ll cherish for decades.

Sometimes you’re choosing between one interesting experience and another, but more often it’s a choice between something new and something familiar.

New experiences are uncertain though. They can seem scary, even when they aren’t truly threatening. It’s actually good and healthy for you to be knocked off balance now and then – it makes you stronger.

When you don’t lean into new experiences, you miss out on the wonderful romance that awaits you.

How fragile do you want to be as a human being? How crusty and set in your ways do you wish to become as you age? Do you want each day to be the same – safe and cocooned till death finally comes for you?

Are you living with that feeling of pep in your step? Do you feel excited for what you get to learn and experience each day? Or has your life become an endless barrage of sameness?

Don’t blame the virus for the sameness. There’s still plenty to explore right now without risking your health or the health of others. You can access a treasure chest of new experiences from your home.

Beware the trap of courting the same old familiar experiences. Stretch your ambition in the direction of some bigger ones now and then. Reach further into the possibility space.

This time is a gift. You could remake your identity during this time. You could develop new skills that you’ll cherish for the rest of your life. You could undertake the biggest creative project of your life – something that stretches beyond your current abilities.

Do it for the experience.

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Health24.com | Staying social can boost healthy ‘grey matter’ in ageing brains

  • Dementia has tremendous costs in terms of treatment and caregiving.
  • Preventing dementia, therefore, is of great importance
  • The findings of a new study suggest that socialising could benefit older adults’ brain health  

Older adults who get together with friends, volunteer or go to classes have healthier brains, which could help them ward off dementia, according to a new study.

Researchers who used brain imaging to examine brain areas involved in mental decline found that greater social engagement made a difference in brain health.

Being socially engaged – even moderately – with at least one relative or friend activates parts of the brain needed to recognise familiar faces and emotions, make decisions and feel rewarded, the study found.

No cure for dementia

“We need to do more research on the details, but that’s the beauty of this – social engagement costs hardly anything, and we do not have to worry about side effects,” said lead author Dr Cynthia Felix, a geriatrician and postdoctoral associate at the University of Pittsburgh Graduate School of Public Health.

“There is no cure for dementia, which has tremendous costs in terms of treatment and caregiving. Preventing dementia, therefore, has to be the focus. It’s the ‘use it or lose it’ philosophy when it comes to the brain,” she said in a university news release.

The researchers drew on information from nearly 300 community-dwelling seniors (average age 83) who had a sensitive brain scan to gauge the integrity of brain cells used for social engagement.

Once brain cells die, dementia typically follows. Researchers said it’s not yet clear whether social engagement keeps brains healthy or if having a healthy brain leads to more socialising.

Either way, the findings suggest that “prescribing” socialisation could benefit older adults’ brain health – similar to the way prescribing physical activity can help prevent diabetes or heart disease. Existing programmes that provide group physical activities would be a good starting point, Felix said.

Social engagement crucial during pandemic

“Our data were collected before the Covid-19 pandemic, but I believe our findings are particularly important right now, since a one-size-fits-all social isolation of all older adults may place them at risk for conditions such as dementia,” she said.

“Older adults should know it is important for their brain health that they still seek out social engagement in safe and balanced ways during the pandemic,” Felix advised.

The findings were reported on 19 October in the Journal of Gerontology: Psychological Sciences.

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Boots to offer 12-minute turnaround on Covid nasal swab test

The £120 nasal swab test will be available to people not showing any symptoms.

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Health24.com | Curbing Covid brought unexpected benefit for asthma patients

  • There was a significant decrease in the average number of asthma hospitalisations during the first part of 2020
  • A possible explanation is that better hygiene as a result of Covid-19 reduced exposure to asthma triggers
  • Enhanced precautions and preventative asthma medications could also have had an effect

Measures enacted to slow the spread of the new coronavirus also appeared to reduce hospitalisations for asthma, a new study finds.

Researchers compared weekly data on hospitalisations at 272 hospitals in Japan in the first five months of 2020 to the same period in 2017, 2018 and 2019.

Asthma hospitalisations in 2017–19 and 2020 showed similar trends until week eight, but in 2020 hospitalisations began to decline in week nine, the study found.

Hospitalisations for Covid-19 were first recorded during week seven of 2020. Further analysis found a significant decrease in the average number of asthma hospitalisations during weeks nine to 22 of this year compared to 2017–19.

Enhanced precautions

The findings were published on 13 October in The Journal of Allergy and Clinical Immunology: In Practice.

“Asthma hospitalisations usually indicate that an individual’s asthma is not currently under control,” corresponding author Dr Atsushi Miyawaki, of the University of Tokyo, said in a journal news release. “This would suggest that asthma control improved during the pandemic. It illustrates the importance of environmental factors when it comes to treating and managing patients with asthma.”

One possible explanation is that increased hygiene to prevent Covid-19 would also reduce exposure to asthma triggers, according to the researchers. Enhanced precautions – such as frequent cleaning and reduced smoking – by people concerned that Covid-19 may trigger asthma may also have helped reduce triggers.

Other possible explanations include people being more likely to use preventative asthma medications, and community Covid-19 prevention measures helping reduce other respiratory infections, which can cause worse asthma.

Image credit: iStock

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Mother and baby units: ‘It’s our job to keep them safe’

Units for new mothers and women with serious mental health issues are facing unique challenges.

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Health24.com | Coronavirus science | Week in review: Obesity, sudden hearing loss, and test swab found in a lung

LATEST SCIENCE AND RESEARCH

READ | Risk of severe Covid-19 high for obese people, regardless of other factors

As the Covid-19 pandemic continues, obesity has been one of the top triggers for severe cases. Outside of the disease, obesity has always had a detrimental effect on health through chronic inflammation, a higher risk of heart disease and a weakened response to viral infections.

But how much does it matter in relation to other conditions, age, sex and race when it comes to contracting a severe coronavirus infection?

To answer this question, Brazilian researchers conducted a meta-analysis of nine studies from five countries on severe Covid-19, which included more than 6 500 patients. More than half were male and had comorbidities such as hypertension (51.51%), diabetes (30.3%), cardiovascular disease (16.66%), lung disease (15.99%), renal disease (7.49%), cancer (5.07%), and immunosuppression (1.8%). A high proportion of patients were smokers and suffered from dyslipidemia – a condition involving high levels of cholesterol or fat in the blood.

They wanted to investigate the prevalence of obesity as a contributing factor in severe Covid-19 cases that required admission to ICU. They also looked at the best treatments that helped obese patients recover from the virus.

The studies they analysed included case studies and series, clinical trials and randomised controlled trials that mentioned obesity. They found that in more than half of severe cases, people suffered from obesity. In terms of other comorbidities, just less than half had hypertension, while type 2 diabetes, lung disease, smokers, cardiovascular disease were each around the 20% mark.

Not only is obesity a major factor for severe Covid-19, the condition also indicates that these patients are also more likely to be infected with the coronavirus in the first place.

PICS | Swab gets stuck inside woman’s lung during coronavirus test

A 51-year-old patient ended up with a snapped coronavirus test swab inside her lung after it was inserted into a breathing tube in her neck, a BMJ case report revealed.

The woman was undergoing brain surgery in a UK hospital to remove a fragment of her skull. As part of her treatment, a tracheostomy tube – placed into the windpipe to assist with breathing – was fitted.

After the operation, medical staff at the University Hospitals of Leicester NHS (National Health Service) Trust sent the patient to undergo a coronavirus test as part of normal protocol before discharging her to a nursing home.

Since the patient had been breathing through the hole in her neck and could have potentially become infected with the virus through this airway, medical staff took a swab through her tracheostomy tube.

However, a nurse carrying out the test felt the swab snap during the procedure, and part of it ended up in the patient’s windpipe.

The test swab is designed to snap into a test tube to be sent to the lab.

READ | ‘Silent’ mutations gave Covid-19 virus an evolutionary edge

Understanding the features of SARS-CoV-2, the virus that causes Covid-19, is crucial for predicting the future, and in a recent study, scientists may have come one step closer.

According to Duke University (DU) researchers, a number of “silent” mutations in the roughly 30 000 letters of the virus’s genetic code may have given it an advantage and caused it to thrive in the human population after crossing over from bats and other wild animals.

“We’re trying to figure out what made this virus so unique,” said lead author Alejandro Berrio, a postdoctoral associate in biologist Greg Wray’s lab at DU.

In their paper, they explain how the subtle changes, or mutations, influenced how the virus unfolded its RNA molecules within human cells.

The study was published in the journal PeerJ.

For their study, the researchers wanted to identify adaptive changes that occurred in the SARS-CoV-2 genome in humans, but not in closely related coronaviruses found in bats and pangolins.

READ | Covid-19: Sudden hearing loss, while rare, occurs in some patients – and needs to be caught early

The first case of sudden hearing loss due to Covid-19 infection was reported in the United Kingdom and doctors are urging people to become aware of the symptom because prompt treatment could completely or at least partially reverse it.

While the report states that the condition is uncommon, doctors warned that if the condition remains undetected, and subsequently untreated, the damage is likely to be irreversible.

The case study was published in BMJ Case Reports and details how a 45-year-old patient, who suffers from asthma, was admitted to hospital following 10 days of Covid-19 symptoms.

In hospital, the patient needed to be intubated and was transferred to the intensive care unit (ICU).

He remained intubated for 30 days and his stay in hospital was further complicated because of a number of other conditions, including pneumonia and anaemia. After going through several courses of medication, including remdesivir, intravenous steroids and plasma exchange (to treat Covid-19), he was extubated and transferred out of the ICU.

A week after leaving the ICU, the patient noticed a ringing in his left ear and a sudden loss of hearing. The patient was officially diagnosed with sudden onset sensorineural hearing loss (SSNHL).

READ | Lockdown: Scientists looked at personality traits to understand why some defy the rules

People with certain common personality traits are less likely to remain at home when government policies are less restrictive, a global survey done during the first wave of the Covid-19 pandemic has found.

The study researchers investigated the so-called Big Five personality traits: conscientiousness, neuroticism, agreeableness, extraversion and openness and its association with complying with lockdown measures.

“The pandemic led us to revisit one of psychology’s most fundamental and most basic questions in a high-stakes context: What determines human behaviour?” the authors wrote.

Their findings were published by the American Psychological Association.

For their study, the research team used data from the “Measuring Worldwide Covid-19 Attitudes and Beliefs” project – a global survey that aimed to assess people’s behaviours and perceptions of others’ behaviours during the pandemic.

The team analysed responses from more than 101 000 participants in 55 countries.

CORONAVIRUS CASES LATEST

SA cases update: 

The latest number of confirmed cases is 715 868.

According to the latest update, 18 968 deaths have been recorded in the country.

There have been 646 170 recoveries.

So far, more than 4.69 million tests have been conducted, with 19 997 new tests reported.

Global cases update:

For the latest global data, follow this interactive map from Johns Hopkins University & Medicine.

Late on Sunday night, positive cases worldwide were more than 42.77 million, while deaths were more than 1.51 million.

The United States had the most cases in the world – more than 8.58 million, as well as the most deaths – almost 225 000.

HEALTH TIPS (as recommended by the NICD and WHO)

• Maintain physical distancing – stay at least one metre away from somebody who is coughing or sneezing

• Practise frequent hand-washing, especially after direct contact with ill people or their environment

• Avoid touching your eyes, nose and mouth, as your hands touch many surfaces and could potentially transfer the virus

• Practise respiratory hygiene – cover your mouth with your bent elbow or tissue when you cough or sneeze. Remember to dispose the tissue immediately after use.

Image credit: Getty Images

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Coronavirus: 14-day quarantine for Covid contacts could be reduced

It comes as a senior Conservative MP criticises leaders of NHS Test and Trace, urging “decisive” change.

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