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Category Archives: Mind Building
Trapping and controlling light at the interface of atomically thin nanomaterials
Light can partake in peculiar phenomena at the nanoscale. Exploring these phenomena can unlock sophisticated applications and provide useful insights into the interactions between light waves and other materials.
In a recent study, scientists at Cornell University propose a novel method by which nanoscale light can be manipulated and transported. These special modes of light transport are known to arise at finely tuned interfaces between slightly different nanomaterials. Minwoo Jung, lead researcher on this study, illustrates this concept through a simple analogy: “A floating tube has a hole in the middle, but a normal balloon doesn’t. No matter how you squeeze the round balloon, it cannot be reshaped like a donut-at least not without popping the balloon, re-knitting the rubber, and re-injecting the air. Thus, a tube and a balloon are distinct in their topology because they are not connected through a smooth deformation.”
Jung further explains that physicists have been interested in gluing two topologically distinct materials side by side so that one of them acts like a balloon and the other like a tube. This means that, at their interface, a process that connects these two materials must occur, much like the poking/popping/re-knitting/re-injecting from a balloon to a tube. Under the right conditions, this process can give rise to a strong channel for transmitting energy or information along the interface. Because this process can be applied to light (which acts as a carrier of energy or information), this branch of physics is called topological photonics.
Jung and his team combined the fascinating concept of topological photonics with an innovative technique that traps light in an atomically thin material. This method brought together two rapidly emerging fields in applied and fundamental physics: graphene nanolight and topological photonics. Jung says, “Graphene is a promising platform for storing and controlling nanoscale light and could be key in the development of on-chip and ultracompact nanophotonic devices, such as waveguides and cavities.”
The research team ran simulations involving a graphene sheet layered on a nanopatterned material that functions as a metagate. This honeycomb-like metagate consists of a solid layer of material with holes of different sizes, centered at the vertices of the hexagons. The varying radii of these holes affect the way in which the photons pass through the material. The scientists found that strategically “gluing” together two different metagates creates a topological effect that confines photons at their interface in a predictable, controllable manner.
Different choices of metagate designs demonstrate the dimensional hierarchy of the device’s topology. Specifically, depending on the metagate geometry, nanolight can be made to flow along one-dimensional edges of the topological interface or can be topologically stored at zero-dimensional (point-like) vertices. Moreover, the metagate allows for on-and-off electric switching of these waveguides or cavities. Such battery-operated topological effects can benefit the technological adoption of topological photonics in practical devices.
Jung’s team is optimistic that the synergistic combination of graphene nanolight and topological photonics will spur advances in relevant research areas, like optics, material sciences, and solid-state physics. Their graphene-based material system is simple, efficient, and suitable for nanophotonic applications: a step forward in harnessing the full potential of light.
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Materials provided by SPIE–International Society for Optics and Photonics. Note: Content may be edited for style and length.
NHS staff sign up to Covid-19 sniffer dog trial
Kettering Hospital staff are among donors providing samples to see if dogs can sniff out the virus.
Singing ‘no riskier than talking’ for virus spread
It does not produce many more respiratory particles than speaking at similar volume, a study finds.
Research shows air pollution could play role in development of cardiometabolic diseases
Air pollution is the world’s leading environmental risk factor, and causes more than nine million deaths per year. New research published in the Journal of Clinical Investigation shows air pollution may play a role in the development of cardiometabolic diseases, such as diabetes. Importantly, the effects were reversible with cessation of exposure.
Researchers found that air pollution was a “risk factor for a risk factor” that contributed to the common soil of other fatal problems like heart attack and stroke. Similar to how an unhealthy diet and lack of exercise can lead to disease, exposure to air pollution could be added to this risk factor list as well.
“In this study, we created an environment that mimicked a polluted day in New Delhi or Beijing,” said Sanjay Rajagopalan, MD, first author on the study, Chief of Cardiovascular Medicine at University Hospitals Harrington Heart and Vascular Institute, and Director of the Case Western Reserve University Cardiovascular Research Institute. “We concentrated fine particles of air pollution, called PM2.5 (particulate matter component < 2.5 microns). Concentrated particles like this develop from human impact on the environment, such as automobile exhaust, power generation and other fossil fuels.”
These particles have been strongly connected to risk factors for disease. For example, cardiovascular effects of air pollution can lead to heart attack and stroke. The research team has shown exposure to air pollution can increase the likelihood of the same risk factors that lead to heart disease, such as insulin resistance and type 2 diabetes.
In the mouse model study, three groups were observed: a control group receiving clean filtered air, a group exposed to polluted air for 24 weeks, and a group fed a high-fat diet. Interestingly, the researchers found that being exposed to air pollution was comparable to eating a high-fat diet. Both the air pollution and high-fat diet groups showed insulin resistance and abnormal metabolism — just like one would see in a pre-diabetic state.
These changes were associated with changes in the epigenome, a layer of control that can masterfully turn on and turn off thousands of genes, representing a critical buffer in response to environmental factors. This study is the first-of-its-kind to compare genome-wide epigenetic changes in response to air pollution, compare and contrast these changes with that of eating an unhealthy diet, and examine the impact of air pollution cessation on these changes.
“The good news is that these effects were reversible, at least in our experiments” added Dr. Rajagopalan. “Once the air pollution was removed from the environment, the mice appeared healthier and the pre-diabetic state seemed to reverse.”
Dr. Rajagopalan explains that if you live in a densely polluted environment, taking actions such as wearing an N95 mask, using portable indoor air cleaners, utilizing air conditioning, closing car windows while commuting, and changing car air filters frequently could all be helpful in staying healthy and limiting air pollution exposure.
Next steps in this research involve meeting with a panel of experts, as well as the National Institutes of Health, to discuss conducting clinical trials that compare heart health and the level of air pollution in the environment. For example, if someone has a heart attack, should they be wearing an N95 mask or using a portable air filter at home during recovery?
Dr. Rajagopalan and his team believe that it is important to address the environment as a population health risk factor and continue to diligently research these issues. The authors also note that these findings should encourage policymakers to enact measures aimed at reducing air pollution.
Affirmative action incentivizes high schoolers to perform better, new research shows
California voters will be asked to approve a return to affirmative action on Nov. 3 with Proposition 16, which would restore the right of the state’s colleges and universities to consider race, ethnicity and gender in admission decisions.
Affirmative action is a contentious issue across the globe, hotly debated in countries such as India, Sri Lanka, Malaysia, Nigeria and Brazil, as well as in the United States. While the direct effects of affirmative action on college admissions are well known, new evidence from India shows that affirmative action has indirect benefits on the behavior of underrepresented high school students, who tend to stay in school longer when they know higher education is within reach.
In a new University of California San Diego study published in the Review of Economics and Statistics, researchers find minority students attain 0.8 additional years of education where affirmative action policies are in place. The study underscores previous theoretical work on affirmative action that shows the opportunity to be admitted to college may motivate students to graduate from high school, according to the study’s author, Gaurav Khanna, assistant professor of economics at UC San Diego’s School of Global Policy and Strategy.
“In the policy space, people have made claims that affirmative action lowers standards and the learning gains for underrepresented students who will ‘no longer work as hard.’ My research suggests the opposite,” Khanna said. “Affirmative action makes going to a good college much more attainable, and actually encourages minority groups to work harder to get into such schools. Without affirmative action, many colleges may not appear attainable, and it may discourage students from even trying.”
India’s federal government instituted affirmative action policies in 1993, reserving 27% of government jobs that are highly sought after for Other Backward Classes (OBCs) — a collective term used by the country’s government to classify castes which are educationally or socially disadvantaged. In 2006, reservations in colleges were implemented.
Other research shows how these affirmative action policies in India increased the representation of minority groups in top colleges, and how the graduates went on to perform well in college and in the subsequent labor market. However, the UC San Diego study explores if affirmative action incentivizes students to stay in school by looking at the educational attainment at pre-collegiate levels.
To answer the question, Khanna compiled a number of data sources, including the Indian National Sample Survey (NSS) to map the trends in educational attainment by birth cohort and social group. Those born before 1976 would be over the age of 18 by the time the federal government policy was implemented in 1994. Thus, he looked at education levels of minority students in this cohort and compared them to education levels attained by OBCs before the affirmative action policies were enacted.
The results show that after affirmative action policies were implemented, there was a marked increase in OBCs’ educational attainment. While non-minorities were still more likely to pursue more education, wide-scale affirmative action helped bridge the education gap by about 40% over a decade and a half.
“The evidence suggests that aspirations respond to such laws and additional research also shows that if peers are seen to benefit from this policy, then a role model effect may encourage educational attainment,” Khanna writes.
While affirmative action is a federal law in India, each state chooses a different level of application. This is defined by the fraction of seats reserved at universities and government job openings reserved for minorities, compared to their population in that state. For example, in the state of Karnataka the policy is stronger with more seats reserved in jobs and colleges, relative to the OBC population. Conversely, in the state of Madhya Pradesh fewer jobs and college seats are reserved for OBCs, as a fraction of their population. Khanna finds that states that had a higher intensity of affirmative action, in terms of the fraction of seats reserved per OBC, saw a sharper increase in the educational attainment of minorities.
Affirmative action: a contentious policy both at home and abroad
Today, in India these policies are an integral part of political platforms and election campaigns; the media covers the policies extensively, and any policy change is met with protests from different factions.
Similarly, in the U.S., the issue is divisive. For example, the Trump administration announced in 2018 that it was abandoning the Obama administration policies that called on universities to consider race as a factor in diversifying campuses. Education Secretary Betsy DeVos stated that “schools should continue to offer equal opportunities for all students.”
Given the debate in both countries, the other question Khanna sought to answer: is this educational response from the minority groups rational in terms of the expected costs and benefits?
With education levels being important for the qualification criteria for government jobs in India, Khanna found that between 2000 and 2005, the fraction of OBCs in public sector jobs rose from 22% to 27%. These jobs are extremely lucrative, especially in rural areas, where they guarantee benefits and job security. As such, increases in the likelihood of getting such jobs can greatly influence the decision made by minority groups.
Khanna writes, “Yet even for members of the minority group who do not get government jobs, an increase in education may translate into benefits (like better health) and high wages as the estimated returns to education in developing countries are between 6% and 13%.”
He concluded, “Indeed, lowering educational inequalities — and possibly wealth inequalities — may be intrinsically valuable to policymakers. In light of these results, policymakers should consider the externalities of affirmative action policies when designing them.”
Health24.com | His body brewed its own alcohol, but a faecal transplant shut the brewery down
- In rare cases, yeast in the gut converts sugar from food into alcohol
- This causes symptoms similar to being drunk
- In a new development, doctors successfully treated a case of auto-brewery syndrome with a faecal transplant
In a first, doctors have used a faecal transplant to treat a rare condition that causes the body to brew its own alcohol.
The disorder, known as auto-brewery syndrome (ABS), occurs when yeast builds up in the gut and converts sugar from food into alcohol. The result is a lot like being drunk: Blood alcohol spikes, causing symptoms such as dizziness, disorientation, coordination problems and mood changes.
And as anyone with ABS knows, it’s a miserable and perplexing condition, according to Barbara Cordell, an adjunct professor at Panola College, in Texas.
Cordell is also president of the nonprofit Auto-Brewery Syndrome Information and Research. Her interest in the condition began through personal experience when her husband developed symptoms – though it took years to trace them to ABS.
‘Exciting’ new case
That is a typical scenario, Cordell said. Few doctors actually recognise and treat the condition, she noted.
That’s why the new case, reported on 18 August in the Annals of Internal Medicine, is “exciting,” Cordell said. It’s the first known instance of doctors treating ABS with a faecal transplant – a procedure largely considered investigational.
Cordell said it could be a “breakthrough” for people with severe cases of ABS that do not respond to simpler fixes, like diet changes.
Faecal transplants involve transferring stool from a healthy donor into the patient’s gastrointestinal tract. The idea is to change the bacterial composition of the gut, hopefully to a healthier balance.
The procedure is sometimes used to treat severe gastrointestinal infections caused by Clostridium difficile bacteria.
Faecal donation from daughter
It is also being tested as a treatment for certain chronic gut conditions, including ulcerative colitis and irritable bowel syndrome (IBS). Dr Danny De Looze, of University Hospital Ghent, in Belgium, recently completed a study of patients with stubborn cases of IBS – and found the transplant can ease their symptoms.
So when De Looze encountered a patient with severe auto-brewery syndrome, a light bulb went off.
“Knowing the success of (faecal transplant) in C. diff, I thought it would be a good idea to treat him the same way,” De Looze said.
The patient, a 47-year-old man, had already tried the known conservative treatments for ABS: a low-carbohydrate diet and anti-fungal medication. Yet his blood alcohol levels remained high and his symptoms persisted.
That all changed after the transplant, using a donation from the man’s adult daughter. Nearly three years later, he has remained symptom-free, according to De Looze. He also regained his driver’s license, which was taken away after a random police check found soaring blood-alcohol levels.
Whether faecal transplants will become an option for more ABS patients is difficult to predict.
Back-to-back antibiotics
ABS, itself, remains mysterious. But among the cases reported so far, there does seem to be a common denominator, Cordell said: Prolonged antibiotic use. It’s thought that in certain vulnerable people, that disrupts the gut’s normal bacterial makeup in a way that allows alcohol-producing yeast to thrive.
De Looze’s patient started noticing symptoms one month after taking back-to-back courses of antibiotics. He’d also had gastric bypass surgery 14 years prior.
According to Cordell, gastric bypass is thought to be one of the factors that make people susceptible to auto-brewery syndrome. The same is true of certain conditions that disrupt the gut’s microbial balance – including Crohn’s disease, short bowel syndrome and obesity.
“But some people with auto-brewery have no underlying conditions,” Cordell said. “We don’t know why they get it.”
A very rare disease
Often, ABS does respond to a low-carb diet and anti-fungal medication. But for particularly tough cases, Cordell said, a faecal transplant makes sense.
“We’re not talking about doing this for everyone,” she stressed. “But this is an option we’ve been thinking about for the sickest patients.”
De Looze said he would “certainly encourage” doctors to try the approach.
Ideally, he noted, a clinical trial would be done to formally test the treatment. “But since this is a very rare disease,” De Looze said, “it will be practically impossible.”
He added that his patient suffered no side effects. However, faecal transplants are not risk-free: The US Food and Drug Administration recently warned that they can transmit serious infections. That was based on reports of six patients who developed new bacterial infections after having faecal transplants to treat C. diff infections.
Image credit: iStock
Buying Appreciation

As I’ve gotten older, I’ve grown much better at making purchases that I don’t regret. This includes clothing, tech, furniture, appliances, and more.
When I was younger, I often made poor choices in this area.
Here’s the key difference.
When I was younger, I would basically ask these types of questions when considering purchase options:
- What’s good enough?
- What can I afford?
- What’s the best value?
- Where can I get the best deal?
- How can I get this for less?
- How can I save money on this?
- What will satisfy me?
- What will get the job done?
- What’s the best bang per buck?
These questions led me to focus mainly on value. I often wanted to feel like I was getting a good deal. To me a good deal meant a reasonable level of quality at a good or great price.
And that’s basically what I got. I’d buy items that were adequate for my needs, and I’d often find ways to get them at good or great prices. The price alone could be a strong motivator.
Today I think differently about making purchases. Now I tend to ask these types of questions when considering a purchase:
- What do I really want?
- What excites me?
- Which option would I appreciate most?
- What would feel too good to have? Is it really too good?
- What would I get if I could afford anything?
- What do I want the simulator to simulate?
- Which option feels abundant?
- Which option feels like I’d need to justify or explain it?
- Which option feels edgy or exciting?
- Where’s the lust? What am I lusting after?
I still love a good deal, but I’ve found it best not to make that my main concern. These days I’d rather buy a great option at a decent price than buy a good option at a great price.
What I’ve discovered is that appreciation is worth paying for. It’s worth paying more for better quality. I define better quality as items that feel a bit indulgent to me. Sometimes these items feel almost sinful.
When I made a so-so purchase, I normally don’t appreciate the item as much after I’ve bought it. Owning it isn’t as exciting as getting it. There’s a bit of a letdown after the purchase is made.
But when I make a really aligned purchase, I typically like and appreciate the item at least as much after I have it and sometimes even more. I’ll often comment, “I like this even more than I thought I would.”
This doesn’t necessarily mean I have to spend extra, although sometimes that can be a factor. It’s more about focusing on my feelings and seeing where they lead. It helps to slide away from being too objective and to consider the subjective lens.
The key is to pay more respect to the emotional reality of a purchase. I now give more weight to how much I’m likely to appreciate and value an item for the time it will be with me. In the past I felt like I always had to have extra justification for that, like any excess emotion had to be balanced with extra logic, especially if I had to pay more for some increased emotional satisfaction. Now I realize that spending for gratification is actually a wise choice in general and that I don’t need to go overboard in trying to justify that.
Consequently, I feel that my life is becoming richer in possessions that I really like. I still fumble sometimes, but I can see that I’m doing a better job of aligning my physical environment with a mindset of abundance.
Interestingly I also find that this attitude helps to drive my income higher because it carries over to the income side. Just as I think about spending to create emotional value, I also think about how different approaches to income generation will create different levels of emotional value. This helps me invest in income streams that enrich my life emotionally. If I feel good about a stream emotionally, it’s easier to keep investing in it, and it also removes some friction.
A common source of friction is when you don’t really like what you’d have to do to increase your income. If you can reduce that friction, it’s easier to grow your income and while enjoying the process.
What kinds of questions do you ask when considering a purchase decision? See if you can articulate what’s going through your mind. Turn that inner mindset into a short list of questions. Then look at those questions, and consider how they may be affecting you. Can you see how your buying mindset links up with your long-term appreciation?
Also notice which possessions you appreciate the most. What mindset did you use for them? What questions did you ask?
When you can identify the mindset (and the questions) that generate the most appreciation and the least regret, you can apply that mindset more deliberately. Then you can shorten it to a quick rule of thumb to use again and again.
Note that this is mostly a subjective mindset, but it carries over to the objective side. Thinking about appreciation is a shortcut that helps me pay a more attention to the full ownership experience, including potential long-term maintenance and support needs.
My rule of them is the title of this post: buying appreciation. That’s a simple shortcut to remind myself of what I really want. I’m not just buying utility or adequacy. I’m buying long-term appreciation.
Health24.com | Cats, dogs and snakebite: One pet has an advantage
One reason why cats have nine lives has emerged from an Australian study.
Cats are twice as likely as dogs to survive the bite of a poisonous snake, according to an international team of researchers. The reason: Cats’ blood clots faster than that of dogs.
For the study, the researchers compared the effects of 11 different snake venoms from around the world on the blood-clotting agents in dogs and cats.
“Snakebite is a common occurrence for pet cats and dogs across the globe and can be fatal,” said co-author Bryan Fry, an associate professor of biological sciences at the University of Queensland in Brisbane, Australia. “This is primarily due to a condition called venom-induced consumptive coagulopathy – where an animal loses its ability to clot blood and sadly bleeds to death.”
Behavioural differences
Australian eastern brown snakes are responsible for about 76% of pet snakebites in Australia each year.
“And while only 31% survive without anti-venom, cats are twice as likely to survive – at 66%,” Fry said in a university news release.
Cats are significantly more likely to survive if they are treated with anti-venom, and researchers said the reason was unclear until now. Dogs probably experience the failure of the blood to clot sooner than cats.
Behavioural differences between cats and dogs also are likely to increase dogs’ odds of death from snakebite.
“Dogs typically investigate with their nose and mouth, which are highly vascularized areas, whereas cats often swat with their paws,” Fry said. “And dogs are usually more active than cats, which is not great after a bite has taken place because the best practice is to remain as still as possible to slow the spread of venom through the body.”
Fast and fatal
Researchers hope their findings will lead to awareness of the short time available to get treatment for snakebitten dogs.
“I’ve had two friends lose big dogs to snakebites, dying in less than 10 minutes even though the eastern brown snakes responsible were not particularly large specimens,” Fry said. “This underscores how devastatingly fast and fatal snake venom can be to dogs.”
The report was published on 18 May in the journal Comparative Biochemistry and Physiology.
Image credit: Unsplash
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Health24.com | Could certain chemicals trigger coeliac disease?
- Coeliac disease is an immune disorder where people can’t tolerate foods containing gluten
- Researchers say that toxic chemicals in a range of products are associated with increased risk of the disorder
- Gender appears to be an important factor in the link between the chemicals and the disorder
Toxic chemicals in a wide range of products are associated with an increased risk of coeliac disease in children and young adults, researchers say.
People with celiac disease – an immune disorder – can’t tolerate foods that contain gluten, a protein found in wheat, rye and barley.
New York University researchers analysed the blood of 30 children and young adults newly diagnosed with coeliac disease and compared results with those from 60 other young people. The investigators found that elevated levels of toxic chemicals found in pesticides, nonstick cookware and fire retardants were linked to a higher risk of having coeliac disease.
“Our study establishes the first measurable tie-in between environmental exposure to toxic chemicals and coeliac disease,” said senior study investigator and paediatric gastroenterologist Dr Jeremiah Levine.
Gender an important factor
“These results also raise the question of whether there are potential links between these chemicals and other autoimmune bowel diseases, which all warrant close monitoring and further study,” Levine added in a university news release.
In the study, children and young adults with high blood levels of pesticide-related chemicals called dichlorodiphenyldichlorethylenes (DDEs) were twice as likely to be newly diagnosed with coeliac disease as those without such levels.
Gender was an important factor in the link between toxic chemicals and risk of coeliac disease.
Females – who account for the majority of coeliac patients – with higher-than-normal pesticide exposure were at least eight times more likely to have coeliac disease.
Females with elevated levels of nonstick chemicals called perfluoroalkyls (PFAs), which are found in products like Teflon, were five to nine times more likely to have coeliac disease.
Only an association
Males were twice as likely to have coeliac disease if they had elevated blood levels of fire-retardant chemicals called polybrominated diphenyl ethers (PBDEs), according to the study.
The findings were published online in May in the journal Environmental Research.
Further research is needed to determine if these toxic chemicals are a direct cause of coeliac disease since this study only showed an association, said study co-investigator and health epidemiologist Dr Leonardo Trasande.
He noted that all the chemicals are known to disrupt animal and human hormone levels, which are crucial in sexual development and immune system function.
Image credit: Getty Images






