Transmission of the amphibian pathogen, Bsal

Researchers at the University of Tennessee Institute of Agriculture’s Amphibian Disease Laboratory are working to understand — and hopefully get ahead of — highly contagious pathogens affecting amphibians in Europe and Asia. One of the pathogens of interest is Batrachochytrium salamandrivorans, or Bsal.

Managed by Debra Miller and Matt Gray, professors in the Department of Forestry, Wildlife and Fisheries, the Amphibian Disease Laboratory is investigating disease management strategies for if, and possibly, when, Bsal makes its way to the United States through international animal trade or other means. Recent findings by Daniel Malagon, former undergraduate student working in the lab, show promising information for disease management of Bsal.

Using existing data from controlled experiments and computer simulations, Malagon found that host contact rates and habitat structure affect transmission rates of Bsal among eastern newts, a common salamander species found throughout eastern North America. Simply put, the higher the population density of the salamanders, the greater the rate of Bsal transmission. Malagon also found that adding habitat complexity, thereby separating the salamanders from each other, causes transmission rates to drop. These findings are similar to the results being observed when human populations follow the COVID-19 mitigation guidelines seen across the globe today.

Malagon’s academic advisor Matt Gray, who is also the chair of the North American Bsal Task Force, states, “Wildlife and humans pathogens are quite similar. In fact, Daniel’s results support the strategy of social distancing being used to mitigate the COVID-19 outbreaks. By reducing host density in newts or humans, contact rates, and therefore transmission, are reduced. Habitat structure also reduced contact rates of newts, so transmission is curtailed in more complex habitats. This may be analogous to COVID-19 environments. A person may be more likely to become infected in a homogenous movie theater compared to walking through a heterogeneous forest, even if density of people was the same.”

This research will support disease mitigation strategies for amphibians and could provide support for infectious disease recommendations for humans as well. “Our results suggest efficient pathogen spread in populations of highly susceptible salamander species, like the eastern newt. These populations will likely be negatively impacted if Bsal reaches North America. We hope our findings will help inform policy and management strategies to prevent the introduction of Bsal into North America,” added Malagon.

This research is in support of Gray and Miller’s National Science Foundation Project #181450, and the paper with these findings was recently published online by Nature Scientific Reports. Malagon, who is now a doctoral student at Clemson University, was supported in this research by the UT Knoxville College Scholars Program. Co-authors on the paper include Luis Melara of the Department of Mathematics, Shippensburg University; Olivia Prosper, formerly with the Department of Mathematics, University of Kentucky, and now with UT Knoxville; Suzanne Lenhart, Department of Mathematics, UT Knoxville; Jim Fordyce, Department of Ecology and Evolutionary Biology, UT Knoxville; and Davis Carter and Anna Peterson, Center for Wildlife Health, Department of Forestry, Wildlife and Fisheries, UT Institute of Agriculture.

Miller also holds an appointment in the Department of Biomedical and Diagnostic Sciences at the UT College of Veterinary Medicine and is currently serving as the interim director of the UT One Health Initiative. Announced in January, the UT One Health Initiative seeks fundamental answers to issues that address the inextricably linked health of humans, animals, plants and the environment as a whole.

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Coronavirus: A&E visits drop sharply as calls to 111 double

The number of people going to A&E in England dropped substantially last month, official figures show.

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Using Paper Tools

While digital tools can be nice for productivity because of their features, they also have many drawbacks:

  • Digital tools tether you to using a digital device, which can be full of highly accessible distractions.
  • Software still tends to be rigid, limited to the capabilities that are actually implemented by the developers.
  • Software tools have a learning curve. The more tools you use, the more learning time you have to invest. For some software it could take a full day or longer just to become modestly productive with it.
  • Software tools often drag you into dealing with upgrades, add-ons, and security and privacy issues.
  • The more software tools you use, the more complicated your tech life becomes, and the more tech issues you’re likely to have.
  • Software tools often have a useful lifespan that’s limited to a few years unless you keep upgrading. Many tools don’t endure for a decade.
  • For each software tool you use, you may get more email because of it – for support, tips, upgrades, privacy policy updates, etc.
  • If you stop using the software, you may not even be able to access what you’ve created with it. You might be locked into years of upgrade cycles, even if you don’t use it that much.
  • Software tools sometimes break and don’t work, so you may have to seek support or search for solutions online, which chews up time.

While there are many benefits to using software tools, there are many hidden costs as well. Consider all the time you’ve spent researching, learning, evaluating, upgrading, and maintaining various software tools. Are you getting a good payoff for your investment when you consider the total time you’ve had to invest?

Now add the additional time you may have lost from digital distractions when you use software tools, especially on an Internet connected device. How often did you break away from using a genuine productivity tool to check email or social media or to look something up online?

I tend to be wary of over-relying on software tools when I think about the total cost of using them. I like using a relatively small number of tools, especially highly flexible ones like Scrivener. I lean towards minimalism in this area, so I don’t have to maintain such a large collection of tools. I also unsubscribe from nonessential emails related to the software I use, so they don’t distract me. I know I can look something up online when I need it.

Often I prefer to turn towards tactile, low-tech tools such as plain paper, spiral notebooks, index cards, file folders, sticky notes, pens, markers, and a marker board. Such tools can be impressively good for productivity.

Here are some of the benefits of working with such tools:

  • It’s easier to get into a deeper, zen-like focus with paper tools. There’s nothing to click on. There are no icons to distract you.
  • The interface is clean and simple. Pick up a pen or marker and put ink on a surface.
  • Such tools are still immensely flexible. You can write or draw anything you want. You can write lists, sketches, and mind maps on a single page if you want, all with the same tools.
  • Writing by hand forces you to slow down. This makes you think more carefully about what you’re creating. It may feel uncomfortable at first if you’re enmeshed in the digital world, but it’s really nice when you get used to it.
  • The simplicity of the tools enables your mind to flow more energy into emotional awareness while you work. This can be really helpful for spotting problems in your ideas early.
  • If you’ll eventually create something in a digital form, you know that the paper version isn’t final. This can take the pressure off and reduce perfectionism. You have space to play with the ideas and see what emerges.
  • Paper tools have no built-in clocks, so you can work more timelessly and really get into the zone. You can always set a digital device to remind you about appointments if necessary. Or work facing a window (or outdoors), and reconnect with the patterns of sunlight.
  • You can lay out a large amount of information at once, easily moving pieces around. Index cards are especially easy to rearrange and reorder.
  • The interface of using your hands with pen, paper, and other offline tools can be more pleasing and enjoyable than using less flexible digital interfaces.
  • Offline tools require no electricity or Internet access. You can use them anywhere.
  • There isn’t much of a learning curve for such tools. You probably already know how to use them. And you may discover new ways to use them with practice.
  • You don’t have to deal with more emails or tech support.
  • When working offline, and you feel tempted to look something up online “real quick,” you may not bother to do so if your digital devices are out of reach. Much of the time those quick lookups aren’t even necessary and would only lead to other distractions anyway. You can maintain a separate paper side list of items to look up later, so you can stay on task.
  • Whatever you create on paper will likely endure for your lifetime if you want it to last that long.
  • You knowledge of how to use paper tools could still be relevant for decades. You don’t need to worry about retraining yourself when they get upgraded. So you can really invest in depth with these tools over time, and they won’t leave you behind.
  • You can still convert anything you create on paper or a marker board into a basic digital form just by photographing it.
  • Time seems to pass more slowly when working offline. You may feel like you have 50% more time to get your work done, especially without the distractions of the digital world.

I especially love index cards for working out ideas, doing deep planning work, and for recording short routines. I use index cards for recording simple processes and checklists too. My morning routine is written on an index card.

I often use index cards to plan my days. I have stable cards that I use for recurring tasks, and I can make new cards for novel tasks. Then I just arrange them in the right order, and there’s my plan for the day. If I don’t finish everything, it’s easy to bump cards to the next day. If I want to rearrange tasks mid-day, I just reshuffle the cards.

I love keeping supplies well-stocked, so I never feel a sense of scarcity when using such tools. I have almost 2500 index cards in my office closet, some thinner and some thicker. I have dozens of pens and markers, so if one runs out, there’s always a backup.

I also like using a 4′ x 3′ marker board on wheels. Then I can move it wherever I want it. I often use it to hash out ideas when I feel like standing and moving around while I think.

My goals for the quarter are written on a piece of paper, and I review them every morning just by looking at the paper. This helps me get focused on my day and think about how what I’m doing today is moving my larger goals forward.

Many plans and ideas for future courses and for Conscious Growth Club are written on paper and filed neatly into file folders. I use a 5-drawer flat file cabinet to store my most accessible files on their sides, so they’re very visible and don’t get buried in a vertical file cabinet. Sometimes I’ll use a drawer to lay out ideas for a project on index cards, and then I can slide the drawer closed when I’m done. It’s like having an extra table top surface, but there’s no visible clutter when the drawer is closed. I’ve layered the bottom of each drawer with a thin rubbery mat, so the cards don’t slide around when I open and close the drawer.

Paper and digital tools aren’t mutually exclusive. I use both. I don’t write blog posts on paper. But I did outline my book by organizing sticky notes into columns on a large sheet of paper. Each sticky note contained a key idea I wanted to include in the book. Each column of sticky notes became a chapter of the book. Laying out the sticky notes in an intelligent order was a nice way to visually organize the book. Then I used software to do the actual writing.

Another thing I like about paper tools is that they help me feel connected to a sense of history. Sometimes when I’m working on paper, I like to light a candle nearby and imagine what it was like for various historical figures to work with simple creative tools. When reading books written hundreds of years ago, I’m often in awe of the writing style and the creativity expressed without the benefit of digital tools. This helps me realize that I don’t need fancy digital tools to do my best creative work.

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Health24.com | Coronavirus morning update: Minister on special leave, Sassa date changes, and immune system ‘storm’

WHAT’S HAPPENING IN SA

Cases update: 

The latest number of confirmed cases is 1 845.

According to Health Minister Zweli Mkhize, 18 deaths have now been recorded in the country.

So far, 63 776 tests have been conducted.

READ MORE |All the confirmed cases of coronavirus in SA

Latest news:

President Cyril Ramaphosa has taken a firm stance against Communications and Digital Technologies Minister Stella Ndabeni-Abrahams, following allegations that Ndabeni-Abrahams breached lockdown regulations by visiting a friend.

On Wednesday, Ramaphosa put Ndabeni-Abrahams on special leave and directed her to apologise publicly after a picture of her having a meal at the home of former deputy minister of higher education Mduduzi Manana went viral on social media.

The post, which appears to be a screengrab of Manana’s Instagram page, shows the two politicians and several others seated at a table.

Ramaphosa summoned Ndabeni-Abrahams to a meeting on Tuesday where he expressed his disapproval and told her that she undermined lockdown regulations which required all citizens to stay at home to curb the spread of Covid-19.

READ MORE | Ramaphosa puts Stella Ndabeni-Abrahams on special leave, orders her to publicly apologise

In a video on Wednesday, Ndabeni-Abrahams apologised to Ramaphosa and all South Africans.

“Fellow South Africans, I would like to convey an apology to President Cyril Ramaphosa, the national command centre [and] the South African society at large for breaching lockdown rules put in place to curb the spread of Covid-19,” Ndabeni-Abrahams said in the video.

“I met with the president yesterday (Tuesday) after a photo was circulated on social media, showing myself at the home of Mr Mduduzi Manana during the lockdown and social distancing period,” Ndabeni-Abrahams said.

She added that she regretted her actions. “I regret the incident and I am deeply sorry for my actions. I hope the president and you, South Africans, will find it in your hearts to forgive me.”

READ MORE | ‘I hope you will find it in your hearts to forgive me’ – Ndabeni-Abrahams apologises

Due to long queues during the lockdown, the SA Social Security Agency’s (Sassa) grant payout days will be changed to protect the elderly.

As from May, disability grants as well as those for the elderly will be paid on the fourth, while others will be paid on the sixth. 

In a statement, Sassa said grant payments for April was brought forward to 30 March to allow people to buy supplies during the lockdown without them being caught up in long queues or exposing themselves to Covid-19. 

However, chaos ensued, including a situation in Dobsonville, Soweto, where a group of young people pushed the elderly out of the way to get to the pay points first. 

READ MORE | Sassa changes payout days after lockdown pay crush

As the number of coronavirus cases in South Africa continues to grow, National Treasury has moved to centralise the sourcing of personal protective equipment from suppliers. 

This comes as countries around the globe scramble to secure scarce medical equipment to fight the virus, which has already killed over 83 000 people worldwide.

Citing a shortage of protective gear, Treasury on Wednesday issued a call for “compliant, particularly local” suppliers of PPE items such as surgical gloves, masks, sanitisers, ventilators and more to submit offers to a central project management office for assessment. 

Other items on the list included overshoes, biohazard bags, cleaning alcohol, disinfectants, protective eyewear and disposable aprons. 

READ MORE | Treasury centralises sourcing of protective gear

Separated parents are now allowed to move their children between houses during the nationwide Covid-19 lockdown, provided they meet certain legal requirements.

While government had previously been unclear about the issue, new regulations regarding the matter were gazetted on Tuesday.

Separated or divorced parents who want to move their children between them during the lockdown, will need a court order or an agreement that is registered with the family advocate, such as a parental responsibilities and rights agreement or a parenting plan.

The responsible parent transporting their child or children must have these documents, or a certified copy, in their possession when travelling.

READ MORE | Lockdown: Separated parents allowed to move kids between houses – new regulations

WHAT’S HAPPENING IN THE REST OF THE WORLD 

Cases update:

For the latest global data, follow this interactive map from Johns Hopkins University & Medicine.

Positive cases worldwide are now close to 1.5 million, while deaths are more than 88 500.

The United States has more than 430 000 cases, and Spain has the second most, with close to 150 000.

Italy has the most deaths with nearly 17 700.

READ MORE | All the confirmed cases worldwide

Latest news:

The UK government is under growing pressure to explain who is now in charge of the country’s response to the coronavirus pandemic as Prime Minister Boris Johnson remains badly ill in intensive care.

The Foreign Secretary Dominic Raab is officially deputising for Johnson. However, the UK’s unwritten constitution and a shaky performance from Raab himself over recent days has thrown the question of who is really in charge of the British government into doubt.

Raab continues to chair meetings in the prime minister’s absence and deputising for him “where necessary,” Downing Street said, but it is not clear he has the authority to make key decisions in the coming weeks.

Questions to the prime minister’s official spokesman and Raab himself over recent days have failed to clarify exactly where power now lies.

READ MORE | The UK government is suffering a coronavirus ‘power vacuum’ after Boris Johnson was put into ICU

President Donald Trump on Tuesday threatened to cut US funding for the World Health Organisation (WHO) after accusing it of pro-China bias.

“We’re going to put a hold on money spent to the WHO. We’re going to put a very powerful hold on it and we’re going to see,” Trump said at the White House coronavirus task force briefing that day.

He made the announcement hours after attacking the organization in a tweet. “The W.H.O. really blew it. For some reason, funded largely by the United States, yet very China centric. We will be giving that a good look,” Trump wrote.

“Fortunately I rejected their advice on keeping our borders open to China early on,” he added. “Why did they give us such a faulty recommendation?”

READ MORE | Trump threatened to cut off funding to the WHO, saying ‘they seem to always err on the side of China’

Wuhan, the Chinese city at the epicentre of the coronavirus pandemic, lifted its lockdown on Wednesday and couples living there rushed to take advantage.

A local marriage application system run by Chinese tech platform Alipay saw a 300% increase in traffic, according to an official post on China’s microblogging site Weibo, causing a temporary logjam.

Alipay also announced in its post that it offers a service to couples to search and see what baby names have already been used by other couples. Alipay is one of the most widely-used payment platforms in China, alongside WeChat.

According to Chinese tech publication Abacus, marriage applications from Wuhan were suspended through February and March while the city’s 11 million residents were subject to its 76-day lockdown.

READ MORE | Wuhan couples were so eager to marry after lockdown that they crashed the marriage application system

LATEST RESEARCH

Last week, Health24 reported on the BCG vaccine that is being trialled in Australia in the hopes of fighting the Covid-19 virus pandemic.

In a nutshell, a team of researchers in Australia will fast-track the BCG vaccine in humans to see how Covid-19 symptoms respond. The study will give a BCG vaccination to frontline Healthcare workers to see if it decreased the likelihood of Vovid-19 virus infection, and potentially if infected, then the severity of disease.

Now, a new study has surfaced, investigating the correlation between the mortality rate of Covid-19 related complications and the universal BCG vaccine policies between countries.

In simple terms – are those nations who make BCG vaccines mandatory at birth less susceptible to high Covid-19 related deaths?

READ MORE | Could the TB vaccine you received at birth help protect against the coronavirus? We asked an expert

Research has shown that older adults and those with underlying medical conditions are more likely to die from Covid-19 related complications than others.

But what explains the severe symptoms in a number of much younger, seemingly healthy people?

Research published in The Lancet earlier in March 2020 suggested that a subgroup of patients with severe Covid-19 symptoms might suffer these complications, not because of their age or underlying conditions, but a so-called “cytokine storm”.

Cytokines are made up of various proteins and are released by the immune cells as a defence response to an intruder, such as a virus. These cytokines have an effect on other cells in the body, which can manifest as inflammation – think of arthritis, as an example – when your immune system is triggered and releases inflammation, manifesting as pain.

READ MORE | Some coronavirus deaths caused by extreme reaction from immune system

Mirroring findings from a similar study in China, the first comprehensive tally of coronavirus infection in American children shows it’s much less likely to cause severe illness.

Children under the age of 18 are far less likely to even be diagnosed with Covid-19 than adults. Although people under the age of 18 make up 22% of the US population, they made up just 1.7% of cases recorded between 12 February and 2 April, the new study found.

Even if kids were made ill by the new coronavirus, that illness was typically mild, said a team led by Lucy McNamara, of the US Centers for Disease Control and Prevention’s Covid-19 Response Team.

Just under 6% of kids with Covid-19 ended up in the hospital, the study found, compared to 10% of adults aged 18 to 64.

READ MORE | US study finds Covid-19 seldom severe in kids

The first community-acquired case of Covid-19 in the United States posed many questions for doctors, but the answers they found led to key changes in federal guidelines for coronavirus testing, according to a case study.

The patient was an otherwise healthy woman in her 40s who was admitted to University of California (UC) Davis Health with a respiratory infection. Doctors suspected community-acquired pneumonia, and measures were put in place to prevent her from infecting others.

Within 24 hours, the woman’s respiratory condition deteriorated, and she was intubated and given antibiotics. Testing over several days failed to identify the source of infection.

Doctors suspected Covid-19, but the patient had not travelled to a high-risk area and had had no contact with anyone who had. As such, she did not meet US Centers for Disease Control and Prevention criteria for coronavirus testing, the authors explained.

READ MORE | How one patient’s battle with Covid-19 changed US testing protocols

HEALTH TIPS (as recommended by the NICD and WHO)

• Avoid contact with people who have respiratory infections 

• Maintain physical distancing – stay at least one metre away from somebody who is coughing or sneezing

• Practise frequent hand-washing, especially after direct contact with ill people or their environment

• Avoid touching your eyes, nose and mouth, as your hands touch many surfaces and could potentially transfer the virus

• Practise respiratory hygiene – cover your mouth with your bent elbow or tissue when you cough or sneeze. Remember to dispose the tissue immediately after use.

READ MORE: Coronavirus 101 

Image credit: Getty Images

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Health24.com | Eat healthy, move your body during coronavirus pandemic

Move over, “Freshman 15”. There’s a new belt-busting threat fuelled by the coronavirus pandemic cramming Americans into their homes, dangerously close to their snacks, suds, sodas, sofas and streaming videos.

Beware gaining “the Covid-19.”

While this repurposing of the disease’s name obviously is light-hearted, the struggle is real. After all, the current situation is a recipe for weight gain.

It doesn’t have to be, though.

Bad and good news

In fact, just as simple things like washing hands, staying home and keeping six feet (1.8m) apart when in public can help slow the spread of the coronavirus, easy options exist for eating healthy and being active. In fact, social media feeds are filled with them.

“The bad news is that we have to contend with the virus,” said Linda Van Horn, chief of the nutrition division in the Department of Preventive Medicine at Northwestern University’s Feinberg School of Medicine in Chicago. “The amazingly good news is that, unlike conditions during the Spanish flu or the bubonic plague, we have the entire internet at our disposal.”

Van Horn mentioned another, even better reminder: The pandemic eventually will end.

So, she asked, wouldn’t it be great to emerge at the same weight and fitness level as before … or better? And if you didn’t follow a healthy diet or have a consistent workout routine, wouldn’t developing one – or both – be a successful takeaway heading into the “new normal” we’ll all soon be facing?

“My goal for myself and all the people I love and care about is to come out of this thing happier, renewed, refreshed and knowing more than ever what matters most,” said Tina Johnson, a certified athletic trainer, fitness model and bodybuilding judge in Richmond, Virginia.

Invest in meal planning

Once the motivation arrives, then it’s time for some guidance. Johnson and Van Horn can help.

For eating healthy, Van Horn recommends starting by “taking stock of what’s in your refrigerator, freezer, cupboard and pantry”.

If you don’t see many fruits, vegetables, whole grains, beans and nuts, put them on the shopping list. If you see lots of chips, cookies and other junk food, think twice about putting them in your grocery cart.

“This is an opportunity to say, ‘If I don’t buy it, I don’t have it. And if I don’t have it, I don’t eat it,'” Van Horn said.

Since most people suddenly have extra time on their hands – she’s saved three hours per day by not commuting to work – Van Horn suggests investing a few minutes into meal planning.

“Once again, go back to your friendly internet and discover the countless recipes you can make with rice, beans, whole grains, fruits and vegetables,” she said. “Try some new cuisines. Have a Greek night or an Asian night.”

‘Just do something’

She also urges getting cooking help from children – of all ages.

“I teach nutrition and it’s surprising how few millennials and Gen Xers know how to cook,” Van Horn said. “This is an opportunity for parents not only to teach kids how to cook, but also to teach them how to be healthy, while working together as family. It’s a win-win-win.”

One last tip from Van Horn: Think twice about what you’re drinking.

“I’d sure rather eat my calories than drink them,” she said.

Water, black coffee or tea are good choices. For a treat, Van Horn said, “I buy lemons and limes and squeeze them into club soda or something else that’s effervescent.”

Something cold and zesty might taste especially good after a workout, even if it’s only a walk around the neighbourhood. For those who are newly homebound, such a stroll is a great way to replace the number of steps your body is accustomed to taking, Johnson said.

“Just do something,” she said. “Make sure you get out of your chair or sofa at least once an hour. Stretch. Move around. Carve time to walk the dog or play outside with your kids. It doesn’t have to be taxing. It will also help with your mood.”

Bodyweight exercises

Johnson knows from experience.

She went from the sleek physique of a college sprinter to wearing a size 12 dress in her 30s. Then a life insurance company asked her to get a check-up. It became her wake-up call. Motivated by a plaque commemorating her track career that hung in her bedroom, she slimmed to a size four and became a competitive bodybuilder. She wears a rubber bracelet that reads, in all caps, “Winning at Life”.

So, fitness is more than her job. And now that job is on hold. She so badly misses her clients and workout buddies that she cried while recording a video meant to encourage her boot campers.

For her individual clients, Johnson has emailed routines they can do at home based on available equipment. For newcomers without a home gym, she said YouTube offers plenty of how-to videos using only bodyweight exercises.

Johnson also is setting up online classes and has started her personal training clients on a guided squat challenge.

Since her pace may be too frantic for many people, her advice is to figure out what you’re willing to do, then get after it.

“Exercise,” she said, “is always the best medicine.”

READ | 5 tips for eating healthier during the coronavirus lockdown 

READ | ‘Stress eating’ while in lockdown? Here are tips to avoid it 

READ | Don’t abandon health eating during coronavirus pandemic

Image credit: iStock

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Coronavirus: Why do we talk about ‘fighting’ illness?

Dominic Raab’s been criticised for his comments on Boris Johnson’s coronavirus, but is this fair?

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Coronavirus pressures ‘put organ transplants at risk’

The coronavirus epidemic is threatening the UK’s organ transplant programme, experts warn.

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Coronavirus: Will summer make a difference?

Other coronaviruses are sensitive to the seasons.

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Children of parents with mental illness have higher risk of injuries

Children to parents suffering from mental illness have a higher risk of injuries than other children, according to a study by researchers at Karolinska Institutet in Sweden. The risk is elevated up to 17 years of age and peaks during the first year of life. The findings highlight the need for parents with mental illness to receive extra support around child injury prevention measures as well as early treatment of mental morbidity among expecting parents.

Between 7-11 percent of all children in Sweden have at least one parent diagnosed with a mental illness, according to the researchers’ estimates. Previous measures to safeguard children have focused mainly on preventing neglect and maltreatment and to a lesser degree on stopping accidents and injuries. However, according to the researchers it might be possible to reduce child injuries by helping parents with mental illness to adopt preventive safety measures in their homes and outside.

“Our results show there is a need for increased support to parents with mental illness, especially during the first year of life,” says Alicia Nevriana, PhD student at the Department of Global Public Health and the study’s corresponding author. “There are already recommendations for new parents to ensure their children’s safety, but we think there is a need to update these recommendations also by taking into account parents’ mental health.”

Children in the ages 0-1 had a 30 percent higher risk of injuries if they had a parent with mental illness. The risk declined with age but remained somewhat higher (6 percent) for children in the ages 13-17. The researchers found that the risk of injuries was slightly higher for common parental mental disorders, such as depression, anxiety and stress-related illnesses, compared to more serious mental illnesses such as schizophrenia and other psychotic disorders. The risk was also slightly higher for maternal compared to paternal mental illness.

Also, the risk was somewhat higher for more uncommon types of injuries caused by for example interpersonal violence compared to more common injuries caused by for example falls or traffic accidents. The researchers note, however, that violence-related injuries are rare also in families with mental illness.

The study, which was done in collaboration with researchers at the University of Manchester in the U.K., followed 1.5 million children residing in Sweden and born between 1996-2011, of whom more than 330,000 had at least one parent diagnosed with a mental illness during that period or five years earlier.

The study does not explain why children of parents with mental illness have a higher risk of injuries. Some plausible explanations may be that some parents with mental illness struggle to adequately supervise their children and to childproof their homes, according to the researchers.

“Mental illness is often associated with worse socioeconomic conditions, which might lead to the family living in a less safe in- and outdoor environment or cannot afford some security measures,” Nevriana says. “We cannot entirely exclude that the higher risks in our study might be partly explained by the family’s socioeconomic conditions, even though we tried to control for socioeconomic factors as best as we could. We have also not studied whether certain medications for mental illness, especially those with an impact on alertness and attention, could affect the children’s risk of injury, and this should be studied in future research.”

Story Source:

Materials provided by Karolinska Institutet. Note: Content may be edited for style and length.

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Off-the-shelf artificial cardiac patch repairs heart attack damage in rats, pigs

Researchers from North Carolina State University have developed an “off-the-shelf” artificial cardiac patch that can deliver cardiac cell-derived healing factors directly to the site of heart attack injury. In a rat model of heart attack, the freezable, cell-free patch improved recovery. The researchers also found similar effects in a pilot study involving a pig model of heart attack.

Cardiac patches are being studied as a promising future option for delivering cell therapy directly to the site of heart attack injury. However, current cardiac patches are fragile, costly, time-consuming to prepare and, since they use live cellular material, increase risks of tumor formation and arrhythmia.

“We have developed an artificial cardiac patch that can potentially solve the problems associated with using live cells, yet still deliver effective cell therapy to the site of injury,” says Ke Cheng, Randall B. Terry, Jr. Distinguished Professor in Regenerative Medicine at NC State’s College of Veterinary Medicine and professor in the NC State/UNC Joint Department of Biomedical Engineering.

Cheng and colleagues from NC State and UNC-Chapel Hill built the patch by first creating a scaffolding matrix from decellularized pig cardiac tissue. Synthetic cardiac stromal cells — made of a biodegradable polymer containing cardiac stromal cell-derived repair factors — were embedded in the matrix. The resulting patch contained all of the therapeutics secreted by the cells, without live cells that could trigger a patient’s immune response.

In a rat model of heart attack, treatment with the artificial cardiac patch resulted in ~50% improvement of cardiac function over a three-week period compared to non-treatment, as well as a ~30% reduction in scarring at the injury site.

The researchers also conducted a seven-day pilot study of heart attack in a pig model, and saw ~30% reduction in scarring in some regions of the pig hearts, as well as stabilized heart function, compared to non-treatment.

Additional experiments demonstrated that artificial patches that had been frozen were equally potent to freshly created patches.

“The patch can be frozen and safely stored for at least 30 days, and since there are no live cells involved, it will not trigger a patient’s immune system to reject it,” Cheng says. “It is a first step toward a truly off-the-shelf solution to cardiac patch therapy.”

Story Source:

Materials provided by North Carolina State University. Note: Content may be edited for style and length.

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