For ‘blade runners’ taller doesn’t necessarily mean faster

Before hitting the track to compete in an officially sanctioned race, some elite Paralympic sprinters must do something most runners would find incredibly unsettling: remove their legs and swap them out with ones that make them shorter.

The unusual mandate results from a recent International Paralympic Committee rule change that lowered the Maximum Allowable Standing Height (MASH) for double, below-the-knee amputees racing in prosthetic legs. The rule, intended to prevent unfair advantages, stems from the long-held assumption that greater height equals greater speed.

But a small, first-of-its kind University of Colorado Boulder study published today in the journal PLOS ONE concludes that isn’t the case.

“We found that height makes no difference when it comes to maximum speed,” said senior author Alena Grabowski, an assistant professor in the Department of Integrative Physiology an Director of the Applied Biomechanics Lab. “These athletes are having to buy new configurations and go through a lot of hardship and expense for a rule that is not based in science.”

For the study, Grabowski and her co-authors recruited five elite sprinters with double below-the-knee amputations for a series of running trials on a treadmill. The runners sampled three different brands of blades, and five different combinations of stiffness and height within each brand for a total of 15 different tests. In each test, they were asked to start at a jog and push themselves to the maximum speed possible. Some achievied speeds as fast as 10.8 meters per second — about a two minute, 30-second per mile pace.

Meanwhile, the researchers measured how the runners’ biomechanics and pace changed with each blade configuration.

They found the shape of the prostheses undoubtedly made a difference in speed, with runners achieving maximum speeds about 8% faster in “J-shaped” prostheses — think the sleek carbon-fiber blades Oscar Pistorius used in his famous 2012 Olympic sprint — than in “C-shaped” prostheses. But stiffness and height made no difference in runner speed.

“Biomechanically, the idea makes sense: Longer legs equal longer steps, so you would think you should be able to run faster,” said first author Paolo Taboga, an assistant professor of biomechanics at Sacramento State University who worked on the study while a postdoctoral researcher in Grabowski’s Applied Biomechanics Lab. “But we found that while you do take longer steps, you cycle your legs slower so in the end the two even out.”

That reality probably holds true for runners with biological legs, too. “Being taller does not make you faster,” said Grabowski.

The assumption that it does is taking a heavy toll on Paralympic hopefuls.

Since the rule change took effect in January 2018, some athletes have had to spend thousands of dollars on new prostheses and months retraining themselves to run at a shorter height.

Team USA Paralympic sprinter Regas Woods, whose profile states his height as 5’10,” had to lower his standing height inches after the change and expressed his discontent on Twitter: “I’m not 5 foot 4. Thanks for making me more disabled.”

Olympic hopeful Blake Leeper, a double-below-the-knee amputee vying to compete against runners with biological legs at the 2020 Games, has also been affected, with the International Association of Athletics Federation (IAAF) prohibiting him from racing in the IAAF World Championships in Qatar last fall due, in part, to the fact that his blades hadn’t been classified under the new standing-height formula.

Some athletes have suffered injuries while trying to adjust to their shorter blades.

The rule could also effectively exclude amputees whose residual limbs are already long from competing at the Paralympic level, noted co-author Owen Beck, now a postdoctoral fellow at Georgia Institute of Technology.

“We would like to see fair and inclusive rules and regulations, which is the beauty of the Paralympic Games,” Beck said.

The authors acknowledge that their sample size of five is small. But so is the pool of double, below-the-knee amputees sprinting at the elite level.

They see the need to do a larger study.

For now, they hope the International Paralympic Committee will take a look at their research and reconsider the height restriction.

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A better pregnancy test for whales

It’s not easy to do pregnancy tests on whales. You can’t just ask a wild ocean animal that’s the size of a school bus to pee on a little stick. For decades, the only way scientists could count pregnant females was by sight and best guesses based on visual characteristics. For the last several years, researchers have relied on hormone tests of blubber collected via darts, but the results were often inconclusive (not negative or positive), and researchers couldn’t confidently say if the animal was pregnant or just ovulating.

Research from the National Institute of Standards and Technology (NIST) and Australia’s Griffith University points to a weakness of that testing and provides a new method for hormone testing that offers better results.

“Previous tests only looked at progesterone in blubber samples,” said Ashley Boggs, a research biologist at NIST who helped to develop the new tests. “We found that androgens, and especially androstenedione in combination with progesterone, are much more likely to be a reliable marker of pregnancy.”

Being able to determine whale pregnancy is important because it offers insight into the health of a population. Whales are sensitive to changes in their environment and can serve as early warning signals that something is amiss, including details about the health of the food web, the impact of ocean noise, and the levels of contaminant exposures. The Marine Mammal Protection Act was enacted in 1972 to protect whales, and since that time stock assessments and protections have been carried out by the National Oceanic and Atmospheric Administration (NOAA), including data on pregnancies. That’s why NOAA came to NIST to try to advance hormone measurement technology for marine mammals.

In recent years, humpback whale numbers have increased dramatically in many places, although they are still considered endangered. The animals’ large size makes it difficult to count or study them using traditional identification methods. Like most protected whales, this species cannot be held in captivity , and most of the information about them must be gained through observation in the wild. But humpbacks can serve as an indicator species for other, more endangered large whales, and by developing bioanalytical measurement techniques for these species that are doing well, scientists can confidently apply them to other, more protected species.

“Up to this point, most measurements had been conducted using immunoassays, which require a ‘one at a time’ approach to hormone measurements,” Boggs said.

“We know that hormones act together in suites to cause large physiological changes. If you focus on only one hormone at a time, you might miss the major hormone of interest or simply run out of money or samples.”

The research team studied female humpbacks along the east coast of Australia during two stages of migration. Fifty-two individuals were randomly sampled before reaching the calving grounds in June/July (austral winter) and again after departing the calving grounds in September/October (austral spring). Before reaching the calving grounds, only one had a high concentration of progesterone, the hormone that has previously been used as an indicator of pregnancy in this species. This number seemed too low to be reliable. The evidence indicated that the animals’ hormone profiles change in late pregnancy, since multiple calves were seen later.

Finding chemical indicators for pregnancy in marine mammals is very different from finding them in humans, where a protein hormone called human chorionic gonadotropin (hCG) is detected right after the implantation of the embryo. Other protein hormones are difficult to use as a standard indicator for pregnancy because their levels vary from one species to the other.

Previous whale reproductive research had relied on the measurement of the hormone progesterone using a test known as enzyme-linked immunosorbent assay, or ELISA. ELISA has been the “go to” assay for years, but NIST scientists have determined that not all species rely on the same hormones during pregnancy, and in addition, some species’ hormone levels exhibit significant shifts during different phases of the gestation process.

NIST researchers realized that a chemical analysis technique called mass spectrometry, which detects compounds based on their masses, would potentially allow the measurement of many hormones simultaneously and could help biologists to understand which hormones can be found at different stages of pregnancy.

The new analysis from NIST and Griffith University scientists allowed for gathering a simultaneous measurement of 11 steroid hormones in each sample of whale blubber using liquid chromatography tandem mass spectrometry. The technique identifies hormones based on molecular size and mass rather than attachment of the hormone to an antibody (as in the current method), ensuring higher accuracy and selectivity.

“By casting a wider net and looking for more hormones, we were able to get a better set of biomarkers,” said Boggs. The same technique will also likely be applicable to other species including North Atlantic right whales, which are dying at alarming rates and considered to be a species in peril.

Boggs noted that correct timing could also improve the tests’ accuracy rates.

“Criteria will change depending on how far along the pregnancy has progressed,” she said. “In some species, progesterone drops off toward the end of pregnancy. And even closely related species can have very different hormonal profiles. Each test would need to be tailored to the species to be accurate, but the beauty of the mass spectrometry method means you don’t have to know which hormone is dominant before you start looking. You can look at them all.”

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Health24.com | Not getting enough sleep? You have plenty of company

More Americans are having trouble falling and staying asleep, and smartphones and technology are probably to blame, researchers report.

Their analysis of data from nearly 165 000 adults nationwide showed that the number who reported difficulty falling asleep at least once a week was up 1.4% between 2013 and 2017, and those who had trouble staying asleep rose 2.7%.

Those percentages may appear small, but it means that as many as five million more adults have sleep problems, according to study leader Zlatan Krizan, a professor of psychology at Iowa State University (ISU), in Ames, Iowa.

“How long we sleep is important, but how well we sleep and how we feel about our sleep is important in its own right,” Krizan said in a university news release. “Sleep health is a multidimensional phenomenon, so examining all the aspects of sleep is crucial for future research.”

The study was published online recently in the journal Sleep Health.

Technology likely a factor

Krizan and his team could not say what’s contributing to the increase in sleep problems, but technology is likely a factor, according to lead author Garrett Hisler. He’s a former ISU graduate student who is now a postdoctoral associate at the University of Pittsburgh.

“We know from our previous research there is a correlation between smartphone use and insufficient sleep among teens,” Hisler said in the news release.

“If we’re on our phone before bed or we’re receiving alerts in the middle of the night, that can make it harder to fall asleep and stay asleep throughout the night,” he explained.

Too little sleep and poor sleep can increase the risk of heart disease, and sleep quality affects overall well-being, the researchers noted.

Krizan said, “We know that how well people sleep is generally very reflective of people’s health and may be an indicator of other conditions. If we want a full picture of the population’s health, it’s important to measure and track these changes in sleep trends over time.”

Image credit: iStock

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Health24.com | Sepsis causes far more deaths worldwide than thought

Sepsis kills more than twice as many people worldwide as once believed, and children in poor regions account for an excessive number of such deaths, researchers say.

Sepsis is an out-of-control immune response to infection that harms organs. People who survive sepsis can have lifelong disabilities.

In 2017, there were 48.9 million cases of sepsis and 11 million sepsis deaths worldwide – that’s one in five deaths that year.

“We are alarmed to find sepsis deaths are much higher than previously estimated, especially as the condition is both preventable and treatable,” said senior author Dr Mohsen Naghavi, a professor of health metrics sciences at the University of Washington School of Medicine in Seattle.

More prevalent in females

Low- and middle-income countries had 85% of the cases, with the most in sub-Saharan Africa, the South Pacific islands near Australia, and South, East and Southeast Asia, the study found.

Sepsis was more prevalent among females than males, and more than 40% of cases occurred in children under age 5, the researchers reported.

From 1990 to 2017, the number of cases fell from 60 million to about 49 million (down 19%), and sepsis deaths fell from nearly 16 million to 11 million (a 30% decrease).

Lower respiratory infection was the most common underlying cause of sepsis-related death in both 1990 and 2017, according to the report published in The Lancet journal.

Naghavi called for renewed focus on sepsis prevention among newborns and on tackling antimicrobial resistance, a key driver of the condition.

Leading killer in hospitals

Lead study author Dr Kristina Rudd said the study highlights the need for basic public health strategies. She’s an assistant professor of critical care medicine at the University of Pittsburgh.

“Vaccines, making sure everyone has access to a toilet and clean drinking water, adequate nutrition for children and maternal health care would address a lot of these cases,” she said in a University of Pittsburgh news release.

Rudd pointed out that the issue hits close to home: Sepsis remains the leading killer of hospital patients in the United States.

“Everyone can reduce their odds of developing it by getting the flu shot, and the pneumonia vaccine when appropriate,” she said. “Beyond that, we need to do a better job preventing hospital-acquired infections and chronic diseases, like diabetes, that make people more susceptible to infections.”

Image credit: iStock

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You Can Change Today

Let’s consider four different variations on the title of this post, each emphasizing a different word.

YOU Can Change Today

You are the driving force of change in your life. You don’t have to wait for something external to happen first. You don’t need anyone else’s permission. If some part of your life is going to change, it’s up to you and you alone.

This is a reminder to take responsibility for your situation. It’s your life. You’ll need to initiate and propel any changes you wish to make. Be proactive about that, not passive.

Even if your current circumstances weren’t entirely of your choosing, you still have the ability to create change. You can influence and direct the path forward.

Change is personal.

You CAN Change Today

Even when you don’t see it, you still have the ability to create change. Change is always a possibility. You’re not stuck in a tunnel. There are exits all around you at every point. You can stop, leave, or change course.

Change is a choice. We don’t always see that option, but it’s there in each moment. When you want something different, you can choose to create change.

If you don’t choose change, you choose the status quo. If you’re happy with the status quo, showing up as usual may be a wise choice. Otherwise remind yourself that you can change the status quo, often by not showing up to it anymore.

There’s a way to change now.

You Can CHANGE Today

Living today the same as you did yesterday is optional. Today could be a little different. Today could be radically different.

Sometimes change happens to us. A big event occurs, and it grabs our attention and makes us focus elsewhere. The shift in focus creates change.

You can direct your attention consciously too. Rattle yourself today instead of waiting to be rattled. Look where you don’t normally look. Listen where you’d usually tune out. Take actions you’ve never taken.

What’s different about today? Today isn’t the same as any other day. It’s new. It’s fresh. It’s unique. It’s an opportunity to experience what you’ve never previously experienced.

Will you use today to repeat the sameness of the past? Will you use today to create something a little different? Will you make today wildly different?

What will you do today that you’ve never done before?

That idea that just popped into your head…

The one you just tried to suppress…

Yup, that one…

Yes, really….

What if you did it today?

You Can Change TODAY

Your power to create change exists now, in the present moment. Change doesn’t happen yesterday or tomorrow, only today. Every yesterday and every tomorrow exists beyond the realm of change. But today is always within that realm.

If you chose to do so, you could be in a new city within hours. You could begin a new job, career, or business today. You could exit or enter a relationship today. You could begin a new lifestyle today. You could invest in something new and different today.

Or you could make simpler changes. You could have that difficult conversation today. You could begin that new exercise program today. You could at least clean the bathroom.

It’s good to remind yourself direct action can make today a day of change.

What part of you wants to change today?

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Health24.com | Why texting while walking is risky business

The dangers of “distracted driving” are well-known, but texting while walking may also be a road hazard, a new research review finds.

Pedestrians who are busy texting are less likely to look both ways before crossing the street and have caused a growing number of “close calls” with cars, the review found. And while chatting on a cellphone or listening to music can be distracting, neither was as bad as texting.

Much of the evidence comes from simulation studies – where researchers observe people during virtual street crossings that pose no real danger. And it’s not clear how often distracted walking factors into traffic crashes, the Canadian researchers said.

“Controlled experiments do not necessarily reflect the real world,” said Alex Epstein, director of transportation safety at the non-profit National Safety Council. He wasn’t part of the study, but reviewed the findings.

Pedestrian deaths on the rise

On the other hand, Epstein said, “it just stands to reason” that if pedestrians are distracted by their phones, that could compromise their safety.

“You need all of your faculties available to navigate the roads,” he said.

The study, published in the journal Injury Prevention, comes at a time when pedestrian deaths are on the rise. In 2018, an estimated 6 283 pedestrians died in traffic crashes on US roads, according to the US National Highway Traffic Safety Administration (NHTSA).

The reasons for the rise are unclear, Epstein said, but several factors are thought to be behind it: higher speed limits in many areas of the country; impaired driving, and distracted driving.

The dangers of distracted driving – whether from using cellphones, fiddling with the car’s navigation system, or talking with passengers – are well-documented. Texting is considered the most worrisome distraction, according to the NHTSA. Sending or reading a text takes a driver’s eyes off the road for about five seconds, the agency says.

Because of that, texting while driving is now against the law in most US states, according to the Governors Highway Safety Association. Many also prohibit drivers from using hand-held cellphones.

Pedestrians’ skills dulled

Much less is known about whether distracted pedestrians contribute to traffic crashes. For the new review, researchers led by Sarah Simmons at the University of Calgary were able to find 14 simulation studies.

Overall, those studies found, texting or browsing on a smartphone compromised people’s virtual street-crossing skills. They were less likely to look both ways before crossing, and the distraction increased their risk of being “hit” or having a close call with a virtual vehicle.

In general, texting and browsing dulled pedestrians’ skills more than talking on a cellphone or listening to music.

The Calgary team also found eight studies in which researchers observed pedestrians in the real world. Again, pedestrians who were busy with their phones were less likely to look around before or during street crossings.

“It’s a mirror of the general issue of distraction,” Epstein said. “We’re more interested in our screens than in the reality around us.”

Getting priorities straight

Steve Marshall directs the Injury Prevention Research Center at the University of North Carolina at Chapel Hill.

“Undoubtedly, pedestrians are more distracted these days, and so are drivers,” said Marshall, who was not involved in the study.

For pedestrians, the message is simple: “Please prioritise your safety over your device,” Marshall said.

However, he stressed, “traffic safety is a communal responsibility”. And the United States has a long way to go in making its streets safer for pedestrians, cyclists and vehicle passengers alike, Marshall said.

He pointed to Oslo, Norway, as an example of what’s possible. The city – which is the size of Washington, D.C. – recently reported that no pedestrian or cyclist was killed on its roads in 2019.

Time to react

Credit was given to several steps that Oslo has taken to boost traffic safety – including lower speed limits, replacing nearly all on-street parking with bike lanes and sidewalks, and closing major downtown streets to cars.

“The US needs to create roads that are designed for the collective safety,” Marshall said. Yet as it stands, he noted, many communities lack even basic sidewalks.

Marshall also pointed to the “No. 1 priority” for drivers: slow down.

“Slowing down gives you more time to react, and it can make the difference between injuring someone and killing someone,” he said.

Image credit: iStock

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Coronavirus: Britons on Diamond Princess cruise ship to be flown home

Only those who are well can travel, and they will be quarantined on their return, it is understood.

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Coronavirus: Two passengers dead from quarantined Diamond Princess

A man and a woman in their 80s were taken off the Diamond Princess in Japan after contracting Covid-19.

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Dame Julie Walters reveals shock of bowel cancer diagnosis

The actress tells Victoria Derbyshire her next film, The Secret Garden, could possibly be her last.

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Health24.com | Vaping causes DNA changes similar to those in cancer

People who vape have potentially cancer-causing changes in their DNA similar to those found in cigarette smokers, according to a new study.

These chemical alterations – called epigenetic changes – can cause genes to malfunction. They are found in nearly all types of cancer, as well as other serious diseases, the researchers noted.

“That doesn’t mean that these people are going to develop cancer,” said study leader Ahmad Besaratinia, an associate professor of preventive medicine at the University of Southern California’s Keck School of Medicine in Los Angeles.

“But what we are seeing is that the same changes in chemical tags detectable in tumours from cancer patients are also found in people who vape or smoke, presumably due to exposure to cancer-causing chemicals present in cigarette smoke and, generally at much lower levels, in electronic cigarettes’ vapour,” he said in a school news release.

Specific chemical tags

Besaratinia and his colleagues said their findings add to a growing list of health issues linked to e-cigarettes.

The study included 45 people who either vaped only, smoked cigarettes only, or did not vape or smoke (control group).

Blood samples were tested for changes in two specific chemical tags attached to DNA that are important for proper gene activity and/or function. Changes in levels of these chemical tags occur at various ages and in diseases such as cancer.

Compared to the control group, vapers and smokers both had significant reductions in both chemical tags. The authors said this is the first study to show that these changes can be detected in vapers’ blood, just as in smokers.

Immediate public policy implications

Many people consider vaping safer than smoking, and more than 25% of US high school students use e-cigarettes, according to the US Centers for Disease Control and Prevention.

Researchers now plan to identify all the genes affected by these chemical changes in vapers, compared to smokers. Besaratinia said the study could have immediate public policy implications.

“The epidemic of teen vaping and the recent outbreak of vaping-related severe lung injury and deaths in the US underscore the importance of generating scientific evidence on which future regulations for electronic cigarette manufacturing, marketing, and distribution can be based,” he said.

The study was published online recently in the journal Epigenetics.

Image credit: unsplash.com

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