The study, published in Depression and Anxiety, is the first to examine the association with depression according to the type of chocolate consumed.

Researchers from UCL worked in collaboration with scientists from the University of Calgary and Alberta Health Services Canada and assessed data from 13,626 adults from the US National Health and Nutrition Examination Survey. Participants’ chocolate consumption was assessed against their scores on the Patient Health Questionnaire, which assesses depressive symptoms.

In the cross-sectional study, a range of other factors including height, weight, marital status, ethnicity, education, household income, physical activity, smoking and chronic health problems were also taken into account to ensure the study only measured chocolate’s effect on depressive symptoms.

After adjusting for these factors, it was found that individuals who reported eating any dark chocolate in two 24-hour periods had 70 per cent lower odds of reporting clinically relevant depressive symptoms than those who reported not eating chocolate at all. The 25 per cent of chocolate consumers who ate the most chocolate (of any kind, not just dark) were also less likely to report depressive symptoms than those who didn’t eat chocolate at all. However researchers found no significant link between any non‐dark chocolate consumption and clinically relevant depressive symptoms.

Depression affects more than 300 million people worldwide, according to the World Health Organisation, and is the leading global cause of disability.

Lead author Dr Sarah Jackson (UCL Institute of Epidemiology & Health Care) said: “This study provides some evidence that consumption of chocolate, particularly dark chocolate, may be associated with reduced odds of clinically relevant depressive symptoms.

“However further research is required to clarify the direction of causation — it could be the case that depression causes people to lose their interest in eating chocolate, or there could be other factors that make people both less likely to eat dark chocolate and to be depressed.

“Should a causal relationship demonstrating a protective effect of chocolate consumption on depressive symptoms be established, the biological mechanism needs to be understood to determine the type and amount of chocolate consumption for optimal depression prevention and management.”

Chocolate is widely reported to have mood‐enhancing properties and several mechanisms for a relationship between chocolate and mood have been proposed.

Principally, chocolate contains a number of psychoactive ingredients which produce a feeling of euphoria similar to that of cannabinoid, found in cannabis. It also contains phenylethylamine, a neuromodulator which is believed to be important for regulating people’s moods.

Experimental evidence also suggests that mood improvements only take place if the chocolate is palatable and pleasant to eat, which suggests that the experience of enjoying chocolate is an important factor, not just the ingredients present.

While the above is true of all types of chocolate, dark chocolate has a higher concentration of flavonoids, antioxidant chemicals which have been shown to improve inflammatory profiles, which have been shown to play a role in the onset of depression.

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The discovery emerged from a two-year study, published in PloS Medicine, which examined the effects of water quality, sanitation, handwashing and nutritional interventions on rates of intestinal worm and Giardia infections in rural Kenya. Water treatment alone was sufficient to cause an 18 percent reduction in infection rates in roundworm (Ascaris) infections; the reduction was 22 percent when water treatment was combined with improved sanitation and handwashing with soap. None of the interventions reduced the prevalence of Giardia infections among the young children studied.

Intestinal worm and protozoan infections affect more than 1 billion children worldwide and are associated with stunted growth and impaired cognitive development. These parasites often reside in the soil and contaminated drinking water or fecal-contaminated surfaces and lead to common infections in children in low resource settings. High re-infection rates have prevented school-based mass drug administration programs from controlling the transmission of these parasitic infections. The study authors hypothesized that improved water quality, sanitation, hygiene and/or nutrition could interrupt the environmental transmission of parasites, but few trials evaluating these interventions have measured actual infections as an outcome. In contrast to aggressive medical treatment programs, the water treatment, sanitation, and handwashing approaches represent a sustainable approach to disease control.

“Out of all the interventions we tested, we were extremely surprised that water treatment appeared to be the most effective at reducing roundworm infections. Water treatment is a relatively unexplored strategy for intestinal worm control,” said Amy Pickering, assistant professor of civil and environmental engineering at Tufts University, and first author of the study. “At least 800 million people in the world are infected by roundworm (Ascaris lumbricoides), so even a relative reduction of 18 percent from water treatment interventions could have a major beneficial impact. Our study also suggests that water treatment could complement large-scale deworming medication delivery programs in the global effort to eliminate roundworm infections.”

With reinfection rates reaching 94 percent after deworming treatment for roundworm infection, a combined approach of mass drug administration and environmental controls (water, sanitation, hygiene) could be critical to gaining an upper hand on these endemic infections, the researchers say.

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Study authors led by Karin Nielsen-Saines at David Geffen UCLA School of Medicine followed 216 infants in Rio de Janeiro who had been exposed to the Zika virus during pregnancy, performing neurodevelopmental testing when the babies ranged in age from 7 to 32 months. These infants’ mothers had had Zika-related symptoms themselves, including rash.

Although many children had normal assessments, 29% scored below average in at least one domain of neurological development, including cognitive performance, fine and gross motor skills and expressive language, Sarah B. Mulkey, M.D., Ph.D., and a colleague write in a companion commentary published online by Nature Medicine July 29, 2019.

The study authors found progressively higher risks for developmental, hearing and eye abnormality depending on how early the pregnancy was at the time the infants were exposed. Because Zika virus has an affinity for immature neurons, even babies who were not born with microcephaly remained at continued risk for suffering abnormalities.

Of note, 24 of 49 (49%) infants who had abnormalities at birth went on to have normal test results in the second or third year of life. By contrast, 17 of 68 infants (25%) who had normal assessments at birth had below-average developmental testing or had abnormalities in hearing or vision by age 32 months.

“This work follows babies who were born in 2015 and 2016. It’s heartening that some babies born with abnormalities tested in the normal range later in life, though it’s unclear whether any specific interventions help to deliver these positive findings,” says Dr. Mulkey, a fetal-neonatal neurologist in the Division of Fetal and Transitional Medicine at Children’s National in Washington, D.C. “And it’s quite sobering that babies who appeared normal at birth went on to develop abnormalities due to that early Zika exposure.”

It’s unclear how closely the findings apply to the vast majority of U.S. women whose Zika infections were asymptomatic.

“This study adds to the growing body of research that argues in favor of ongoing follow-up for Zika-exposed children, even if their neurologic exams were reassuring at birth,” Dr. Mulkey adds. “As Zika-exposed children approach school age, it’s critical to better characterize the potential implications for the education system and public health.”

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In a study that will appear August 2 in the journal Science Advances, the team discovered that it could nudge these quantum materials to undergo transitions between “dynamical phases” — essentially, jumping between two states in which the atoms behave in completely different ways.

“This happens abruptly, and it resembles the phase transitions we see in systems like water becoming ice,” said study co-author Ana Maria Rey. “But unlike that tray of ice cubes in the freezer, these phases don’t exist in equilibrium. Instead, atoms are constantly shifting and evolving over time.”

The findings, she added, provide a new window into materials that are hard to investigate in the laboratory.

“If you want to, for example, design a quantum communications system to send signals from one place to another, everything will be out of equilibrium,” said Rey, a fellow at JILA, a joint institute between CU Boulder and the National Institute of Standards and Technology (NIST). “Such dynamics will be the key problem to understand if we want to apply what we know to quantum technologies.”

Scientists have observed similar transitions before in ultracold atoms, but only among a few dozen charged atoms, or ions.

Rey and her colleagues, in contrast, turned to clouds made up of tens of thousands of uncharged, or neutral, fermionic atoms. Fermionic atoms, she said, are the introverts of the periodic table of elements. They don’t want to share their space with their fellow atoms, which can make them harder to control in cold atom laboratories.

“We were really wandering in a new territory not knowing what we would find,” said study coauthor Joseph Thywissen, a professor of physics at the University of Toronto.

To navigate that new territory, the researchers took advantage of the weak interactions that do occur between neutral atoms — but only when those atoms bump into each other in a confined space.

First, Thywissen and his team in Canada cooled a gas made up of neutral potassium atoms to just a fraction of a degree below absolute zero. Next, they tuned the atoms so that their “spins” all pointed in the same direction.

Such spins are a natural property of all atoms, Thywissen explained, a bit like Earth’s magnetic field, which currently points to the north.

Once the atoms were all standing in formation, the group then tweaked them to change how strongly they interacted with each other. And that’s where the fun began.

“We ran the experiment using one kind of magnetic field, and the atoms danced in one way,” Thywissen said. “Later, we ran the experiment again with a different magnetic field, and the atoms danced in a completely different way.”

In the first dance — or when the atoms barely interacted at all — these particles fell into chaos. The atomic spins began to rotate at their own rates and quickly all pointed in different directions.

Think of it like standing in a room filled with thousands of clocks with second hands all ticking at different tempos.

But that was only part of the story. When the group increased the strength of the interactions between atoms, they stopped acting like disordered individuals and more like a collective. Their spins still ticked, in other words, but they ticked in sync.

In this synchronous phase, “the atoms are no longer independent,” said Peiru He, a graduate student in physics at CU Boulder and one of the lead authors of the new paper. “They feel each other, and the interactions will drive them to align with each other.”

With the right tweaks, the group also discovered that it could do something else: turn back time, causing both the synchronized and disordered phases to revert back to their initial state.

In the end, the researchers were only able to maintain those two different dynamical phases of matter for about 0.2 seconds. If they can increase that time, He said, they may be able to make even more interesting observations.

“In order to see richer physics, we probable have to wait longer,” He said.

Other coauthors on the paper include Scott Smale, Ben Olsen, Kenneth Jackson, Haille Sharum and Stefan Trotzky from the University of Toronto and Jamir Marino from JILA.

“All the little ways in which our everyday thinking about social stuff is unconscious or uncontrollable,” wrote Calvin Lai, assistant professor of psychology in Arts & Sciences at Washington University in St. Louis, in an article in DCist. “The stuff that we don’t realize is influencing us when we make decisions.”

Along with a broader cultural awareness of implicit bias is idea that the actions that they influence can be changed by eliminating the bias itself.

Change the bias, changes in the behavior will follow. It seems logical enough.

If true, reducing implicit bias could be put to practical use for anything from ending discrimination (removing a bias in favor of white males) to losing weight (dialing down a cookie bias).

In a meta-analysis of research papers published on the subject of implicit bias, however, Lai found that the evidence does not show this kind of causal relationship.

The research is published in the Journal of Personality and Social Psychology.

Lai worked with Patrick Forscher, of the University of Arkansas, to systematically review 492 studies that dealt with changing people’s “automatic mental processes,” the uncontrollable, unconscious mental processes that have come to be known in particular contexts as “implicit bias.”

The studies contained more than 87,000 participants. After crunching the numbers, Lai and Forscher saw that studies suggest biases can, in fact, be changed — although not dramatically.

When they honed in, looking at 63 studies that explicitly considered a link between changes in bias and changes in actions, however, they found no evidence of a causal relationship.

“We definitely didn’t expect this,” Lai said. “And it challenges assumptions about the relationship between implicit bias and behavior.”

Lai suggested four possible reasons that a link was not established in the meta-analysis:

Measurement errors: The way outcomes were measured may have picked up on changes unrelated to the underlying bias. For example, Lai said, such a measurement would be analogous to “moving the mercury around within a thermometer rather than changing the heat in the room.”

Confounds: After tests to measure an implicit bias, something happened, unrelated to the changed subjects’ behavior.

Measured too narrow of a bias: Appeared to assess the same associations, but maybe the effects were too broad to capture a change associated with the change in bias. For example, the implicit bias measured was about broad attitudes toward White vs. Black people, but the behaviors measured were about behavior toward a specific person of a particular race. In that case, the attitude measured may have been too general.

No causal relationship: Implicit bias doesn’t affect behavior at all.

This last option doesn’t sit well with Lai. “It would open a theoretical can of worms because there are decades of experiments in other lines of research showing evaluation without conscious intention or control,” he said.

However, Lai said there is a more effective way to change these behaviors; one that doesn’t rely on changing people’s implicit biases: ridding society of the features that cause people to act in a biased way.

For example, reducing subjectivity makes it more difficult for a person’s biases to affect decision-making. Instead of relying on a “gut feeling” for a hiring decision, for example, lay out the requirements first, and stick to them.

Or, in the cookie realm, don’t have any on hand — not at home or at the office — and don’t drive past the bakery on the way home.

On an individual level, Lai said, “Equip people with strategies to resist the environment’s biasing influence.

“The power of counterstereotypes is not to be underestimated,” Lai wrote in a paper describing possible ways to counteract implicit biases. “And if counterstereotypical encounters become typical, shift in attitudes and beliefs will follow.”

Lai points out that this study was heavily constrained by the available literature. The studies they included focused on brief interventions and assessments and was heavily skewed toward a certain demographic: university students.

“At this time, we can’t distinguish between these potential explanations for the results,” Lai said. “Carefully controlled studies need to be conducted to rule out — or rule in — these explanations.”

The longitudinal study, published in PLOS Medicine, reports the most robust evidence to date that social contact earlier in life could play an important role in staving off dementia.

“Dementia is a major global health challenge, with one million people expected to have dementia in the UK by 2021, but we also know that one in three cases are potentially preventable,” said the study’s lead author, Dr Andrew Sommerlad (UCL Psychiatry).

“Here we’ve found that social contact, in middle age and late life, appears to lower the risk of dementia. This finding could feed into strategies to reduce everyone’s risk of developing dementia, adding yet another reason to promote connected communities and find ways to reduce isolation and loneliness.”

The research team used data from the Whitehall II study, tracking 10,228 participants who had been asked on six occasions between 1985 and 2013 about their frequency of social contact with friends and relatives. The same participants also completed cognitive testing from 1997 onwards, and researchers referred to the study subjects’ electronic health records up until 2017 to see if they were ever diagnosed with dementia.

For the analysis, the research team focused on the relationships between social contact at age 50, 60 and 70, and subsequent incidence of dementia, and whether social contact was linked to cognitive decline, after accounting for other factors such as education, employment, marital status and socioeconomic status.

The researchers found that increased social contact at age 60 is associated with a significantly lower risk of developing dementia later in life. The analysis showed that someone who saw friends almost daily at age 60 was 12% less likely to develop dementia than someone who only saw one or two friends every few months.

They found similarly strong associations between social contact at ages 50 and 70 and subsequent dementia; while those associations did not reach statistical significance, the researchers say that social contact at any age may well have a similar impact on reducing dementia risk.

Social contact in mid to late life was similarly correlated with general cognitive measures.

Previous studies have found a link between social contact and dementia risk, but they did not have such long follow-up times, so they could not rule out the possibility that the beginnings of cognitive decline may have been causing people to see fewer people, rather than the other way around. The long follow-up in the present study strengthens the evidence that social engagement could protect people from dementia in the long run.

The researchers say there are a few explanations for how social contact could reduce dementia risk.

“People who are socially engaged are exercising cognitive skills such as memory and language, which may help them to develop cognitive reserve — while it may not stop their brains from changing, cognitive reserve could help people cope better with the effects of age and delay any symptoms of dementia,” said senior author Professor Gill Livingston (UCL Psychiatry).

“Spending more time with friends could also be good for mental wellbeing, and may correlate with being physically active, both of which can also reduce the risk of developing dementia,” added Professor Livingston, who previously led a major international study outlining the lifecourse factors that affect dementia risk.

The researchers were supported by Wellcome and the National Institute for Health Research UCLH Biomedical Research Centre, while the Whitehall II study is supported by the US National Institutes of Health, UK Medical Research Council and the British Heart Foundation.

The study was conducted by researchers in UCL Psychiatry, UCL Epidemiology & Public Health, Camden & Islington NHS Foundation Trust and Inserm.

Dr Kalpa Kharicha, Head of Innovation, Policy and Research at the Campaign to End Loneliness, said: “We welcome these findings that show the benefits of frequent social contact in late/middle age on dementia risk. As we found in our Be More Us Campaign, almost half of UK adults say that their busy lives stop them from connecting with other people. It’s important we make changes to our daily lives to ensure we take the time to connect with others. We need more awareness of the benefits that social wellbeing and connectedness can have to tackle social isolation, loneliness and reduce dementia risk.”

Fiona Carragher, Chief Policy and Research Officer at Alzheimer’s Society, said: “There are many factors to consider before we can confirm for definite whether social isolation is a risk factor or an early sign of the condition — but this study is a step in the right direction. We are proud of supporting work which helps us understand the condition better — it is only through research that we can understand true causes of dementia and how best to prevent it.

“As the number of people in the UK with dementia is set to rise to one million by 2021, we must do what we can to reduce our risk — so along with reducing your alcohol intake and stopping smoking, we encourage people across the country to get out into the sunshine, and do something active with family and friends.

“The Government’s recent emphasis on health prevention is a welcome opportunity to reduce the risk of dementia across society. We now need to see Ministers prioritise better support initiatives to help people reduce the risk of dementia, and look forward to seeing this when the results of the Green Paper on Prevention are published later in the year.”