Can you move to the beat, or do you have two left feet? Apparently, how well we can time our movement to music depends somewhat on our innate genetic ability, and this skill was previously thought to be a uniquely human trait. While animals also react to hearing noise, or might make rhythmic sounds, or be trained to respond to music, this isn’t the same as the complex neural and motor processes that work together to enable us to naturally recognize the beat in a song, respond to it or even predict it. This is referred to as beat synchronicity.

Only relatively recently, research studies (and home videos) have shown that some animals seem to share our urge to move to the groove. A new paper by a team at the University of Tokyo provides evidence that rats are one of them. “Rats displayed innate — that is, without any training or prior exposure to music — beat synchronization most distinctly within 120-140 bpm (beats per minute), to which humans also exhibit the clearest beat synchronization,” explained Associate Professor Hirokazu Takahashi from the Graduate School of Information Science and Technology. “The auditory cortex, the region of our brain that processes sound, was also tuned to 120-140 bpm, which we were able to explain using our mathematical model of brain adaptation.”

But why play music to rats in the first place? “Music exerts a strong appeal to the brain and has profound effects on emotion and cognition. To utilize music effectively, we need to reveal the neural mechanism underlying this empirical fact,” said Takahashi. “I am also a specialist of electrophysiology, which is concerned with electrical activity in the brain, and have been studying the auditory cortex of rats for many years.”

The team had two alternate hypotheses: The first was that the optimal music tempo for beat synchronicity would be determined by the time constant of the body. This is different between species and much faster for small animals compared to humans (think of how quickly a rat can scuttle). The second was that the optimal tempo would instead be determined by the time constant of the brain, which is surprisingly similar across species. “After conducting our research with 20 human participants and 10 rats, our results suggest that the optimal tempo for beat synchronization depends on the time constant in the brain,” said Takahashi. “This demonstrates that the animal brain can be useful in elucidating the perceptual mechanisms of music.”

The rats were fitted with wireless, miniature accelerometers, which could measure the slightest head movements. Human participants also wore accelerometers on headphones. They were then played one-minute excerpts from Mozart’s Sonata for Two Pianos in D Major, K. 448, at four different tempos: Seventy-five percent, 100%, 200% and 400% of the original speed. The original tempo is 132 bpm and results showed that the rats’ beat synchronicity was clearest within the 120-140 bpm range. The team also found that both rats and humans jerked their heads to the beat in a similar rhythm, and that the level of head jerking decreased the more that the music was sped up.

“To the best of our knowledge, this is the first report on innate beat synchronization in animals that was not achieved through training or musical exposure,” said Takahashi. “We also hypothesized that short-term adaptation in the brain was involved in beat tuning in the auditory cortex. We were able to explain this by fitting our neural activity data to a mathematical model of the adaptation. Furthermore, our adaptation model showed that in response to random click sequences, the highest beat prediction performance occurred when the mean interstimulus interval (the time between the end of one stimulus and the start of another) was around 200 milliseconds (one-thousandth of a second). This matched the statistics of internote intervals in classical music, suggesting that the adaptation property in the brain underlies the perception and creation of music.”

As well as being a fascinating insight into the animal mind and the development of our own beat synchronicity, the researchers also see it as an insight into the creation of music itself. “Next, I would like to reveal how other musical properties such as melody and harmony relate to the dynamics of the brain. I am also interested in how, why and what mechanisms of the brain create human cultural fields such as fine art, music, science, technology and religion,” said Takahashi. “I believe that this question is the key to understand how the brain works and develop the next-generation AI (artificial intelligence). Also, as an engineer, I am interested in the use of music for a happy life.”

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Researchers from the Positron Lab in the UTA Department of Physics utilized a process called auger-mediated positron sticking (AMPS) to develop a novel spectroscopic tool to measure the electronic structure of the surface of materials selectively.

A new article, “Photoemission spectroscopy using virtual photons emitted by positron sticking: A complementary probe for top-layer surface electronic structures,” published in the journal Physical Review Letters (PRL), details the new technique. In addition, the online magazine Physics published a Viewpoint article on the publication, titled “Spectroscopy That Doesn’t Scratch the Surface,” which explains why the paper is important to the field. Viewpoint articles are commissioned by PRL editors for papers they believe will draw broad interest.

Alex Fairchild, postdoctoral scholar in the Positron Lab, is the study’s lead author. Co-authors include Varghese Chirayath, assistant professor of research; Randall Gladen, postdoctoral researcher; Ali Koymen, professor of physics; and Alex Weiss, professor and chair of the UTA Department of Physics. Bernardo Barbiellini, professor of physics at LUT University in Finland, also contributed to the project.

The AMPS process, in which positrons (antimatter of electrons) stick directly to surfaces followed by electron emission, was first observed and described by Saurabh Mukherjee, a graduate student, along with Weiss and other colleagues, in 2010 at UTA. Those results were published in a paper in PRL.

“Alex (Fairchild) and Varghese figured out how to use this phenomenon that we discovered in 2010 to measure the top layer and get information about the electronic structure and the behavior of the electrons in the top layer,” Weiss said. “That will determine a material’s many properties, including conductivity, and can have important implications for building devices.”

Fairchild said the AMPS process is unique because it uses virtual photons to measure the topmost atomic layer.

“This is different from typical techniques like photoemission spectroscopy, where a photon penetrates multiple layers into the bulk of a material and therefore contains the combined information of the surface and subsurface layers,” Fairchild said.

“Our AMPS results showed how virtual photons emitted following positron-sticking interact preferably with electrons that extend further into the vacuum than with electrons that were more localized to the atomic site,” Chirayath said. “Our results are thus essential to understand how positrons interact with surface electrons and are extremely important to understand other similarly surface-selective, positron-based techniques.”

Weiss noted that the UTA Positron Lab is currently the only place this technique could have been developed, due to the capabilities of its positron beam.

“At present, UTA probably has the only lab in the world that has a positron beam that can get down to the low energies needed to observe this phenomenon,” Weiss said.

The study was supported by funding from the Welch Foundation and the National Science Foundation.

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Materials provided by University of Texas at Arlington. Original written by Greg Pederson. Note: Content may be edited for style and length.

The international team of researchers led by Elena Goun, an associate professor of chemistry at MU, discovered high levels of NR could not only increase someone’s risk of developing triple-negative breast cancer, but also could cause the cancer to metastasize or spread to the brain. Once the cancer reaches the brain, the results are deadly because no viable treatment options exist at this time, said Goun, who is the corresponding author on the study.

“Some people take them [vitamins and supplements] because they automatically assume that vitamins and supplements only have positive health benefits, but very little is known about how they actually work,” Goun said. “Because of this lack of knowledge, we were inspired to study the basic questions surrounding how vitamins and supplements work in the body.”

Following the death of her 59-year-old father only three months after being diagnosed with colon cancer, Goun was moved by her father’s passing to pursue a better scientific understanding of cancer metabolism, or the energy through which cancer spreads in the body. Since NR is a known supplement for helping increase levels of cellular energy, and cancer cells feed off of that energy with their increased metabolism, Goun wanted to investigate NR’s role in the development and spread of cancer.

“Our work is especially important given the wide commercial availability and a large number of ongoing human clinical trials where NR is used to mitigate the side effects of cancer therapy in patients,” Goun said.

The researchers used this technology to compare and examine how much NR levels were present in cancer cells, T cells and healthy tissues.

“While NR is already being widely used in people and is being investigated in so many ongoing clinical trials for additional applications, much of how NR works is a black box — it’s not understood,” Goun said. “So that inspired us to come up with this novel imaging technique based on ultrasensitive bioluminescent imaging that allows quantification of NR levels in real time in a non-invasive manner. The presence of NR is shown with light, and the brighter the light is, the more NR is present.”

Goun said the findings of the study emphasize the importance of having careful investigations of potential side effects for supplements like NR prior to their use in people who may have different types of health conditions. In the future, Goun would like to provide information that could potentially lead to the development of certain inhibitors to help make cancer therapies like chemotherapy more effective in treating cancer. The key to this approach, Goun said, is to look at it from a personalized medicine standpoint.

“Not all cancers are the same in every person, especially from the standpoint of metabolic signatures,” Goun said. “Often times cancers can even change their metabolism before or after chemotherapy.”

“A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism” was published in the Journal of Biosensors and Bioelectronics. Funding was provided by grants from the European Research Council (ERC-2019-COG, 866338) and Swiss National Foundation (51NF40_185898), as well as support from NCCR Chemical Biology.

Other authors on the study are Arkadiy Bazhin, Pavlo Khodakivskyi, Ekaterina Solodnikova and Aleksey Yevtodiyenko at MU; Tamara Maric at the Swiss Federal Institute of Technology; Greta Maria Paola Giordano Attianese, George Coukos and Melita Irving at The Ludwig Institute for Cancer Research in Switzerland; and Magali Joffraud and Carles Cantó at the Nestlé Institute of Health Sciences in Switzerland. Bazhin, Khodakivskyi, Mikhaylov, Solodnikova, Yevtodiyenko and Goun are also affiliated with the Swiss Federal Institute of Technology. Mikhaylov, Yevtodiyenko and Goun are also affiliated with SwissLumix SARL in Switzerland.

In addition to cameras, astronomers also use instruments known as spectrographs to study celestial object. A spectrograph breaks the light from an object into its component colors, in other words it creates a precise rainbow. Studying the strengths of the different colors in the rainbow from an object can tell astronomers various details about the object such as its motion, temperature, and chemical composition.

This new instrument, called PFS (Prime Focus Spectrograph), breaks visible light rainbows into two components: the red side and the blue side. So it might be more correct to refer to the data sets as half-rainbows. Combined with a third kind of detector which can see the infrared light invisible to humans, that makes one-and-a-half rainbows for an object studied with all three types of detectors.

Together with a widefield camera (HSC: Hyper Suprime-Cam), PFS will help launch the Subaru Telescope 2.0 project which will reveal the nature of dark matter and dark energy, structure formation in the Universe, and the physical processes of galaxy formation and evolution.

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“The new temple is roughly the same size and on a similar alignment as the neighboring Tempio Grande, and was built at roughly the same Archaic time,” explains Franceschini. “This duplication of monumental buildings in an Etruscan city is rare, and indicates an exceptional finding,” adds Pasieka. The team discovered the temple when working on the Vulci Cityscape project, which was launched in 2020 and aimed to research the settlement strategies and urbanistic structures of the city of Vulci. Vulci was one of the twelve cities of the Etruscan federation and in pre-Roman times was one of the most important urban centers in what is now Italy.

New discoveries about city design and development

“We studied the entire northern area of Vulci, that’s 22.5 hectares, using geophysical prospecting and Ground Penetrating Radar,” explains Pasieka. “We discovered remains from the city’s origins that had previously been overlooked in Vulci and are now better able to understand the dynamics of settlement and the road system, besides identifying different functional areas in the city.” The researchers were able in 2021 to uncover the first sections of wall, made of solid tuff. “Our knowledge about the appearance and organization of Etruscan cities has been limited until now,” says Franceschini. “The intact strata of the temple are offering us insights into more than a thousand years of development of one of the most important Etruscan cities.”

Over the coming years the scientists want to study the different phases of use and the precise architectural appearance of the temple in more depth, in order to learn more about the religion of the Etruscans, the social structures in Vulci and what the lives of the city’s inhabitants were really like.

Fritz Thyssen Foundation and Gerda Henkel Foundation funding the excavation

The project is being funded by the Fritz Thyssen Foundation (2020-2022) and the Gerda Henkel Foundation (2022-2023) along with the University of Mainz’s research area “40,000 Years of Human Challenges: Perception, Conceptualization and Coping in Premodern Societies.” The departments of classical archeology at the University of Freiburg and at the University of Mainz are working together with the Vulci Foundation, which administers the archeological park “Parco Naturalistico Archeologico di Vulci,” and the Italian national monument authority, Soprintendenza Archeologia, Belle Arti e Paesaggio per la provincia di Viterbo e per l’Etruria meridionale.

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Innovations in terrestrial transportation technologies, such as cars, trains, and aircraft, have driven historical technologies and industries so far; now, a similar breakthrough is occurring in space thanks to electric propulsion technology.

Electric propulsion is a technique utilizing electromagnetic fields to accelerate a propellant and to generate thrust that propels a spacecraft. Space agencies have pioneered electric propulsion technology as the future of space exploration.

Already, several space missions have successfully been completed using electric propulsion devices, such as gridded ion thrusters and Hall thrusters. Solar power is converted into thrust energy when the propellant becomes ionized, i.e., a plasma, and gets accelerated by electromagnetic fields. Yet, the electrodes necessary for these devices limit their lifetime, since they get exposed to and damaged by the plasma, especially at a high-power level.

To circumvent this, scientists have turned to electrodeless plasma thrusters. One such technology harnesses radio frequency (rf) to generate plasma. An antenna emits radio waves into a cylindrical chamber to create plasma, where a magnetic nozzle channels and accelerates the plasma to generate thrust. MN rf plasma thrusters, or helicon thrusters as they are sometimes known, offer simplicity, operational flexibility, and a potentially high thrust-to-power ratio.

But the development of MN rf plasma thrusters has been stymied by the conversion efficiency of the rf power to thrust energy. Early experiments generated single digit conversion rates, but more recent studies have reached a modest outcome of 20%.

In a recent study, Professor Kazunori Takahashi, from Tohoku University’s Department of Electrical Engineering, has achieved a 30% conversion efficiency.

Whilst mature electric propulsion devices often use xenon gas, which is expensive and difficult to supply in sufficient quantities, the current 30% efficiency was obtained with argon propellant. This indicates that a MN rf plasma thruster would reduce the cost and the resource load from the Earth.

“Applying a cusp-type magnetic field inhibited the energy loss that generally occurs to the plasma source wall,” Takahashi said. “The breakthrough opens the door to advances in high-power space transportation technology.”

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Ordinary solid matter consists of atoms organized in a crystal lattice. The chemical character of the atoms and lattice symmetry define the properties of the matter, for instance, whether it is a metal, a semiconductor or and electric insulator. The lattice symmetry may be changed by ambient conditions such as temperature or high pressure, which can induce structural transitions and transform even an electric insulator to an electric conductor, that is, a metal.

Larger identical entities such as nanoparticles or atomically precise metal nanoclusters can also organize into a crystal lattice, to form so called meta-materials. However, information on how to engineer the growth of such materials from their building blocks has been scarce since the crystal growth is a typical self-assembling process.

Now, first insights into engineering crystal growth by atomically precise metal nanoclusters have been achieved in a study performed by researchers in Singapore, Saudi Arabia and Finland. They synthesized metal clusters consisting of only 25 gold atoms, one nanometer in diameter. These clusters are soluble in water due to the ligand molecules that protect the gold. This cluster material is known to self-assemble into well-defined close packed single crystals when the water solvent is evaporated. However, the researcher found a novel concept to regulate the crystal growth by adding tetra-alkyl-ammonium molecular ions in the solvent. These ions affect the surface chemistry of the gold clusters, and their size and concentration were observed to have an impact on the size, shape, and morphology of the formed crystals. Remarkably, high-resolution electron microscopy images of some of the crystals revealed that they consist of polymeric chains of clusters with four-gold-atom interparticle links. The demonstrated surface chemistry opens now new ways to engineer metal cluster -based meta-materials for investigations of their electronic and optical properties.

The cluster materials were synthesized in the National University of Singapore, the electron microscopy imaging was done at the King Abdullah University of Science and Technology in Saud Arabia, and the theoretical modelling was done at the University of Jyvaskyla, Finland.

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The research team led by Vlad Tereshenko and Oskar Aszmann from the Clinical Laboratory for Bionic Limb Reconstruction at MedUni Vienna’s Department of Plastic, Reconstructive and Aesthetic Surgery discovered this facet of the interaction between nerves and muscles — which was previously unknown to science — in the course of its preclinical research on facial nerves and muscles. After a nerve has been injured or severed, it is no longer able to control the motor function of the facial muscles, resulting in facial paralysis in the animal model.

In some cases, the scientists observed spontaneous recovery of muscle function days or weeks after the nerve lesion. Using novel, complex techniques, they were able to establish that the autonomic nervous system takes over the function of the injured nerve, as it were. “Until now, we were unaware that the autonomic nervous system can control muscle motor function with nerve impulses. As we have seen in our experiments, the parasympathetic nerve fibres form new functional neuromuscular synapses to do this. At the same time, the patterns of the muscle fibres are modified and, hence, the physiological properties of the autonomously reinnervated muscles are changed,” explains first author Vlad Tereshenko, outlining the key findings from the study.

Potential actor in nerve reconstruction

Following injuries or certain diseases, nerves can temporarily or permanently lose their ability to provide motor control to muscles. Well-established therapeutic concepts such as the relocation of nerves or nerve transplants are now available to remedy the resultant motor deficits. However, clinical outcomes may be affected by several factors, such as the slow rate of nerve regeneration or the lack of donor nerves. “By identifying this previously unknown ability of the autonomic nervous system, we have discovered a new potential actor in nerve reconstruction. The results of our study can therefore help to improve existing therapeutic measures and to develop new ones,” says Vlad Tereshenko, looking into the future. Follow-up studies are expected to deepen our knowledge of this new facet of the neuromuscular system. One of the questions to be addressed is whether and how autonomic nerve fibres can be surgically relocated in order to restore muscle function on a temporary or permanent basis.

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