Northwestern University materials scientists have developed new design principles that could help spur development of future quantum materials used to advance (IoT) devices and other resource-intensive technologies while limiting ecological damage.

“New path-breaking materials and computing paradigms are required to make data centers more energy-lean in the future,” said James Rondinelli, professor of materials science and engineering and the Morris E. Fine Professor in Materials and Manufacturing at the McCormick School of Engineering, who led the research.

The study marks an important step in Rondinelli’s efforts to create new materials that are non-volatile, energy efficient, and generate less heat — important aspects of future ultrafast, low-power electronics and quantum computers that can help meet the world’s growing demand for data.

Rather than certain classes of semiconductors using the electron’s charge in transistors to power computing, solid-state spin-based materials utilize the electron’s spin and have the potential to support low-energy memory devices. In particular, materials with a high-quality persistent spin texture (PST) can exhibit a long-lived persistent spin helix (PSH), which can be used to track or control the spin-based information in a transistor.

Although many spin-based materials already encode information using spins, that information can be corrupted as the spins propagate in the active portion of the transistor. The researchers’ novel PST protects that spin information in helix form, making it a potential platform where ultralow energy and ultrafast spin-based logic and memory devices operate.

The research team used quantum-mechanical models and computational methods to develop a framework to identify and assess the spin textures in a group of non-centrosymmetric crystalline materials. The ability to control and optimize the spin lifetimes and transport properties in these materials is vital to realizing the future of quantum microelectronic devices that operate with low energy consumption.

“The limiting characteristic of spin-based computing is the difficulty in attaining both long-lived and fully controllable spins from conventional semiconductor and magnetic materials,” Rondinelli said. “Our study will help future theoretical and experimental efforts aimed at controlling spins in otherwise non-magnetic materials to meet future scaling and economic demands.”

Rondinelli’s framework used microscopic effective models and group theory to identify three materials design criteria that would produce useful spin textures: carrier density, the number of electrons propagating through an effective magnetic field, Rashba anisotropy, the ratio between intrinsic spin-orbit coupling parameters of the materials, and momentum space occupation, the PST region active in the electronic band structure. These features were then assessed using quantum-mechanical simulations to discover high-performing PSHs in a range of oxide-based materials.

The researchers used these principles and numerical solutions to a series of differential spin-diffusion equations to assess the spin texture of each material and predict the spin lifetimes for the helix in the strong spin-orbit coupling limit. They also found they could adjust and improve the PST performance using atomic distortions at the picoscale. The group determined an optimal PST material, Sr3Hf2O7, which showed a substantially longer spin lifetime for the helix than in any previously reported material.

“Our approach provides a unique chemistry-agnostic strategy to discover, identify, and assess symmetry-protected persistent spin textures in quantum materials using intrinsic and extrinsic criteria,” Rondinelli said. “We proposed a way to expand the number of space groups hosting a PST, which may serve as a reservoir from which to design future PST materials, and found yet another use for ferroelectric oxides — compounds with a spontaneous electrical polarization. Our work also will help guide experimental efforts aimed at implementing the materials in real device structures.”

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Materials provided by Northwestern University. Original written by Alex Gerage. Note: Content may be edited for style and length.

The team found forecasts were 20% more accurate, and uncertainty was reduced by 15%, when incorporating information about the size and shape of the CMEs in the volunteer analysis. The data was captured by thousands of members of the public during the latest activity in the Solar Stormwatch citizen science project, which was devised by Reading researchers and has been running since 2010.

The findings support the inclusion of wide-field CME imaging cameras on board space weather monitoring missions currently being planned by agencies like NASA and ESA.

Dr Luke Barnard, space weather researcher at the University of Reading’s Department of Meteorology, who led the study, said: “CMEs are sausage-shaped blobs made up of billions of tonnes of magnetised plasma that erupt from the Sun’s atmosphere at a million miles an hour. They are capable of damaging satellites, overloading power grids and exposing astronauts to harmful radiation.

“Predicting when they are on a collision course with Earth is therefore extremely important, but is made difficult by the fact the speed and direction of CMEs vary wildly and are affected by solar wind, and they constantly change shape as they travel through space.

“Solar storm forecasts are currently based on observations of CMEs as soon as they leave the Sun’s surface, meaning they come with a large degree of uncertainty. The volunteer data offered a second stage of observations at a point when the CME was more established, which gave a better idea of its shape and trajectory.

“The value of additional CME observations demonstrates how useful it would be to include cameras on board spacecraft in future space weather monitoring missions. More accurate predictions could help prevent catastrophic damage to our infrastructure and could even save lives.”

In the study, published in AGU Advances, the scientists used a brand new solar wind model, developed by Reading co-author Professor Mathew Owens, for the first time to create CME forecasts.

The simplified model is able to run up to 200 simulations — compared to around 20 currently used by more complex models — to provide improved estimates of the solar wind speed and its impact on the movement of CMEs, the most harmful of which can reach Earth in 15-18 hours.

Adding the public CME observations to the model’s predictions helped provide a clearer picture of the likely path the CME would take through space, reducing the uncertainty in the forecast. The new method could also be applied to other solar wind models.

The Solar Stormwatch project was led by Reading co-author Professor Chris Scott. It asked volunteers to trace the outline of thousands of past CMEs captured by Heliospheric Imagers — specialist, wide-angle cameras — on board two NASA STEREO spacecraft, which orbit the Sun and monitor the space between it and Earth.

The scientists retrospectively applied their new forecasting method to the same CMEs the volunteers had analysed to test how much more accurate their forecasts were with the additional observations.

Using the new method for future solar storm forecasts would require swift real-time analysis of the images captured by the spacecraft camera, which would provide warning of a CME being on course for Earth several hours or even days in advance of its arrival.

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Materials provided by University of Reading. Note: Content may be edited for style and length.

Although the newest gene drives have been proven to spread efficiently as designed in laboratory settings, concerns have been raised regarding the safety of releasing such systems into wild populations. Questions have emerged about the predictability and controllability of gene drives and whether, once let loose, they can be recalled in the field if they spread beyond their intended application region.

Now, scientists at the University of California San Diego and their colleagues have developed two new active genetic systems that address such risks by halting or eliminating gene drives in the wild. On Sept.18, 2020 in the journal Molecular Cell, research led by Xiang-Ru Xu, Emily Bulger and Valentino Gantz in the Division of Biological Sciences offers two new solutions based on elements developed in the common fruit fly.

“One way to mitigate the perceived risks of gene drives is to develop approaches to halt their spread or to delete them if necessary,” said Distinguished Professor Ethan Bier, the paper’s senior author and science director for the Tata Institute for Genetics and Society. “There’s been a lot of concern that there are so many unknowns associated with gene drives. Now we have saturated the possibilities, both at the genetic and molecular levels, and developed mitigating elements.”

The first neutralizing system, called e-CHACR (erasing Constructs Hitchhiking on the Autocatalytic Chain Reaction) is designed to halt the spread of a gene drive by “shooting it with its own gun.” e-CHACRs use the CRISPR enzyme Cas9 carried on a gene drive to copy itself, while simultaneously mutating and inactivating the Cas9 gene. Xu says an e-CHACR can be placed anywhere in the genome.

“Without a source of Cas9, it is inherited like any other normal gene,” said Xu. “However, once an e-CHACR confronts a gene drive, it inactivates the gene drive in its tracks and continues to spread across several generations ‘chasing down’ the drive element until its function is lost from the population.”

The second neutralizing system, called ERACR (Element Reversing the Autocatalytic Chain Reaction), is designed to eliminate the gene drive altogether. ERACRs are designed to be inserted at the site of the gene drive, where they use the Cas9 from the gene drive to attack either side of the Cas9, cutting it out. Once the gene drive is deleted, the ERACR copies itself and replaces the gene-drive.

“If the ERACR is also given an edge by carrying a functional copy of a gene that is disrupted by the gene drive, then it races across the finish line, completely eliminating the gene drive with unflinching resolve,” said Bier.

The researchers rigorously tested and analyzed e-CHACRs and ERACRs, as well as the resulting DNA sequences, in meticulous detail at the molecular level. Bier estimates that the research team, which includes mathematical modelers from UC Berkeley, spent an estimated combined 15 years of effort to comprehensively develop and analyze the new systems. Still, he cautions there are unforeseen scenarios that could emerge, and the neutralizing systems should not be used with a false sense of security for field-implemented gene drives.

“Such braking elements should just be developed and kept in reserve in case they are needed since it is not known whether some of the rare exceptional interactions between these elements and the gene drives they are designed to corral might have unintended activities,” he said.

According to Bulger, gene drives have enormous potential to alleviate suffering, but responsibly deploying them depends on having control mechanisms in place should unforeseen consequences arise. ERACRs and eCHACRs offer ways to stop the gene drive from spreading and, in the case of the ERACR, can potentially revert an engineered DNA sequence to a state much closer to the naturally-occurring sequence.

“Because ERACRs and e-CHACRs do not possess their own source of Cas9, they will only spread as far as the gene drive itself and will not edit the wild type population,” said Bulger. “These technologies are not perfect, but we now have a much more comprehensive understanding of why and how unintended outcomes influence their function and we believe they have the potential to be powerful gene drive control mechanisms should the need arise.”