People affected by obesity or who are overweight are at increased risk for high cholesterol and high blood pressure — factors that heighten risk of cardiovascular disease; as well as insulin resistance, a precursor to Type 2 diabetes. Globally, overweight and obesity contributed to 2.4 million deaths in 2020, according to the American Heart Association’s 2023 Statistical Update.

Behavioral weight loss programs can help people lose and maintain a healthy weight by encouraging lifestyle and behavior changes, such as eating healthy foods and increasing physical activity. Regaining some weight is common after behavioral weight loss programs. Some observational studies suggest this weight change pattern of weight loss followed by weight regain may increase cardiovascular risk. However, according to the authors of this analysis, data from randomized trials and long-term follow-up studies is lacking.

“Many doctors and patients recognize that weight loss is often followed by weight regain, and they fear that this renders an attempt to lose weight pointless,” said study co-senior author Susan A. Jebb, Ph.D., a professor of diet and population health at the University of Oxford in the United Kingdom. “This concept has become a barrier to offering support to people to lose weight. For people with overweight or obesity issues, losing weight is an effective way to reduce the risk of Type 2 diabetes and cardiovascular disease.”

In this review, researchers assessed international scientific studies available in 2018 to compare risk factors for cardiovascular disease and Type 2 diabetes among people who followed an intensive behavioral weight loss program to those who followed a less intensive or no weight loss program. The studies in the analysis included diet and/or exercise interventions, partial or total meal replacement, intermittent fasting, or financial incentives contingent on weight loss. The studies took place in a variety of settings and included varying modes of delivery (in person, app-based, telephone, etc.).

Researchers combined the results of 124 studies totaling more than 50,000 participants, with an average follow-up of 28 months. They used the combined results to estimate changes in risk factors for cardiovascular disease and Type 2 diabetes after weight loss. The average weight loss across the different studies ranged from 2-5 kilograms, or 5-10 pounds. Weight regain averaged 0.12 to 0.32 kg (0.26 pounds to 0.7 pounds) a year. Participants were an average age 51 years old, with a body mass index of 33, which is considered obese.

Compared to people in a less intensive program and those in no weight loss program, participants who lost weight through an intensive weight loss program had lower risk factors for cardiovascular disease and Type 2 diabetes. These lower risk factors lasted for at least five years after the weight loss program ended.

Based on pooled results of the studies reviewed, on average:

• Systolic blood pressure, the top number in a blood pressure reading, was 1.5 mm Hg (millimeters of mercury) lower at one year, and 0.4 mm Hg lower at five years after participation in an intensive weight loss program.
• In addition, the percentage of HbA1c, a protein in red blood cells used to test for diabetes, was reduced by 0.26 at both one and five years after participation in an intensive weight loss program.
• The ratio of total cholesterol to good cholesterol – known as high-density lipoprotein (HDL) cholesterol — was 1.5 points lower one year and five years after participation in an intensive weight loss program.

These changes are important because they represent improvements at the population level, Jebb explained.

In a preliminary finding, the decreased risk of being diagnosed with cardiovascular disease or Type 2 diabetes also appeared to remain lower even after weight regain. However, few studies followed people for more than 5 years and “more information is needed to confirm whether this potential benefit persists,” Jebb said.

“Most trials look at whether new treatments are effective and focus on weight change in the short-term rather than the effect on later disease,” Jebb said. “Individual studies are often too small to detect differences between groups in the incidence of cardiovascular conditions because, fortunately, they affect only a small proportion of the whole group, and studies may not continue long enough to see the effects on ‘hard’ outcomes, such as a new diagnosis of Type 2 diabetes or a heart attack.

“Our findings should provide reassurance that weight loss programs are effective in controlling cardiovascular risk factors and very likely to reduce the incidence of cardiovascular disease,” she said.

Evidence suggests that cardiovascular health is improved by following the American Heart Association’s Life’s Essential 8 health metrics: eating healthy food, being physically active, not smoking, getting enough sleep, maintaining a healthy weight, and controlling cholesterol, blood sugar and blood pressure levels.

The analysis had several limitations: information included in the review was not updated after 2019 and the review focused on research papers published in English, so eligible studies written in other languages may have been missed.

An accompanying editorial notes that much remains to be understood about various weight loss interventions, their long-term impact and how this impact may be diminished by regaining weight. Behavioral weight loss programs constitute the backbone of weight management in clinical practice. However, they are often resource intensive, and emerging medication therapies are expensive, according to editorial authors Vishal N. Rao, M.D., M.P.H., and Neha J. Pagidipati, M.D., M.P.H., both from the division of cardiology at Duke University School of Medicine in Durham, North Carolina.

“The present study has interesting implications for the impact of weight regain that may occur after pharmacologic therapies,” they write. “What is still unknown is whether these temporary improvements in weight and cardiometabolic risk factors after weight loss intervention (behavioral or pharmacological) lead to long-term clinical benefit. In other words, is it better to have lost and regained than never to have lost at all?”

The team of scientists from the USA, California, France, the Netherlands, Chile and Hawaii observed 18 asteroids sharing the orbit of Neptune, known as Neptunian Trojans. They are between 50 and 100 km in size and are located at a distance of around 4.5 billion kilometres from the Sun. Asteroids orbiting this far away are faint and so are challenging for astronomers to study. Before the new work, only about a dozen Neptunian Trojans had been studied, requiring the use of some of the largest telescopes on Earth.

The new data were gathered over the course of two years using the WASP wide field camera on the Palomar Observatory telescope in California, the GMOS cameras on the Gemini North and South telescopes in Hawaii and Chile, and the LRIS camera on the Keck Telescope in Hawaii.

Of the 18 observed Neptunian Trojans, several were much redder than most asteroids, and compared with other asteroids in this group looked at in previous studies. Redder asteroids are expected to have formed much further from the Sun; one population of these is known as the Cold Classical trans-Neptunian objects found beyond the orbit of Pluto, at around 6 billion kilometres from the Sun. The newly observed Neptunian Trojans are also unlike asteroids located in the orbit of Jupiter, which are typically more neutral in colour.

The redness of the asteroids implies that they contain a higher proportion of more volatile ices such as ammonia and methanol. These are extremely sensitive to heat, and can rapidly transform into gas if the temperature rises, so are more stable at large distances from the Sun.

The location of the asteroids at the same orbital distance as Neptune also implies that they are stable on timescales comparable to the age of the Solar System. They effectively act as a time-capsule, recording the initial conditions of the Solar System.

The presence of redder asteroids among the Neptunian Trojans suggests the existence of a transition zone between more neutral coloured and redder objects. The redder Neptunian asteroids may have formed beyond this transition boundary before being captured into the orbit of Neptune. The Neptunian Trojans would have been captured into the same orbit as the planet Neptune as the ice giant planet migrated from the inner solar system to where it is now, some 4.5 billion kilometres from the Sun.

Lead author Dr Bryce Bolin of the NASA Goddard Space Flight Centre said, “In our new work we have more than doubled the sample of Neptunian Trojans studied with large telescopes. It’s exciting to find the first evidence of redder asteroids in this group.”

“Because we have a larger sample of Neptunian Trojans with measured colours, we can now start to see major differences between asteroid groups. Our observations also show that the Neptunian Trojans are also different in colour compared to asteroid groups even further from the Sun. A possible explanation may be that the processing of the surfaces of asteroids by the Sun’s heat may have different effects for asteroids at varying solar distances.”

According to a new paper by Concordia researchers published in the Journal of Cognition and Development, the answer largely depends on age.

The study compared two groups of preschoolers: one of three-year-olds, the other of five-year-olds. The children participated in Zoom meetings featuring a video of a young woman and a small robot with humanoid characteristics (head, face, torso, arms and legs) called Nao sitting side by side. Between them were familiar objects that the robot would label correctly while the human would label them incorrectly, e.g., referring to a car as a book, a ball as a shoe and a cup as a dog.

Next, the two groups of children were presented with unfamiliar items: the top of a turkey baster, a roll of twine and a silicone muffin container. Both the robot and the human used different nonsense terms like “mido,” “toma,” “fep” and “dax” to label the objects. The children were then asked what the object was called, endorsing either the label offered by the robot or by the human.

While the three-year-olds showed no preference for one word over another, the five-year-olds were much more likely to state the term provided by the robot than the human.

“We can see that by age five, children are choosing to learn from a competent teacher over someone who is more familiar to them — even if the competent teacher is a robot,” says the paper’s lead author, PhD candidate Anna-Elisabeth Baumann. Horizon Postdoctoral Fellow Elizabeth Goldman and undergraduate research assistant Alexandra Meltzer also contributed to the study. Professor and Concordia University Chair of Developmental Cybernetics Diane Poulin-Dubois in the Department of Psychology supervised the study.

The researchers repeated the experiments with new groups of three- and five-year-olds, replacing the humanoid Nao with a small truck-shaped robot called Cozmo. The results resembled those observed with the human-like robot, suggesting that the robot’s morphology does not affect the children’s selective trust strategies.

Baumann adds that, along with the labelling task, the researchers administered a naive biology task. The children were asked if biological organs or mechanical gears formed the internal parts of unfamiliar animals and robots. The three-year-olds appeared confused, assigning both biological and mechanical internal parts to the robots. However, the five-year-olds were much more likely to indicate that only mechanical parts belonged inside the robots.

“This data tells us that the children will choose to learn from a robot even though they know it is not like them. They know that the robot is mechanical,” says Baumann.

Being right is better than being human

While there has been a substantial amount of literature on the benefits of using robots as teaching aides for children, the researchers note that most studies focus on a single robot informant or two robots pitted against each other. This study, they write, is the first to use both a human speaker and a robot to see if children deem social affiliation and similarity more important than competency when choosing which source to trust and learn from.

Poulin-Dubois points out that this study builds on a previous paper she co-wrote with Goldman and Baumann. That paper shows that by age five, children treat robots similarly to how adults do, i.e., as depictions of social agents.

“Older preschoolers know that robots have mechanical insides, but they still anthropomorphize them. Like adults, these children attribute certain human-like qualities to robots, such as the ability to talk, think and feel,” she says.

“It is important to emphasize that we see robots as tools to study how children can learn from both human and non-human agents,” concludes Goldman. “As technology use increases, and as children interact with technological devices more, it is important for us to understand how technology can be a tool to help facilitate their learning.”