Health24.com | Some psoriasis meds may also help prevent heart disease

  • Plaque in the arteries of people with psoriasis increases the risk of coronary artery disease
  • Treatment with biologic therapy reduced coronary plaque by 6% to 8% after one year
  • This is as effective as statin therapy on heart arteries

Biologic therapy for the skin condition psoriasis may reduce patients’ risk of heart disease, new research suggests.

Chronic inflammation in people with psoriasis is associated with the development of plaque in heart arteries, which increases the risk of coronary artery disease. In biologic therapy, patients receive protein-based infusions to reduce inflammation.

“This is the first time an imaging study in humans has shown what one year of ongoing, untreated inflammation can do to arteries of the heart, and that we can reverse this damage,” said study senior author Dr Nehal Mehta. He’s chief of the inflammation and cardiometabolic diseases lab at the US National Heart, Lung, and Blood Institute.

Prone to rupture

“Untreated inflammation is dangerous. You are just waiting for a heart attack or stroke to happen,” Mehta added.

This study focused on a dangerous type of coronary plaque called lipid-rich necrotic core. It’s composed of dead cells and cell debris, and is prone to rupture. Ruptured plaque can lead to a heart attack or stroke.

The study included 209 patients, aged 37 to 62, with psoriasis. They were selected to receive biologic therapy (124 patients) or assigned to the control group and received topical creams and light therapy (85 patients).

After one year of treatment, CT scans showed that patients who received biologic therapy had an 8% decrease in coronary plaque, while those in the control group had a slight increase.

The findings held even after the researchers adjusted for cardiovascular risk factors and psoriasis severity. The study was published on 15 September in the journal Circulation: Cardiovascular Imaging.

Just as beneficial as statin therapy

“Having inflamed plaque that is prone to rupture increases the risk of heart attack fivefold within 10 years,” Mehta said in a journal news release.

Treatment with cholesterol-lowering statins reduces coronary plaque approximately 6% to 8%, Mehta noted. “Similarly, our treatment with biologic therapy reduced coronary plaque by the same amount after one year. These findings suggest that biologic therapy to treat psoriasis may be just as beneficial as statin therapy on heart arteries,” he added.

Along with psoriasis patients, the study findings could have implications for people with other chronic inflammatory conditions such as HIV, lupus and rheumatoid arthritis, who also have an increased risk of heart disease, according to the researchers.

“We have never before been able to show healing of an inflamed plaque like this in humans. Biologic therapy reduces systemic inflammation and immune activation, and it has a favourable impact on improving overall vascular health,” Mehta said.

The authors said a larger study is needed to confirm the results.

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Emissions could add 15 inches to 2100 sea level rise

An international effort that brought together more than 60 ice, ocean and atmosphere scientists from three dozen international institutions has generated new estimates of how much of an impact Earth’s melting ice sheets could have on global sea levels by 2100. If greenhouse gas emissions continue apace, Greenland and Antarctica’s ice sheets could together contribute more than 15 inches (38 centimeters) of global sea level rise — and that’s beyond the amount that has already been set in motion by Earth’s warming climate.

The results point to a greater range of possibilities, from ice sheet change that decreases sea level by 3.1 in (7.8 cm), to increasing it by 12 in (30 cm) by 2100, with different climate scenarios and climate model inputs. The regional projections show the greatest loss in West Antarctica, responsible for up to 7.1 in (18 cm) of sea level rise by 2100 in the warmest conditions, according to the research.

“The Amundsen Sea region in West Antarctica and Wilkes Land in East Antarctica are the two regions most sensitive to warming ocean temperatures and changing currents, and will continue to lose large amounts of ice,” said He?le?ne Seroussi, an ice scientist at NASA’s Jet Propulsion Laboratory in Southern California. Seroussi led the Antarctic ice sheet modeling in the ISMIP6 effort. “With these new results, we can focus our efforts in the correct direction and know what needs to be worked on to continue improving the projections.”

Different groups within the ISMIP6 community are working on various aspects of the ice sheet modeling effort. All are designed to better understand why the ice sheets are changing and to improve estimates of how much ice sheets will contribute to sea level rise. Other recent ISMIP6 studies include:

  • How historical conditions and warming ocean temperatures that melt floating ice shelves from below play a significant role in Antarctic ice loss? (Reese et al, 2020)
  • How sudden and sustained collapse of the floating ice shelves impact the Antarctic ice sheet as a whole? (Sun et al., 2020)
  • How to convert large scale climate output into local conditions that ice sheet models can use? (Barthel et al, 2020; Slater et al; 2019, 2020; Nowicki et al., 2020, and Jourdain et al., 2020)

“It took over six years of workshops and teleconferences with scientists from around the world working on ice sheet, atmosphere, and ocean modeling to build a community that was able to ultimately improve our sea level rise projections,” Nowicki said. “The reason it worked is because the polar community is small, and we’re all very keen on getting this problem of future sea level right. We need to know these numbers.”

The new results will help inform the Sixth IPCC report scheduled for release in 2022.

Results from this effort are in line with projections in the Intergovernmental Panel on Climate Change’s (IPCC) 2019 Special Report on Oceans and the Cryosphere. Meltwater from ice sheets contribute about a third of the total global sea level rise. The IPCC report projected that Greenland would contribute 3.1 to 10.6 inches (8 to 27 cm) to global sea level rise between 2000-2100 and Antarctica could contribute 1.2 to 11 inches (3 to 28 cm).

These new results, published this week in a special issue of the journal The Cryosphere, come from the Ice Sheet Model Intercomparison Project (ISMIP6) led by NASA’s Goddard Space Flight Center in Greenbelt, Maryland. The study is one of many efforts scientists are involved in to project the impact of a warming climate on melting ice sheets, understand its causes and track sea level rise.

“One of the biggest uncertainties when it comes to how much sea level will rise in the future is how much the ice sheets will contribute,” said project leader and ice scientist Sophie Nowicki, now at the University at Buffalo, and formerly at NASA Goddard. “And how much the ice sheets contribute is really dependent on what the climate will do.”

“The strength of ISMIP6 was to bring together most of the ice sheet modeling groups around the world, and then connect with other communities of ocean and atmospheric modelers as well, to better understand what could happen to the ice sheets,” said Heiko Goelzer, a scientist from Utrecht University in the Netherlands, now at NORCE Norwegian Research Centre in Norway. Goelzer led the Greenland ice sheet ISMIP6 effort.

With warming air temperatures melting the surface of the ice sheet, and warming ocean temperatures causing ocean-terminating glaciers to retreat, Greenland’s ice sheet is a significant contributor to sea level rise. The ISMIP6 team investigated two different scenarios the IPCC has set for future climate to predict sea level rise between 2015 and 2100: one with carbon emissions increasing rapidly and another with lower emissions.

In the high emissions scenario, they found that the Greenland ice sheet would lead to an additional global sea level rise of about 3.5 inches (9 cm) by 2100. In the lower emissions scenario, the loss from the ice sheet would raise global sea level by about 1.3 inches (3 cm). This is beyond what is already destined to be lost from the ice sheet due to warming temperatures between pre-industrial times and now; previous studies have estimated that ‘locked in’ contribution to global sea level rise by 2100 to be about a quarter-inch (6 millimeters) for the Greenland ice sheet.

The ISMIP6 team also analyzed the Antarctic ice sheet to understand how much ice melt from future climate change would add to sea level rise, beyond what recent warming temperatures have already put in motion. Ice loss from the Antarctic ice sheet is more difficult to predict: In the west, warm ocean currents erode the bottom of large floating ice shelves, causing loss; while the vast East Antarctic ice sheet can gain mass, as warmer temperatures cause increased snowfall.

Story Source:

Materials provided by NASA/Goddard Space Flight Center. Original written by Kate Ramsayer. Note: Content may be edited for style and length.

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Health24.com | Your sex affects your genes for body fat, cancer and birth weight

  • Whether we are male or female affects our physiology in profound ways 
  • Disease biology may, therefore, remain obscured when males and females are considered as a single group
  • Differentiating between the sexes can thus lead to an improved, more personal medicinal approach 

Researchers say your biological sex affects gene expression in nearly every type of tissue – influencing body fat, cancer and birth weight.

Gene expression is the amount of product created by a gene for cell function, the international team of researchers explained.

They said their findings could prove important for personalised medicine, creating new drugs and predicting patient outcomes.

“These discoveries suggest the importance of considering sex as a biological variable in human genetics and genomics studies,” said project leader Barbara Stranger, an associate professor of pharmacology at Northwestern University Feinberg School of Medicine in Chicago.

Unreported links

The researchers analysed 44 types of healthy human tissue from 838 people to find out if there were differences between women and men in the average amount of gene expression.

They discovered that 37% of all human genes were expressed at different levels in women and men in at least one type of tissue.

They also identified 369 instances where a genetic variant present in males and females affected gene expression to a different degree in each sex. This led to the discovery of 58 previously unreported links between genes and blood pressure, cholesterol levels, breast cancer and body fat percentage.

Gender differences in gene expression were also found for genes involved in how the body responds to medications, how women control blood sugar levels in pregnancy, how the immune system functions and how cancer develops.

Critical component of personalised medicine

“If specific genes or genetic variants contribute differentially to a given trait in males and females, it could suggest sex-specific biomarkers, therapeutics and drug dosing,” Stranger said in a Northwestern news release.

“In the future, such knowledge may form a critical component of personalised medicine or may reveal disease biology that remains obscured when considering males and females as a single group,” she said.

The study was published in the journal Science.

Image credit: iStock

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Health24.com | How to keep your kids trim through quarantine

  • During the school year, schools provide learners with regular exercise
  • Currently, while at home, kids don’t get enough exercise, which can lead to overweight 
  • Parents are advised to schedule physical activities for their children and provide them with a healthy diet

A lot of kids have been pushing up the scale numbers while home during the pandemic – and parents need to take steps to prevent the dreaded “quarantine 15”, an expert says.

“During the school year, most parents rely on schools to provide their child with regular exercise,” said Dr Joyce Samuel, an associate professor of paediatrics at McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth).

Get outside every day

“Because of the ongoing situation surrounding Covid-19, it is important for parents to focus on their child’s health and ensure they are getting the proper exercise and nutrition to avoid child obesity,” Samuel said in a centre news release.

If your children are learning remotely, she noted there are plenty of apps with videos for short, home-based workouts that usually require little or no equipment. Another option is to get outside for a daily 30-minute walk or jog.

“As long as you are maintaining physical distancing and staying with members of your household, this is a safe way to get some fresh air and regular exercise,” Samuel said.

Other exercise suggestions for children include: jumping rope or running to help strengthen bones; playing games like tug-of-war to strengthen muscles; aerobic activities like bike riding or walking to benefit the heart; outdoor sports; scooter riding; tag, and neighbourhood scavenger hunts.

Schedule activities for children several times a week, Samuel said.

Many kids are stressed

In terms of diet, provide children with meals that have both protein and produce. Frozen fruits and vegetables are a good, cheaper alternative to fresh produce, as long as there’s no added sugar, syrup or salt.

Limit unhealthy drinks and snacks like chips, cookies, candy and gummies. Encourage children to drink water instead of soda, juices or sports drinks.

“As parents, we need to understand that a healthy diet and exercise provide great benefits to our children’s minds and bodies,” Samuel said. “Many kids are stressed right now due to all of the uncertainty surrounding Covid-19, and doing regular exercise is a great way to relieve stress and develop healthy habits at a young age.”

Adequate sleep is also crucial in preventing obesity: eight to 10 hours a night for teens and nine to 12 hours a night for children ages six to 12. Reducing screen time can also help lower the risk of becoming overweight.

“Later bedtimes have been shown to be associated with obesity, so putting the devices away at a reasonable bedtime and getting back to a more typical sleep schedule is another way to combat obesity,” Samuel said.

Image credit: iStock

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Health24.com | Simply smiling may boost your outlook

  • Participants in a study clenched a pen between their teeth to replicate a smile
  • It was found that this ‘fake smile’ caused participants to view things in a more positive light
  • This has great implications for those suffering from mental health issues like anxiety and depression

Smiling can trick your mind into being more positive, according to a new study.

Researchers at the University of South Australia found that the simple act of moving your facial muscles into a smile can make you view the world more positively.

“When your muscles say you’re happy, you’re more likely to see the world around you in a positive way,” said lead researcher Fernando Marmolejo-Ramos, a human and artificial cognition expert at the university.

The motions of a smile

He and his colleagues studied how people interpret various images of facial and bodily expressions that range from happy to sad, based on whether or not they were smiling themselves.

The study involved 256 volunteers from Japan, Poland, Spain and Sweden. Participants were asked to hold a pen between their teeth, an act that forces facial muscles to replicate the motions of a smile.

They were then shown images of facial expressions that ranged from frowning to smiling, and videos of a person walking in different positions, ranging from “sad walking” to “happy walking”.

The participants viewed each image or video with and without a pen in their teeth, and then evaluated if the evoked emotion was “happy” or “sad”.

The researchers observed that the participants were more likely to view a broader range of the images and videos as “happy” when smiling themselves.

Interesting implications

“In our research, we found that when you forcefully practice smiling, it stimulates the amygdala – the emotional centre of the brain – which releases neurotransmitters to encourage an emotionally positive state,” Marmolejo-Ramos said in a university news release.

The results suggest that everyone, and particularly those suffering from mental health issues like anxiety and depression, may benefit from the simple act of smiling.

“For mental health, this has interesting implications. If we can trick the brain into perceiving stimuli as ‘happy,’ then we can potentially use this mechanism to help boost mental health,” Marmolejo-Ramos said. “A ‘fake it till you make it’ approach could have more credit than we expect.”

The study was published recently in the journal Experimental Psychology.

Image credit: iStock

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Coronavirus testing: What’s going wrong?

Empty testing centres, overstretched labs and rising demand – what is behind the UK’s problems?

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How to Invite Emotional Consent

In my previous post, I addressed the importance of emotional consent. In this post I’ll share how to ask for emotional consent when you want to have a heart-to-heart with someone.

It’s pretty straightforward in terms of the words. The intention behind it is what matters most.

You could start with a line like this:

  • I want to share my thoughts and feelings about ___.
  • Something’s really bothering me, and I’d like to discuss it with you.
  • I’m feeling stressed/worried/anxious/____.
  • I’m stuck on ____.
  • I’d love some help with ___.
  • I had a really difficult experience a while back.
  • There’s something I think you should know about me.

Then add something like this:

  • Is this a good time?
  • Can we have that kind of discussion?
  • Do you want to hear about it?
  • Is it okay if I tell you about it?
  • Are you in a good place to hear about this now?
  • When would be a good time to talk about this? (if it’s already a normal part of your relationship to have these discussions, so there’s at least some pre-consent for that)
  • I need to vent my feelings to someone… can you play that role for me?

And then if the other person consents willingly, you can have that kind of discussion.

It’s also important to let the person be free to withhold consent or to get clarification, so honor their choice if they follow up with something like this:

  • This isn’t a good time. How about ____?
  • I’m not up for that. Maybe you could discuss this with ____ instead?
  • How deep do you want to go?
  • Do you need a certain kind of response?
  • Are you wanting empathy and understanding, a solution to a problem, both, or something else?
  • Unfortunately I’m too tired/distracted to do that now, so I don’t think I can be a good listener at this time. I hope you understand. How about ____?
  • Do you sense this would be a 20-minute discussion or a 2-hour one?
  • If I’m not available, how would you handle this instead?
  • What’s your intention for such a conversation?

The words are just to give you some examples. It’s best to use your own words and match them to the situation and to how you feel.

What’s important here is that you invite the other person to enter freely into an emotional discussion or connection with you. Don’t demand it. Don’t assume that you’re entitled to it. Don’t try to make the other person wrong for declining. Give the person space to say yes or no without trying to box them in. Think abundance here, not scarcity, even if you’re feeling emotionally needy.

If you make emotional invitations with a hidden agenda or some attachment to how the other person responds, you’ll probably pick up some resistance when making such invites, especially in the person’s tone of voice or body language. People can often sense when you’re trying to manipulate them instead of honorably asking for their help.

Some people are really good at this. They respect that sharing emotional intimacy can be risky or draining, and they know it’s best if the other person can say yes genuinely and not feel baited or trapped.

Other people could definitely stand to improve in this area, especially by letting go of entitlement and attachment to outcomes.

Hearts connect best when they choose each other freely, not when one tries to manipulate or control the other.

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Coronavirus: Trial urges people to call 111 before going to A&E

The pilots aim to help hospitals cope with winter pressures, including coronavirus and flu.

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People’s life goals relate to their personality type

In the first research of its kind, a new University of California, Davis, study suggests that for the most part, people formulate goals consistent with their personality traits — and an individual’s goals are related to how their personality subsequently changes over time.

The study surveyed more than 500 students when they started college, each year during college, and 20 years later on their goals related to being creative, having a successful career, having a family, being wealthy, or being active in religion or politics. The goals of these UC Berkeley students — about half were still responding after two decades — remained relatively stable over time, though there were some notable changes.

“This study was a unique opportunity to examine how individuals’ personalities and major life goals were related to each other across two decades of life,” said Olivia E. Atherton, the lead author of the study and former doctoral student in psychology at UC Davis. “We found that, in many ways, one’s personality shapes the types of life goals that are valued, and as a result of pursuing those goals, personality changes.”

Successful people stress goals

Various enormously successful people, such as Albert Einstein, have noted the importance of goals, researchers said. Einstein once said, for example: “If you want to live a happy life, tie it to a goal, not to people or things.” The personality characteristics he possessed were likely the driving force behind the types of goals he aimed to achieve, researchers said.

“Einstein’s tendency to be creative, curious, and intellectual likely fueled his scientific goals, as well as his more aesthetic goals, such as his passion for playing the violin,” the study authors wrote.

The study, “Stability and Change in Personality Traits and Major Life Goals from College to Midlife,” was published in late August in the Personality and Social Psychology Bulletin.

Besides Atherton, co-authors include Richard Robins, a professor of psychology who is director of the UC Davis Personality, Self and Emotion Lab; as well as Emily Grijalva, University of Buffalo; and Brent W. Roberts, University of Illinois, Urbana-Champaign.

The personality traits examined in the present study are termed the “Big Five” in psychology. They are neuroticism, extraversion, openness to experience, agreeableness and conscientiousness. These five traits broadly capture most of the ways in which people differ from one another, and they are related to a wide range of important life outcomes.

Researchers examined these traits, along with aesthetic goals (wanting to be creative and artistic); economic goals (wanting to have a successful career and be wealthy); family/relationship goals (wanting to be married and have children); hedonistic goals (wanting to have fun and experience pleasure); political goals (wanting to have influence in public affairs); religious goals (wanting to participate in religious institutions); and social goals (wanting to help others in need).

.” .. We found that, on average, individuals increased in agreeableness and conscientiousness, decreased in neuroticism, and showed little change in openness to experience and extraversion from age 18 to 40,” researchers said.

Some goals become less relevant

They also found that people place less importance on all goals over time, suggesting that individuals winnow the goals they value with age, presumably because they are achieving milestones associated with those goals and thus, the goals become less important as a result.

“By identifying their own personal strengths and limitations, middle-aged adults may place less importance on certain major life goals because some goals may no longer be viewed as self-relevant,” researchers said.

The authors did find that personality traits are related to major life goal development over time. For example, individuals who become more agreeable, kind and compassionate, also tend to place more emphasis on social and family/relationship goals over time. And, individuals who become more responsible, organized and self-controlled tend to value more economic and family goals.

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Epidemics and pandemics can exacerbate xenophobia, bigotry

When viruses, parasites and other pathogens spread, humans and other animals tend to hunker down with immediate family and peer groups to avoid outsiders as much as possible.

But could these instincts, developed to protect us from illnesses, generalize into avoidance of healthy individuals who simply look, speak or live differently?

Jessica Stephenson, an assistant professor in the Department of Biological Sciences in the Kenneth P. Dietrich School of Arts and Sciences, coauthored a paper exploring the answer, which was recently published in the Proceedings of the Royal Society of London, Series B.

One example noted in the study showed that black garden ants exposed to a fungus clustered together in groups much smaller than researchers could predict by chance, which effectively limited the spread of disease. Similar behaviors seen among 19 non-human primate species were also credited for lowering direct spread of parasites.

Human beings share these same biological impulses to separate into modular social groups. However, when pathogens are spreading, humans tend to also adopt a set of behaviors that are “hypervigilant and particularly error prone,” the researchers wrote.

“It’s interesting and really disappointing,” Stephenson said. And as COVID-19 continues its spread, humans are even more susceptible to the impulse.

“During epidemics, humans tend to become overly sensitive, so any sort of physical abnormality that somebody has suddenly becomes a potential indicator of infection. We become much more bigoted, we pay way more attention to things that differentiate people from what we perceive as our own phenotype. People who look different from us and sound different from us, which, of course, leads to a lot more xenophobia,” said Stephenson, who runs Stephenson Lab of Disease Ecology and Evolutionary Parasitology at Pitt.

A prior Stephenson study published in The Royal Society Biology Letters in November 2019 outlined how individuals differ in their response to potential contagion. In both humans and the guppies she studied, the individuals most susceptible to the disease showed the strongest avoidance.

During that study, male guppies were placed in a large tank, flanked by a smaller one containing a group of three female guppies that were visibly infected with parasites. Many males preferred to spend time near the female guppies, despite the risk of contagion. But some male guppies strongly avoided the other fish. The socially distant male guppies were later shown to be highly susceptible to worm infections.

Stephenson said human beings are generally “normal social animals in many of our behavioral responses to infectious diseases.” But, if humans choose social urges over infection control, efforts such as global disease surveillance and centralized public health responses could be wasted, she said.

“That the vast majority of our species has largely squandered the potential payoffs of these benefits is again consistent with other social animals: the cost of social distancing itself can outweigh the cost of contracting the disease,” Stephenson said.

But humans have a leg up on fish: access to information and means of virtual communication. Stephenson’s 2020 study noted that synchronous communication, virtual or not, can mitigate some of the effects of confinement. Computer-mediated discussions can also promote more equal participation from minority groups.

“For some, no amount of Zoom and FaceTime can make up for the lost benefits of social interactions. These frustrating, if wholly natural, behavioral decisions will result in the persistence of COVID-19 until the advent of perhaps our greatest advantage over other species facing emerging infectious diseases: vaccination.”

“We shouldn’t discriminate against different groups in our social distancing, or in our efforts to work together to beat the virus,” she added. “But I think our natural, evolved tendencies would be to associate only within our ingroups. We have to fight that natural antipathy towards people who differ from ourselves, and not shut down.”

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