Becoming Aware of Your Reflections

Once when I was going through customs at the airport in Winnipeg, Canada to visit Rachelle, I got pulled aside for extra questioning. The suspicious young agent somehow convinced himself that I was on an errand of ill intent and interrogated me about my reasons for visiting. He went through the files on my laptop, searching for evidence of illegal activity. He read through the recent text messages on my cell phone. Much to his chagrin, I wasn’t actually crossing the border to destroy Canadian society, so he came up empty handed and grudgingly waved me through, although for good measure he gave me a bonus lecture about the risks of doing anything illegal while visiting Canada.

I felt mostly creeped out afterwards, as if I someone had just vomited fear into my personal energy matrix. It took me several hours to slough off those feelings. Fortunately hanging out with Rachelle and the other nice people of Winnipeg was all it took to bring me back up again.

At the time I blamed that event on the overzealous agent, but if I look back on it now, I can interpret the whole experience as a reflection – and perhaps an amplification – of my own thoughts and beliefs at the time.

Even before I got to that agent, I approached the customs area with a suspicious vibe. I didn’t trust the agents, so when I was asked about the reasons for my visit, I gave a vague answer – “tourism” – which of course made the guy suspicious that I was hiding something. Who travels from Las Vegas to Winnipeg for tourism?

If I’d been a tad less suspicious and a bit more open with the agents, I probably wouldn’t have been subjected to the extra grilling.

I’ve seen similar patterns echoed back to me through blogging as well. When I’d write about a topic while feeling guarded about getting a negative reaction, my posts would attract plenty of criticism and judgmental responses. But when I fully owned what I was writing about, and I felt unattached to how people would react, there usually weren’t any negative responses to speak of.

I’m reminded of an episode of Star Trek: The Next Generation where the ship is being shaken by energy waves of increasing magnitude, and the waves are getting so strong that they’re about to tear the ship apart. But it turned out that the ship’s own shields were causing these violent waves. The waves were proportionate reflections of the shield energy. Once the shields were dropped, the waves stopped, and the ship was no longer in danger.

One important zone of clarity is your relationship with reality. Reality will often reflect back to you what you put out, even when you’re unaware of this relationship. I think it would be an exaggeration to say that this happens with a magical degree of perfect balance, but the effect is there nonetheless.

Occasional missteps aren’t usually such a big deal, but if you see recurring patterns in what reality seems to be reflecting back to you, consider that you may actually be creating these effects more powerfully than you previously realized.

When you identify a recurring result in your life that you don’t feel aligned with, pause now and then to ask yourself, How am I creating this? Don’t ask this question with an attitude of blame but rather with an attitude of curiosity. Consider the possibility that your own thoughts or actions are causing or contributing to these outcomes.

Suppose, for instance, that you keep encountering a significant lack of social support in your life. Maybe everyone around you seems indifferent to your goals, and no one seems to lift a finger to help you. You may believe that you’re taking positive actions such as behaving gregariously and generously with other people. You may believe that you’re a good person, that you have worthy goals, and that you deserve some help. But if you privately feel distrustful of people, if you’re pretending to care about helping others but you don’t really care that much, or if your thoughts are otherwise out of alignment with the outcome you seek, then you can expect that people will subtly pick up on your true intentions, and they may respond with some resistance in return.

You’ll likely find it easier to spot these waves of reflection in other people. Perhaps someone tells you about a persistent problem they’re having, and it’s abundantly obvious to you how this person is creating that very problem. You may think to yourself, Well… duh! Of course that’s what you’re going to experience. Meanwhile the person remains completely oblivious to the causal links between thoughts, actions, and results.

You may also know that if you share your honest impressions with the person, they’ll probably be surprised, insulted, or defensive. They’re unlikely to see what you’re seeing. They’re too close to the situation to see it through the lens of self-created reflections coming back to them. So you may offer up a polite response instead.

I think it’s wise to assume that you’re also blind to many of your own self-created reflections. What you’re experiencing from life is in many ways just basic feedback regarding what you’re putting out.

Now the mistake people make here is to attempt to alter the reflections by doing even more of what caused them in the first place.

As I dealt with the overzealous border agent, I became increasingly annoyed with him. I asked if he could speed up the process, suggesting that I had more important things to do (like hang out with friends). I made facial expressions and shifted my body language to overtly communicate my irritation with his behavior. I did even more of what invited these reflections in the first place. Did this help my situation? Of course not. It simply motivated the agent to hold me up longer as he searched in vain for evidence of increasingly far-fetched breeches of Canadian law.

Have you ever done something similar by doubling down on an approach that clearly isn’t working?

When life threatens you with a financial problem, do you tighten up and go even deeper into the scarcity mindset that gave rise to this problem in the first place? Or do you use the challenge as an invitation to shift into abundance mode, such as by being more generous than usual?

When you’re stressed at work, do you procrastinate even more, thereby amplifying the stress? Or do you turn towards relaxation and find a way to play your way through the work instead?

If you go deeper into the thoughts, feelings, and energy patterns that give rise to your problems, you’ll attract more and bigger versions of those same problems. You’ll be like the character in that Star Trek episode who keeps calling “more shields, more shields, more shields” till the ship is about to be torn apart, never realizing that the shields are causing the problem.

Which persistent problems in your life might you actually be creating? Is it possible that you’re creating financial scarcity by acting like a financially scarce person would? Is it possible you’re creating social disconnection? Is it possible you’re creating the health status of your body? Again I’m not suggesting 100% perfect causality here, but can you entertain the possibility that your own thoughts and behaviors may be contributing to your results?

You may not learn the real truth until you deliberately shift your patterns of thought and behavior and give yourself the opportunity to see different patterns being reflected back. That’s when it will finally dawn on you that you’ve been playing a major role in creating your experiences all along. It’s when you break the old patterns and try something incongruent with your previous mindset that you can finally see the causal links that were previously hidden to you.

I suggest that you start small here. Test this idea when it doesn’t feel super critical. When you’re experiencing scarcity, try donating a small amount of money online to a cause you like. When you’re bored at work, play one of your favorite songs, shake out your body, and take a dance break for a few minutes. When you’re feeling angry, try sending someone a thank you note. If you don’t like the outcomes you’ve been experiencing, try setting a radically different cause in motion, and see how it affects your results.

Turn towards the patterns that feel more loving and more powerful to you, even if you can only manage this for a short time. When you disrupt your previous patterns, you’ll also raise your awareness of the old reflections you’ve been serving up unconsciously. And this will help you step into a zone of power that lets you change those patterns – and improve your results too.

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Health24.com | Fish oil supplements might help men become dads

Couples struggling to get pregnant might want to add a little more fish in their diet, a new study says.

Young men who take fish oil supplements appear to have better sperm quality and higher testosterone levels than those who don’t, as well as larger testicles, researchers report.

Better sperm count

Although it wasn’t tested as part of the study, all these male reproductive factors should lead to overall improved fertility in young men taking fish oil, said lead researcher Tina Kold Jensen, a professor of environmental medicine at the University of Southern Denmark.

“Because they have a better sperm count, as a group they would have a better chance of fertilising an egg,” Jensen said.

Fertility supplements haven’t always had a great track record.

For example, supplements containing zinc and folic acid don’t appear to boost male fertility despite their reputation, according to a study published this month in the Journal of the American Medical Association.

And this latest study can’t prove a direct cause-and effect link between fish oil and the improvements in sperm counts and testosterone levels, much less an improvement in overall fertility, noted Albert Salas-Huetos, a postdoctoral researcher of male infertility at the University of Utah School of Medicine in Salt Lake City.

“With one observational study, it’s impossible to recommend fish oil to a general population,” said Salas-Huetos, who wrote an editorial accompanying the study. “Well-designed randomised clinical trials are necessary to establish a causal relationship.”

A lot of omega-3

The study and editorial were published in the journal JAMA Network Open.

But there’s reason in the data to believe that the omega-3 fatty acids in fish oil had a direct effect on sperm count and testosterone levels, Jensen argued.

Sperm cells contain a lot of omega-3 fatty acid, so it would make sense that increasing your intake would lead to healthier sperm, Jensen said.

The study involved nearly 1 700 young Danish men who reported for a compulsory medical examination between 2012 and 2017 to determine their fitness to serve in the military.

“They were healthy 18- or 19-year-old men with no diseases and no knowledge of their fertility,” Jensen said. The researchers offered the men $74 to complete an additional questionnaire and provide semen and blood samples.

About 6% of the men reported using fish oil supplements within the past three months, and half of those said they’d taken them 60 or more days during that period, researchers said.

Same effect in older men

These men had significantly higher semen volume and total sperm count, researchers found.

Interestingly, the study found no significant difference in sperm quality when they looked at men taking other sorts of daily supplements, Jensen said.

“The men who took multivitamins or B vitamins or C vitamin didn’t have the same effect,” Jensen said. “To me, that points to the fact that it could be the fish oil and not just the healthiness of the men or their healthier lifestyle.”

Jensen added that she would expect to see the same effect in older men taking fish oil supplements

Two previous clinical trials found that older men had better sperm counts after 14 weeks of eating nuts as a means of improving their omega-3 intake, Jensen said.

Jensen said she would definitely recommend taking fish oil supplements to try and improve male fertility.

Sperm quality declines

“It would be even better to eat more fish, to make sure you have a healthy diet with a lot of fish included,” Jensen said.

While he stopped short of a recommendation, Salas-Huetos said the new study is an important step in figuring out the factors that influence male fertility.

“As you know, human sperm quality has declined worldwide in the last 50 years,” Salas-Huetos said. “It’s really important to find the factors that are associated with human semen decline.”

Pollution, smoking, alcohol, lack of physical activity, stress and unhealthy diets have been associated with a decline in semen quality, Salas-Huetos said.

Image credit: iStock

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Health24.com | 6 weight loss strategies that’ll get you closer to your #BodyGoals

If you, like tons of other women around the world, are hell-bent on finally winning the weight loss battle in 2020 then you’re going to have to approach it more deliberately and with a tight strategy.

But first thing’s first: don’t beat yourself up for not staying the course last year. There’s nothing wrong with going right back to the start and taking it from there. As long as you’ve still got time and energy, you haven’t let yourself down yet.

And I don’t know about you, but there’s an extreme sense of newness in 2020 — it feels like the year that we’re all finally going to knuckle down, get our ducks in a row, our goals in order and finally win the wars we’ve been fighting in ourselves.

READ MORE: 9 Common Mistakes People Make When It Comes To Weight Loss, According To A Celeb Trainer

With that said, life coach and author Paula Quinsee reckons that there’s very little you can achieve without the right mindset and the right strategies in place.

“With the right mindset and a solid plan, there are very few things you can’t achieve — this is the starting point of any goal,” she says.

We asked her to help us unpack some of the most effective strategies we can use to make this year different… to finally get to the finish line of the weight loss race.

1/ Understand your why

If you’re not clear on why weight loss is your goal, then your motivation to achieve it won’t stand firm.

“People need to understand the why behind their goals,” Quinsee says. “Yes, you might want to lose weight but it’s not so much about the goal than it is about what the goal will do for you.”

In a sense, losing weight is only but a vehicle that’s taking to you to where you want to be. And your why can be anything — you might want to lose weight to feel more confident, get healthier, become more energetic for your kids and so on. If it matters to you, it is valid.

2/ Set a realistic time frame

Working towards a goal aimlessly and with no time frame leaves a lot of room for excuses. A deadline, so to speak, not only encourages some form of discipline, but it’s also important for helping keep track of your progress (we’ll get to why this matters in a moment). But in setting those time frames, it’s also vital that they are realistic for the way that your life is set up.

“Giving yourself an unrealistic time frame for your goal is setting yourself up for failure,” Quinsee explains. “You will end up feeling disappointed, let down and the self-blaming and loathing can derail you from the entire goal itself.”

3/ Break your goals down into smaller ones

We’re always told to dream big and what makes a big dream attainable? All the smaller dreams in between and all the little wins that eventually lead us to our big picture.

“Often, people look at the big goal and they get overwhelmed by it. But if you break a goal down into much more manageable bite-size chunks, then you will find that the process becomes a lot less daunting,” Quinsee says.

4/ Set yourself up for success

It’s important to know and be extremely conscious of your weaknesses, and to make sure your strategy includes things that work around them.

“If you know that you’re not a disciplined person when it comes to exercise then make sure that you set yourself up for success by getting a personal trainer,” Quinsee says. “In that way, you will know that someone is always holding you accountable. This could even be a workout buddy or anyone that can help support, motivate and encourage you throughout.”

5/ Always track and measure your progress

A lot of the time we’re so busy focused on the goal that we miss how far we’ve come in our journey, how much we’ve achieved and the progress that we’ve made.

“Every small little step forward is success and it’s so important to not only note, but to celebrate those little victories and small signs of progress,” Quinsee says. “The acknowledgement of these is what will keep you going.”

6/ Put incentives in place

A strategy that works really well is creating a personal rewards system for every time you achieve a small goal or objective.

“You can even reward yourself for just being disciplined and attending all the workout classes you planned to attend that week,” Quinsee says. “The key is to always seek out the positive sides of your experience and to acknowledge them.”

This article was originally published on www.womenshealthsa.co.za

Image credit: iStock

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China coronavirus: UK tests come back negative

A total of 31 tests have concluded and there are no confirmed cases in Britain, government says.

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Can lithium halt progression of Alzheimer’s disease?

There remains a controversy in scientific circles today regarding the value of lithium therapy in treating Alzheimer’s disease. Much of this stems from the fact that because the information gathered to date has been obtained using a multitude of differential approaches, conditions, formulations, timing and dosages of treatment, results are difficult to compare. In addition, continued treatments with high dosage of lithium render a number of serious adverse effects making this approach impracticable for long term treatments especially in the elderly.

In a new study, however, a team of researchers at McGill University led by Dr. Claudio Cuello of the Department of Pharmacology and Therapeutics, has shown that, when given in a formulation that facilitates passage to the brain, lithium in doses up to 400 times lower than what is currently being prescribed for mood disorders is capable of both halting signs of advanced Alzheimer’s pathology such as amyloid plaques and of recovering lost cognitive abilities. The findings are published in the most recent edition of the Journal of Alzheimer’s Disease.

Building on their previous work

“The recruitment of Edward Wilson, a graduate student with a solid background in psychology, made all the difference,” explains Dr. Cuello, the study’s senior author, reflecting on the origins of this work. With Wilson, they first investigated the conventional lithium formulation and applied it initially in rats at a dosage similar to that used in clinical practice for mood disorders. The results of the initial tentative studies with conventional lithium formulations and dosage were disappointing however, as the rats rapidly displayed a number of adverse effects. The research avenue was interrupted but renewed when an encapsulated lithium formulation was identified that was reported to have some beneficial effects in a Huntington disease mouse model.

The new lithium formulation was then applied to a rat transgenic model expressing human mutated proteins causative of Alzheimer’s, an animal model they had created and characterized. This rat develops features of the human Alzheimer’s disease, including a progressive accumulation of amyloid plaques in the brain and concurrent cognitive deficits.

“Microdoses of lithium at concentrations hundreds of times lower than applied in the clinic for mood disorders were administered at early amyloid pathology stages in the Alzheimer’s-like transgenic rat. These results were remarkably positive and were published in 2017 in Translational Psychiatry and they stimulated us to continue working with this approach on a more advanced pathology,” notes Dr. Cuello.

Encouraged by these earlier results, the researchers set out to apply the same lithium formulation at later stages of the disease to their transgenic rat modelling neuropathological aspects of Alzheimer’s disease. This study found that beneficial outcomes in diminishing pathology and improving cognition can also be achieved at more advanced stages, akin to late preclinical stages of the disease, when amyloid plaques are already present in the brain and when cognition starts to decline.

“From a practical point of view our findings show that microdoses of lithium in formulations such as the one we used, which facilitates passage to the brain through the brain-blood barrier while minimizing levels of lithium in the blood, sparing individuals from adverse effects, should find immediate therapeutic applications,” says Dr. Cuello. “While it is unlikely that any medication will revert the irreversible brain damage at the clinical stages of Alzheimer’s it is very likely that a treatment with microdoses of encapsulated lithium should have tangible beneficial effects at early, preclinical stages of the disease.”

Moving forward

Dr. Cuello sees two avenues to build further on these most recent findings. The first involves investigating combination therapies using this lithium formulation in concert with other interesting drug candidates. To that end he is pursuing opportunities working with Dr. Sonia Do Carmo, the Charles E. Frosst-Merck Research Associate in his lab.

He also believes that there is an excellent opportunity to launch initial clinical trials of this formulation with populations with detectable preclinical Alzheimer’s pathology or with populations genetically predisposed to Alzheimer’s, such as adult individuals with Down Syndrome. While many pharmaceutical companies have moved away from these types of trials, Dr. Cuello is hopeful of finding industrial or financial partners to make this happen, and, ultimately, provide a glimmer of hope for an effective treatment for those suffering from Alzheimer’s disease.

Story Source:

Materials provided by McGill University. Note: Content may be edited for style and length.

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Health24.com | Real talk: Does pooping affect weight loss?

Anyone who has ever hit the bathroom at Makro to emerge a new person has probably wondered (beyond “What is it about this place?”) whether pooping actually affects weight loss.

It’s a fair question. A nice, productive poo (I think you know what I’m talking about without me having to describe) can make you feel lighter and leaner and more comfortable in your jeans. Being “stuck” (a.k.a. constipated) makes you feel… the opposite. But is that lighter feeling after pooping real?

Turns out, it can be — but only a bit, says dietician Mitzi Dulan, author of The Pinterest Diet. “It’s actually fairly simple,” she says. “Depending on your size and how regular you are, your poo can vary from 450g to 1.8kg. It’s likely to be on the higher end if you haven’t pooped for a few days.”

Wait… how much does poo weigh?

If you’re thinking, “Four 1.8kg, seriously?!” I get it… that’s not exactly a small amount if you’re struggling to lose weight. But you have to remember that your poo is made up of some pretty heavy stuff: Specifically, it’s about 75 percent water, per UMass Memorial Healthcare, with the rest being composed of bacteria, mucous, dead blood cells, and duh, food remains.

READ MORE: 10 Ways To Make Yourself Poop First Thing In The Morning

That said, you have to think big picture here. Even 1.8kg isn’t a significant amount of weight at the end of the day, since the number on the scale will consistently swing up and down as your bowel movements do. In other words, when you’re backed up, your weight will increase a bit, and after you relieve yourself, it’ll drop.

Either way, pooping won’t affect your weight in any huge way — even if it does feel like you just dropped five kilos. That amazing feeling is more about de-bloating than actual loss of body mass. Sorry!

Oh, tell me more about weight loss versus de-bloating.

Bloating is that awful, uncomfortable, full feeling that strikes when your digestive system has trapped air or gas inside it, and it can be downright painful, not to mention make you look puffy AF. Even though your stomach might appear bigger when you’re bloated, bloating doesn’t necessarily mean you’ve gained actual weight (in terms of body mass).

“Pooping can reduce bloating and help you fit more comfortably in your clothes so you feel smaller overall,” says Dulan. “It’s not like after you poo you should be saying, ‘This is my new weight!’”

If you’re trying to track weight loss, Dulan suggests weighing yourself at similar times in the morning, sans clothes, to avoid letting your poos (or lack thereof) trick the scale. “If you have to go to the bathroom, go ahead because it will lower the scale a little bit,” she says. “But if you don’t need to poo, don’t sit on the toilet trying to go so you weigh less. It won’t be a substantial difference.”

Ah, so what affects my ability to poo?

While the direct connection between pooping and weight loss is minimal (again, sorry!), there is one aspect of the link that you can use to your benefit: “Eating a diet that’s higher in fibre causes you to not only be more regular, but it can also help you lose weight,” says dietician Brigitte Zeitlin, a nutritionist at B Nutritious.

How so? Stocking up on enough fibre throughout your day helps push food through your system to avoid constipation before it starts. “It actually stimulates your GI tract to promote movement,” says Zeitlin. Beyond that, a high-fibre diet may help ward off certain cancers, especially that of the colon, and help regulate blood sugar and reduce cholesterol, studies show.

READ MORE: The 12 Best Foods For When You’re Super-Constipated

And when it comes to your weight, fibre fills you up like few nutrients can. “Fibre is found in three things: fruits, vegetables and whole grains,” says Zeitlin. “If you’re incorporating fibre at every meal and snack, you’re making sure you’re eating one of these fabulous foods that promote weight loss and a healthy lifestyle. In addition, you’re probably removing other things that aren’t as great [from your diet].”

That said, don’t overdo it on the F word: Zeitlin recommends women aim for 25 to 30 grams of fibre per day, because getting much more than that can not only constipate you but cause other GI distress symptoms, too.

According to Duke University, regularly consuming more than 70 grams of fibre may lead to bloating, gas, diarrhoea, cramps and a decrease in appetite. Eating too much fibre can also limit nutrient absorption and even cause intestinal blockages (that’s pretty serious stuff).

To get a healthy amount of fibre every day, try having a cup of a high-fibre food as part of your breakfast, like a cup of berries with Greek yoghurt (it’s high in probiotics, which “promote healthy GI bacteria to help move things along,” says Zeitlin). You should also aim to eat two fistfuls of veggies at both lunch and dinner to keep your digestive system — and your weight — as regular as possible.

Oh, and don’t forget about all the other stuff you do all day that affects how often you poo (fibre is just one piece of the puzzle!). As WH previously reported, you might find yourself pooping less frequently if you:

  • don’t drink enough water
  • forget to manage your stress levels
  • change your schedule or travel frequently (hi, holiday constipation)
  • experience hormonal changes (thanks to PMS, pregnancy, or menopause)
  • take certain OTC or prescription medications
  • change up your diet or caloric intake
  • don’t engage in regular physical activity

Of course, the reverse of all these factors is true, too; some medications can make you poo more often, as can your overall activity/hydration/caffeine levels. It’s all one big balancing act.

So how do I find my “normal”?

If you’re hoping for an exact number of bowel movements that’s considered “healthy” or “normal,” so sorry (gosh, I keep apologising here). There is no one number, because the range of normal varies from person to person. Anywhere from three times a day to once every three days is generally considered healthy, so as long as you fall somewhere along that spectrum (and aren’t experiencing anything painful or out of the ordinary), you’re good.

READ MORE: 6 Reasons You’re Seeing Blood On Your Toilet Paper

Now, if you are experiencing something painful or out of the ordinary, you should contact your doctor. Depending on the issue, he or she may refer you to a gastroenterologist. According to Penn Medicine, having the following symptoms for any extended period of time (i.e. more than a few days) warrants a phone call or visit:

  • consistently off-coloured poo (like pale, red, or black stool) or colour changes not related to new dietary habits
  • sudden changes to the frequency of your bowel movements
  • bloody stool
  • severe abdominal pain while pooping
  • poo that floats (which can be a sign of infection)
  • poo that smells unusual or especially odorous

The bottom line? It’s important to know that a slowdown in your regular bathroom habits may make you feel like you’ve gained a bunch of weight, but that’s really not the case. A combination of bloating and discomfort — along with a couple extra grams of poo — can make the situation seem more dire than it actually is.

When you do finally go, you’ll feel lighter than air… but you’ll still only weigh a leeeettle less than before. So if weight loss is your goal, you’ll need to think outside the bathroom — good thing WH is here for that!

This article was originally published onwww.womenshealthsa.co.za 

Image credit: Unsplash/Tim Mossholder

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China coronavirus: Death toll rises as disease spreads

Fifteen more people have died from the virus in China, as the country celebrates Lunar New Year.

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NHS staff urged to help service tackle climate change

Staff are encouraged to drive to work less and bring in reusable cups and bottles as part of NHS climate plans.

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Honoring Negative Predictions

There are situations in life where we develop fairly consistent negative predictions regarding how those situations will turn out, but then we don’t actually honor those predictions.

For instance, suppose you’ve had some corporate jobs, and they’ve never turned out well for you. You never really liked them. They’ve never put you in situations where you’ve deeply enjoyed your work each day and where you’ve felt aligned with the company’s purpose. Suppose that something about these jobs always felt off to you.

And suppose that currently you find yourself unemployed and wanting some income. Does it make sense to apply for another corporate job?

If you repeat this type of experience again, it may yield some income for you, but it will likely hurt your sense of clarity because you’ll be deliberately acting in opposition to the clarity you’ve already developed. You already know this isn’t likely to lead to a positive outcome. You’re already able to predict that the outcome won’t be very good.

So why would you repeat what’s likely to be a predictable mistake? Why would you make a deliberately bad decision like this?

Well… note that you can still do this. People do such things often. But you also have to accept that if you’re willing to do this, it absolutely will hurt your ability to have clarity. How can you possibly hope to have more clarity if you’re failing to act in alignment with the clarity you’ve already achieved?

If you desire clarity, then clarity must become a high value in your life. You have to elevate it to a level of importance and keep it there.

Otherwise if something else is more important to you than clarity, such as having a stable job, you’ll keep going back to the stable job even if it degrades your experience of clarity. Or if you need a relationship more than you need clarity, you may often find yourself in a confusing relationship.

One obvious way to improve your experience of clarity is to stop doing whatever opposes your current best predictions. Stop taking those actions that give you a negative outcome, which you’ll perceive as a negative internal reaction.

This doesn’t mean that you have to avoid every negative situation. Just start avoiding the most predictable ones. Stop taking the actions that you already know aren’t going to lead to positive outcomes with positive internal reactions.

The sheer obviousness of this stares us right in the face, doesn’t it?

How can you expect to discover foods you like if you always keep eating foods you already know you don’t like? It’s never going to happen. You’ll never get clarity about the foods you love if you’re wasting time eating what you don’t like. The way out of this trap is to stop eating the foods you don’t like. Reject them soundly. Honor your best predictions.

What would happen to a kid who adamantly refused to eat certain foods that she didn’t like? Eventually the parents would get a clue and would stop offering her those unwanted foods. And then she’d have a much better chance of being offered foods that she actually liked. This isn’t particularly complicated, right? Just say no to what you don’t want, and you’ll have a better chance of getting what you do want.

But what if this same child doesn’t object. Or what if she only puts up some token resistance and then eventually caves in and grudgingly accepts the unwanted food? Well… most likely the parents will keep offering her that same food in the future, right? If they learn that she tolerates it, then she’ll be given more of what she tolerates.

Moreover, if the parents keep giving her tolerable but still mostly undesirable meals, then what chance will she have of discovering more desirable foods? Very little, unless some outside force disturbs the situation.

Are you succumbing to this pattern in any areas of your life?

Are you tolerating a job that you don’t really like?

Are you tolerating a relationship that isn’t what you actually want?

Are you tolerating living in a city that you don’t like living in?

If you’re doing anything along those lines, then here’s a big dose of clarity for you. As long as you’re willing to keep doing those things – as long as you’re willing to tolerate these situations – you’ll make it essentially impossible to improve your sense of clarity. You’re absolutely going to stay confused, and you’re very likely to keep experiencing what you don’t want.

That’s pretty much a given, isn’t it? How are you supposed to map out what you want while you’re still tolerating what you don’t want? Those paths are incompatible.

Is it absolutely guaranteed that if you leave such situations, you’ll find something better? Not quite. But it’s highly likely, especially if you haven’t explored much of the possibility space yet. If there’s an expansive space you haven’t explored yet, you have a good chance of finding something much better than the merely tolerable.

That said, you may have to explore a bit to find it. But isn’t it better to explore and have real hope of finding something better than not to explore and cling to irrational false hope?

The lesson here is both simple and unpopular. When you’ve figured out what you don’t want, stop doing it. Stop doing what’s similar to it as well. Say no loudly and proudly. You needn’t explain yourself. You needn’t apologize for your lack of interest. Just let your no be a no. This is critical if you ever hope to discover your bigger yes.

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Opioid dependence found to permanently change brains of rats

Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, published Jan. 14, 2020 in PNAS, researchers at University of California San Diego School of Medicine found that opioid dependence produced permanent changes in the brains of rats.

More specifically, researchers reported that dependence on oxycodone, a potent opioid painkiller, led to permanent neuro-adaptations of the central nucleus of the amygdala (CeA) at the level of the nociceptin system, a brainwide network that modulates transmission of pain. Downregulation or suppression of the nociceptin system in the CeA led to an increase in activation of GABA receptors in rats highly addicted to opioids. The discovery is consistent with previous findings reporting CeA neuroa-daptations after cocaine and alcohol dependence.

When researchers restored nociceptin levels in the CeA, it resulted in normalization of GABAergic transmission and a reduction of the rats’ opioid consumption.

“This suggests the nociceptin system may be a promising target for the treatment of opioid use disorder,” said senior author Giordano de Guglielmo, PharmD, PhD, assistant professor in the Department of Psychiatry at UC San Diego School of Medicine.

“To reveal the role of nociceptin in the central nucleus of the amygdala, we used a multidisciplinary approach with behavioral models, molecular biology and electrophysiology,” said first author Marsida Kallupi, PharmD, PhD, assistant professor in the Department of Psychiatry. “That allowed us to conclude that downregulation of this peptide may be partially responsible for excessive opioid addiction-like behaviors.”

Currently, opioid maintenance therapy is the first-line treatment for opioid dependence, which involves using alternative, less damaging medications, such as methadone, buprenorphine and naltrexone. These three drugs are the only treatments approved by the U.S. Food and Drug Administration, but all have limitations, either because they act against different receptors, pose safety concerns or are less effective due to the need for strict adherence to treatment.

Both methadone and buprenorphine target mu-opioid receptors in the brain. The new research builds upon past behavioral and neurochemical studies suggesting the nociceptin system and its receptors (NOP) are also involved in opioid tolerance and reward, addiction to multiple drugs and modulation of stress. Interestingly, while the research demonstrates that NOP is implicated in development of opioid dependence, it conversely blocks effects of morphine-based opioids.

De Guglielmo said several efforts are already underway testing small molecule drugs that target the nociception system, and have produced positive effects in reducing alcohol-seeking behaviors and biology in rats. The new findings indicate they may offer similar potential therapeutic benefit for opioid addiction.

Every day, according to the National Institute on Drug Abuse, more than 130 people in the United States die after overdosing on opioids. Two out of three drug overdose deaths involve an opioid. From 1999 to 2017, the last year for which data is available, almost 400,000 Americans lost their lives to opioids, with 47,600 fatal overdoses in 2017 alone. It’s estimated 2.1 million Americans have an opioid use disorder.

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Materials provided by University of California – San Diego. Original written by Scott LaFee. Note: Content may be edited for style and length.

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