Gene therapy blocks painful hereditary disorder

A single dose of gene therapy was enough to stop the painful swelling attacks caused by angiodema.

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Trees struggle to ‘breathe’ as climate warms

Trees are struggling to sequester heat-trapping carbon dioxide (CO2) in warmer, drier climates, meaning that they may no longer serve as a solution for offsetting humanity’s carbon footprint as the planet continues to warm, according to a new study led by Penn State researchers.

“We found that trees in warmer, drier climates are essentially coughing instead of breathing,” said Max Lloyd assistant research professor of geosciences at Penn State and lead author on the study recently published in Proceedings of the National Academy of Sciences. “They are sending CO2 right back into the atmosphere far more than trees in cooler, wetter conditions.”

Through the process of photosynthesis, trees remove CO2 from the atmosphere to produce new growth. Yet, under stressful conditions, trees release CO2 back to the atmosphere, a process called photorespiration. With an analysis of a global dataset of tree tissue, the research team demonstrated that the rate of photorespiration is up to two times higher in warmer climates, especially when water is limited. They found the threshold for this response in subtropical climates begins to be crossed when average daytime temperatures exceed roughly 68 degrees Fahrenheit and worsens as temperatures rise further.

The results complicate a widespread belief about the role of plants in helping to draw down, or use, carbon from the atmosphere, providing new insight into how plants could adapt to climate change. Importantly, the researchers noted that as the climate warms, their findings demonstrate that plants could be less able to draw CO2 out of the atmosphere and assimilate the carbon necessary to help the planet cool down.

“We have knocked this essential cycle off balance,” Lloyd said. “Plants and climate are inextricably linked. The biggest draw down of CO2 from our atmosphere is photosynthesizing organisms. It’s a big knob on the composition of the atmosphere, so that means small changes have a large impact.”

Plants currently absorb an estimated 25% of the CO2 emitted by human activities each year, according to the U.S. Department of Energy, but this percentage is likely to decrease in the future as the climate warms, Lloyd explained, especially if water is scarcer.

“When we think about climate futures, we predict that CO2 will go up, which in theory is good for plants because those are the molecules they breathe in,” Lloyd said. “But we’ve shown there will be a tradeoff that some prevailing models don’t account for. The world will be getting warmer, which means plants will be less able to draw down that CO2.”

In the study, the researchers discovered that variation in the abundance of certain isotopes of a part of wood called methoxyl groups serves as a tracer of photorespiration in trees. You can think of isotopes as varieties of atoms, Lloyd explained. Just as you might have vanilla and chocolate versions of ice cream, atoms can have different isotopes with their own unique “flavors” due to variations in their mass. The team studied levels of the methoxyl “flavor” of isotope in wood samples from about thirty specimens of trees from a variety of climates and conditions throughout the world to observe trends in photorespiration. The specimens came from an archive at the University of California, Berkeley, that contains hundreds of wood samples collected in the 1930s and 40s.

“The database was originally used to train foresters how to identify trees from different places around the world, so we repurposed it to essentially reconstruct these forests to see how well they were taking in CO2,” Lloyd said.

Until now, photorespiration rates could only be measured in real time using living plants or well-preserved dead specimens that retained structural carbohydrates, which meant that it was nearly impossible to study the rate at which plants draw down carbon at scale or in the past, Lloyd explained.

Now that the team has validated a way to observe photorespiration rate using wood, he said the method could offer researchers a tool for predicting the how well trees might “breathe” in future and how they fared in past climates.

The amount of carbon dioxide in the atmosphere is rapidly rising; it is already greater than at any time in the last 3.6 million years, according to the National Oceanic and Atmospheric Administration. But that period is relatively recent in geologic time, Lloyd explained.

The team will now work to unearth photorespiration rates in the ancient past, up to tens of millions of years ago, using fossilized wood. The methods will allow researchers to explicitly test existing hypotheses regarding the changing influence of plant photorespiration on climate over geologic time.

“I’m a geologist, I work in the past,” Lloyd said. “So, if we’re interested in these big questions about how this cycle worked when the climate was very different than today, we can’t use living plants. We may have to go back millions of years to better understand what our future might look like.”

Other authors on the paper are Rebekah A. Stein, Daniel A. Stolper, Daniel E. Ibarra and Todd E. Dawson of the University of California, Berkeley; Richard S. Barclay and Scott L. Wing of the Smithsonian National Museum of Natural History and David W. Stahle of the University of Arkansas.

The work was funded in part by the Agouron Institute, the Heising-Simons Foundation, and the U.S. National Science Foundation.

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Climate change threatens older elephants most, jeopardizing African elephants’ future

A collaborative team of researchers from the University of Massachusetts Amherst and the Wildlife Conservation Society (WCS), which runs the world’s largest field conservation program, has conducted first-of-its kind research into how global climate change affects African elephants. The work, published recently in PLOS Sustainability and Transformation,shows that older elephants will have markedly decreased chances of survival, which will not only drastically reduce the species’ overall ability to weather the changing climate but will send ripple effects throughout the surrounding landscape. The team has also modelled possible mitigation scenarios, which WCS is already implementing.

Africa’s Greater Virunga Landscape (GVL) is a 15,700-square-kilometer area of savannas, mountains and lakes in Uganda, Rwanda and the Democratic Republic of Congo. It is home to the largest land animals in Africa, with seven national parks, three tropical high-forest reserves and three wildlife reserves, three of which are world heritage sites, covering 88% of the area. It is also home to a population of African elephants whose numbers have dropped so precipitously over the past century that they are now listed as critically endangered by the International Union for Conservation’s Red List.

Elephants play a key role in modifying and sustaining their landscapes by dispersing the seeds of the plants they feed upon, felling trees and enriching soil fertility with their dung. They also play an important role in many African cultures.

To date, few studies have focused on the dynamics of the environment, climate change, elephant demography and how the changing habitat influences elephants over long periods. To get a clearer picture of what the elephants’ future might look like and what we can do to best ensure their survival, lead author Simon Nampindo, who completed this research as part of his Ph.D. in environmental conservation for UMass Amherst and who is now country director for WCS Uganda, and Timothy Randhir, professor of environmental conservation at UMass Amherst, built a systems dynamic model. “This model,” says Nampindo, “can look at all the different environmental and population dynamics within a system. For the first time, we’re able to get a comprehensive vision of what the future might look like for African elephants in the face of climate change.”

Nampindo and Randhir built their model using data on the numbers of elephants, historical changes in the landscape and different future climate-change scenarios representing 1.6 º, 2.8º and 4.3º Celsius of warming over the next 80 years. Finally, they charted the effect each of the climate scenarios would have on five elephant age brackets: under 10 years old, 11 — 30, 31 — 40, 41 — 50, and more than 50 years old, because, as Randhir puts it “any impact on one age class has a community effect throughout the entire population.”

“We found that the older elephants will be massively affected by warming under every scenario,” says Nampindo. “Elephants are matriarchal — their leaders are the older cows, and the herds depend on their wisdom, long memories and ability to outsmart prey, and if they are lost to changing climate, it will wreak havoc on the surviving, younger herds, as well as change the genetic profiles and structures of the herd. There will also be ripple effects through the GVL’s landscape.”

“But,” says Randhir, “this model not only tells us what the threats are, we can also use it to tell us which policy possibilities will be most effective in helping African elephants to survive.”

In the case of a species like the elephant, which migrates widely across national boundaries, it is especially important to also understand how differing policies could affect future herds so that management agencies can coordinate their responses.

In particular, Nampindo and Randhir find that a coordinated GVL management strategy at the national, regional and local levels is needed to address poaching threats. Well-funded anti-poaching efforts are essential, but they also point to the importance of community-led programs and education in the front-line towns and villages where human-elephant interaction is common. The GVL landscape must also be managed appropriately to reduce the impact of habitat fragmentation, fire and invasive species.

“These results are very important to WCS,” says Nampindo. “If we can do a good job at protecting elephants, our efforts will reverberate to other species, such as lions and mountain gorillas.”

“More broadly,” says Randhir, “the most exciting thing about this systems dynamic modeling is that it can be adapted to any migratory species that move across political boundaries, from fish to birds to lions.”

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Exposure to even moderate levels of radon linked to increased risk of stroke

Radon is the second leading cause of lung cancer. Now a new study has found exposure to this invisible, odorless gas is also linked to an increased risk of stroke. The study, which examined exposures in middle age to older female participants, found an increased risk of stroke among those exposed to high and even moderate concentrations of the gas compared to those exposed to the lowest concentrations. The study is published in the January 31, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study does not prove that exposure to radon causes stroke; it only shows an association.

Radon is a naturally occurring radioactive gas produced when metals like uranium or radium break down in rocks and soil. The gas can make its way into homes through cracks in basement walls and floors, construction joints and gaps around pipes.

“Radon is an indoor air pollutant that can only be detected through testing that measures concentrations of the gas in homes,” said study author Eric A. Whitsel, MD, MPH, of the University of North Carolina in Chapel Hill. “Our research found an increased risk of stroke among participants exposed to radon above — and as many as two picocuries per liter (pCi/L) below — concentrations that usually trigger Environmental Protection Agency recommendations to install a home radon mitigation system.”

The study involved 158,910 female participants with an average age of 63 who did not have stroke at the start of the study. They were followed for an average of 13 years. During the study, there were 6,979 strokes among participants.

To determine radon exposures, researchers linked participants’ home addresses to radon concentration data from the U.S. Geological Survey and the U.S. Environmental Protection Agency (EPA).

The EPA recommends that average indoor radon concentrations do not exceed four picocuries per liter (pCi/L). For concentrations this high, the EPA recommends installing a radon mitigation system to lower radon levels in the home.

Participants were divided into three groups. The highest group had homes in areas where average radon concentrations were more than four pCi/L. The middle group lived in areas with average concentrations between two and four pCi/L. The lowest group lived in areas with average concentrations of less than two pCi/L.

In the group with the highest radon exposures, there were 349 strokes per 100,000 person-years compared to 343 strokes in the middle group and 333 strokes in group with the lowest exposure. Person-years represent both the number of people in the study and the amount of time each person spends in the study.

After adjusting for factors such as smoking, diabetes and high blood pressure, researchers found participants in the highest group had a 14% increased risk of stroke compared to those in the lowest group. Those in the middle group had a 6% increased risk.

“It’s important to note that we found an increased stroke risk among those exposed to radon concentrations as much as two pCi/L below the current lung cancer-based threshold for recommending radon mitigation,” said Whitsel. “More studies are needed to confirm our findings. Confirmation would present an opportunity to improve public health by addressing an emerging risk factor for stroke.”

A limitation of the study was that it included only female participants who were middle age or older and primarily white, so the results may not be the same for other populations.

The study was funded by the National Institute of Environmental Health Sciences and National Heart, Lung, and Blood Institute.

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The Spiritual Meaning of Illness

Several days after I posted the 2024 Intentions video, I succumbed to an illness – fever, aches, pains, chills, runny nose, sneezing, coughing, nausea, etc. At Rachelle’s suggestion I took a COVID test – and tested positive. Whoa! This was my first time getting COVID (as far as I’m aware). I’ve been vaccinated and double-boosted, but my last booster was about 18 months ago. I guess I’m boosted now. 😷

While meditating on the meaning and purpose of this illness, I tried to tune in and communicate with the Spirit of COVID directly. This resulted in a fascinating dialogue, including the invitation to co-create this new video with COVID. I was feeling a little better at the time of the recording but still had a mild fever of 99.0º.

This may sound odd, but I dare say that I enjoyed having COVID – and not in a masochistic way. On a physical level, the symptoms were about what you’d expect, but since I spent more time interfacing with the experience at the spirit level, I related to it more meaningfully and purposefully. COVID’s visit was surprising at first, but it didn’t feel unwelcome or threatening. As I got extra rest and let my body recover, another part of me was fully engaged in listening and dialoguing. And that aspect of the experience was deep, rich, and even beautiful.

I realize now that I related to COVID much like a psychedelic experience. A psychedelic journey can create physical symptoms such as nausea, dizziness, or vomiting, but that isn’t the real purpose of it. Similarly, I recognized that COVID didn’t just randomly show up to make me sick. I could put my focus (and thereby my intentionality) on the physical aspects, but I wasn’t limited to that framing. I saw that the symptoms were there to get my attention and to encourage me to physically rest, so I could focus on the inner experience of it and communicate with it.

COVID not only had a personal message to share with me, but it also invited me to channel a message to share with everyone. I included both in the video. COVID’s message to all starts at 10:05.

With this video I focused on fairly tight editing to make it efficient to watch, creative use of B-roll, integrating sound effects, a little humor, and some modest use of visual effects. None of the B-roll I used included sound, so all the sounds were added separately.

Enjoy the video! I also invite you to share your feedback in the YouTube comments.

The next video will be about my experience of going to see Depeche Mode in concert on December 1st while a bit shroomie. 🍄

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Pharmacists to prescribe drugs for minor illnesses in England

Chemists in England can supply antibiotics and other treatments without patients seeing a doctor.

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What is the UK Covid inquiry and how does it work?

The second round of public hearings examined how ministers made decisions during the pandemic.

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Record Dry January saved people £118 on average

A survey suggests one in five drinkers gave up alcohol this January.

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AI-powered app can detect poison ivy

Poison ivy ranks among the most medically problematic plants. Up to 50 million people worldwide suffer annually from rashes caused by contact with the plant, a climbing, woody vine native to the United States, Canada, Mexico, Bermuda, the Western Bahamas and several areas in Asia.

It’s found on farms, in woods, landscapes, fields, hiking trails and other open spaces. So, if you go to those places, you’re susceptible to irritation caused by poison ivy, which can lead to reactions that require medical attention. Worse, most people don’t know poison ivy when they see it.

To find poison ivy before it finds you, University of Florida scientists published a new study in which they use artificial intelligence to confirm that an app can identify poison ivy.

Nathan Boyd, a professor of horticultural sciences at the UF/IFAS Gulf Coast Research and Education Center near Tampa, led the research. Renato Herrig, a post-doctoral researcher in Boyd’s lab, designed the app.

“We were the first to do this, and it was designed as a tool for hikers or others working outdoors,” Boyd said. “The app uses a camera to identify in real-time if poison ivy is present and provides you with a measure of certainty for the detection. It also functions even if you don’t have connectivity to the internet.”

The next step is to make the app commercially available, and there’s no timetable for that yet, Boyd said.

For the study, researchers collected thousands of images of poison ivy from five locations: Alderman’s Ford Conservation Park and Hillsborough River State Park, both in Florida; Eufala National Wildlife Refuge in Alabama; York River State Park in Virgina and Fall Creek Falls State Park in Tennessee.

They labeled images, and in each image, scientists put boxes around the leaves and stems of the plant. The boxed images were critical because poison ivy has a unique leaf arrangement and shape. Scientists use those characteristics to identify the plant.

They then ran the images through AI programs and taught a computer to recognize which plants are poison ivy. They also included images of plants that are not poison ivy or plants that look like poison ivy to be certain the computer learns to distinguish them.

“We believe that by integrating an object-detection algorithm, public health and plant science, our research can encourage and support further investigations to understand poison ivy distribution and minimize health concerns,” Boyd said. In their future work UF/IFAS researchers hope to expand the use of the app to identify more noxious plants.

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Black summer bushfires in Australia wiped $2.8 billion from tourism supply chain

A first of its kind study of the 2019-2020 ‘Black Summer’ bushfires in Australia has revealed that the tourism industry nationwide took an immediate hit of $2.8 billion in total output to its broader supply chains and almost 7300 jobs disappeared nationwide.

The fires four years ago triggered widespread tourism shutdowns in many parts of the country in the lead up to the peak Christmas and New Year season, resulting in $1.7 billion direct losses to the tourism industry, which triggered the larger drop in supply chain output.

“These results are an illustration of what can be expected in the future not only in Australia, but in other nations that are vulnerable to climate-change driven disasters,” said Vivienne Reiner, a PhD student with the Centre for Integrated Sustainability Analysis in the Faculty of Science and lead author of the study, published in Economics of Disasters and Climate Change.

“It’s important to note that our study, which measured tourism’s losses through Australian supply chains, did not quantify other economic costs, such as the supply-chain impacts of losses from agriculture or forestry, which were also substantially impacted by the fires,” she said.

While the fires had the biggest impact on Australia’s east coast, the impact from tourism losses was national and felt across the economy, the researchers found.

“Tourism is a vital Australian industry. Before the fires that started in 2019, statistics showed that in rural areas 8 percent, or almost one in 12 people, were employed in jobs connected to the tourism industry,” Ms Reiner said. “As well, tourism is a top export, with travel services responsible for more export income than natural gas in 2018-19.”

Associate Professor Arunima Malik, a co-author who heads the Centre for Integrated Sustainability Analysis and is also affiliated with the Business School, said: “With bushfires increasing compared to other natural disasters and expected to intensify due to climate change, it is important for countries such as Australia to quantify their economic impact as part of routine practice, including supply-chain spillovers.”

Co-author Professor Manfred Lenzen, also with ISA in the School of Physics, said: “Although the losses we calculated only represented a small fraction of the nation’s economic output, Australia’s reputation as a pristine destination could become permanently damaged under global warming, with fewer people travelling within and to Australia in our peak holiday season.”

The research showed varied impact nationwide across the supply chain, including in job losses:

  • New South Wales: 3171 jobs
  • Victoria: 1430 jobs
  • Queensland: 1499 jobs
  • South Australia: 516 jobs
  • Western Australia: 479 jobs
  • Tasmania: 13 jobs
  • Australian Capital Territory: 110 jobs
  • Northern Territory: 75 jobs.

The researchers warn that the Australian economy could face further losses as the effects from climate change increase.

Ms Reiner said: “As part of the Asia Pacific — the world’s most disaster-prone region — Australian tourism has a lot to gain from climate-change mitigation. In terms of responses, studies such as ours also help indicate hotspots in supply chains where rebuilding may be required in communities and industries.

“By including the entire supply chain in our research, using input-output analysis, we calculated total output losses of $2.8 billion, which is a 61 percent increase on direct damages identified.”

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