Exclusive: Keir Starmer Cabinet Ally Pledges To Ramp Up Support For Embattled PM

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One of Keir Starmer’s closest cabinet allies has vowed to step up his support for the embattled prime minister.

Lord Hermer said the PM’s working class background will help him deliver for voters and see off “populists” on the left and right of British politics.

The attorney general’s comments, in a speech on Tuesday night, will come just hours after Starmer made a plea for cabinet unity following days of bitter Labour in-fighting.

The prime minister was even forced to insist he will still be Labour leader come the next general election amid mounting speculation about his future.

Hermer will tell the Law for Change group that things like the Hillsborough Law, the Employment Rights Bill and improved rights for renters prove Starmer is on the side of ordinary people.

He will say: “When the law helps extend rights and delivers justice where it’s most needed, it earns not just respect, but belief.

“Not as a shield for the status quo, particularly when that status quo may fail too many. But as a promise that across the country, we all stand equal before the law, and no one stands alone.”

Hermer will add: “That’s what this prime minister believes in – the idea that power can be rebalanced, that the law can and should evolve to meet the changing needs of society.

“Injustices can be addressed, wrongs can be made right, through graft, patience and, above all, determination. That’s the story of the man I know, Keir Starmer.

“Populists to the left and right say you don’t need any of that. Just ban this thing, leave this convention. All will be well. But who is left to pick up the pieces, when it all goes south? Working class people. Like the family Keir Starmer grew up in.”

A source close to Hermer told HuffPost UK he wanted to help Starmer see off the twin threats of both Reform UK and the Tories.

He said: “He will be ramping up his efforts in the coming months in support of the rule of law as a platform for change, and of the prime minister.

“Populists falsely claim there are some easy, magical solutions to his country’s challenges, but the attorney general and the prime minister both completely understand you need proper solutions to give rights to working class people and tackle inequality.

“He will be making the case that because of Keir’s working class background, he gets the challenges this country faces.

“But the PM also understands the risks – Reform’s false solutions wouldn’t harm Nigel Farage and his friends, but working class people in this country.”

Starmer’s government was rocked last week by a briefing war which saw No.10 sources accuse health secretary Wes Streeting of plotting to replace him.

But that backfired on Downing Street, with Streeting emerging stronger from the row and the PM facing calls to sack Morgan McSweeney, his chief of staff.

In an attempt to draw a line under the controversy, Starmer told the weekly cabinet meeting on Tuesday morning that the government must get back to “working as a team”.

His spokesman said: “He said distractions meant our focus shifted from where it mattered most – working every day in the service of the British people

“People were rightly impatient for change and we have to deliver that rather than talking about ourselves. That means working as a team offering opportunity and security and delivering on our mandate.”

In an interview with the Daily Mirror published this morning, Starmer insisted he will still be Labour leader at the next election despite a poll suggesting only a third of his own voters want him to.

Asked directly if he will still be PM when the country next goes to the polls, he said: “Yes, I will. Let me be really clear – every minute that’s not spent talking about and dealing with the cost of living is a minute wasted of the political work of this government.

“That’s my response to last week. I remain utterly focused on what matters to me most, which is bearing down on the cost of living and making people feel better off.”

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Catherine’s first speech in two years calls for dignity for carers

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The Princess of Wales tells business leaders about the importance of supporting families with young children.

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Eleven countries added to methanol poisoning warning list

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The Foreign Office list now includes India, Morocco and Nepal following a “global increase” in reported cases.

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7 Unconventional Habits Longevity Experts Swear By

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When talking about how to improve longevity, we often think of well-known healthy habits like staying physically active, eating a balanced diet that includes lots of whole foods, and managing stress levels.

And while those behaviors are, indeed, the cornerstones of a long, healthy life, there are other less-obvious habits that can make a significant difference, too. We asked longevity experts for their recommendations beyond the standard ones that immediately come to mind.

Before we dive in, it’s important to note that increasing longevity isn’t just about adding years to our lives. It’s about improving the quality of those extra years. That’s where the conversation about lifespan vs. health span comes in.

Lifespan refers to the total duration of one’s life from birth to death, while health span refers to the “period of life spent in good functional health,” Dr. Douglas Vaughan, director of the Potocsnak Longevity Institute at Northwestern University’s Feinberg School of Medicine, told HuffPost.

“It reflects quality of life and physiological integrity — not just survival,” he added.

Advancing age is a top risk factor for developing health conditions such as certain cancers, heart disease and dementia. Increasing your lifespan isn’t as meaningful if you’re not able to enjoy those additional years due to debilitating physical or mental health challenges

“Simply extending lifespan would likely also increase the burden of disease, resulting in a larger portion of one’s lifespan being affected by poor health,” said Sebastian Brandhorst, research associate professor at the University of Southern California’s Leonard Davis School of Gerontology. “Instead, researchers aim to develop strategies to increase health span, by definition delaying the onset of disease and increasing the quality of life well into the older age.”

Health span is sometimes defined as years spent “free from chronic disease” — a definition that Erin Martinez, a Kansas State University associate professor who specializes in healthy aging and adult development, takes issue with.

“I have a chronic disease and always will, yet I consider myself healthy and thriving. Health span isn’t about achieving some disease-free ideal; it’s about your definition of good health and vitality,” she explained.

Instead, we should think of health span as existing on a spectrum, “not a pass/fail grade,” said Martinez.

“Getting sick doesn’t mean your health span is over or that you’ve failed. Your definition of ‘good health’ simply evolves. The cliché is true: It’s not about the years in your life, but the life in your years,” she added.

Below, learn more about the seven healthy habits our longevity experts swear by:

1. Living With Purpose

One of the strongest predictors of a long and fulfilling life is having a sense of purpose — “a clear ‘why’ for your days,” said Martinez.

“The Japanese call this ikigai, or ‘reason for being,’” she added. “Purpose does not have to be grand or world-changing; it can be found in small, meaningful pursuits like tending a garden, caring for a pet, nurturing relationships, or contributing to your community.”

“When you have something that makes you feel needed and gives your life direction, you are more likely to care for your health, stay socially connected and maintain emotional resilience,” Martinez continued.

2. Staying Socially Connected

The Harvard Study of Adult Development, a longitudinal study that’s now been going on for 87 years and counting, found the strongest predictor of a long, happy and healthy life is the quality of our relationships.

In other words, leading a healthy lifestyle isn’t just an individual journey. The people you surround yourself with affect everything from your dietary choices to your mental health to your mortality, Brandhorst said.

“For example, female Okinawans, representing some of the world’s highest proportions of women who live to age 100 and above, traditionally form social support groups in childhood and stay together throughout their lives,” he said.

In fact, our social connections are “as protective as any [pharmaceutical] drug,” Vaughan explained.

“Social integration and meaningful relationships lower inflammation, blunt stress-hormone responses, and reduce all-cause mortality as powerfully as quitting smoking,” he said. “People with close friends or community ties are consistently healthier, happier, and live longer independent of income, diet or exercise.”

Social connection and forming relationships with people of different ages can help improve your longevity.

10’000 Hours via Getty Images

Social connection and forming relationships with people of different ages can help improve your longevity.

3. Having Relationships With People Of Different Ages

Having strong social connections is predictive of longevity and other positive health outcomes. And research has found that maintaining intergenerational relationships, in particular, “offers powerful benefits for long-term health and well-being,” Martinez said.

“Whether you are mentoring younger people, learning from older adults or simply engaging with neighbors of all ages, these interactions keep your mind sharp, your perspective broad and your sense of belonging strong,” she said.

Intergenerational relationships can improve physical and cognitive health, reduce social isolation and improve life satisfaction, according to research on the topic.

“In short, meaningful connections, especially across age groups, are one of the most valuable investments you can make in your longevity,” Martinez said.

4. Avoiding Risky Behaviors

In some ways, this recommendation is so simple, it’s easy to overlook it: “The surest way to extend life is not to shorten it,” Vaughan said.

That means generally avoiding unsafe behaviors over a lifetime — things like smoking, consuming alcohol, using drugs or driving distractedly.

These habits may “sound unremarkable, but low-risk behavior is the single largest contributor to exceptional longevity in long-term cohort studies,” Vaughan said.

5. Volunteering In Your Community For A Cause You Care About

Donating your time, skills and energy isn’t just good for your community, it’s good for your longevity too, Martinez said.

“Volunteering creates social bonds, encourages physical activity and fosters a sense of purpose that directly counters loneliness and depression,” she pointed out. “Studies consistently find that people who volunteer tend to live longer and report higher levels of happiness and fulfillment at every age.”

The key is to find a way to engage with your community that feels meaningful to you so volunteering doesn’t become just another obligation on your calendar. Martinez suggests reflecting on your personal interests and values and then seeking opportunities that are in alignment.

“If you are passionate about food security, volunteer at a local food pantry or help with a Kitchen Restore project,” Martinez suggested. “If you love working with youth, consider 4-H, the Boys & Girls Club, or after-school programs. If you enjoy hands-on work, try Habitat for Humanity or mentoring students in trade or design programs.”

Remember: “When your service aligns with your passions and expertise, everyone benefits,” she added.

Volunteering provides a sense of purpose, which boosts your health.

Luis Alvarez via Getty Images

Volunteering provides a sense of purpose, which boosts your health.

6. Adjusting Your Daily Eating Window

When it comes to longevity, what you eat has a significant impact. Ideally, that’s lots of whole foods including vegetables, fruit, nuts, legumes and whole grains, while minimizing consumption of ultra-processed foods. But some research indicates there may be long-term health benefits to when we eat, too.

One such example is time-restricted eating, a type of intermittent fasting in which you limit nutrient intake to a set number of hours per day (usually about eight to 10 hours).

“For example: first meal — defined as caloric intake, so coffee with cream and sugar definitely counts — of the day at 8 a.m. and the last caloric intake at 6 p.m,” Brandhorst said. “This simple eating pattern aligns digestive function with other systemic signaling, such as sleep, which provides health benefits, such as weight loss, improved heart health and the regulation of blood sugar levels.”

That being said, this type of eating pattern may not be advisable (or sustainable) for everyone. Those who are under the age of 18, pregnant or nursing, or have a history of eating disorders should avoid it. Always consult with your doctor before implementing these practices — especially if you have a chronic health condition or take medication.

7. Maintaining A Consistent Sleep Schedule

For adults, getting seven to nine hours of shut-eye a night is associated with a host of positive health benefits in the short term like better mood and improved focus and problem-solving abilities. But logging enough hours on a consistent schedule — that means going to bed and waking up around the same time each day, even on weekends — can have positive effects on your well-being in the longer term, too.

“Sleep is the body’s nightly repair program. Consistent sleep timing and quality restore metabolic balance, preserve vascular function and stabilize immune signaling,” Vaughan said.

“Chronically short or erratic sleep accelerates biological aging markers such as epigenetic drift and insulin resistance, while steady circadian rhythm is linked to healthier lifespan trajectories,” he added.

In addition to keeping your sleep and wake times consistent, getting sunlight within a couple of hours of waking up, limiting light exposure at night and avoiding exercising or eating too close to bedtime can also help maintain circadian alignment.

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How do cold weather health alerts work?

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The weather alert service warns the public when high or low temperatures could damage their health.

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AI vs superbugs: UK invests millions to tackle drug-resistant infections

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The UK turns to artificial intelligence (AI) to reverse the rising numbers of infections that shrug off antibiotics.

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A surprising CBD advance calms pain without side effects

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Many people use CBD-infused oils and lotions believing they offer an easy and relatively low-risk way to ease discomfort. However, scientists still have a limited understanding of how CBD actually interacts with the nervous system.

The popularity of cannabis-based products has risen sharply over the past ten years. One major reason is the 2018 federal decision to remove hemp from the Controlled Substances Act, which allowed hemp-derived CBD to be legally sold and widely distributed. As a result, CBD is now commonly available in oils, creams, and cosmetic items. It is widely accepted that CBD does not cause a ‘high’, but its effects within the human brain and body remain poorly understood. At this time, the Food and Drug Administration only approves CBD as an additional treatment for certain types of epilepsy, and it advises against its use during pregnancy.

“We need to understand more about this compound, what mechanisms it interacts with in the brain, its impact on the body, and whether it is a potentially safer solution for treating the chronic pain epidemic,” said Kuan Hong Wang, PhD, professor of Neuroscience and member of the Del Monte Institute for Neuroscience at the University of Rochester. Working with researchers at Harvard Medical School and Boston Children’s Hospital, Wang’s lab recently showed in mice that they could deliver CBD directly to the brain to relieve neuropathic pain without producing harmful side effects. These results were published in Cell Chemical Biology.

A New Way to Deliver CBD to the Brain

The main obstacle for researchers was the blood-brain barrier, a protective system that shields the brain from harmful substances. While essential for brain health, this barrier significantly limits how much CBD can enter the brain, especially because CBD does not dissolve well in water. As a result, very little of the CBD taken in its usual oil form reaches the brain.

To address this challenge, staff scientist Jingyu Feng, PhD, the study’s first author, helped create a specialized delivery method called inclusion-complex-enhanced nano-micelle formulation, or CBD-IN. This approach encloses CBD molecules within water-soluble nano-micelles, which are considered safe for use in foods and medicines.

Tests in mice showed that CBD-IN triggered pain relief within half an hour. Importantly, the mice did not experience the common side effects often linked to conventional pain medications, such as problems with balance, movement, or memory. “The pain relief also lasted through repeated use,” said Feng. “We did not see its effect wear off over time.”

How CBD-IN Affects the Nervous System

With the help of imaging tools and genetic mapping, the researchers found that CBD-IN reduces excessive nerve activity in areas of the brain and spinal cord involved in processing touch and pain. This effect only appeared in regions experiencing abnormal activation, such as after a nerve injury. Healthy neurons were unaffected.

Another unexpected result was that CBD-IN did not rely on the well-known cannabinoid receptors (CB1 and CB2) typically involved when THC or other cannabis compounds act in the body. “Instead, CBD-IN seems to influence broader electrical and calcium signaling in nerve cells, offering a new way to control nerve hyperactivity without triggering the ‘high’ or dependency risks associated with traditional cannabinoids or opioids,” Feng said.

Potential for Treating Chronic Pain and Other Brain Disorders

“The broader implication of this research is that nanotechnology can make natural compounds like CBD more effective and precise,” said Wang, co-senior author of the study. “By enhancing brain delivery and targeting only disease-related neural overactivity, this strategy could open new doors for treating chronic pain and possibly other neurological disorders, such as epilepsy or neurodegenerative diseases, where abnormal nerve activity plays a central role.”

This work was carried out through a collaboration involving the University of Rochester, Harvard Medical School, and Boston Children’s Hospital. Additional contributors include Jessica Page, PhD, and Leeyup Chung, PhD, both co-first authors, and Zhigang He, PhD, co-senior author, from Harvard Medical School. Funding was provided by the National Institutes of Health and the Del Monte Institute for Neuroscience.

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Chronic pain may dramatically raise your blood pressure

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  • Chronic pain appears to play a meaningful role in raising the risk of developing high blood pressure.
  • How long the pain lasts and where it occurs both influence that risk, and part of the connection is explained by depression and inflammation.
  • Researchers say the results underscore how important effective pain management can be for preventing and controlling high blood pressure, a major driver of cardiovascular disease and death.

Chronic Pain Linked to Rising Blood Pressure Risk

Chronic pain in adults may raise the likelihood of developing high blood pressure, and factors such as where the pain is located, how widespread it is, and whether a person also has depression appear to play important roles. These findings come from new research published today (November 17) in Hypertension, an American Heart Association journal.

An evaluation of health information from more than 200,000 adults in the U.S. showed that individuals who experienced chronic pain throughout their bodies had a higher chance of developing high blood pressure compared to those reporting no pain, short-term discomfort, or pain limited to one region.

“The more widespread their pain, the higher their risk of developing high blood pressure,” said lead study author Jill Pell, M.D., C.B.E., the Henry Mechan Professor of Public Health at the University of Glasgow in the United Kingdom. “Part of the explanation for this finding was that having chronic pain made people more likely to have depression, and then having depression made people more likely to develop high blood pressure. This suggests that early detection and treatment of depression, among people with pain, may help to reduce their risk of developing high blood pressure.”

Understanding High Blood Pressure and Its Dangers

High blood pressure and hypertension occur when blood presses too strongly against vessel walls, increasing the chance of heart attack or stroke. High blood pressure, including stage one or stage two hypertension (blood pressure readings from 130/80 mm Hg to 140/90 mm Hg or higher), affects nearly half of adults in the U.S. It is also the leading cause of death nationally and worldwide, according to the 2025 joint American Heart Association/American College of Cardiology guideline endorsed by 11 other organizations.

Earlier studies show that chronic musculoskeletal pain — pain in the hip, knee, back or neck/shoulder that lasts for at least three months — is the most common form of long-term pain in the general population. The new study examined how the presence, type, and distribution of pain across the body relate to later high blood pressure.

Inflammation and depression are already recognized as contributing factors for high blood pressure; however, Pell noted that no previous research had evaluated how much these elements might explain the connection between long-lasting pain and future hypertension.

How Researchers Collected and Measured Pain Data

Participants completed a baseline questionnaire describing whether they had experienced pain in the previous month that interfered with daily activities. They identified whether the pain occurred in the head, face, neck/shoulder, back, stomach/abdomen, hip, knee or across the entire body. Those reporting pain also indicated whether symptoms had persisted for more than three months.

Depression was assessed through a questionnaire asking about depressed mood, disinterest, restlessness or lethargy during the previous two weeks. Inflammation was measured using blood tests for C-reactive protein (CRP).

Key Findings After Long-Term Follow-Up

After an average follow-up period of 13.5 years, the results showed:

  • Nearly 10% of all participants developed high blood pressure.
  • Compared to people without pain, those with chronic widespread pain faced the greatest increase in risk (75% higher), while short-term pain was associated with a 10% higher risk and chronic pain in a single location was tied to a 20% higher risk.
  • When looking at pain locations, chronic widespread pain was linked to a 74% higher risk of high blood pressure; chronic abdominal pain to a 43% higher risk; chronic headaches to a 22% higher risk; chronic neck/shoulder pain to a 19% higher risk; chronic hip pain to a 17% higher risk; and chronic back pain to a 16% higher risk.
  • Depression (11.3% of participants) and inflammation (0.4% of participants) explained 11.7% of the connection between chronic pain and high blood pressure.

“When providing care for people with pain, health care workers need to be aware that they are at higher risk of developing high blood pressure, either directly or via depression. Recognizing pain could help detect and treat these additional conditions early,” Pell said.

Expert Perspective on Pain, Inflammation and Hypertension

Daniel W. Jones, M.D., FAHA, chair of the 2025 American Heart Association/American College of Cardiology High Blood Pressure Guideline and dean and professor emeritus of the University of Mississippi School of Medicine in Jackson, Mississippi, said, “It is well known that experiencing pain can raise blood pressure in the short term, however, we have known less about how chronic pain affects blood pressure. This study adds to that understanding, finding a correlation between the number of chronic pain sites and that the association may be mediated by inflammation and depression.”

Jones, who was not involved in the study, recommended further research using randomized controlled trials to explore how different pain management strategies influence blood pressure. He highlighted the importance of understanding how Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen may raise blood pressure.

“Chronic pain needs to be managed within the context of the patients’ blood pressure, especially in consideration of the use of pain medication that may adversely affect blood pressure,” said Jones.

Study Limitations and Participant Characteristics

The researchers noted that the study population mainly consisted of middle-aged or older white adults of British origin, which means the findings may not apply to people of other racial or ethnic backgrounds or younger age groups. Pain levels were self-reported, and the study relied on clinical diagnostic coding, a single pain assessment, and two blood pressure measurements.

How the Study Was Designed

Study details, background and design:

  • The analysis used data from the UK Biobank, a large population-based project that recruited more than 500,000 adults ages 40-69 between 2006 and 2010. Participants lived in England, Scotland and Wales.
  • This study focused on 206,963 adults. The average age was 54 years; 61.7% were women, and 96.7% were white adults.
  • Overall, 35.2% of participants reported chronic musculoskeletal pain; 62.2% reported chronic pain at one body site; 34.9% had chronic pain at two to three musculoskeletal sites; and 3.2% reported pain at four sites.
  • Compared with participants without pain, those reporting pain were more often women, had less healthy lifestyle patterns, larger waist circumference, higher body mass index (BMI), more long-term health issues, and were more likely to live in areas with higher unemployment, lower home and car ownership, and more overcrowding.
  • Researchers adjusted for factors associated with both pain and high blood pressure, including self-reported smoking status, alcohol intake, physical activity, sedentary time, sleep duration, and fruit and vegetable consumption.
  • Data from the UK Biobank was gathered through a touch-screen questionnaire, interview, physical measurements (height, weight, BMI, waist circumference, blood pressure), and blood samples for cholesterol and blood sugar (hemoglobin A1c).
  • Hospital records were used to identify high blood pressure using standard International Statistical Classification of Diseases and Related Problems and diagnostic codes (ICD-10 codes).
  • The follow-up period was measured from baseline until one of these events occurred: a diagnosis of high blood pressure, the participant’s death, or the end of available follow-up records. The first of these events marked the end of follow-up for each participant.
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Bake Off winner and Strictly star John Whaite reveals steroid addiction

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The Strictly runner-up says he began taking steroids because he was unhappy with his body.

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CRISPR unlocks a new way to defeat resistant lung cancer

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Researchers at ChristianaCare’s Gene Editing Institute have demonstrated that turning off the NRF2 gene with CRISPR technology can make lung cancer cells responsive to chemotherapy again. By blocking this gene, the treatment restores how tumors react to common cancer drugs and slows their growth. The study was published on November 14 in the journal Molecular Therapy Oncology.

This advance builds on more than ten years of work at the Gene Editing Institute, where scientists have closely investigated NRF2 and its role in therapy resistance. Their findings showed consistent results in both laboratory tests using human lung cancer cell lines and in animal studies designed to mirror real tumor behavior.

“We’ve seen compelling evidence at every stage of research,” said Kelly Banas, Ph.D., lead author of the study and associate director of research at the Gene Editing Institute. “It’s a strong foundation for taking the next step toward clinical trials.”

Expanding the Impact Beyond One Cancer Type

The study focused on lung squamous cell carcinoma, a fast-growing form of non-small cell lung cancer (NSCLC) that represents 20% to 30% of all lung cancer cases, according to the American Cancer Society. More than 190,000 people in the U.S. are expected to receive a lung cancer diagnosis in 2025.

Although the work concentrated on this specific disease, the findings point to broader applications. NRF2 overactivity plays a major role in chemotherapy resistance in several solid tumors, including cancers of the liver, esophagus and head and neck. These results indicate that CRISPR approaches aimed at NRF2 could eventually help restore drug sensitivity across multiple treatment-resistant cancers.

“This is a significant step toward overcoming one of the biggest challenges in cancer therapy — drug resistance,” Banas said. “By targeting a key transcription factor that drives resistance, we’ve shown that gene editing can re-sensitize tumors to standard treatment. We’re hopeful that in clinical trials and beyond, this is what will allow chemotherapy to improve outcomes for patients and could enable them to remain healthier during the entirety of their treatment regimen.”

Pinpointing a Mutation That Shields Tumors

The team focused on a tumor-specific mutation in the NRF2 gene known as R34G. NRF2 serves as a master controller of how cells respond to stress, and when it becomes overly active, cancer cells are better able to survive chemotherapy.

To counter this, researchers used CRISPR/Cas9 to engineer lung cancer cells carrying the R34G mutation and then knocked out the NRF2 gene. This change restored the cells’ responsiveness to widely used chemotherapy drugs such as carboplatin and paclitaxel. In animal models, tumors treated directly with CRISPR to remove NRF2 grew more slowly and responded more effectively to chemotherapy.

“This work brings transformational change to how we think about treating resistant cancers,” said Eric Kmiec, Ph.D., senior author of the study and executive director of the Gene Editing Institute. “Instead of developing entirely new drugs, we are using gene editing to make existing ones effective again.”

Significant Benefits Even With Partial Gene Editing

One of the most notable findings was that editing only 20% to 40% of tumor cells was enough to enhance chemotherapy response and reduce tumor size. This insight is important for clinical treatment, since altering every cancer cell in a tumor may not be possible.

For mouse studies, the researchers delivered CRISPR using lipid nanoparticles (LNPs), a non-viral system that offers efficiency while limiting the risk of unwanted genetic changes. Sequencing showed that the edits were highly targeted to the mutated NRF2 gene, with very few unintended modifications elsewhere in the genome.

“The power of this CRISPR therapy lies in its precision. It’s like an arrow that hits only the bullseye,” said Banas. “This level of specificity with minimal unanticipated genomic side effects offers real hope for the cancer patients who could one day receive this treatment.”

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