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Study outlines concerns around natural psychoactive substances
New research finds that over a period of 17 years, people in the United States increased their use of natural psychoactive substances, believing them to be safe. This has led to many reports of adverse symptoms in adults and children alike.
Share on PinterestPeople have been using natural psychoactive substances for hundrends, or even thousands, of years in traditional medicine and as a part of spiritual practices.
Because these substances come from sources such as plants and mushrooms, many people believe them to be safe to use.
However, because they interfere with biological processes in the central nervous system, they can be a threat to human health. These interferences can also cause euphoria and altered states of consciousness.
For these reasons, many people are now using natural psychoactive substances for recreational purposes.
New research has studied trends in the number of people in the United States who reported adverse reactions as a result of exposure to psychoactive substances during 2000–2017.
The Center for Injury Research and Policy at the Research Institute at Nationwide Children’s Hospital in Columbus, OH, collaborated with the Ohio State University College of Medicine, also in Columbus, to conduct this study.
In the new study paper — which appears in the journal Clinical Toxicology — the researchers explain that at a global level, many such substances remain improperly regulated. This means that it can be very easy for people to obtain them via online channels.
“Opium, cocaine, and marijuana are the most commonly used and are included in the 1961 United Nations Convention on Narcotics,” the study authors write.
However, they add, “While these three well-known plant-based substances are highly regulated, other natural psychoactive substances are not currently under international control through this convention or its amendments. Lack of regulation has led to an increase in their availability, especially on the internet.”
35% of exposures occurred in teenagers
For the new study, the researchers accessed data from the National Poison Data System regarding exposures to natural psychoactive substances in U.S. populations.
They found that between January 1, 2000 and December 31, 2017, the National Poison Data System processed up to 67,369 cases of dangerous exposure to natural psychoactive drugs. This is an average of 3,743 cases per year, or around 10 cases per day.
“These substances have been associated with a variety of serious medical outcomes, including seizures and coma in adults and children,” warns study co-author Henry Spiller, the director of the Central Ohio Poison Center at Nationwide Children’s Hospital.
Between 2000 and 2017, there was a general increase in the rate of exposures to natural psychoactive substances. However, there was a decrease in the exposure to most individual substances — with a few notable exceptions.
During this time, there was a 150% increase in exposure to marijuana, a 64% increase in exposure to nutmeg (which contains the hallucinogenic substance myristicin), and a 4,948.9% increase in exposure to kratom, the leaves of which contain potent mind-altering substances.
Spiller points out that 47% of the exposures to natural psychoactive substances in 2000–2017 were to marijuana, which is now legal — for medical or recreational purposes — in 33 states, the District of Columbia, Guam, Puerto Rico, and the U.S. Virgin Islands.
“As more states continue to legalize marijuana in various forms, parents and healthcare providers should treat it like any other medication: locked up, away, and out of sight of children,” Spiller advises. He warns that “[w]ith edibles and infused products especially, curious children are mistaking them for kid-friendly candy or food, and that poses a very real risk for harm.”
According to the study findings, 41% of the dangerous exposures occurred in people aged 19 and older, and as many as 35% occurred in people aged 13–19.
Males reported the most instances (64%) of exposure to natural psychoactive substances, and almost all (91%) of the exposures took place inside the home.
Besides marijuana, the substances to which exposure rates increased between 2000 and 2017 were Jimson weed, which accounted for 21% of exposures, and hallucinogenic mushrooms, which accounted for 16%.
Concerns regarding regulations
Kratom, khat (which contains the stimulant cathinone), various anticholinergic (central nervous system-disruptive) plants, and hallucinogenic mushrooms accounted for most hospital admissions due to exposure to natural psychoactive substances. They also accounted for most cases of serious medical outcomes.
Exposure to kratom, in particular, accounted for 8 of the 42 deaths in 2000–2017 that occurred due to natural psychoactive substances.
Also, 7 of the 42 deaths occurred in people under 18, and 5 of the 42 deaths occurred in people aged 13–19. These deaths were caused by exposure to anticholinergic plants, hallucinogenic mushrooms, kava kava, or marijuana. Two of the 42 deaths occurred in children aged 12 or younger, and both were due to exposure to marijuana.
The researchers point out that some of the plants that yield potentially dangerous psychoactive substances — particularly kratom — are not currently appropriately regulated in the U.S. In their study paper, they write:
“Kratom is currently classified as a dietary supplement, and therefore does not receive the same U.S. Food and Drug Administration quality and safety oversight as other drugs.”
This is despite the fact that “[t]he U.S. Drug Enforcement Administration (DEA) [have] voiced concerns about kratom due to its addictive potential and the deaths associated with its use,” the investigators add.
“In 2016, the DEA announced [their] intent to list kratom as a Schedule I drug, which it withdrew less than 2 months later due to negative public response,” write Spiller and team.
Based on accumulating evidence — including the results of this study — Spiller and colleagues suggest that federal institutions increase their efforts to regulate natural psychoactive substances, especially kratom, more strictly.
What are the benefits of neem oil for the skin?
Neem oil is an extract of the neem tree. Some practitioners of traditional Chinese and Ayurvedic medicine use neem oil to treat conditions ranging from ulcers to fungal infections.
This type of oil contains several compounds, including fatty acids and antioxidants, that can benefit the skin.
Below, find out about the uses and potential benefits of neem oil, as well as the risks. We also provide tips for using neem oil on the skin.
Share on PinterestNeem oil derives from the fruits and seeds of the neem tree. These trees grow mainly in the Indian subcontinent.
Neem oil is rich in fatty acids, such as palmitic, linoleic, and oleic acids, which help support healthy skin. The oil is, therefore, a popular ingredient in skin care products.
The leaf of the plant also provides health benefits. The leaves contain plant compounds called flavonoids and polyphenols, which have antioxidant, anti-inflammatory, and antibacterial properties.
Also, the Environmental Protection Agency (EPA) note that neem oil contains azadirachtin, a natural pesticide.
Researchers have only recently begun to examine how plant compounds influence health and disease. As a result, few scientific studies have investigated the use of neem oil in general skincare or as a treatment for skin conditions.
Authors of a 2013 review of the available research into medicinal uses of neem concluded that its extracts can help treat a variety of skin conditions, including:
The following are some benefits of neem oil and the evidence behind these claims.
First, however, it is important to note that most of the studies involved cell lines or animals. Those that did involve humans only included small numbers of participants. This makes it difficult to draw conclusions about the effectiveness of neem in the general population.
Anti-aging effects
A 2017 study investigated the anti-aging effects of topical neem leaf extract in hairless mice. The researchers first exposed the mice to skin-damaging ultraviolet B radiation. They then applied neem oil to the skin of some of the rodents.
The team concluded that the oil was effective in treating the following symptoms of skin aging:
The researchers also found that the extract boosted levels of a collagen-producing enzyme called procollagen and a protein called elastin.
Collagen gives the skin structure, making it look plump and full, while elastin helps retain the skin’s shape.
Production of these compounds decreases as people age. This eventually leads to dry, deflated-looking, thin skin and the formation of wrinkles.
Promoting wound healing
Research suggests that neem oil may help enhance wound healing.
In one 2010 animal study, researchers discovered that neem oil showed superior wound healing effects, compared with Vaseline. Specifically, the rats that received topical neem oil healed more quickly. They also developed stronger and more resilient tissue at the sites of their wounds.
A similar 2013 study compared the effects of saline and neem oil on wound healing in rats. Those that received neem oil healed faster and did not develop raised scars.
The researchers speculated that compounds in neem oil may promote blood vessel and connective tissue growth, thus enhancing wound healing.
A 2014 study investigated whether a gel containing neem oil and St. John’s wort could help reduce skin toxicity from radiation therapy. The study involved 28 human participants who were receiving radiation therapy for head and neck cancer.
All participants experienced some reduction in skin toxicity following treatment with the gel. However, it is important to note that this study did not include a placebo control.
Fighting skin infections
A 2019 study examined the antibacterial properties of cosmetic products containing neem compounds. The authors found that soaps containing extracts of neem leaf or neem bark prevented the growth of several strains of bacteria.
Most people can use neem oil safely. However, the EPA consider the oil to be a “low toxicity” substance. It can, for example, cause allergic reactions, such as contact dermatitis.
Also, while ingesting trace amounts of neem oil will likely not cause harm, consuming large quantities can cause adverse effects, especially in children. These may include:
People should use organic, cold-pressed neem oil. The oil should have a cloudy, yellow-brown color and a strong odor.
Neem oil is generally safe to apply to the skin. However, it is very potent, so it may be a good idea to test it on a small patch of skin before applying it more extensively.
To perform a patch test, mix a couple drops of neem oil with water or liquid soap. Apply the mixture to a small area of skin on the arm or the back of the hand.
If the skin becomes red, inflamed, or itchy, dilute the neem oil further by adding more water or liquid soap. Test this mixture on a different area of skin and watch for any signs of irritation.
People who are allergic to neem oil may develop hives or a rash after a patch test. If this happens, stop using the oil — and any products that contain it — immediately.
Treating skin conditions
Some people use neem oil to treat various skin conditions, including infections and acne.
To use it as a spot treatment, apply a small amount of diluted oil to the affected skin. Let the mixture soak into the skin, then rinse it off with warm water.
Neem oil has a particularly strong odor. To disguise it, try mixing neem oil with a carrier oil, such as jojoba, coconut, or almond oil. Carrier oils also help the skin absorb neem oil.
Neem oil has a long history of use in traditional Chinese and Ayurvedic medicine. Despite this, researchers have only recently begun exploring the potential applications of neem oil in Western medicine.
Neem oil contains fatty acids, antioxidants, and antimicrobial compounds, and these can benefit the skin in a range of ways. Research shows that these compounds may help fight skin infections, promote wound healing, and combat signs of skin aging.
To use neem oil as part of a skincare routine, mix it with water or a carrier oil. It is important to do a patch test when trying neem oil for the first time.
Neem oil is available for purchase online.
Some people experience a reaction to neem oil, such as contact dermatitis. If this occurs, stop using the oil.
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How to treat female hair loss
Female hair loss can happen for a variety of reasons, such as genetics, changing hormone levels, or as part of the natural aging process.
There are various treatment options for female hair loss, including topical medications, such as Rogaine. Other options include light therapy, hormone therapy, or in some cases, hair transplants.
Eating a nutritious diet and maintaining a healthy lifestyle can also help keep hair healthy.
Share on PinterestThe Food and Drug Administration (FDA) approves Minoxidil to treat hair loss. Sold under the name Rogaine, as well as other generic brands, people can purchase topical Minoxidil over-the-counter (OTC). Minoxidil is safe for both males and females, and people report a high satisfaction rate after using it.
Minoxidil stimulates growth in the hairs and may increase their growth cycle. It can cause hairs to thicken and reduce the appearance of patchiness or a widening hair parting.
Minoxidil treatments are available in two concentrations: the 2% solution requires twice daily application for the best results, while the 5% solution or foam requires daily use.
While the instinct may be to choose the stronger solution, this is not necessary. Studies posted to the International Journal of Women’s Dermatology and the Journal of the American Academy of Dermatology found that 2% minoxidil was effective for females with androgenetic alopecia, or pattern baldness.
If a person finds success with minoxidil, they should continue using it indefinitely. When a person stops using minoxidil, the hairs that depended on the drug to grow will likely fall out within 6 months.
Side effects from minoxidil are uncommon and generally mild. Some females may experience irritation or an allergic reaction to ingredients in the product, such as alcohol or propylene glycol. Switching formulas or trying different brands may alleviate symptoms.
Some females may also experience increased hair loss at first when using minoxidil. This typically stops after the first few months of treatment as the hair gets stronger.
Additionally, misapplying minoxidil or applying it to the forehead or too much of the neck may cause hair growth in these areas. Only apply minoxidil to the scalp to avoid these side effects.
Low-level light therapy may not be sufficient treatment for hair loss on its own, but it may act to amplify the effects of other hair loss treatments, such as minoxidil.
A trial posted to the Indian Journal of Dermatology, Venereology, and Leprology found that compared to control groups, adding low light therapy to regular 5% minoxidil treatment for androgenetic alopecia helped improve the recovery of the hairs and the participants’ overall satisfaction with their treatment.
Researchers will need to carry out further research to help strengthen these results.
The drug ketoconazole may help treat hair loss in some cases, such as androgenetic alopecia, where inflammation of the hair follicles often contributes to hair loss.
One review posted to the International Journal of Women’s Dermatology noted that topical ketoconazole might help reduce inflammation and improve the strength and look of the hair.
Ketoconazole is available as a shampoo. Nizoral is the best known brand and is available for purchase over the counter and online. Nizoral contains a low concentration of ketoconazole, but stronger concentrations will require a prescription from a doctor.
Some females may also respond to corticosteroid injections. Doctors use this treatment only when necessary, for conditions such as alopecia areata. Alopecia areata results in a person’s hair falling out in random patches.
According to the National Alopecia Areata Foundation, injecting corticosteroids directly into the hairless patch may encourage new hair growth. However, this not may prevent other hair from falling out. Topical corticosteroids, which are available as creams, lotions, and other preparations, may also reduce hair loss.
Early evidence suggests that injections of platelet-rich plasma may also help reduce hair loss. A plasma-rich injection involves a doctor drawing the person’s blood, separating the platelet-rich plasma from the blood, and injecting it back into the scalp at the affected areas. This helps speed up tissue repair.
A recent review posted to Aesthetic Plastic Surgery noted that most studies suggest that this therapy reduces hair loss, increases hair density, and increases the diameter of each hair.
However, because most studies up until now have been very small, the review calls for more research using platelet-rich plasma for androgenic alopecia.
If hormone imbalances due to menopause, for example, cause hair loss, doctors may recommend some form of hormone therapy to correct them.
Some possible treatments include birth control pills and hormone replacement therapy for either estrogen or progesterone.
Other possibilities include antiandrogen medications, such as spironolactone. Androgens are hormones that can speed up hair loss in some women, particularly those with polycystic ovary syndrome, who typically produce more androgens.
Antiandrogens can stop the production of androgens and prevent hair loss. These medications may cause side effects, so always talk to the doctor about what to expect and whether antiandrogens are suitable.
In some cases where the person does not respond well to treatments, doctors may recommend hair transplantation. This involves taking small pieces of the scalp and adding them to the areas of baldness to increase the hair in the area naturally. Hair transplant therapy can be more costly than other treatments and is not suitable for everybody.
Some minor hair loss may happen due to clogged pores on the scalp. Using medicated shampoos designed to clear the pores from dead skin cells may help promote healthy hair. This may help clear minor signs of hair loss.
Massaging the scalp may increase circulation in the area and help clean away dandruff. This helps keep the scalp and hair follicles healthy.
The most common cause of hair loss in females is androgenetic alopecia, which has strong links to genetics and can run in families.
According to the International Journal of Women’s Dermatology, hair loss from androgenetic alopecia may start at a young age. Some females may begin losing their hair in their late teens or early twenties, though most females may not begin to lose their hair until their 40s or older.
Both males and females can develop androgenetic alopecia, but they experience it in different ways. Males tend to experience a receding hairline or bald spot on top of their head, while females tend to present different symptoms.
In females, the parting at the center of the hair often becomes more defined or wider. Females may also experience thinning hairs, and hair may appear more thin or patchy overall.
These symptoms are due to a thinning of each hair strand. The hairs also have a shorter life cycle, and hairs only stay on the head for a shorter period.
Female pattern hair loss is a progressive condition. Females may only notice a slightly wider parting in their hair at first, but as symptoms progress, this can become more noticeable.
Other forms of alopecia, such as alopecia areata, may cause one or more patches of complete baldness.
Other factors may play a role in hair loss, such as inflammatory conditions that affect the scalp and hormone imbalances. Doctors may want to investigate these possible causes if the person does not respond to typical treatments.
While losing hair at a young age may be concerning, hair loss is a reality for many people as they age. One study posted to the Indian Journal of Dermatology, Venereology, and Leprology noted that up to 75% of females would experience hair loss from androgenetic alopecia by the time they are 65 years old.
While many females look for ways to treat hair loss while they are young, at some point, most people accept hair loss as a natural part of the aging process.
Some people may choose to wear head garments or wigs as a workaround to hair loss. Others work with their aging hair by wearing a shorter haircut that may make thin hair less apparent.
Hair loss can affect both males and females. Hair loss in females may have a range of causes, though the most common is androgenetic alopecia.
There are a variety of treatments for hair loss for females, including OTC hair loss treatments, which are generally effective. Anyone experiencing hair loss should visit their doctor who can diagnose any underlying factors.
If a doctor suspects there is another underlying cause or the person does not respond well to OTC treatments, they will look into other treatment options.
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